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Transcriptional regulation in the development and dysfunction of neocortical projection neurons
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作者 Ningxin Wang Rong Wan Ke Tang 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第2期246-254,共9页
Glutamatergic projection neurons generate sophisticated excitatory circuits to integrate and transmit information among different cortical areas,and between the neocortex and other regions of the brain and spinal cord... Glutamatergic projection neurons generate sophisticated excitatory circuits to integrate and transmit information among different cortical areas,and between the neocortex and other regions of the brain and spinal cord.Appropriate development of cortical projection neurons is regulated by certain essential events such as neural fate determination,proliferation,specification,differentiation,migration,survival,axonogenesis,and synaptogenesis.These processes are precisely regulated in a tempo-spatial manner by intrinsic factors,extrinsic signals,and neural activities.The generation of correct subtypes and precise connections of projection neurons is imperative not only to support the basic cortical functions(such as sensory information integration,motor coordination,and cognition)but also to prevent the onset and progression of neurodevelopmental disorders(such as intellectual disability,autism spectrum disorders,anxiety,and depression).This review mainly focuses on the recent progress of transcriptional regulations on the development and diversity of neocortical projection neurons and the clinical relevance of the failure of transcriptional modulations. 展开更多
关键词 autism spectrum disorders COGNITION differentiation excitatory circuits intellectual disability NEOCORTEX neurodevelopmental disorders projection neuron specification transcriptional regulation
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How do lateral septum projections to the ventral CA1 influence sociability?
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作者 Dan Wang Di Zhao +12 位作者 Wentao Wang Fengai Hu Minghu Cui Jing Liu Fantao Meng Cuilan Liu Changyun Qiu Dunjiang Liu Zhicheng Xu Yameng Wang Yu Zhang Wei Li Chen Li 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第8期1789-1801,共13页
Social dysfunction is a risk factor for several neuropsychiatric illnesses.Previous studies have shown that the lateral septum(LS)-related pathway plays a critical role in mediating social behaviors.Howeve r,the role ... Social dysfunction is a risk factor for several neuropsychiatric illnesses.Previous studies have shown that the lateral septum(LS)-related pathway plays a critical role in mediating social behaviors.Howeve r,the role of the connections between the LS and its downstream brain regions in social behavio rs remains unclea r.In this study,we conducted a three-chamber test using electrophysiological and chemogenetic approaches in mice to determine how LS projections to ventral CA1(vCA1)influence sociability.Our res ults showed that gamma-aminobutyric acid(GABA)-e rgic neuro ns were activated following social experience,and that social behavio rs were enhanced by chemogenetic modulation of these neurons.Moreover,LS GABAergic neurons extended their functional neural connections via vCA1 glutamatergic pyramidal neurons,and regulating LSGABA→vCA1Gluneural projections affected social behaviors,which were impeded by suppressing LSprojecting vCA1 neuronal activity or inhibiting GABAAreceptors in vCA1.These findings support the hypothesis that LS inputs to the vCA1 can control social prefe rences and social novelty behaviors.These findings provide new insights rega rding the neural circuits that regulate sociability. 展开更多
关键词 chemogenetics GABA receptor GABAergic neurons glutamatergic neurons lateral septum neural excitability neural projection social novelty social preference ventral CA1
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Cascading multi-segment rupture process of the 2023 Turkish earthquake doublet on a complex fault system revealed by teleseismic P wave back projection method
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作者 Bonan Cao Zengxi Ge 《Earthquake Science》 2024年第2期158-173,共16页
