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EfficientNetB1 Deep Learning Model for Microscopic Lung Cancer Lesion Detection and Classification Using Histopathological Images
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作者 Rabia Javed Tanzila Saba +3 位作者 Tahani Jaser Alahmadi Sarah Al-Otaibi Bayan AlGhofaily Amjad Rehman 《Computers, Materials & Continua》 SCIE EI 2024年第10期809-825,共17页
Cancer poses a significant threat due to its aggressive nature,potential for widespread metastasis,and inherent heterogeneity,which often leads to resistance to chemotherapy.Lung cancer ranks among the most prevalent ... Cancer poses a significant threat due to its aggressive nature,potential for widespread metastasis,and inherent heterogeneity,which often leads to resistance to chemotherapy.Lung cancer ranks among the most prevalent forms of cancer worldwide,affecting individuals of all genders.Timely and accurate lung cancer detection is critical for improving cancer patients’treatment outcomes and survival rates.Screening examinations for lung cancer detection,however,frequently fall short of detecting small polyps and cancers.To address these limitations,computer-aided techniques for lung cancer detection prove to be invaluable resources for both healthcare practitioners and patients alike.This research implements an enhanced EfficientNetB1 deep learning model for accurate detection and classification using histopathological images.The proposed technique accurately classifies the histopathological images into three distinct classes:(1)no cancer(benign),(2)adenocarcinomas,and(3)squamous cell carcinomas.We evaluated the performance of the proposed technique using the histopathological(LC25000)lung dataset.The preprocessing steps,such as image resizing and augmentation,are followed by loading a pretrained model and applying transfer learning.The dataset is then split into training and validation sets,with fine-tuning and retraining performed on the training dataset.The model’s performance is evaluated on the validation dataset,and the results of lung cancer detection and classification into three classes are obtained.The study’s findings show that an enhanced model achieves exceptional classification accuracy of 99.8%. 展开更多
关键词 Colon cancer EfficientNetB1 histopathological image processing transfer learning health risks
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Pulmonary Edema and Pleural Effusion Detection Using Efficient Net-V1-B4 Architecture and AdamW Optimizer from Chest X-Rays Images
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作者 Anas AbuKaraki Tawfi Alrawashdeh +4 位作者 Sumaya Abusaleh Malek Zakarya Alksasbeh Bilal Alqudah Khalid Alemerien Hamzah Alshamaseen 《Computers, Materials & Continua》 SCIE EI 2024年第7期1055-1073,共19页
