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从Peoples看罗尔斯对国家是理性行为体的批判
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作者 刘贺青 《华中科技大学学报(社会科学版)》 CSSCI 2008年第3期18-22,共5页
大多数国际关系理论流派都把国家作为理性的行为体,然而罗尔斯在其晚年的著作《万民法》中却拒绝把国家作为国际关系分析的单元,而把人民(Peoples)作为国际关系的行为主体,因为后者既是理性的、又是合理性的。但是从罗尔斯对世界国家的... 大多数国际关系理论流派都把国家作为理性的行为体,然而罗尔斯在其晚年的著作《万民法》中却拒绝把国家作为国际关系分析的单元,而把人民(Peoples)作为国际关系的行为主体,因为后者既是理性的、又是合理性的。但是从罗尔斯对世界国家的分类以及人民同非人民社会的关系来看,人民和国家之间的差别并不大,这说明如何体现出国家的合理性仍然是一个难题。 展开更多
关键词 peoples 罗尔斯 国家 理性 合理性
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Epidemic Hemorrhagic Fever in Hubei Frovince,The Peoples Repulic of China: A Clinical and Serological Study
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作者 MyronS.Cohenl Jordi Casals +7 位作者 G.D.Hsiung Hsi-enKwei Chien-chingChin Hsin-chenGe Chin-minHsiang PyundW.Lee ClarenceJ.Gibbs D.CarletonGajdusek 《武汉大学学报(医学版)》 CAS 1981年第1期11-27,共17页
Between July 1975 and April 1980, 71 patients were admitted to the 2ndAttached Hospital of Hubei Provincial Medical College in Wuchang withthe diagnosis of Epidemic Hemorrhagic Fever (EHF). The clinical courseamong th... Between July 1975 and April 1980, 71 patients were admitted to the 2ndAttached Hospital of Hubei Provincial Medical College in Wuchang withthe diagnosis of Epidemic Hemorrhagic Fever (EHF). The clinical courseamong these patients was similar to that described for patients with KoreanHemorrhagic Fever, Nephropathica Epidemica of Scandanavia and Hemor-rhagic Fever with Renal Syndrome of the U.S.S.R. The overall mortalitywas 11.2%. Sera obtaincd from some of these patients as well as frompatients admitted to the First Attached Hospital of Hubei Provincial Me-dical College were tested against an antigen associated with Korean He-morrhagic Fever and showed exceedingly high antibody titers. We concludethat EHF in Centfal China represents the same disease process as KoreanHemorrhagic Fever. 展开更多
关键词 In EHF Epidemic Hemorrhagic Fever in Hubei Frovince The peoples Repulic of China A Clinical and Serological Study
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Resource Extraction in the Territories of Indigenous Peoples: The Quest for Cultural Rights
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作者 Apparao Thamminaina 《Cultural and Religious Studies》 2017年第4期196-204,共9页
The rapid industrial growth amidst the resource-rich habitats of indigenous people results in an unprecedented and inescapable influence of the other. Most often, such interactions are exploitative for the indigenous ... The rapid industrial growth amidst the resource-rich habitats of indigenous people results in an unprecedented and inescapable influence of the other. Most often, such interactions are exploitative for the indigenous communities. Besides this, the development induced displacement escalate the fear of loss of "cultural practices" among the indigenous peoples. The "official" argument often confines to the fact that the people are displaced with better facilities to a place few kilometres away from the original habitat. Such an argument forces to establish harmony between development and the displaced and ignores cultural rights and customary boundaries. In such cases, indigenous peoples negotiate for the protection of cultural rights with the corporate establishments and statutory bodies using a variety of means. This idea is explored in the context of the resistance movement organized by the indigenous Kondhs of Niyamgiri region of Odisha, India. 展开更多
关键词 indigenous peoples cultural rights IDENTITY DEVELOPMENT Kondhs
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Historical Course Follows Climate Change: Patterns of the Northern Hemisphere — From Peoples’ Migration until the Industrial Revolution (3<sup>rd</sup>-18<sup>th</sup>Century)
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作者 Werner Schneider Elias Salameh 《Open Journal of Geology》 2018年第13期1167-1194,共28页
