Overweight or obesity has become a serious public health problem in the world, scientists are concentrating their efforts on exploring novel ways to treat obesity. Nowadays, the availabilities of bariatric surgery and...Overweight or obesity has become a serious public health problem in the world, scientists are concentrating their efforts on exploring novel ways to treat obesity. Nowadays, the availabilities of bariatric surgery and pharmacotherapy have enhanced obesity treatment, but it should has support from diet, physical exercise and lifestyle modification, especially the functional food. Resistant starch, an indigestible starch, has been studied for years for its beneficial effects on regulating blood glucose level and lipid metabolism. The aim of this review is to summarize the effect of resistant starch on weight loss and the possible mechanisms. According to numerous previous studies it could be concluded that resistant starch can reduce fat accumulation, enhance insulin sensitivity, regulate blood glucose level and lipid metabolism. Recent investigations have focused on the possible associations between resistant starch and incretins as well as gut microbiota. Resistant starch seems to be a promising dietary fiber for the prevention or treatment of obesity and its related diseases.展开更多
With the specified basic flow in the Northern Hemisphere winter, a study is made of the structure characteristics and mechanism of the principal mode of atmospheric low-frequency variability in terms of a linear barot...With the specified basic flow in the Northern Hemisphere winter, a study is made of the structure characteristics and mechanism of the principal mode of atmospheric low-frequency variability in terms of a linear barotropic model. Statistical and dynamical analyses of the model results indicate that the mode and the related dominant-forcing excitation zone are featured by evident spatial distribution and that the mechanism responsible for the mode bears fetation to the zonal asymmetry of the basic flow and the associated barotropic energy conversion.展开更多
The onion fly, Delia antiqua, is a major underground agricultural pest that can enter pupal diapause in the summer and winter seasons. However, little is known about its molecular regulation due to the lack of genomic...The onion fly, Delia antiqua, is a major underground agricultural pest that can enter pupal diapause in the summer and winter seasons. However, little is known about its molecular regulation due to the lack of genomic resources. To gain insight into the possible mechanism of summer diapause （SD）, high-throughput RNA-Seq data were generated from non-diapause （ND） and SD （initial, maintenance and quiescence phase） pupae. Three pair-wise comparisons were performed and identified, 1380, 1471 and 435, and were significantly regulated transcripts. Further analysis revealed that the enrichment of several functional terms related to juvenile hormone regulation, cell cycle, carbon hydrate and lipid metabolism, innate immune and stress responses, various signalling transductions, ubiquitin-dependent proteosome, and variation in cuticular and cytoskeleton components were found between ND and SD and between different phases of SD. Global characterization oftranscriptome profiling between SD and ND contributes to the in-depth elucidation of the molecular mechanism of SD. Our results also offer insights into the evolution of insect diapause and support the importance of using the onion fly as a model to compare the molecular regulation events of summer and winter diapauses.展开更多
Using National Centers for Environmental Prediction/National Centre for Atmospheric Research（NCEP/NCAR） reanalysis data and monthly Hadley Center sea surface temperature（SST） data,and selecting a representative Ea...Using National Centers for Environmental Prediction/National Centre for Atmospheric Research（NCEP/NCAR） reanalysis data and monthly Hadley Center sea surface temperature（SST） data,and selecting a representative East Asian winter monsoon（EAWM） index,this study investigated the relationship between EAWM and East Asian summer monsoon（EASM） using statistical analyses and numerical simulations.Some possible mechanisms regarding this relationship were also explored.Results indicate a close relationship between EAWM and EASM：a strong EAWM led to a strong EASM in the following summer,and a weak EAWM led to a weak EASM in the following summer.Anomalous EAWM has persistent impacts on the variation of SST in the tropical Indian Ocean and the South China Sea,and on the equatorial atmospheric thermal anomalies at both lower and upper levels.Through these impacts,the EAWM influences the land-sea thermal contrast in summer and the low-level atmospheric divergence and convergence over the Indo-Pacific region.It further affects the meridional monsoon circulation and other features of the EASM.Numerical simulations support the results of diagnostic analysis.The study provides useful information for predicting the EASM by analyzing the variations of preceding EAWM and tropical SST.展开更多