This paper presents a novelmulticlass systemdesigned to detect pleural effusion and pulmonary edema on chest Xray images,addressing the critical need for early detection in healthcare.A new comprehensive dataset was f... This paper presents a novelmulticlass systemdesigned to detect pleural effusion and pulmonary edema on chest Xray images,addressing the critical need for early detection in healthcare.A new comprehensive dataset was formed by combining 28,309 samples from the ChestX-ray14,PadChest,and CheXpert databases,with 10,287,6022,and 12,000 samples representing Pleural Effusion,Pulmonary Edema,and Normal cases,respectively.Consequently,the preprocessing step involves applying the Contrast Limited Adaptive Histogram Equalization(CLAHE)method to boost the local contrast of the X-ray samples,then resizing the images to 380×380 dimensions,followed by using the data augmentation technique.The classification task employs a deep learning model based on the EfficientNet-V1-B4 architecture and is trained using the AdamW optimizer.The proposed multiclass system achieved an accuracy(ACC)of 98.3%,recall of 98.3%,precision of 98.7%,and F1-score of 98.7%.Moreover,the robustness of the model was revealed by the Receiver Operating Characteristic(ROC)analysis,which demonstrated an Area Under the Curve(AUC)of 1.00 for edema and normal cases and 0.99 for effusion.The experimental results demonstrate the superiority of the proposedmulti-class system,which has the potential to assist clinicians in timely and accurate diagnosis,leading to improved patient outcomes.Notably,ablation-CAM visualization at the last convolutional layer portrayed further enhanced diagnostic capabilities with heat maps on X-ray images,which will aid clinicians in interpreting and localizing abnormalities more effectively. 展开更多
关键词 image classification decision support system EfficientNet-V1-B4 AdamW optimizer pulmonary edema pleural effusion chest X-rays
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A lightweight symmetric image encryption cryptosystem in wavelet domain based on an improved sine map
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作者 陈柏池 黄林青 +2 位作者 蔡述庭 熊晓明 张慧 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第3期266-276,共11页
In the era of big data,the number of images transmitted over the public channel increases exponentially.As a result,it is crucial to devise the efficient and highly secure encryption method to safeguard the sensitive ... In the era of big data,the number of images transmitted over the public channel increases exponentially.As a result,it is crucial to devise the efficient and highly secure encryption method to safeguard the sensitive image.In this paper,an improved sine map(ISM)possessing a larger chaotic region,more complex chaotic behavior and greater unpredictability is proposed and extensively tested.Drawing upon the strengths of ISM,we introduce a lightweight symmetric image encryption cryptosystem in wavelet domain(WDLIC).The WDLIC employs selective encryption to strike a satisfactory balance between security and speed.Initially,only the low-frequency-low-frequency component is chosen to encrypt utilizing classic permutation and diffusion.Then leveraging the statistical properties in wavelet domain,Gaussianization operation which opens the minds of encrypting image information in wavelet domain is first proposed and employed to all sub-bands.Simulations and theoretical analysis demonstrate the high speed and the remarkable effectiveness of WDLIC. 展开更多
关键词 image encryption discrete wavelet transform 1D-chaotic system selective encryption Gaussianization operation