In this study,the vertical components of broadband teleseismic P wave data recorded by China Earthquake Network are used to image the rupture processes of the February 6th,2023 Turkish earthquake doublet via back proj... In this study,the vertical components of broadband teleseismic P wave data recorded by China Earthquake Network are used to image the rupture processes of the February 6th,2023 Turkish earthquake doublet via back projection analysis.Data in two frequency bands(0.5-2 Hz and 1-3 Hz)are used in the imaging processes.The results show that the rupture of the first event extends about 200 km to the northeast and about 150 km to the southwest,lasting~90 s in total.The southwestern rupture is triggered by the northeastern rupture,demonstrating a sequential bidirectional unilateral rupture pattern.The rupture of the second event extends approximately 80 km in both northeast and west directions,lasting~35 s in total and demonstrates a typical bilateral rupture feature.The cascading ruptures on both sides also reflect the occurrence of selective rupture behaviors on bifurcated faults.In addition,we observe super-shear ruptures on certain fault sections with relatively straight fault structures and sparse aftershocks. 展开更多
关键词 2023 Turkish earthquake doublet back projection method cascading segmented rupture process coseismic triggering super-shear ruptures
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Onto Orthogonal Projections in the Space of Polynomials Pn[x]
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作者 Jean-Francois Niglio 《Journal of Applied Mathematics and Physics》 2023年第1期22-45,共24页
In this article, I consider projection groups on function spaces, more specifically the space of polynomials P<sub>n</sub>[x]. I will show that a very similar construct of projection operators allows us to... In this article, I consider projection groups on function spaces, more specifically the space of polynomials P<sub>n</sub>[x]. I will show that a very similar construct of projection operators allows us to project into the subspaces of P<sub>n</sub>[x] where the function h &#8712;P<sub>n</sub>[x] represents the closets function to f &#8712;P<sub>n</sub>[x] in the least square sense. I also demonstrate that we can generalise projections by constructing operators i.e. in R<sup>n+1</sup> using the metric tensor on P<sub>n</sub>[x]. This allows one to project a polynomial function onto another by mapping it to its coefficient vector in R<sup>n+1</sup>. This can be also achieved with the Kronecker Product as detailed in this paper. 展开更多
关键词 Polynomials and projections projections The Kronecker Product Idempotent Operators
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基于Projection VOF方法的熔模铸造蜡模充型过程数值模拟 被引量:2
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作者 杨铭 廖敦明 +2 位作者 陈宇豪 陈涛 顾建华 《铸造》 CAS 北大核心 2023年第2期107-114,共8页
针对熔模铸造蜡模充型过程数值模拟软件自主开发,建立了流动场和温度场数学模型,采用Cross-WLF粘度模型描述蜡料的流变性能,基于Projection VOF方法进行蜡料流动过程速度场、压力场以及自由表面的求解。通过试验测量获取了K512型蜡料的... 针对熔模铸造蜡模充型过程数值模拟软件自主开发,建立了流动场和温度场数学模型,采用Cross-WLF粘度模型描述蜡料的流变性能,基于Projection VOF方法进行蜡料流动过程速度场、压力场以及自由表面的求解。通过试验测量获取了K512型蜡料的热物理性能和流变性能的相关数据,拟合得到粘度模型参数。分别在蜡料常粘度和变粘度模型两种条件下对扳机铸件蜡模充型过程进行模拟,结果表明,所建立蜡模充型过程数学模型能较好地描述蜡料的动态流变特性和传热行为。 展开更多
关键词 熔模铸造 蜡模充型 数值模拟 projection VOF方法
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Approximately Conformal,Equivalent and Equidistant Map Projections 被引量:1
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作者 Miljenko LAPAINE Nedjeljko FRANCULA 《Journal of Geodesy and Geoinformation Science》 2022年第3期33-40,共8页
If geodetic coordinates from an ellipsoid are included in the equations of a projection for mapping a sphere instead of geographical coordinates,the result will be a projection of the ellipsoid into a plane.This will ... If geodetic coordinates from an ellipsoid are included in the equations of a projection for mapping a sphere instead of geographical coordinates,the result will be a projection of the ellipsoid into a plane.This will slightly change the distortion distribution of the initial map projection.The question is to what extent the replacement of geographical with geodetic coordinates will affect this change.In this paper,we deal with conformal,equal-area and equidistant projections of the sphere,which we modify by using geodetic coordinates instead of geographical ones.The result will be an approximately conformal,approximately equal-area and approximately equidistant projection.It is shown that in this case the maximum distortion of the angles in approximately conformal projections will be approximately 23.09′,the maximum distortion of the area in approximately equal-area projections less than 0.7% and the maximum distortion of lengths in approximately equidistant projections less than 0.7%,therefore on the maps imperceptible. 展开更多
关键词 map projections double mapping approximately conformal projection approximately equal-area projection approximately equidistant projection
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New hybrid inertial CQ projection algorithms with line-search process for the split feasibility problem
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作者 DANG Ya-zheng WANG Long YANG Yao-heng 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 2023年第1期144-158,共15页