This paper relates to the statement that the so-called “Little Ice Age” (RCC 6: 1.350-1.800 A.D.) represents—besides the 8k-Event (8.200-8.000 yr cal. B.P.)—the fastest and strongest onset in Holocene History [1].... This paper relates to the statement that the so-called “Little Ice Age” (RCC 6: 1.350-1.800 A.D.) represents—besides the 8k-Event (8.200-8.000 yr cal. B.P.)—the fastest and strongest onset in Holocene History [1]. Its intention focuses on the correlation of interplaying natural processes (i.e. solar energy variation, aerosols, oceanic currents, volcanism as part of plate tectonics, heat flow) with social/political evidence through the time-span of Peoples’ Migration until Industrial Revolution (3rd-18th Century). The time-span comprises the cool/wet/respectively dry climate phase of the P.M. (260-550), a Climate Optimum (600-1.100 A.D.) owning a final Thermal Maximum (1.100-1.260 A.D.) and the “little Ice Age” (1.350-1.800 A.D.), the latter intercalated by the Sp&#246;rer Minimum (1.460-1.550 A.D.) and the Maunder Minimum (1.650-1.720 A.D.). Thereby, an average temperature difference of 1.0&#176;C - 2.0&#176;C seems sufficient for incising climatic/cultural consequences [2]. It has become obvious that a Climate Optimum primarily provides constructive life conditions;however with a problematic final as the following “Effect-Chain” tells: balanced agricultural/cultural population growth → rich harvests → satisfying nourishment → health, encouragement → overpopulation under favorable materialistic conditions → increasing stress → lack of food, high prices → revolts → migration. In contrast, cool/wet/resp. dry conditions originate destructive/depressive conditions (see Peoples’ Migration) which initiate the following “Effect Chain”: bad agricultural conditions → poor/no harvesting → famine → disease, growing death rate → social, political revolts, wars → human cruelties with psychic/religious background (inquisition, witch-combustion → general chaos (30 yr-war) → death, migration (maritime endeavors, colonization). Furthermore, it should be stressed that volcanic aerosols play besides the solar influx variation—an important role on climate/cultural change [3]. However, the effects of oceanic currents’ heat flow of Mid-Oceanic Ridges and Hot Spots, as well as Earth-Magnetism and Sun/Earth Geometry are poorly understood in this context (Example: Iceland as hot spot situated on the Mid-Atlantic Ridge having been working since 40 Ma). The Chapter-introducing citations play a challenging role in regard to Science Criticism and touch the so-called 95% Confidence line (accepted realm of causal interrelation and according recommendation to Society [4]). 展开更多
关键词 Little Ice Age Climate-Change Social/Political Concern Psychic/Spiritual Implication VOLCANISM Plate Tectonics peoples MIGRATION Northern HEMISPHERE Natural/Cultural Effect-Chains Science Criticism
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“PEOPLES ON”理念在科技馆展项设计应用中的理论探索
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作者 李慧 《美与时代(城市)》 2016年第12期91-92,共2页
科技馆的核心是"教育","教育"本身是严肃的,但是"教育"的体验过程则不然。当代科技馆旨在通过丰富有趣的展教方式来传播信息,因此在科技馆的设计当中,展示形式越来越丰富,也越来越强调观者的参与和互动,... 科技馆的核心是"教育","教育"本身是严肃的,但是"教育"的体验过程则不然。当代科技馆旨在通过丰富有趣的展教方式来传播信息,因此在科技馆的设计当中,展示形式越来越丰富,也越来越强调观者的参与和互动,力求调动一切有利因素使观者成功接受信息。以"PEOPLES ON"(人际互动)理念为切入点,在丰富其理论的同时进一步探索应用的方式,通过人际互动理念扩大展项的外延作用,使观者能够更大程度地通过参与来学习知识。"PEOPLES ON"理念将"学习空间"外延到人与人之间,注重开发人际对学习的促进作用,使人与人之间的影响能够成为信息传播的助力。 展开更多
关键词 peoples ON 人际互动 科技馆 应用
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Bridge-building for Friendship between the Peoples——Visit of a CAFIU Delegation to Ireland and Germany
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《International Understanding》 2002年第2期17-19,共3页
关键词 Bridge-building for Friendship between the peoples
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Leveraging the Strength of NGOs in Deepening Friendship between the Chinese and Cambodian Peoples and between the Chinese and Lao Peoples
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作者 Zhang Yaowu Li Yuanxing 《International Understanding》 2013年第4期9-12,共4页
In late October,at the invitation of friendly organizations in Cambodia and Laos,a Chinese NGO Delegation visited the two countries.The delegation was made up of 6 members from the Chinese Association for Internationa... In late October,at the invitation of friendly organizations in Cambodia and Laos,a Chinese NGO Delegation visited the two countries.The delegation was made up of 6 members from the Chinese Association for International Understanding,Chinese People’s Association for Peace and Disarmament,China NGO Network for International Exchanges and China Foundation for Peace and Development respectively.Though the visit 展开更多
