目的 评价脱氧核苷酸钠治疗初治继发性肺结核临床疗效及安全性。方法 94例初治继发性肺结核患者随机分为对照组47例与试验组47例,对照组给予标准化疗方案,3HRES/3HRE;试验组在对照组的基础上给予脱氧核苷酸钠注射液150 m L＋5%葡萄糖注...目的 评价脱氧核苷酸钠治疗初治继发性肺结核临床疗效及安全性。方法 94例初治继发性肺结核患者随机分为对照组47例与试验组47例,对照组给予标准化疗方案,3HRES/3HRE;试验组在对照组的基础上给予脱氧核苷酸钠注射液150 m L＋5%葡萄糖注射液体250 m L静脉滴注,1次/d。均以28 d为1个周期,连续治疗1周期。比较2组临床疗效、治疗前后血清糖链抗原125（CA125）、糖链抗原199（CA199）、肝肾功能以及不良反应发生情况。结果 治疗后,对照组临床总有效率为78.72%,显著低于试验组的93.62%（P〈0.05）。2组治疗后血清CA125、CA199水平均显著降低,且试验组显著小于对照组（P〈0.05）;血清ALT、AST、Cr及BUN浓度水平与治疗前相比,差异无统计学意义。对照组不良反应发生率为6.38%,试验组为10.64%,差异无统计学意义。结论 脱氧核苷酸钠治疗初治继发性肺结核的临床疗效显著,安全性高。展开更多
Antigenic determinants expressed on the bacterial cell surface are of importance in the serological characterization and microbiological diagnosis. The bacterial strains carrying these identical or similar antigenic e...Antigenic determinants expressed on the bacterial cell surface are of importance in the serological characterization and microbiological diagnosis. The bacterial strains carrying these identical or similar antigenic epitopes might react with antibodies produced against other strains. In this study, strong immunogenicity and antigenic cross reactivity were demonstrated among V. cholerae O1, S. flexnerii 2a and H. influenzae b surface components. The enzyme linked immunosorbent assay （ELISA） results were supported by Western blot analysis, where at least 20 antigenic bands, were obtained in each of the reactions, when the surface components were reacted with the homologous antisera. The indirect ELISA results also demonstrated high degree of antigenic relatedness between the surface components of these species, where each surface component was reacted with the heterologous antisera. Western blot analysis also revealed cross reactions between the surface components suggesting common distribution of antigens/epitopes in these bacterial species. This study, thus, gave a clear idea of the level of antigenic sharing and variations among the pathogenic V. cholerae O1, S. flexneri 2a and H. influenzae b strains, which in future, may help in selecting a proper candidate for vaccines and immunodiagnostics development.展开更多
特征提取和健康状态的辨识是复杂系统健康状态评估中的关键问题。提出一种新的健康状态评估方法,该方法分为3个步骤:首先,采用经验模态分解(empirical model decomposition,EMD)和奇异值分解(singular value decomposition,SVD)来提取...特征提取和健康状态的辨识是复杂系统健康状态评估中的关键问题。提出一种新的健康状态评估方法,该方法分为3个步骤:首先,采用经验模态分解(empirical model decomposition,EMD)和奇异值分解(singular value decomposition,SVD)来提取振动信号的特征变量。然后,运用马田系统(Mahalanobis-Taguchi system,MTS)构造马氏空间,并对其进行优化,从而降低特征变量的维度。最后,提出了一种健康度(health index,HI)的概念,并且用来对复杂系统健康问题进行评估。该方法成功地应用在轴承的健康状态评估中。展开更多
文摘目的 评价脱氧核苷酸钠治疗初治继发性肺结核临床疗效及安全性。方法 94例初治继发性肺结核患者随机分为对照组47例与试验组47例,对照组给予标准化疗方案,3HRES/3HRE;试验组在对照组的基础上给予脱氧核苷酸钠注射液150 m L＋5%葡萄糖注射液体250 m L静脉滴注,1次/d。均以28 d为1个周期,连续治疗1周期。比较2组临床疗效、治疗前后血清糖链抗原125（CA125）、糖链抗原199（CA199）、肝肾功能以及不良反应发生情况。结果 治疗后,对照组临床总有效率为78.72%,显著低于试验组的93.62%（P〈0.05）。2组治疗后血清CA125、CA199水平均显著降低,且试验组显著小于对照组（P〈0.05）;血清ALT、AST、Cr及BUN浓度水平与治疗前相比,差异无统计学意义。对照组不良反应发生率为6.38%,试验组为10.64%,差异无统计学意义。结论 脱氧核苷酸钠治疗初治继发性肺结核的临床疗效显著,安全性高。
文摘Antigenic determinants expressed on the bacterial cell surface are of importance in the serological characterization and microbiological diagnosis. The bacterial strains carrying these identical or similar antigenic epitopes might react with antibodies produced against other strains. In this study, strong immunogenicity and antigenic cross reactivity were demonstrated among V. cholerae O1, S. flexnerii 2a and H. influenzae b surface components. The enzyme linked immunosorbent assay （ELISA） results were supported by Western blot analysis, where at least 20 antigenic bands, were obtained in each of the reactions, when the surface components were reacted with the homologous antisera. The indirect ELISA results also demonstrated high degree of antigenic relatedness between the surface components of these species, where each surface component was reacted with the heterologous antisera. Western blot analysis also revealed cross reactions between the surface components suggesting common distribution of antigens/epitopes in these bacterial species. This study, thus, gave a clear idea of the level of antigenic sharing and variations among the pathogenic V. cholerae O1, S. flexneri 2a and H. influenzae b strains, which in future, may help in selecting a proper candidate for vaccines and immunodiagnostics development.
文摘特征提取和健康状态的辨识是复杂系统健康状态评估中的关键问题。提出一种新的健康状态评估方法,该方法分为3个步骤:首先,采用经验模态分解(empirical model decomposition,EMD)和奇异值分解(singular value decomposition,SVD)来提取振动信号的特征变量。然后,运用马田系统(Mahalanobis-Taguchi system,MTS)构造马氏空间,并对其进行优化,从而降低特征变量的维度。最后,提出了一种健康度(health index,HI)的概念,并且用来对复杂系统健康问题进行评估。该方法成功地应用在轴承的健康状态评估中。