In this paper, we propose two hybrid inertial CQ projection algorithms with linesearch process for the split feasibility problem. Based on the hybrid CQ projection algorithm, we firstly add the inertial term into the ... In this paper, we propose two hybrid inertial CQ projection algorithms with linesearch process for the split feasibility problem. Based on the hybrid CQ projection algorithm, we firstly add the inertial term into the iteration to accelerate the convergence of the algorithm, and adopt flexible rules for selecting the stepsize and the shrinking projection region, which makes an optimal stepsize available at each iteration. The shrinking projection region is the intersection of three sets, which are the set C and two hyperplanes. Furthermore, we modify the Armijo-type line-search step in the presented algorithm to get a new algorithm.The algorithms are shown to be convergent under certain mild assumptions. Besides, numerical examples are given to show that the proposed algorithms have better performance than the general CQ algorithm. 展开更多
关键词 split feasible problem INERTIAL Armijo-type line-search technique projection algorithm CONVERGENCE
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Simulations and Projections of Winter Sea Ice in the Barents Sea by CMIP6 Climate Models
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作者 Rongrong PAN Qi SHU +3 位作者 Zhenya SONG Shizhu WANG Yan HE Fangli QIAO 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2023年第12期2318-2330,共13页
Dramatic changes in the sea ice characteristics in the Barents Sea have potential consequences for the weather and climate systems of mid-latitude continents,Arctic ecosystems,and fisheries,as well as Arctic maritime ... Dramatic changes in the sea ice characteristics in the Barents Sea have potential consequences for the weather and climate systems of mid-latitude continents,Arctic ecosystems,and fisheries,as well as Arctic maritime navigation.Simulations and projections of winter sea ice in the Barents Sea based on the latest 41 climate models from the Coupled Model Intercomparison Project Phase 6(CMIP6)are investigated in this study.Results show that most CMIP6 models overestimate winter sea ice in the Barents Sea and underestimate its decreasing trend.The discrepancy is mainly attributed to the simulation bias towards an overly weak ocean heat transport through the Barents Sea Opening and the underestimation of its increasing trend.The methods of observation-based model selection and emergent constraint were used to project future winter sea ice changes in the Barents Sea.Projections indicate that sea ice in the Barents Sea will continue to decline in a warming climate and that a winter ice-free Barents Sea will occur for the first time during 2042-2089 under the Shared Socioeconomic Pathway 585(SSP5-8.5).Even in the observation-based selected models,the sensitivity of winter sea ice in the Barents Sea to global warming is weaker than observed,indicating that a winter ice-free Barents Sea might occur earlier than projected by the CMIP6 simulations. 展开更多
关键词 Arctic sea ice Barents Sea ocean heat transport sea ice projection CMIP6
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CMIP6 Evaluation and Projection of Precipitation over Northern China:Further Investigation
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作者 Xiaoling YANG Botao ZHOU +1 位作者 Ying XU Zhenyu HAN 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2023年第4期587-600,共14页
Based on 20 models from phase 6 of the Coupled Model Intercomparison Project(CMIP6),this article explored possible reasons for differences in simulation biases and projected changes in precipitation in northern China ... Based on 20 models from phase 6 of the Coupled Model Intercomparison Project(CMIP6),this article explored possible reasons for differences in simulation biases and projected changes in precipitation in northern China among the allmodel ensemble(AMME),“highest-ranked”model ensemble(BMME),and“lowest-ranked”model ensemble(WMME),from the perspective of atmospheric circulations and moisture budgets.The results show that the BMME and AMME reproduce the East Asian winter circulations better than the WMME.Compared with the AMME and WMME,the BMME reduces the overestimation of evaporation,thereby improving the simulation of winter precipitation.The three ensemble simulated biases for the East Asian summer circulations are generally similar,characterized by a stronger zonal pressure gradient between the mid-latitudes of the North Pacific and East Asia and a northward displacement of the East Asian westerly jet.However,the simulated vertical moisture advection is improved in the BMME,contributing to the slightly higher performance of the BMME than the AMME and WMME on summer precipitation in North and Northeast China.Compared to the AMME and WMME,the BMME projects larger increases in precipitation in northern China during both seasons by the end of the 21st century under the Shared Socioeconomic Pathway 5-8.5(SSP5-8.5).One of the reasons is that the increase in evaporation projected by the BMME is larger.The projection of a greater dynamic contribution by the BMME also plays a role.In addition,larger changes in the nonlinear components in the BMME projection contribute to a larger increase in winter precipitation in northern China. 展开更多
