[Objectives]To establish the quality standard of hospital preparation Jiedu Shengxue granules.[Methods]Scleromitrion diffusum and Prunella vulgaris in Jiedu Shengxue granules were qualitatively identified by thin laye...[Objectives]To establish the quality standard of hospital preparation Jiedu Shengxue granules.[Methods]Scleromitrion diffusum and Prunella vulgaris in Jiedu Shengxue granules were qualitatively identified by thin layer chromatography(TLC).A high performance liquid chromatography(HPLC)was established to determine the content of notoginsenoside R1 in the granule.[Results]The traditional Chinese medicinal materials in Jiedu Shengxue granules could be identified by TLC,and the characteristic spots were stable and clear.Notoginsenoside R1 had a good linear relationship in the range of 10.45-104.5μg/mL,with an average recovery of 98.52%and RSD=2.36%.[Conclusions]TLC and HPLC,as the quality control methods of Jiedu Shengxue granules,have high accuracy and good repeatability,which lays a foundation for the quality control of this mixture.展开更多
Panax notoginseng is an ancient Chinese medicinal plant that has great clinical value in regulating cardiovascular disease in China.As a single component of panax notoginosides,notoginsenoside R1(NGR1)belongs to the p...Panax notoginseng is an ancient Chinese medicinal plant that has great clinical value in regulating cardiovascular disease in China.As a single component of panax notoginosides,notoginsenoside R1(NGR1)belongs to the panaxatriol group.Many reports have demonstrated that NGR1 exerts multiple pharmacological effects in ischemic stroke,myocardial infarction,acute renal injury,and intestinal injury.Here,we outline the available reports on the pharmacological effects of NGR1 in ischemia-reperfusion(I/R)injury.We also discuss the chemistry,composition and molecular mechanism underlying the anti-I/R injury effects of NGR1.NGR1 had significant effects on reducing cerebral infarct size and neurological deficits in cerebral I/R injury,ameliorating the impaired mitochondrial morphology in myocardial I/R injury,decreasing kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin in renal I/R injury and attenuating jejunal mucosal epithelium injury in intestinal I/R injury.The various organ anti-I/R injury effects of NGR1 are mainly through the suppression of oxidative stress,apoptosis,inflammation,endoplasmic reticulum stress and promotion of angiogenesis and neurogenesis.These findings provide a reference basis for future research of NGR1 on I/R injury.展开更多
基金Supported by Guangxi Hospital Preparation Quality Improvement Project of Zhuang and Yao Ethnic Medicines(GZZJ202015)Key Research and Development Plan of Guangxi Department of Science and Technology(GK AB21196057)+3 种基金High-level TCM Key Discipline(Zhuang Pharmacology)Construction Project of State Administration of Traditional Chinese Medicine(GZYYRJH[2022]226)Guangxi TCM Multidisciplinary Innovative Team Project(GZKJ2309)"Qingmiao Engineering"Talent Cultivation Project of Guangxi International Zhuang Medical Hospital(2022001)"High-level Talent Cultivation and Innovation Team"Project of Guangxi University of Chinese Medicine(2022A008).
文摘[Objectives]To establish the quality standard of hospital preparation Jiedu Shengxue granules.[Methods]Scleromitrion diffusum and Prunella vulgaris in Jiedu Shengxue granules were qualitatively identified by thin layer chromatography(TLC).A high performance liquid chromatography(HPLC)was established to determine the content of notoginsenoside R1 in the granule.[Results]The traditional Chinese medicinal materials in Jiedu Shengxue granules could be identified by TLC,and the characteristic spots were stable and clear.Notoginsenoside R1 had a good linear relationship in the range of 10.45-104.5μg/mL,with an average recovery of 98.52%and RSD=2.36%.[Conclusions]TLC and HPLC,as the quality control methods of Jiedu Shengxue granules,have high accuracy and good repeatability,which lays a foundation for the quality control of this mixture.
文摘Panax notoginseng is an ancient Chinese medicinal plant that has great clinical value in regulating cardiovascular disease in China.As a single component of panax notoginosides,notoginsenoside R1(NGR1)belongs to the panaxatriol group.Many reports have demonstrated that NGR1 exerts multiple pharmacological effects in ischemic stroke,myocardial infarction,acute renal injury,and intestinal injury.Here,we outline the available reports on the pharmacological effects of NGR1 in ischemia-reperfusion(I/R)injury.We also discuss the chemistry,composition and molecular mechanism underlying the anti-I/R injury effects of NGR1.NGR1 had significant effects on reducing cerebral infarct size and neurological deficits in cerebral I/R injury,ameliorating the impaired mitochondrial morphology in myocardial I/R injury,decreasing kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin in renal I/R injury and attenuating jejunal mucosal epithelium injury in intestinal I/R injury.The various organ anti-I/R injury effects of NGR1 are mainly through the suppression of oxidative stress,apoptosis,inflammation,endoplasmic reticulum stress and promotion of angiogenesis and neurogenesis.These findings provide a reference basis for future research of NGR1 on I/R injury.
