In dentistry,orthodontic root resorption is a long-lasting issue with no effective treatment strategy,and its mechanisms,especially those related to senescent cells,remain largely unknown.Here,we used an orthodontic i...In dentistry,orthodontic root resorption is a long-lasting issue with no effective treatment strategy,and its mechanisms,especially those related to senescent cells,remain largely unknown.Here,we used an orthodontic intrusion tooth movement model with an L-loop in rats to demonstrate that mechanical stress-induced senescent cells aggravate apical root resorption,which was prevented by administering senolytics(a dasatinib and quercetin cocktail).展开更多
The coordination compounds,{Cu[CH<sub>3</sub>C<sub>6</sub>H<sub>4</sub>N（CH<sub>2</sub>COO）<sub>2</sub>]}.2H<sub>2</sub>O and{Cu[CH<sub>3...The coordination compounds,{Cu[CH<sub>3</sub>C<sub>6</sub>H<sub>4</sub>N（CH<sub>2</sub>COO）<sub>2</sub>]}.2H<sub>2</sub>O and{Cu[CH<sub>3</sub>OC<sub>6</sub>H<sub>4</sub>N（CH<sub>2</sub>COO）<sub>2</sub>]}.2H<sub>2</sub>O,have been prepared and its crystal struc-tures determined.The final discrepancy factors are R=0.052,R<sub>w</sub>=0.061 for（I）and R=0.052,R<sub>w</sub>=0.039 for（Ⅱ）.The geometry of the coordination poly-hedron with Cu（Ⅱ）is a distorted tetragonal pyramid for（Ⅰ）and an unsym-metrical and extended tetragonal bipyramid for（Ⅱ）,respectively.The re-sults of EHMO calculations indicate that the ligand mainly provided thefield with very few of its electrons being coordinated to the central atom.展开更多
目的本研究目的在于评估Ortho One PROMT评分在预测半月板撕裂可修复性方面的准确性,检验其是否具备解决术前半月板手术方式预测困难的能力。方法纳入本院2019年3月至2019年12月因半月板损伤而接受关节镜下手术者55膝58侧半月板。本研...目的本研究目的在于评估Ortho One PROMT评分在预测半月板撕裂可修复性方面的准确性,检验其是否具备解决术前半月板手术方式预测困难的能力。方法纳入本院2019年3月至2019年12月因半月板损伤而接受关节镜下手术者55膝58侧半月板。本研究分为两个部分。第一部分:评分过程由两位医生按Ortho One PROMT评分细则分别对半月板损伤者进行独立评分,并根据得分预测半月板手术术式。第二部分:将两位评分医生预测的半月板手术术式分别与手术医生的实际手术术式进行一致性比较,最终评价Ortho One PROMT评分在预测半月板撕裂可修复性方面的准确性、敏感度及特异度。结果评分医生预测半月板修复的平均正确率为86.9%,平均敏感度为86.9%,平均特异度为87.5%,平均阳性预测值92.9%,平均阴性预测值为77.9%;预测半月板切除的平均正确率为87.5%,平均敏感度为87.5%,平均特异度为86.9%,平均阳性预测值为77.9%,平均阴性预测值为92.9%。两位评分医生的预测结果与手术医生的实际术式高度一致(k=0.78,k=0.67)。结论Ortho One PROMT评分预测半月板撕裂可修复性不仅简便、可操作性强,而且具有良好的准确性、敏感度和特异度,能够有效解决当前术前半月板手术方式预测困难的问题,具有一定的临床应用推广价值。展开更多
Ternary complexes of terbium with ortho (and para) aminobenzoic acid and 1.10 phenanthroline were introduced into silica gel by the sol-gel method. The luminescence behavior of the solid-state samples was studied duri...Ternary complexes of terbium with ortho (and para) aminobenzoic acid and 1.10 phenanthroline were introduced into silica gel by the sol-gel method. The luminescence behavior of the solid-state samples was studied during the sol-gel aging process by means of emission, excitation spectra, lifetimes and quantum efficiencies.展开更多
Neimadian-point is a newly-found acupointwith a good analgesic effect. 306 orthopedic op-erations on extremities were underNeimadian-point acupuncture anesthesia withgood results. 198 cases with complete clinicalmate...Neimadian-point is a newly-found acupointwith a good analgesic effect. 306 orthopedic op-erations on extremities were underNeimadian-point acupuncture anesthesia withgood results. 198 cases with complete clinicalmaterials were selected and analyzed in the pa-per.展开更多
The mesomorphie properties of title complexes are investigated by means of DSC and polarizing microscopy. The mesophase temperature ranges of complexes are wider than that of corresponding organic ligands. The bridgin...The mesomorphie properties of title complexes are investigated by means of DSC and polarizing microscopy. The mesophase temperature ranges of complexes are wider than that of corresponding organic ligands. The bridging groups of the complexes have profoand effects on the mesomorphic behavior, When the bridging groups are opticallhy active. the compleve show chiral展开更多
