Objective To determine whether the measurement of serum prolactin (PRL) and estradiol (E2) is effective and reliable to estimate the returning time of menses during breastfeedingMethods Serum PRL and E2 were measured ...Objective To determine whether the measurement of serum prolactin (PRL) and estradiol (E2) is effective and reliable to estimate the returning time of menses during breastfeedingMethods Serum PRL and E2 were measured in 703 breastfeeding mothers during the period of <2 , > 2, 3, 4, 5 and 6- 9 months postpartum. Radio-immunoassay (RIA) was used to measure the levels of PRL and E2. The cervical mucus, sexual behaviors and vagina bleeding were also monitored since 56 d after postpantum. Results (1) The average level of serum PRL and E2was 8. 16, 3. 66, 0. 69 in the fully breastfeeding, mixed-feeding and bottle-feeding groups respectively. It showed that 92. 55% mother returned menses -within 6 months of postpartum in the bottle-feeding group. (2) According to the results, the levels of serum Prolactin and Estradiol were related to the feeding ways, but not completely related to the duration of postpartum. (3) By using the ratio of PRL to E2to estimate the time of menses return among the breastfeeding mothers, we found that when the ratio became 0. 60, the subjects' menses would returen. .The sensitivity and the specificity of this method were 89. 85% and 90. 68% respectively.Conclusion The measurement of serum PRL and E2is a simple, effective and reliable method to estimate the return time of menses during breastfeeding period. If possible, it should be promoted for clinical use to prepare for their fertility return.展开更多
目的:分析产后风湿症与血清催乳素(PRL)、孕酮(P)水平的关系及柴胡桂枝汤加减治疗的临床价值。方法:选择2015年1月—2017年2月于医院分娩且发生产后风湿症的86例患者作为观察组,选择同期在本院体检的50例正常健康女性作为对照组,观察组...目的:分析产后风湿症与血清催乳素(PRL)、孕酮(P)水平的关系及柴胡桂枝汤加减治疗的临床价值。方法:选择2015年1月—2017年2月于医院分娩且发生产后风湿症的86例患者作为观察组,选择同期在本院体检的50例正常健康女性作为对照组,观察组分别于产程开始前、产后42 d及产后6个月抽取外周静脉血,对照组于入院当日抽取外周静脉血,采用放射免疫法测定PRL、P水平的变化,并将观察组随机分为A、B组各43例,A组采用柴胡桂枝汤加减治疗,B组采用常规碳酸钙D3颗粒补钙处理,比较两组治疗效果及治疗前后中医证候积分的变化,测定两组视觉模拟评分(VAS)及爱丁堡产后抑郁量表(EPDS)评分的变化,记录两组疼痛持续时间、肢体压痛数目、关节肿胀数目。结果:观察组产程开始前及产后42 d PRL、P均高于对照组(P<0.05),产后42 d、产后6个月,观察组PRL、P均较产程开始时降低,比较差异有统计学意义(P<0.05);A组治疗总有效率为95.35%,明显高于B组的72.09%,比较差异有统计学意义(P<0.05);治疗前,A、B组肢体疼痛、关节肿胀、畏恶风寒、神疲乏力、面色萎黄等中医证候积分比较差异无统计学意义(P>0.05),停药4周,两组上述积分均降低,A组各积分均低于B组(P<0.05);治疗前,两组VAS评分、EPDS评分、疼痛持续时间、肢体压痛数目及关节肿胀数目比较差异无统计学意义(P>0.05),停药4周,A组上述指标均低于或少于B组(P<0.05)。结论:产后风湿症的发病可能与产后PRL、P水平变化有关,且与产后抑郁存在一定的联系,采用柴胡桂枝汤加减治疗产后风湿症疗效肯定,可改善患者症状及体征,减轻关节疼痛,减轻患者产后抑郁程度,促进其恢复。展开更多
文摘Objective To determine whether the measurement of serum prolactin (PRL) and estradiol (E2) is effective and reliable to estimate the returning time of menses during breastfeedingMethods Serum PRL and E2 were measured in 703 breastfeeding mothers during the period of <2 , > 2, 3, 4, 5 and 6- 9 months postpartum. Radio-immunoassay (RIA) was used to measure the levels of PRL and E2. The cervical mucus, sexual behaviors and vagina bleeding were also monitored since 56 d after postpantum. Results (1) The average level of serum PRL and E2was 8. 16, 3. 66, 0. 69 in the fully breastfeeding, mixed-feeding and bottle-feeding groups respectively. It showed that 92. 55% mother returned menses -within 6 months of postpartum in the bottle-feeding group. (2) According to the results, the levels of serum Prolactin and Estradiol were related to the feeding ways, but not completely related to the duration of postpartum. (3) By using the ratio of PRL to E2to estimate the time of menses return among the breastfeeding mothers, we found that when the ratio became 0. 60, the subjects' menses would returen. .The sensitivity and the specificity of this method were 89. 85% and 90. 68% respectively.Conclusion The measurement of serum PRL and E2is a simple, effective and reliable method to estimate the return time of menses during breastfeeding period. If possible, it should be promoted for clinical use to prepare for their fertility return.
文摘目的:分析产后风湿症与血清催乳素(PRL)、孕酮(P)水平的关系及柴胡桂枝汤加减治疗的临床价值。方法:选择2015年1月—2017年2月于医院分娩且发生产后风湿症的86例患者作为观察组,选择同期在本院体检的50例正常健康女性作为对照组,观察组分别于产程开始前、产后42 d及产后6个月抽取外周静脉血,对照组于入院当日抽取外周静脉血,采用放射免疫法测定PRL、P水平的变化,并将观察组随机分为A、B组各43例,A组采用柴胡桂枝汤加减治疗,B组采用常规碳酸钙D3颗粒补钙处理,比较两组治疗效果及治疗前后中医证候积分的变化,测定两组视觉模拟评分(VAS)及爱丁堡产后抑郁量表(EPDS)评分的变化,记录两组疼痛持续时间、肢体压痛数目、关节肿胀数目。结果:观察组产程开始前及产后42 d PRL、P均高于对照组(P<0.05),产后42 d、产后6个月,观察组PRL、P均较产程开始时降低,比较差异有统计学意义(P<0.05);A组治疗总有效率为95.35%,明显高于B组的72.09%,比较差异有统计学意义(P<0.05);治疗前,A、B组肢体疼痛、关节肿胀、畏恶风寒、神疲乏力、面色萎黄等中医证候积分比较差异无统计学意义(P>0.05),停药4周,两组上述积分均降低,A组各积分均低于B组(P<0.05);治疗前,两组VAS评分、EPDS评分、疼痛持续时间、肢体压痛数目及关节肿胀数目比较差异无统计学意义(P>0.05),停药4周,A组上述指标均低于或少于B组(P<0.05)。结论:产后风湿症的发病可能与产后PRL、P水平变化有关,且与产后抑郁存在一定的联系,采用柴胡桂枝汤加减治疗产后风湿症疗效肯定,可改善患者症状及体征,减轻关节疼痛,减轻患者产后抑郁程度,促进其恢复。