关键词 CMIP6 ensemble evaluation and projection moisture budget atmospheric circulation
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Molecular mechanisms of lesion-induced axonal sprouting in the corticofugal projection:the role of glial cells
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作者 Leechung Chang Nobuhiko Yamamoto 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第6期1259-1260,共2页
After injury of the central nervous system(CNS),neuronal circuits are known to remodel for functional recovery.In general,there are two strategies for the remodeling:axonal regeneration and sprouting(Figure 1A).Axonal... After injury of the central nervous system(CNS),neuronal circuits are known to remodel for functional recovery.In general,there are two strategies for the remodeling:axonal regeneration and sprouting(Figure 1A).Axonal regeneration is re-growth of injured neurons themselves,but axons hardly regenerate in the adult mammalian CNS(Silver and Miller,2004).On the other hand,axonal sprouting is new growth from intact or spared neurons to the denervated target by forming axon collaterals,compensating for damaged circuits.This process is a more effective way for circuit remodeling,as it does not necessarily require long axonal elongation. 展开更多
关键词 AXONAL projection FIGURE
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An Isogeometric Cloth Simulation Based on Fast Projection Method
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作者 Xuan Peng Chao Zheng 《Computer Modeling in Engineering & Sciences》 SCIE EI 2023年第3期1837-1853,共17页
A novel continuum-based fast projection scheme is proposed for cloth simulation.Cloth geometry is described by NURBS,and the dynamic response is modeled by a displacement-only Kirchhoff-Love shell element formulated d... A novel continuum-based fast projection scheme is proposed for cloth simulation.Cloth geometry is described by NURBS,and the dynamic response is modeled by a displacement-only Kirchhoff-Love shell element formulated directly on NURBS geometry.The fast projection method,which solves strain limiting as a constrained Lagrange problem,is extended to the continuum version.Numerical examples are studied to demonstrate the performance of the current scheme.The proposed approach can be applied to grids of arbitrary topology and can eliminate unrealistic over-stretching efficiently if compared to spring-based methodologies. 展开更多
关键词 Cloth simulation isogeometric analysis strain limiting fast projection
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Robust least squares projection twin SVM and its sparse solution
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作者 ZHOU Shuisheng ZHANG Wenmeng +1 位作者 CHEN Li XU Mingliang 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2023年第4期827-838,共12页
Least squares projection twin support vector machine(LSPTSVM)has faster computing speed than classical least squares support vector machine(LSSVM).However,LSPTSVM is sensitive to outliers and its solution lacks sparsi... Least squares projection twin support vector machine(LSPTSVM)has faster computing speed than classical least squares support vector machine(LSSVM).However,LSPTSVM is sensitive to outliers and its solution lacks sparsity.Therefore,it is difficult for LSPTSVM to process large-scale datasets with outliers.In this paper,we propose a robust LSPTSVM model(called R-LSPTSVM)by applying truncated least squares loss function.The robustness of R-LSPTSVM is proved from a weighted perspective.Furthermore,we obtain the sparse solution of R-LSPTSVM by using the pivoting Cholesky factorization method in primal space.Finally,the sparse R-LSPTSVM algorithm(SR-LSPTSVM)is proposed.Experimental results show that SR-LSPTSVM is insensitive to outliers and can deal with large-scale datasets fastly. 展开更多
关键词 OUTLIERS robust least squares projection twin support vector machine(R-LSPTSVM) low-rank approximation sparse solution
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Tensor Train Random Projection
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作者 Yani Feng Kejun Tang +2 位作者 Lianxing He Pingqiang Zhou Qifeng Liao 《Computer Modeling in Engineering & Sciences》 SCIE EI 2023年第2期1195-1218,共24页
