目的:探究第2.1版前列腺影像报告与数据系统(prostate imaging reporting and data system,PI-RADS v2.1)联合前列腺特异抗原(prostate specific antigen,PSA)、前列腺特异抗原密度(prostate specific antigen density,PSAD)在前列腺癌(...目的:探究第2.1版前列腺影像报告与数据系统(prostate imaging reporting and data system,PI-RADS v2.1)联合前列腺特异抗原(prostate specific antigen,PSA)、前列腺特异抗原密度(prostate specific antigen density,PSAD)在前列腺癌(prostate cancer,PCa)诊断中的应用价值。方法:选择2016年5月—2021年6月于南通市第二人民医院进行治疗的90例疑似前列腺癌患者作为研究对象。90例患者分别进行多参数核磁共振(mp-MRI)检查,对患者的前列腺图像进行PIRADS v2.1评分及PI-RADS v2.1评分联合PSA、PSAD诊断。以患者前列腺穿刺取组织进行病理检查结果为金标准,分析患者的PSA、PSAD水平及PI-RADS v2.1评分联合PSA、PSAD对前列腺癌的敏感度、特异度、阳性预测值和阴性预测值。结果:90例疑似PCa患者,病理学诊断结果:恶性肿瘤42例,良性肿瘤48例。良性患者和恶性患者游离前列腺特异性抗原(f-PSA)对比,差异无统计学意义(P>0.05),良性患者PSAD、总前列腺特异性抗原(t-PSA)低于恶性肿瘤,f-PSA/t-PSA高于恶性肿瘤,差异均有统计学意义(P<0.05)。PI-RADS v2.1评分联合PSA、PSAD诊断准确率高于PI-RADS v2.1评分,差异有统计学意义(P<0.05)。PI-RADS v2.1评分联合PSA、PSAD检测的敏感度、特异度、阳性预测值、阴性预测值均高于PI-RADS v2.1评分,差异均有统计学意义(P<0.05)。结论:对前列腺癌患者的诊断中,PI-RADS v2.1评分具有较高的准确性,但PI-RADS v2.1评分联合PSA、PSAD检测在敏感度、特异度和准确度更有参考价值。展开更多
OBJECTIVE To investigate the relationship between the clinicopatho- logical stage and serum prostate specific antigen(PSA)concentration and PSAdensity(PSAD)in patients with prostate cancer. METHODS The clinicopatholog...OBJECTIVE To investigate the relationship between the clinicopatho- logical stage and serum prostate specific antigen(PSA)concentration and PSAdensity(PSAD)in patients with prostate cancer. METHODS The clinicopathological stage was determined on the basis of a pathological examination and clinical data in 65 prostate cancer patients treated by radical prostatectomy.PSA and PSAD were measured before the operation.The Spearman rank correlation was applied to evaluate the relationship between the clinicopathological stage,serum PSAconcentration and PSAD. RESULTS Patients with higher PSA and PSAD were significantly more likely to have higher clinical stages,a higher Gleason score,positive surgical margins,capsular penetration,and seminal vesicle invasion(each P<0.05). But there was no significant association between PSA and lymph node metastasis(P=0.053).The levels of serum PSA concentration and PSAD were significantly correlated with the clinical stage(P<0.05)in the prostate cancer patients. CONCLUSION The level of both PSA and PSAD were significantly correlated with the clinical stage(P<0.05)in the prostate cancer patients.But PSAD may be a more powerful predictor of clinical stage and prognosis than PSA.展开更多
文摘OBJECTIVE To investigate the relationship between the clinicopatho- logical stage and serum prostate specific antigen(PSA)concentration and PSAdensity(PSAD)in patients with prostate cancer. METHODS The clinicopathological stage was determined on the basis of a pathological examination and clinical data in 65 prostate cancer patients treated by radical prostatectomy.PSA and PSAD were measured before the operation.The Spearman rank correlation was applied to evaluate the relationship between the clinicopathological stage,serum PSAconcentration and PSAD. RESULTS Patients with higher PSA and PSAD were significantly more likely to have higher clinical stages,a higher Gleason score,positive surgical margins,capsular penetration,and seminal vesicle invasion(each P<0.05). But there was no significant association between PSA and lymph node metastasis(P=0.053).The levels of serum PSA concentration and PSAD were significantly correlated with the clinical stage(P<0.05)in the prostate cancer patients. CONCLUSION The level of both PSA and PSAD were significantly correlated with the clinical stage(P<0.05)in the prostate cancer patients.But PSAD may be a more powerful predictor of clinical stage and prognosis than PSA.