关键词 Leveraging the Strength of NGOs in Deepening Friendship between the Chinese and Cambodian peoples and between the Chinese and Lao peoples
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Bamboo: Close Friends of Moinba And Lhoba Peoples
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作者 ADA 《China's Tibet》 1997年第6期27-27,共1页
关键词 BAMBOO Close Friends of Moinba And Lhoba peoples
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Brazil's Indigenous Peoples and Their Autobiographical Narratives
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作者 Suzane Lima Costa 《Journal of Literature and Art Studies》 2016年第9期996-1008,共13页
When considering indigenous people in Brazil, both in academic and non-academic settings, the individuals' names are almost always ignored for the sake of representing their collectivity as communities, as Peoples. D... When considering indigenous people in Brazil, both in academic and non-academic settings, the individuals' names are almost always ignored for the sake of representing their collectivity as communities, as Peoples. Discussing autobiographies or indigenous biographies is still an uncommon endeavor, even in our field of Letters/Liberal Arts or in Indigenous Ethnology. However, since the beginning of the process of reclaiming the lands that once belonged to them, the indigenous Peoples have been producing autobiographical narratives, demonstrating how this genre of text production--traditionally linked to the development of the Western individual---can constitute and be appropriated in different Amerindian translations. It is fi'om this perspective that I intend to present a discussion about those text productions, analyzing what their collective signatures express, and how their proper names are constructed and signified on behalf of the group. 展开更多
关键词 indigenous people AUTOBIOGRAPHY MEMORY IDENTITY
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公司董事对公司债权人之信义义务与注意义务——加拿大最高法院“Peoples Department Stores Inc. (Trustee of) v. Wise”案述评 被引量:15
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作者 房绍坤 王洪平 《环球法律评论》 北大核心 2005年第4期503-512,共10页
在本案中,初审法院法官支持原告的诉讼主张,认为公司董事在公司濒临破产时,对公司债权人负有信义义务。上诉法院推翻了一审判决,认为公司董事仅对公司负有信义义务,本案被告董事并未违反任何义务。最终,终审法院维持了上诉法院的判决。... 在本案中,初审法院法官支持原告的诉讼主张,认为公司董事在公司濒临破产时,对公司债权人负有信义义务。上诉法院推翻了一审判决,认为公司董事仅对公司负有信义义务,本案被告董事并未违反任何义务。最终,终审法院维持了上诉法院的判决。加拿大最高法院的这一判决澄清了业界所广泛关注的一个问题,即公司董事对公司债权人的义务。不论是与加拿大以前的法律相比,还是与国外其他国家的法律相比,该判决都赋予了公司债权人更加广泛的潜在权利。最为重要的是,该判决未将公司债权人的此等权利与“公司濒临破产”这一要件事实联结在一起。此外,该判决还明确了公司董事对公司债权人总是负有注意义务这一重要公司法规则。 展开更多
关键词 公司董事 公司债权人 信义义务 注意义务 peoples Department Stores Inc.(Trustee of)v.Wise”案 合同责任 《公司法》
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Towards complex scenes: A deep learning-based camouflaged people detection method for snapshot multispectral images
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作者 Shu Wang Dawei Zeng +3 位作者 Yixuan Xu Gonghan Yang Feng Huang Liqiong Chen 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第4期269-281,共13页
Camouflaged people are extremely expert in actively concealing themselves by effectively utilizing cover and the surrounding environment. Despite advancements in optical detection capabilities through imaging systems,... Camouflaged people are extremely expert in actively concealing themselves by effectively utilizing cover and the surrounding environment. Despite advancements in optical detection capabilities through imaging systems, including spectral, polarization, and infrared technologies, there is still a lack of effective real-time method for accurately detecting small-size and high-efficient camouflaged people in complex real-world scenes. Here, this study proposes a snapshot multispectral image-based camouflaged detection model, multispectral YOLO(MS-YOLO), which utilizes the SPD-Conv and Sim AM modules to effectively represent targets and suppress background interference by exploiting the spatial-spectral target information. Besides, the study constructs the first real-shot multispectral camouflaged people dataset(MSCPD), which encompasses diverse scenes, target scales, and attitudes. To minimize information redundancy, MS-YOLO selects an optimal subset of 12 bands with strong feature representation and minimal inter-band correlation as input. Through experiments on the MSCPD, MS-YOLO achieves a mean Average Precision of 94.31% and real-time detection at 65 frames per second, which confirms the effectiveness and efficiency of our method in detecting camouflaged people in various typical desert and forest scenes. Our approach offers valuable support to improve the perception capabilities of unmanned aerial vehicles in detecting enemy forces and rescuing personnel in battlefield. 展开更多