The Ortho-SUV frame,a novel external fixator,can effectively treat limb deformities and fractures.Its kinematics is used when it is necessary to achieve bone movements with high precision.In this work,the kinematics m...The Ortho-SUV frame,a novel external fixator,can effectively treat limb deformities and fractures.Its kinematics is used when it is necessary to achieve bone movements with high precision.In this work,the kinematics model of the Ortho-SUV frame is established by six pose parameters,and its forward and inverse solutions are given.There is no need to solve nonlinear high-coupling equations with trigonometric functions in this solution method due to its special structure.By numerical examples and simulated orthopedic experiment of tibial fracture,the correctness and accuracy of the kinematics model and its solutions are verified.Besides,on the basis of kinematics analysis,the position workspace and orientation workspace of the Ortho-SUV frame are simulated in Matlab,which can help surgeons choose suitable device dimensions.The kinematics analysis provides a theoretical basis for the Ortho-SUV frame to be used in orthopedic treatment.展开更多
Ointment-like poly(ortho esters) were synthesized from the reaction of 3, 9-bis (methylene)-2, 4, 8, 10-tetraoxaspiro [5. 5]undecane with PEG -400, N, N-bis (2-hydroxyethyl)-n-hexadecylamine and N,N-bis(2-hydroxyethyl...Ointment-like poly(ortho esters) were synthesized from the reaction of 3, 9-bis (methylene)-2, 4, 8, 10-tetraoxaspiro [5. 5]undecane with PEG -400, N, N-bis (2-hydroxyethyl)-n-hexadecylamine and N,N-bis(2-hydroxyethyl) palmitamide respectively. The influence of the catalyst on the intrinsic viscosity of polymers was also展开更多
TPGS approved by FDA can be used as a P-gp inhibitor to effectively reverse multi-drug resistance(MDR)and as an anticancer agent for synergistic antitumor effects.However,the comparatively high critical micelle concen...TPGS approved by FDA can be used as a P-gp inhibitor to effectively reverse multi-drug resistance(MDR)and as an anticancer agent for synergistic antitumor effects.However,the comparatively high critical micelle concentration(CMC),low drug loading(DL)and poor tumor target limit its further clinical application.To overcome these drawbacks,the pH-sensitive star-shaped TPGS copolymers were successfully constructed via using pentaerythritol as the initial materials,ortho esters as the pH-triggered linkages and TPGS active-ester as the terminated MDR material.The amphiphilic star-shaped TPGS copolymers could self-assemble into free and doxorubicin(DOX)-loaded micelles at neutral aqueous solutions.The micelles exhibited the lower CMC(8.2×10^(−5) mg/ml),higher DL(10.8%)and long-term storage and circulation stability,and showed enhanced cellular uptake,apoptosis,cytotoxicity,and growth inhibition for in vitro MCF-7/ADR and/or MCF-7/ADR multicellular spheroids and in vivo MCF-7/ADR tumors via efficiently targeted drug release at tumoral intracellular pH(5.0),MDR reversal of TPGS,and synergistic effect of DOX and TPGS.Therefore,the pH-sensitive micelles self-assembled from star-shaped TPGS copolymers with ortho ester linkages are potentially useful to clinically transform for enhanced MDR cancer treatment.展开更多
基金supported by JST,CREST Grant Number JPMJCR22L5,Japan。
文摘In dentistry,orthodontic root resorption is a long-lasting issue with no effective treatment strategy,and its mechanisms,especially those related to senescent cells,remain largely unknown.Here,we used an orthodontic intrusion tooth movement model with an L-loop in rats to demonstrate that mechanical stress-induced senescent cells aggravate apical root resorption,which was prevented by administering senolytics(a dasatinib and quercetin cocktail).
基金Subject supported by the Doctoral Foundation of National Education Commission of China
文摘The coordination compounds,{Cu[CH<sub>3</sub>C<sub>6</sub>H<sub>4</sub>N（CH<sub>2</sub>COO）<sub>2</sub>]}.2H<sub>2</sub>O and{Cu[CH<sub>3</sub>OC<sub>6</sub>H<sub>4</sub>N（CH<sub>2</sub>COO）<sub>2</sub>]}.2H<sub>2</sub>O,have been prepared and its crystal struc-tures determined.The final discrepancy factors are R=0.052,R<sub>w</sub>=0.061 for（I）and R=0.052,R<sub>w</sub>=0.039 for（Ⅱ）.The geometry of the coordination poly-hedron with Cu（Ⅱ）is a distorted tetragonal pyramid for（Ⅰ）and an unsym-metrical and extended tetragonal bipyramid for（Ⅱ）,respectively.The re-sults of EHMO calculations indicate that the ligand mainly provided thefield with very few of its electrons being coordinated to the central atom.