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A Cross-Plane Color Image Encryption Algorithm Based on 1D-SLM
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作者 Xiaohong Wang Huiqing Wu +1 位作者 Yuying Ma Shuzhen Huang 《Computer Systems Science & Engineering》 SCIE EI 2023年第7期1093-1108,共16页
With the rapid development of 5G technology,it has become fast and easy for people to transmit information on the Internet.Digital images can express information more intuitively,so transmitting information through im... With the rapid development of 5G technology,it has become fast and easy for people to transmit information on the Internet.Digital images can express information more intuitively,so transmitting information through images has excellent applications.This paper uses a new chaotic system called 1D-Sin-Logistic-Map(1D-SLM).1D-SLM has two control parameters,which can provide larger parameter space,and the parameter space in the chaotic state is continuous.Through Lyapunov exponent analysis(LE),bifurcation diagrams analysis,spectral entropy analysis(SE),and 0-1 test,it is verified that 1D-SLM has complex dynamic behavior and is very suitable for cryptography.Compared with other 1D chaotic systems,the 1D-SLM has a larger Lyapunov exponent(LE)and spectral entropy(SE).For color image encryption algorithms,only relying on chaotic mapping is not enough to ensure security.So combined with 1D-SLM,we design a color image encryption algorithm,which is implemented by plane expansion,which reduces the correlation between the three channels of color images.The experimental results show that the proposed cross-plane color image encryption algorithm is safe and resistant to common attack methods. 展开更多
关键词 Chaos theory chaotic system 1D-SLM image encryption information security
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双清一号(珞珈三号01星)多模式成像样例数据集 被引量:1
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作者 王密 杨芳 +2 位作者 李德仁 潘俊 戴荣凡 《电子与信息学报》 EI CAS CSCD 北大核心 2024年第6期2299-2310,共12页
针对当前多数高分辨遥感卫星面向用户服务存在获取数据种类单一问题,该文公开了双清一号(珞珈三号01星)多模式成像样例数据集,涵盖了面阵推扫、面阵推帧和视频凝视等多种成像模式,包含城市、水体、山区、机场等不同目标区域的典型数据... 针对当前多数高分辨遥感卫星面向用户服务存在获取数据种类单一问题,该文公开了双清一号(珞珈三号01星)多模式成像样例数据集,涵盖了面阵推扫、面阵推帧和视频凝视等多种成像模式,包含城市、水体、山区、机场等不同目标区域的典型数据样本。该数据集由信号数据解码、Bayer插值、相对辐射校正、几何定位、视频稳像和3维重建等步骤处理构建;同时,对在轨定标、兴趣区产品快速生产、高清视频几何稳像和多角度3维重建等关键算法做了深入探讨和研究。最后,对样本数据集从图像标准产品、凝视视频产品和实景3维产品等3个方面进行了可视化展示和定量化精度评价。 展开更多
关键词 双清一号 多模式成像 视频稳像 3维重建
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MRI T_2 star mapping、T_1 images与3D DESS融合图在隐匿性膝关节软骨损伤中的应用 被引量:4
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作者 范伟雄 杨志企 +3 位作者 程凤燕 黄健 于昭 侯文忠 《临床医学工程》 2017年第4期437-439,共3页
目的探讨T_2 star mapping、T_1 images与3D DESS融合伪彩图在关节软骨损伤中的诊断价值。方法对26例关节软骨损伤患者行T_2 star mapping、T_1 images和3D DESS扫描,并将T_1 images、T_2 star mapping与3D DESS图像融合,评价患者股骨... 目的探讨T_2 star mapping、T_1 images与3D DESS融合伪彩图在关节软骨损伤中的诊断价值。方法对26例关节软骨损伤患者行T_2 star mapping、T_1 images和3D DESS扫描,并将T_1 images、T_2 star mapping与3D DESS图像融合,评价患者股骨、胫骨、髌骨关节软骨损伤程度并与关节镜结果对比,计算融合伪彩图诊断软骨损伤的特异性、敏感性及与关节镜诊断结果一致性。结果 T_1 images-3D DESS融合伪彩图诊断关节软骨损伤的敏感度、特异度及Kappa值分别为92.8%、93.0%、0.769,T_2 star mapping-3D DESS融合伪彩图诊断关节软骨损伤的敏感度、特异度及Kappa值分别为91.4%、94.2%、0.787。结论 T_2 star mapping、T_1 images与3D DESS融合伪彩图在关节软骨早期损伤评价上优于关节镜。 展开更多