关键词 Camouflaged people detection Snapshot multispectral imaging Optimal band selection MS-YOLO Complex remote sensing scenes
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Proximity to corridors benefits bird communities in vegetated interrow vineyards in Mendoza, Argentina
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作者 Andrea Paula Goijman Agustín Zarco 《Avian Research》 SCIE CSCD 2024年第2期147-155,共9页
Management under ecological schemes and increasing habitat heterogeneity,are essential for enhancing biodiversity in vineyards.Birds provide several contributions to agriculture,for example pest control,recreation and... Management under ecological schemes and increasing habitat heterogeneity,are essential for enhancing biodiversity in vineyards.Birds provide several contributions to agriculture,for example pest control,recreation and enhancing human mental health,and have intrinsic value.Birds are also ideal model organisms because they are easy to survey,and species respond differently to agricultural land use at different scales.Vegetated borders of crops are key for many species of birds,and distance to the border have been found to be an important factor in vineyard-dominated agroecosystems.We evaluate if there are differences in the bird assemblage,between the interior compared to borders within vineyards,using a hierarchical community occupancy model.We hypoth-esized that occupancy of birds is greater in environments with greater heterogeneity,which in this study was considered to be contributed by the proximity to vegetated corridors.We expected that vineyard borders close to corridors will have higher bird occupancy than the center of the vineyard.The research was conducted in three vineyards with biodiversity-friendly management practices,in Gualtallary,Mendoza,Argentina.Bird surveys were conducted over three breeding seasons from 2018 to 2020.Occupancy and richness of the bird community was more closely associated with the borders adjacent to the corridors than with the interior of the vineyards,as we initially predicted,although the assemblage of birds did not differ much.More than 75%of the registered species consume exclusively or partially invertebrates.Biodiversity-friendly management and ecological schemes,together with vegetated corridors provide multiple benefits for biodiversity conservation.These ap-proaches not only minimize the use of agrochemicals but also prioritize soil cover with spontaneous vegetation,which supports a diverse community of insectivorous bird species,potentially contributing to pest control. 展开更多
关键词 Avian Bayesian analysis Field scale agroecosystem Management Multi-species occupancy model Nature’s contributions to people
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Alcohol and illicit drugs:prevalence of alcohol and illicit drug use and their predictors in young people from Argentina,Bulgaria,Chile and Romania
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作者 Daniel Vankov David Jankovszky +2 位作者 Borislav Vankov Martin Galanternik Claudia Rodriguez 《Global Health Journal》 2024年第1期16-23,共8页
