Hepatic lipid homeostasis is not only essential for maintain-ing normal cellular and systemic metabolic function but is also closely related to the steatosis of the liver.The contro-versy over the nomenclature of non-...Hepatic lipid homeostasis is not only essential for maintain-ing normal cellular and systemic metabolic function but is also closely related to the steatosis of the liver.The contro-versy over the nomenclature of non-alcoholic fatty liver dis-ease(NAFLD)in the past three years has once again sparked in-depth discussions on the pathogenesis of this disease and its impact on systemic metabolism.Pituitary-targeted gland axes(PTGA),an important hormone-regulating system,are indispensable in lipid homeostasis.This review focuses on the roles of thyroid hormones,adrenal hormones,sex hor-mones,and their receptors in hepatic lipid homeostasis,and summarizes recent research on pituitary target gland axes-related drugs regulating hepatic lipid metabolism.It also calls on researchers and clinicians to recognize the concept of endocrine-associated fatty liver disease(EAFLD)and to re-examine human lipid metabolism from the macroscopic perspective of homeostatic balance.展开更多
基金supported in part by a grant from the Jilin Province Health Talent Special Project(2022scz01,2020scz59)the Jilin Provincial Department of Science and Technology Project(20230508073RC).
文摘Hepatic lipid homeostasis is not only essential for maintain-ing normal cellular and systemic metabolic function but is also closely related to the steatosis of the liver.The contro-versy over the nomenclature of non-alcoholic fatty liver dis-ease(NAFLD)in the past three years has once again sparked in-depth discussions on the pathogenesis of this disease and its impact on systemic metabolism.Pituitary-targeted gland axes(PTGA),an important hormone-regulating system,are indispensable in lipid homeostasis.This review focuses on the roles of thyroid hormones,adrenal hormones,sex hor-mones,and their receptors in hepatic lipid homeostasis,and summarizes recent research on pituitary target gland axes-related drugs regulating hepatic lipid metabolism.It also calls on researchers and clinicians to recognize the concept of endocrine-associated fatty liver disease(EAFLD)and to re-examine human lipid metabolism from the macroscopic perspective of homeostatic balance.