文摘目的本研究目的在于评估Ortho One PROMT评分在预测半月板撕裂可修复性方面的准确性,检验其是否具备解决术前半月板手术方式预测困难的能力。方法纳入本院2019年3月至2019年12月因半月板损伤而接受关节镜下手术者55膝58侧半月板。本研究分为两个部分。第一部分:评分过程由两位医生按Ortho One PROMT评分细则分别对半月板损伤者进行独立评分,并根据得分预测半月板手术术式。第二部分:将两位评分医生预测的半月板手术术式分别与手术医生的实际手术术式进行一致性比较,最终评价Ortho One PROMT评分在预测半月板撕裂可修复性方面的准确性、敏感度及特异度。结果评分医生预测半月板修复的平均正确率为86.9%,平均敏感度为86.9%,平均特异度为87.5%,平均阳性预测值92.9%,平均阴性预测值为77.9%;预测半月板切除的平均正确率为87.5%,平均敏感度为87.5%,平均特异度为86.9%,平均阳性预测值为77.9%,平均阴性预测值为92.9%。两位评分医生的预测结果与手术医生的实际术式高度一致(k=0.78,k=0.67)。结论Ortho One PROMT评分预测半月板撕裂可修复性不仅简便、可操作性强,而且具有良好的准确性、敏感度和特异度,能够有效解决当前术前半月板手术方式预测困难的问题,具有一定的临床应用推广价值。
文摘Ternary complexes of terbium with ortho (and para) aminobenzoic acid and 1.10 phenanthroline were introduced into silica gel by the sol-gel method. The luminescence behavior of the solid-state samples was studied during the sol-gel aging process by means of emission, excitation spectra, lifetimes and quantum efficiencies.
文摘Neimadian-point is a newly-found acupointwith a good analgesic effect. 306 orthopedic op-erations on extremities were underNeimadian-point acupuncture anesthesia withgood results. 198 cases with complete clinicalmaterials were selected and analyzed in the pa-per.
文摘The mesomorphie properties of title complexes are investigated by means of DSC and polarizing microscopy. The mesophase temperature ranges of complexes are wider than that of corresponding organic ligands. The bridging groups of the complexes have profoand effects on the mesomorphic behavior, When the bridging groups are opticallhy active. the compleve show chiral
基金National Key Research & Development Program of China(No.2017YFB1302901)
文摘The Ortho-SUV frame,a novel external fixator,can effectively treat limb deformities and fractures.Its kinematics is used when it is necessary to achieve bone movements with high precision.In this work,the kinematics model of the Ortho-SUV frame is established by six pose parameters,and its forward and inverse solutions are given.There is no need to solve nonlinear high-coupling equations with trigonometric functions in this solution method due to its special structure.By numerical examples and simulated orthopedic experiment of tibial fracture,the correctness and accuracy of the kinematics model and its solutions are verified.Besides,on the basis of kinematics analysis,the position workspace and orientation workspace of the Ortho-SUV frame are simulated in Matlab,which can help surgeons choose suitable device dimensions.The kinematics analysis provides a theoretical basis for the Ortho-SUV frame to be used in orthopedic treatment.
文摘Ointment-like poly(ortho esters) were synthesized from the reaction of 3, 9-bis (methylene)-2, 4, 8, 10-tetraoxaspiro [5. 5]undecane with PEG -400, N, N-bis (2-hydroxyethyl)-n-hexadecylamine and N,N-bis(2-hydroxyethyl) palmitamide respectively. The influence of the catalyst on the intrinsic viscosity of polymers was also
基金This work is financially supported by the National Natural Science Foundation of China(No.51803001)the Research Foundation of Education Department of Anhui Province of China(No.KJ2018ZD003 and KJ2018A0006)the Academic and Technology Introduction Project of Anhui University(AU02303203).
文摘TPGS approved by FDA can be used as a P-gp inhibitor to effectively reverse multi-drug resistance(MDR)and as an anticancer agent for synergistic antitumor effects.However,the comparatively high critical micelle concentration(CMC),low drug loading(DL)and poor tumor target limit its further clinical application.To overcome these drawbacks,the pH-sensitive star-shaped TPGS copolymers were successfully constructed via using pentaerythritol as the initial materials,ortho esters as the pH-triggered linkages and TPGS active-ester as the terminated MDR material.The amphiphilic star-shaped TPGS copolymers could self-assemble into free and doxorubicin(DOX)-loaded micelles at neutral aqueous solutions.The micelles exhibited the lower CMC(8.2×10^(−5) mg/ml),higher DL(10.8%)and long-term storage and circulation stability,and showed enhanced cellular uptake,apoptosis,cytotoxicity,and growth inhibition for in vitro MCF-7/ADR and/or MCF-7/ADR multicellular spheroids and in vivo MCF-7/ADR tumors via efficiently targeted drug release at tumoral intracellular pH(5.0),MDR reversal of TPGS,and synergistic effect of DOX and TPGS.Therefore,the pH-sensitive micelles self-assembled from star-shaped TPGS copolymers with ortho ester linkages are potentially useful to clinically transform for enhanced MDR cancer treatment.