Background:Alcohol and illicit drugs(AID)continue to be a major global health concern.Although preventable,AID is linked to millions of deaths annually worldwide.The situation is particularly grave for young people,wi... Background:Alcohol and illicit drugs(AID)continue to be a major global health concern.Although preventable,AID is linked to millions of deaths annually worldwide.The situation is particularly grave for young people,with AID being a major direct risk factor for disability-adjusted youth life-years lost and death.It further contributes to assaults,road crashes,accidental poisoning,and suicide,leading to long-term issues and public health concerns.Objective:This study aimed at disclosing current AID prevalence data for Argentinian,Bulgarian,Chilean and Romanian youth.It shed light on the predictors of AID in young people from those countries.Method:The study used an online survey to gather data from people aged 18 to 25(n=1,297).The survey was underpinned by the theory of planned behaviour(TPB).Predictors were investigated separately for drinking alcohol and using illicit drugs.Results:Our data revealed that across the four target countries,49%to 90%of the participants drank alcohol,and 8%to 35%used illicit drugs in the past three months.Between 20%and 91%of them intended to drink,and between 8%and 31%intended to use illicit drugs in the following three months.Our TPB model predicted statistically significant(P<0.001)amounts of variance in drinking alcohol(between 61%and 72%)and using illicit drugs(between 20.3%and 74.4%).Intention was consistent in significantly predicting both behaviours.Evidence around the predictive validity of self-efficacy,age and gender was mixed across the investigated countries.Conclusion:This research provided an update on the scarce AID epidemiological data.It also supplied evidence about what theoretically-informed measures might be useful targets of interventions in the case of Argentina,Bulgaria,Chile and Romania.This new knowledge of understanding substance abuse determinants and prevalence may help researchers and practitioners better meet young people's health prevention needs. 展开更多
关键词 Young people ALCOHOL Ilicit drugs INTENTION SELF-EFFICACY
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Bowel preparation experiences and needs before follow-up colonoscopy in older adult postoperative colorectal cancer patients: A qualitative study
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作者 Bin He Yi Xin +3 位作者 Rui Li Fu-Cai Lin Guang-Ming Zhang Hai-Jing Zhu 《World Journal of Gastrointestinal Surgery》 SCIE 2024年第9期2968-2978,共11页
BACKGROUND The bowel preparation process prior to colonoscopy determines the quality of the bowel preparation,which in turn affects the quality of the colonoscopy.Colono-scopy is an essential procedure for postoperati... BACKGROUND The bowel preparation process prior to colonoscopy determines the quality of the bowel preparation,which in turn affects the quality of the colonoscopy.Colono-scopy is an essential procedure for postoperative follow-up monitoring of colorec-tal cancer(CRC)patients.Previous studies have shown that advanced age and a history of colorectal resection are both risk factors for inadequate bowel prepara-tion.However,little attention has been paid to the bowel preparation experiences and needs of predominantly older adult postoperative CRC patients.AIM To explore the experiences and needs of older adult postoperative CRC patients during bowel preparation for follow-up colonoscopy.METHODS Fifteen older adult postoperative CRC patients who underwent follow-up colonoscopy at a tertiary hospital in Shanghai were selected using purposive sampling from August 2023 to November 2023.The phenomenological method in qualitative research was employed to construct an interview outline and conduct semi-structured interviews with the patients.Colaizzi's seven-step analysis was utilized to organize,code,categorize,summarize,and verify the interview data.RESULTS The results of this study were summarized into four themes and eight sub-themes:(1)Inadequate knowledge about bowel preparation;(2)Decreased physiological comfort during bowel preparation(gastrointestinal discomfort and sleep deprivation caused by bowel cleansing agents,and hunger caused by dietary restrictions);(3)Psychological changes during different stages of bowel preparation(pre-preparation:Fear and resistance due to previous experiences;during preparation:Irritation and helplessness caused by taking bowel cleansing agents,and post-preparation:Anxiety and worry while waiting for the colonoscopy);and(4)Needs related to bowel preparation(detailed instructions from healthcare professionals;more ideal bowel cleansing agents;and shortened waiting times for colonoscopy).CONCLUSION Older adult postoperative CRC patients'knowledge of bowel preparation is not adequate,and they may encounter numerous difficulties and challenges during the process.Healthcare professionals should place great emphasis on providing instruction for their bowel preparation. 展开更多