Introduction Stroke is an important disease that is prevalent worldwide[1–3]. Ischemic stroke accounts for 80%of stroke cases.Currently, evidence-based effective treatments for ischemic stroke are limited, and only i...Introduction Stroke is an important disease that is prevalent worldwide[1–3]. Ischemic stroke accounts for 80%of stroke cases.Currently, evidence-based effective treatments for ischemic stroke are limited, and only intravenous thrombolysis with Alteplase (a commercially available throm-展开更多
In the 21st century, the public are more informed, mainly via the Internet, about health and medical products and have become more knowledgeable about matters relating to their health conditions and well-being in curi...In the 21st century, the public are more informed, mainly via the Internet, about health and medical products and have become more knowledgeable about matters relating to their health conditions and well-being in curing and preventing illnesses. They often self-medicate themselves with various health products and over-the-counter （OTC） medicines apart from prescribed pharmaceutical drugs （PD）. Some of those non-prescribed products may have doubtful quality control and contain harmful additives or unchecked ingredients; thus their usefulness is in doubt. The increasing popularity world-wide of using Chinese medicines （CM） and related OTC functional products has raised concerns over their concomitant use with PD and the consequential adverse effects. In most cases the alleged causes of adverse effects are linked with herbal sources, although the authorised information on the interactions between CM-PD is not plentiful in the literature. There is an urgent need for such a data base. The future professionals in health and medical care should be knowledgeable or aware of what their patients have been taking or given. In actual practice the patients may receive both treatments intentionally or unintentionally, with or without the awareness of the practitioner. In these situations a reliable database for interactions between CM-PD will be extremely useful for consultation when treatment problems appear or during emergency situations. Their combining of medications may be involved with possible outcomes of adverse reactions or beneficial effects. Such a database will be welcomed by both practitioners of herbal medicines and orthodox medicine practitioners in the emerging trend of integrative medicine. The author has been involved in various research projects of basic and clinical aspects in mainly CM among other herbal and PD. Examples will be given largely on those related to these disciplines as illustrations in this overview.展开更多
基金supported by the National Natural Science Foundation major international(regional)joint research project(81220108006)to WJYoung Scientists Fund of National Natural Science Foundation(81200292),Young Scientists Fund of National Natural Science Foundation(81200655)to LSShanghai Rising-Star Program(13QA1402900)and Hong Kong Scholars Program(XJ2013035)to HL
文摘Overweight or obesity has become a serious public health problem in the world, scientists are concentrating their efforts on exploring novel ways to treat obesity. Nowadays, the availabilities of bariatric surgery and pharmacotherapy have enhanced obesity treatment, but it should has support from diet, physical exercise and lifestyle modification, especially the functional food. Resistant starch, an indigestible starch, has been studied for years for its beneficial effects on regulating blood glucose level and lipid metabolism. The aim of this review is to summarize the effect of resistant starch on weight loss and the possible mechanisms. According to numerous previous studies it could be concluded that resistant starch can reduce fat accumulation, enhance insulin sensitivity, regulate blood glucose level and lipid metabolism. Recent investigations have focused on the possible associations between resistant starch and incretins as well as gut microbiota. Resistant starch seems to be a promising dietary fiber for the prevention or treatment of obesity and its related diseases.
基金This work is supported by the National Natural Science Foundation of China.
文摘With the specified basic flow in the Northern Hemisphere winter, a study is made of the structure characteristics and mechanism of the principal mode of atmospheric low-frequency variability in terms of a linear barotropic model. Statistical and dynamical analyses of the model results indicate that the mode and the related dominant-forcing excitation zone are featured by evident spatial distribution and that the mechanism responsible for the mode bears fetation to the zonal asymmetry of the basic flow and the associated barotropic energy conversion.
基金Acknowledgments This work was supported by Par-Eu Scholars Program, and The National Natural Science Foundation of China （31372265）, Coordinated Research Project of the International Atomic Energy Agency （18268/R0）, and National Key Program of Science and Technology Foun- dation Work of China （2015FY210300）. Conceived and designed the research： BC. Performed the experiments： FLS, DYE ZBH Analyzed the data and wrote the paper： YJH, BC, YJZ.