This work proposes a Tensor Train Random Projection(TTRP)method for dimension reduction,where pairwise distances can be approximately preserved.Our TTRP is systematically constructed through a Tensor Train(TT)represen... This work proposes a Tensor Train Random Projection(TTRP)method for dimension reduction,where pairwise distances can be approximately preserved.Our TTRP is systematically constructed through a Tensor Train(TT)representation with TT-ranks equal to one.Based on the tensor train format,this random projection method can speed up the dimension reduction procedure for high-dimensional datasets and requires fewer storage costs with little loss in accuracy,comparedwith existingmethods.We provide a theoretical analysis of the bias and the variance of TTRP,which shows that this approach is an expected isometric projectionwith bounded variance,and we show that the scaling Rademacher variable is an optimal choice for generating the corresponding TT-cores.Detailed numerical experiments with synthetic datasets and theMNIST dataset are conducted to demonstrate the efficiency of TTRP. 展开更多
关键词 Tensor Train random projection dimension reduction
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Face Templates Encryption Technique Based on Random Projection and Deep Learning
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作者 Mayada Tarek 《Computer Systems Science & Engineering》 SCIE EI 2023年第3期2049-2063,共15页
Cancellable biometrics is the solution for the trade-off between two concepts:Biometrics for Security and Security for Biometrics.The cancelable template is stored in the authentication system’s database rather than ... Cancellable biometrics is the solution for the trade-off between two concepts:Biometrics for Security and Security for Biometrics.The cancelable template is stored in the authentication system’s database rather than the original biometric data.In case of the database is compromised,it is easy for the template to be canceled and regenerated from the same biometric data.Recoverability of the cancelable template comes from the diversity of the cancelable transformation parameters(cancelable key).Therefore,the cancelable key must be secret to be used in the system authentication process as a second authentication factor in con-junction with the biometric data.The main contribution of this paper is to tackle the risks of stolen/lost/shared cancelable keys by using biometric trait(in different feature domains)as the only authentication factor,in addition to achieving good performance with high security.The standard Generative Adversarial Network(GAN)is proposed as an encryption tool that needs the cancelable key during the training phase,and the testing phase depends only on the biometric trait.Additionally,random projection transformation is employed to increase the proposed system’s security and performance.The proposed transformation system is tested using the standard ORL face database,and the experiments are done by applying different features domains.Moreover,a security analysis for the proposed transformation system is presented. 展开更多
关键词 Cancelable biometrics(CBs) random projection ORL face database generative adversarial network(GAN)
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Microwave-Assisted Au and Ag Nanoparticle Synthesis: An Energy Phase-Space Projection Analysis
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作者 Victor J. Law Denis P. Dowling 《American Journal of Analytical Chemistry》 CAS 2023年第4期149-174,共26页
Microwave-assisted synthesis of gold and silver nanoparticles, as a function of Green Chemistry, non Green Chemistry, and four applicator types are reported. The applicator types are Domestic microwave ovens, commerci... Microwave-assisted synthesis of gold and silver nanoparticles, as a function of Green Chemistry, non Green Chemistry, and four applicator types are reported. The applicator types are Domestic microwave ovens, commercial temperature controlled microwave chemistry ovens (TCMC), digesters, and axial field helical antennae. For each of these microwave applicators the process energy budget where estimated (Watts multiplied by process time = kJ) and energy density (applied energy divided by suspension volume = kJ·ml<sup>-1</sup>) range between 180 ± 176.8 kJ, and 79.5 ± 79 kJ·ml<sup>-1</sup>, respectively. The axial field helical field an-tenna applicator is found to be the most energy efficient (0.253 kJ·m<sup>-1</sup> per kJ, at 36 W). Followed by microwave ovens (4.47 ± 3.9 kJ·ml<sup>-1</sup> per 76.83 ± 39 kJ), and TCMC ovens (2.86 ± 2.3 kJ·m<sup>-1</sup> per 343 ± 321.5 kJ). The digester applicators have the least energy efficiency (36.2 ± 50.7 kJ·m<sup>-1</sup> per 1010 ± 620 kJ). A comparison with reconstructed ‘non-thermal’ microwave oven inactivation microorganism experiments yields a power-law signature of n = 0.846 (R<sup>2</sup> = 0.7923) four orders of magnitude. The paper provides a discussion on the Au and Ag nanoparticle chemistry and bio-chemistry synthesis aspects of the microwave applicator energy datasets and variation within each dataset. The visual and analytical approach within the energy phase-space projection enables a nanoparticle synthesis route to be systematically characterized, and where changes to the synthesis are to be mapped and compared directly with historical datasets. In order to help identify lower cost nanoparticle synthesis, in addition to potentially reduce synthesis energy to routes informed changes to potentially reduce synthesis energy budget, along with nanoparticle morphology and yield. 展开更多
关键词 Turkevich Microwave-Assisted Synthesis Ag AU HYDROXYAPATITE Nanoparticle FUNCTIONALIZATION Energy Phase-Space projection
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A Relation between Resolvents of Subdifferentials and Metric Projections to Level Sets
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作者 Hiroko Okochi 《Applied Mathematics》 2023年第6期428-435,共8页
An equation concerning with the subdifferential of convex functionals defined in real Banach spaces and the metric projections to level sets is shown. The equation is compared with the resolvents of general monotone o... An equation concerning with the subdifferential of convex functionals defined in real Banach spaces and the metric projections to level sets is shown. The equation is compared with the resolvents of general monotone operators, and makes the geometric properties of differential equations expressed by subdifferentials clear. Hence, it can be expected to be useful in obtaining the steepest descents defined by the convex functionals in Banach spaces. Also, it gives a similar result to the Lagrange multiplier method under certain conditions. 展开更多
关键词 SUBDIFFERENTIAL Convex Functional Monotone Operator RESOLVENT Lagrange Multiplier Banach Space Metric projection
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Research on Automatic Elimination of Laptop Computer in Security CT Images Based on Projection Algorithm and YOLOv7-Seg
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作者 Fei Wang Baosheng Liu +1 位作者 Yijun Tang Lei Zhao 《Journal of Computer and Communications》 2023年第9期1-17,共17页
In civil aviation security screening, laptops, with their intricate structural composition, provide the potential for criminals to conceal dangerous items. Presently, the security process necessitates passengers to in... In civil aviation security screening, laptops, with their intricate structural composition, provide the potential for criminals to conceal dangerous items. Presently, the security process necessitates passengers to individually present their laptops for inspection. The paper introduced a method for laptop removal. By combining projection algorithms with the YOLOv7-Seg model, a laptop’s three views were generated through projection, and instance segmentation of these views was achieved using YOLOv7-Seg. The resulting 2D masks from instance segmentation at different angles were employed to reconstruct a 3D mask through angle restoration. Ultimately, the intersection of this 3D mask with the original 3D data enabled the successful extraction of the laptop’s 3D information. Experimental results demonstrated that the fusion of projection and instance segmentation facilitated the automatic removal of laptops from CT data. Moreover, higher instance segmentation model accuracy leads to more precise removal outcomes. By implementing the laptop removal functionality, the civil aviation security screening process becomes more efficient and convenient. Passengers will no longer be required to individually handle their laptops, effectively enhancing the efficiency and accuracy of security screening. 展开更多
关键词 Instance Segmentation projection CT Image 3D Segmentation Real-Time Detection
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The projection-specific signals that establish functionally segregated dopaminergic synapses
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作者 Akiko Terauchi 《四川生理科学杂志》 2023年第9期1742-1742,共1页