关键词 Older people Colorectal cancer COLONOSCOPY Bowel preparation Health promotion NURSING Qualitative research
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Attitudes Toward People Who Stutter in the Chinese Context: An Exploratory Study on the Impact of Knowledge Sources
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作者 Ran AN Judith D.OXLEY John A.TETNOWSKI 《Chinese Journal of Applied Linguistics》 2024年第4期591-611,687,共22页
The public’s attitudes can affect the experience of stuttering of people who stutter.This study investigated the attitudes held by the public about people who stutter in China.A web-based written survey with closed a... The public’s attitudes can affect the experience of stuttering of people who stutter.This study investigated the attitudes held by the public about people who stutter in China.A web-based written survey with closed and open-ended questions was implemented to develop a rich understanding.One hundred and two respondents in 26 provinces and 3 municipalities provided comments on people who stutter in their life aspects such as personality,speech,social life,work,life participation,education,dating and marriage,capability,and communication skills.The predominantly negative attitudes towards the overall domains were identified.Attitudes to people who stutter varied according to the different sources of knowledge.Familiarity with people who stutter might reduce stereotypes.However,knowledge from the media might aggravate stereotypes.Implications and future research orientation were also discussed. 展开更多
关键词 public’s attitudes people who stutter personality communication skills FAMILIARITY media
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Strengthening Active Aging through Older People’s Association and Economic Activity of the Older People in Nepal
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作者 Hom Nath Chalise James Brightman 《Advances in Aging Research》 CAS 2024年第2期15-24,共10页
Aging is a natural lifelong process ending in death. Many older people are living in poverty. Older people are generally considered dependent on others as they grow older. The purpose of this article is to explore the... Aging is a natural lifelong process ending in death. Many older people are living in poverty. Older people are generally considered dependent on others as they grow older. The purpose of this article is to explore the entrepreneurship activities of Nepalese older adults. Data for this study were collected from the project Help Age International (HAI) implemented in Nepal. Qualitative data observations and interviews were used to collect data. The findings of this study show the formation of the Older People’s Association (OPA) has supported many older people to participate outside the home in various social activities. Moreover, regular deposits through OPAs offer little help. OPAs support older people in their need of financial support to implement minor entrepreneurship. Older people who received support were pleased and were actively involved in their activities and also regularly deposited money in them. Subsequently, older people’s participation in social activities has increased and also helped to lower elderly abuse, loneliness, and depression. Local governments should promote such activities which will help with healthy aging. 展开更多
关键词 Aging in Nepal Active Aging Older People’s Association Older People Healthy Aging
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Correlation between psychological traits and the use of smart medical services in young and middle-aged adults: An observational study
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作者 Hu Zhang Yan Liu Rui Gu 《World Journal of Psychiatry》 SCIE 2024年第8期1224-1232,共9页
