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Total synthesis of a putative yuzurimine-type Daphniphyllum alkaloid C_(14)–epi-deoxycalyciphylline H
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作者 Jingping Hu Jing Xu 《Chinese Chemical Letters》 SCIE CAS CSCD 2024年第4期336-339,共4页
One of the largest subfamilies within the famous Daphniphyllum alkaloid family is made up of the yuzurimine-type(or macrodaphniphyllamine-type) alkaloids. Their complex aza-polycyclic caged structures, several contigu... One of the largest subfamilies within the famous Daphniphyllum alkaloid family is made up of the yuzurimine-type(or macrodaphniphyllamine-type) alkaloids. Their complex aza-polycyclic caged structures, several contiguous stereogenic centers, and vicinal all-carbon quaternary centers make these alkaloids formidable challenge for synthetic chemists. Recently, synthesis of these alkaloids has received extensive attention from our community. Herein, we wish to report the total synthesis of C_(14)–epideoxycalyciphylline H, a putative member of yuzurimine-type alkaloid subfamily. Key transformations employed in our approach include an intramolecular Prins reaction and a Pd-catalyzed enyne cycloisomerization. In addition, synthesis of a daphnezomine L-type alkaloid, paxdaphnidine A, was also studied. 展开更多
关键词 Total synthesis Daphniphyllum alkaloids Yuzurimine-type alkaloids prins reaction Enyne cycloisomerization
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Efficient Synthesis of Beraprost Sodium
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作者 WANG Yue HOU Dalong +2 位作者 LV Haoze ZHANG Baozhen WANG Ensi 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2016年第4期581-585,共5页
An efficient and straightforward synthesis ofberaprost sodium was developed with dicyclopentadiene as a starting material, a one-pot reaction product 5 as key intermediate and the Prins reaction and the Homer-Wadswort... An efficient and straightforward synthesis ofberaprost sodium was developed with dicyclopentadiene as a starting material, a one-pot reaction product 5 as key intermediate and the Prins reaction and the Homer-Wadsworth-Emmons reaction as key steps. The structures of the key intermediate and the target compound were confirmed by 1H NMR, 13C NMR and MS. The purity of beraprost sodium identified by high performance liquid chromatography(HPLC) was identical to that of Japanese Pharmacopoeia(16th). This development will be used for the industrial synthesis of beraprost sodium. 展开更多
关键词 Beraprost sodium One-pot reaction prins reaction Homer-Wadsworth-Emmons reaction
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