Dopaminergic projections regulate various brain functions and are implicated in many neuropsychiatric disorders. There are two anatomically and functionally distinct dopaminergic projections connecting the midbrain to... Dopaminergic projections regulate various brain functions and are implicated in many neuropsychiatric disorders. There are two anatomically and functionally distinct dopaminergic projections connecting the midbrain to striatum: nigrostriatal, whichcontrols movement, and mesolimbic, which regulates motivation. However, how these discrete dopaminergic synaptic connections are established is unknown. Through an unbiased search, we identify that two groups of antagonistic TGF-β family members, bone morphogenetic protein (BMP)6/BMP2 and transforming growth factor (TGF)-β2, regulate dopaminergic synapse development of nigrostriatal and mesolimbic neurons, respectively. Projection-preferential expression of their receptors contributes to specific synapse development. Downstream, Smad1 and Smad2 are specifically activated and required for dopaminergic synapse development and function in nigrostriatal vs. mesolimbic projections. Remarkably, Smad1 mutant mice show motor defects, whereas Smad2 mutant mice show lack of motivation. These results uncover the molecular logic underlying the proper establishment of functionally segregated dopaminergic synapses and may provide strategies to treat relevant, projection-specific disease symptoms by targeting specific BMPs/TGF-β and/or Smads. 展开更多
关键词 projection MOTIVATION SPECIFIC
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基于RASCIL的W-projection和W-stacking并行算法实测研究
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作者 杨秋萍 朵琳 《天文研究与技术》 CSCD 2023年第1期73-82,共10页
在射电干涉阵的大视场成像中,W-projection和W-stacking是两类主要成像方法,本文对这两种成像方法进行了并行实测研究。首先分析了两种成像方法的基本原理框架,在此基础上对两种成像方法并行实现的关键因素进行讨论和分析。利用已经校... 在射电干涉阵的大视场成像中,W-projection和W-stacking是两类主要成像方法,本文对这两种成像方法进行了并行实测研究。首先分析了两种成像方法的基本原理框架,在此基础上对两种成像方法并行实现的关键因素进行讨论和分析。利用已经校准的射电干涉阵观测数据对两种成像方法基于射电天文模拟、校准和成像库(Radio Astronomy Simulation,Calibration,and Imaging Library,RASCIL)分别进行并行策略研究和并行计算实验。通过对并行计算时间、并行效率和并行资源配置模式的分析,得到了两种成像方法基于RASCIL(https://gitlab.com/ska-telescope/external/rascil)的并行计算性能,结果表明,两种成像方法都适合采用Strong Scaling的并行资源配置模式进行并行计算,基于RASCIL的W-stacking并行计算还有比较大的性能提升空间。 展开更多
关键词 射电干涉阵 大视场成像 W-projection W-stacking 并行计算 RASCIL
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Projection of precipitation extremes over South Asia from CMIP6 GCMs 被引量:1
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作者 Adnan ABBAS Asher S BHATTI +5 位作者 Safi ULLAH Waheed ULLAH Muhammad WASEEM ZHAO Chengyi DOU Xin Gohar ALI 《Journal of Arid Land》 SCIE CSCD 2023年第3期274-296,共23页
Extreme precipitation events are one of the most dangerous hydrometeorological disasters,often resulting in significant human and socio-economic losses worldwide.It is therefore important to use current global climate... Extreme precipitation events are one of the most dangerous hydrometeorological disasters,often resulting in significant human and socio-economic losses worldwide.It is therefore important to use current global climate models to project future changes in precipitation extremes.The present study aims to assess the future changes in precipitation extremes over South Asia from the Coupled Model Intercomparison Project Phase 6(CMIP6)Global Climate Models(GCMs).The results were derived using the modified Mann-Kendall test,Sen's slope estimator,student's t-test,and probability density function approach.Eight extreme precipitation indices were assessed,including wet days(RR1mm),heavy precipitation days(RR10mm),very heavy precipitation days(RR20mm),severe precipitation days(RR50mm),consecutive wet days(CWD),consecutive dry days(CDD),maximum 5-day precipitation amount(RX5day),and simple daily intensity index(SDII).The future changes were estimated in two time periods for the 21^(st) century(i.e.,near future(NF;2021-2060)and far future(FF;2061-2100))under two Shared Socioeconomic Pathway(SSP)scenarios(SSP2-4.5 and SSP5-8.5).The results suggest increases in the frequency and intensity of extreme precipitation indices under the SSP5-8.5 scenario towards the end of the 21^(st) century(2061-2100).Moreover,from the results of multimodel ensemble means(MMEMs),extreme precipitation indices of RR1mm,RR10mm,RR20mm,CWD,and SDII demonstrate remarkable increases in the FF period under the SSP5-8.5 scenario.The spatial distribution of extreme precipitation indices shows intensification over the eastern part of South Asia compared to the western part.The probability density function of extreme precipitation indices suggests a frequent(intense)occurrence of precipitation extremes in the FF period under the SSP5-8.5 scenario,with values up to 35.00 d for RR1mm and 25.00-35.00 d for CWD.The potential impacts of heavy precipitation can pose serious challenges to the study area regarding flooding,soil erosion,water resource management,food security,and agriculture development. 展开更多
关键词 precipitation extremes extreme precipitation indices climate change Coupled Model Intercomparison Project 6(CMIP6) Global Climate Model(GCM) South Asia
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