BACKGROUND Psychological problems affect economic development.However,there is a huge gap between mental health service resources and mental health service needs.Existing mental health service technology and platforms... BACKGROUND Psychological problems affect economic development.However,there is a huge gap between mental health service resources and mental health service needs.Existing mental health service technology and platforms cannot meet all the diverse mental health needs of people.Smart medicine is a new medical system based online that can effectively improve the quality and efficiency of medical services and make mental health services accessible.AIM To explore the level of intelligent medical use among young and middle-aged people and its correlation with psychological factors.METHODS Convenience sampling was used to select 200 young and middle-aged patients with medical experience at the Third People's Hospital of Chengdu between January 2022 and January 2023 as the research subjects.The general condition Questionnaire,Eysenck Personality Questionnaire,Symptom Checklist-90,General Health Questionnaire,and Smart Medical Service Use Intention Questionnaire were used to collect data.Pearson’s correlation was used to analyze the correlation between the participants’willingness to use smart medical services and their personality characteristics,psychological symptoms,and mental health.RESULTS The results revealed that the mental health of young and middle-aged people was poor,and some had psycho-logical problems such as anxiety,depression,and physical discomfort.Familiarity,acceptance,and usage of smart healthcare in this population are at a medium level,and these levels correlate with psychological characteristics.Acceptance was positively correlated with E,and negatively correlated with P,anxiety,fear,anxiety/insomnia,and social dysfunction.The degree of use was negatively correlated with P,obsessive-compulsive symptoms,depression,anxiety,hostility,paranoia,and somatic symptoms.CONCLUSION The familiarity,acceptance,and usage of smart medical services among the middle-aged and young groups are related to various psychological characteristics. 展开更多
关键词 Young and middle-aged people Smart healthcare Willingness to serve Psychological characteristics Questionnaire survey RELEVANCE
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Associations of PNPLA3 and LEP genetic polymorphisms with metabolic-associated fatty liver disease in Thai people living with human immunodeficiency virus
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作者 Kanuengnit Choochuay Punna Kunhapan +6 位作者 Apichaya Puangpetch Sissades Tongsima Pornpen Srisawasdi Abhasnee Sobhonslidsuk Somnuek Sungkanuparph Mohitosh Biswas Chonlaphat Sukasem 《World Journal of Hepatology》 2024年第3期366-378,共13页
BACKGROUND The prevalence of metabolic-associated fatty liver disease(MAFLD)is a growing public health issue in people living with human immunodeficiency virus(PLWH).However,the pathophysiology of MAFLD is still unkno... BACKGROUND The prevalence of metabolic-associated fatty liver disease(MAFLD)is a growing public health issue in people living with human immunodeficiency virus(PLWH).However,the pathophysiology of MAFLD is still unknown,and the role of genetic variables is only now becoming evident.AIM To evaluate the associations of gene-polymorphism-related MAFLD in PLWH.METHODS The study employed transient elastography with a controlled attenuation parameter≥248 dB/m to identify MAFLD in patients from a Super Tertiary Hospital in central Thailand.Candidate single-nucleotide polymorphisms(SNPs)were genotyped using TaqMan®MGB probe 5'nuclease assays for seven MAFLD-related genes.Statistical analyses included SNP frequency analysis,Fisher's Exact and Chi-square tests,odds ratio calculations,and multivariable logistic regression.RESULTS The G-allele carriers of PNPLA3(rs738409)exhibited a two-fold rise in MAFLD,increasing by 2.5 times in MAFLD with human immunodeficiency virus infection.The clinical features and genetic patterns imply that LEP rs7799039 A-allele carriers had a nine times(P=0.001)more significant chance of developing aberrant triglyceride among PLWH.CONCLUSION The current study shows an association between PNPLA3 rs738409 and LEP rs7799039 with MAFLD in PLWH. 展开更多
关键词 PNPLA3 LEP Metabolic-associated fatty liver disease People living with HIV THAI
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Hepatitis C virus eradication in people living with human immunodeficiency virus:Where are we now?