文摘The onion fly, Delia antiqua, is a major underground agricultural pest that can enter pupal diapause in the summer and winter seasons. However, little is known about its molecular regulation due to the lack of genomic resources. To gain insight into the possible mechanism of summer diapause （SD）, high-throughput RNA-Seq data were generated from non-diapause （ND） and SD （initial, maintenance and quiescence phase） pupae. Three pair-wise comparisons were performed and identified, 1380, 1471 and 435, and were significantly regulated transcripts. Further analysis revealed that the enrichment of several functional terms related to juvenile hormone regulation, cell cycle, carbon hydrate and lipid metabolism, innate immune and stress responses, various signalling transductions, ubiquitin-dependent proteosome, and variation in cuticular and cytoskeleton components were found between ND and SD and between different phases of SD. Global characterization oftranscriptome profiling between SD and ND contributes to the in-depth elucidation of the molecular mechanism of SD. Our results also offer insights into the evolution of insect diapause and support the importance of using the onion fly as a model to compare the molecular regulation events of summer and winter diapauses.
基金the support from the National Natural Science Foundation of China (NSFC) under Grant Nos. 40675045 and 41065004NSFC-Yunnan Joint Foundation under Grant No. U0833602
文摘Using National Centers for Environmental Prediction/National Centre for Atmospheric Research（NCEP/NCAR） reanalysis data and monthly Hadley Center sea surface temperature（SST） data,and selecting a representative East Asian winter monsoon（EAWM） index,this study investigated the relationship between EAWM and East Asian summer monsoon（EASM） using statistical analyses and numerical simulations.Some possible mechanisms regarding this relationship were also explored.Results indicate a close relationship between EAWM and EASM：a strong EAWM led to a strong EASM in the following summer,and a weak EAWM led to a weak EASM in the following summer.Anomalous EAWM has persistent impacts on the variation of SST in the tropical Indian Ocean and the South China Sea,and on the equatorial atmospheric thermal anomalies at both lower and upper levels.Through these impacts,the EAWM influences the land-sea thermal contrast in summer and the low-level atmospheric divergence and convergence over the Indo-Pacific region.It further affects the meridional monsoon circulation and other features of the EASM.Numerical simulations support the results of diagnostic analysis.The study provides useful information for predicting the EASM by analyzing the variations of preceding EAWM and tropical SST.
基金supported by the Natural Science Foundation of Guangdong Province, China (2017A030313869)the Science and Technology Project of Guangzhou City, China (201607010325)
文摘Introduction Stroke is an important disease that is prevalent worldwide[1–3]. Ischemic stroke accounts for 80%of stroke cases.Currently, evidence-based effective treatments for ischemic stroke are limited, and only intravenous thrombolysis with Alteplase (a commercially available throm-
基金the support from the Joint Chair in Traditional Chinese Medicine Program(New South Wales Office of Science Research,The University of Sydney and University of Western Sydney,Australia)
文摘In the 21st century, the public are more informed, mainly via the Internet, about health and medical products and have become more knowledgeable about matters relating to their health conditions and well-being in curing and preventing illnesses. They often self-medicate themselves with various health products and over-the-counter （OTC） medicines apart from prescribed pharmaceutical drugs （PD）. Some of those non-prescribed products may have doubtful quality control and contain harmful additives or unchecked ingredients; thus their usefulness is in doubt. The increasing popularity world-wide of using Chinese medicines （CM） and related OTC functional products has raised concerns over their concomitant use with PD and the consequential adverse effects. In most cases the alleged causes of adverse effects are linked with herbal sources, although the authorised information on the interactions between CM-PD is not plentiful in the literature. There is an urgent need for such a data base. The future professionals in health and medical care should be knowledgeable or aware of what their patients have been taking or given. In actual practice the patients may receive both treatments intentionally or unintentionally, with or without the awareness of the practitioner. In these situations a reliable database for interactions between CM-PD will be extremely useful for consultation when treatment problems appear or during emergency situations. Their combining of medications may be involved with possible outcomes of adverse reactions or beneficial effects. Such a database will be welcomed by both practitioners of herbal medicines and orthodox medicine practitioners in the emerging trend of integrative medicine. The author has been involved in various research projects of basic and clinical aspects in mainly CM among other herbal and PD. Examples will be given largely on those related to these disciplines as illustrations in this overview.