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作者 Anna Maria Spera Pasquale Pagliano Valeria Conti 《World Journal of Hepatology》 2024年第5期661-666,共6页
Hepatitis C virus(HCV)/human immunodeficiency virus(HIV)co-infection still involves 2.3 million patients worldwide of the estimated 37.7 million living with HIV,according to World Health Organization.People living wit... Hepatitis C virus(HCV)/human immunodeficiency virus(HIV)co-infection still involves 2.3 million patients worldwide of the estimated 37.7 million living with HIV,according to World Health Organization.People living with HIV(PLWH)are six times greater affected by HCV,compared to HIV negative ones;the greater prevalence is encountered among people who inject drugs and men who have sex with men:the risk of HCV transmission through sexual contact in this setting can be increased by HIV infection.These patients experience a high rate of chronic hepatitis,which if left untreated progresses to end-stage liver disease and hepato-cellular carcinoma(HCC)HIV infection increases the risk of mother to child vertical transmission of HCV.No vaccination against both infections is still available.There is an interplay between HIV and HCV infections.Treatment of HCV is nowadays based on direct acting antivirals(DAAs),HCV treatment plays a key role in limiting the progression of liver disease and reducing the risk of HCC development in mono-and coinfected individuals,especially when used at an early stage of fibrosis,reducing liver disease mortality and morbidity.Since the sustained virological response at week 12 rates were observed in PLWH after HCV eradication,the AASLD has revised its simplified HCV treatment algorithm to also include individuals living with HIV.HCV eradication can determine dyslipidemia,since HCV promotes changes in serum lipid profiles and may influence lipid metabolism.In addition to these apparent detrimental effects on the lipid profile,the efficacy of DAA in HCV/HIV patients needs to be considered in light of its effects on glucose metabolism mediated by improvements in liver function.The aim of the present editorial is to describe the advancement in HCV treatment among PLWH. 展开更多
关键词 HEPATITIS People living with human immunodeficiency virus Direct acting antivirals Highly active antiretroviral therapy CO-INFECTION
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Socio-Demographic and Occupational Aspects of HIV-HBV Co-Infection in Bangui, Central African Republic (CAR): Hospital-Based Cross-Sectional Study
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作者 Gaspard Tékpa Hermione Dahlia Mossoro-Kpinde +2 位作者 Jessy Guylaine Nazilari Gertrude Komoyo Saint Calvaire Henri Diémer 《Advances in Infectious Diseases》 CAS 2024年第2期310-321,共12页
Objective: HIV-HBV co-infection is a major public health problem that has not been sufficiently explored in the Central African workplace. The aim of this study was to assess the frequency of HIV-HBV co-infection amon... Objective: HIV-HBV co-infection is a major public health problem that has not been sufficiently explored in the Central African workplace. The aim of this study was to assess the frequency of HIV-HBV co-infection among people who living with HIV (PLHIV) in the infectious and tropical diseases department of the Centre Hospitalier Universitaire de lAmiti Sino-Centrafricaine in Bangui. Methods: A retrospective study was carried out from January 1, 2010 to December 31, 2021 in the Infectious and Tropical Diseases Department at the Amiti Sino-Centrafricaine University Hospital. It included the files of all PLHIV, which included the results of HBV serology. A standardized form was used to collect socio-demographic and professional data by documentary review. Data was analysed using Epi-Info 7 software. Means, proportions were calculated as well as Chi square witch was significant if p-value was below 0.05. Results: The study included 265 patients, 188 were women (70.1%) and 77 men (29.1%), giving a sex ratio of 0.45. Mean age was 35.8 years, higher in men (40 years) than in women (35.8 years) (p 0.0001). The age groups 25 to 34 (37.7%) and 35 to 44 (33.6%) were in the majority (71.3%). The majority of PLHIV were unemployed (57.1%), including housewives (43.0%). HBV prevalence was 14.3%, including 7.2% among the unemployed, who account for half of all co-infections. The search for associations between HIV-HBV co-infection and all socio-demographic characteristics (age, sex, marital status) and socio-professional categories showed no significant difference (p 0.05). Conclusion: PLHIV were predominantly young adults, female, and unemployed;no occupation was significantly associated with co-infection. The vast majority of co-infected people were not covered by the occupational health system (unemployed or informal sector). Urgent action is needed to improve workers access to occupational medicine in CAR. 展开更多
关键词 People Living with HIV HIV-HBV Co-Infection OCCUPATION Informal Sector
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