关键词 膝关节 关节软骨 磁共振成像 T2 star mapping T1 imageS 3D DESS
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T_(1)-mapping鉴别腮腺常见肿瘤的初探
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作者 文宝红 张赞霞 +3 位作者 朱靖 付坤 张勇 程敬亮 《放射学实践》 CSCD 北大核心 2024年第2期189-194,共6页
目的:探讨T_(1)-mapping和分段读出DWI(RESOLVE-DWI)在腮腺常见肿瘤鉴别诊断中的价值。方法:回顾性分析2018年6月-2022年8月经病理证实的169例腮腺常见肿瘤患者的T_(1)-mapping及分段读出DWI资料。其中,多形性腺瘤85例,Warthin瘤32例,... 目的:探讨T_(1)-mapping和分段读出DWI(RESOLVE-DWI)在腮腺常见肿瘤鉴别诊断中的价值。方法:回顾性分析2018年6月-2022年8月经病理证实的169例腮腺常见肿瘤患者的T_(1)-mapping及分段读出DWI资料。其中,多形性腺瘤85例,Warthin瘤32例,恶性肿瘤52例。测量并比较三组肿瘤的T_(1)及ADC值,运用受试者工作特征(ROC)曲线评价T_(1)、ADC及二者联合(T_(1)+ADC)对腮腺肿瘤的鉴别诊断价值。采用Delong检验比较各参数的AUC的差异。结果:三组肿瘤的T_(1)值和ADC值的差异均有统计学意义(P<0.001);组间两两比较,差异均有统计学意义(P<0.001);多形性腺瘤的T_(1)值及ADC值最高;恶性肿瘤次之,Warthin瘤最低。T_(1)和ADC鉴别多形性腺瘤与Warthin瘤、多形性腺瘤与恶性肿瘤、Warthin瘤与恶性肿瘤的AUC分别为0.914和0.997、0.664和0.869、0.835和0.695,Delong检验显示2个参数AUC的差异均无统计学意义(P>0.05)。T_(1)+ADC鉴别多形性腺瘤与Warthin瘤、多形性腺瘤与恶性肿瘤的AUC均显著高于T_(1)(1.000 vs.0.914、0.873 vs.0.664,P均<0.001);T_(1)+ADC鉴别Warthin瘤与恶性肿瘤的AUC显著高于T_(1)(0.895 vs.0.835,P<0.001)和ADC(0.895 vs.0.695,P<0.001)。结论:T_(1)-mapping和RESOLVE-DWI有助于鉴别诊断腮腺常见肿瘤,二者联合诊断可提高鉴别诊断效能。 展开更多
关键词 腮腺肿瘤 磁共振成像 T_(1)-mapping 弥散加权成像
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基于MRI影像组学构建PD-1/PD-L1抑制剂治疗dMMR/MSI-H直肠癌疗效的预测模型
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作者 张岚 周彦汝 +3 位作者 韩鼎盛 张嘉诚 何旭 刘鹏 《中国医学计算机成像杂志》 CSCD 北大核心 2024年第3期343-348,共6页
目的:探讨MRI影像组学模型在程序性细胞死亡蛋白-1(PD-1)/程序性细胞死亡-配体1(PD-L1)抑制剂联合全程新辅助治疗(TNT)局部进展期直肠癌(LARC)的疗效预测价值。方法:收集河南中医药大学第一附属医院PD-1/PD-L1抑制剂联合TNT治疗的80例... 目的:探讨MRI影像组学模型在程序性细胞死亡蛋白-1(PD-1)/程序性细胞死亡-配体1(PD-L1)抑制剂联合全程新辅助治疗(TNT)局部进展期直肠癌(LARC)的疗效预测价值。方法:收集河南中医药大学第一附属医院PD-1/PD-L1抑制剂联合TNT治疗的80例错配修复基因缺陷(dMMR)/微卫星高度不稳定(MSI-H)基因型中低位LARC患者的临床和影像资料。将入组患者按7∶3比例分为训练集和测试集,提取影像组学特征,从中筛选并构建影像组学模型。描绘影像组学模型的Rad-score与病理金标准之间的受试者工作特征(ROC)曲线,计算曲线下面积(AUC),并评价模型的诊断效能。采用决策曲线分析(DCA)计算风险阈值的范围,并评估临床获益情况。收集湖南省人民医院25例dMMR/MSI-H基因型LARC患者的影像资料作为外部验证集。结果:训练集、测试集及外部验证集三者之间的临床特征无统计学差异(P>0.05)。经过降维处理、t检验及一致性检验以及LASSO交叉验证后,筛选出一阶偏度特征和体积2个特征构建影像组学模型。训练集、测试集和外部验证集的影像组学预测模型ROC曲线的AUC、灵敏度、特异度、阳性预测值和阴性预测值分别为0.920、97.1%、85.7%、91.9%、94.7%;0.885、80.0%、88.9%、92.3%、72.7%;0.875、87.5%、88.9%、93.3%、80.0%。DCA曲线显示,当风险阈值范围为0%~82%时,采用影像组学模型预测LARC患者为病理完全缓解(pCR)的获益大于将所有患者都视为pCR或者无病理完全缓解(npCR)。结论:基于MRI影像组学构建的dMMR/MSI-H型局部进展期直肠癌PD-1/PD-L1抑制剂联合全程新辅助放化疗疗效预测模型,有较大潜力为不同基因分型的直肠癌患者制定个体化治疗策略提供量化依据。 展开更多
关键词 磁共振成像 影像组学 直肠肿瘤 局部进展期 程序性细胞死亡蛋白-1/程序性细胞死亡-配体1 全程新辅助放化疗
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MRI检查指标、血清骨钙素、MMP-1及IL-1对膝骨关节炎合并软骨损伤的预测价值
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作者 郑菲 黄琛慧 +2 位作者 陈小玫 魏景欣 刘彪 《临床和实验医学杂志》 2024年第9期949-952,共4页
目的探讨磁共振成像(MRI)及血清骨钙素、基质金属蛋白酶(MMP-1)及白细胞介素-1(IL-1)对膝骨关节炎合并软骨损伤的预测价值。方法回顾性分析2021年8月至2023年5月广西贵港市人民医院收治的84例膝骨关节炎患者的临床资料。入院后均行关节... 目的探讨磁共振成像(MRI)及血清骨钙素、基质金属蛋白酶(MMP-1)及白细胞介素-1(IL-1)对膝骨关节炎合并软骨损伤的预测价值。方法回顾性分析2021年8月至2023年5月广西贵港市人民医院收治的84例膝骨关节炎患者的临床资料。入院后均行关节镜检查,依据检查结果是否合并软骨损伤分组,分为合并组(n=40)与未合并组(n=44)。比较两组资料[性别、年龄、体重指数、合并疾病(高血压、高脂血症、糖尿病)、病变部位(左膝、右膝)、饮酒史、吸烟史]、MRI不同区域软骨T_(2)值[股骨外侧(LF)、股骨内侧(MF)、胫骨外侧(LT)、胫骨内侧(MT)、髌骨区(P)]以及血清骨钙素、MMP-1、IL-1水平。通过多因素采取非条件Logistic逐步回归分析明确膝骨关节炎合并软骨损伤的危险因素。通过受试者操作特征(ROC)曲线分析MRI不同区域软骨T_(2)值、血清骨钙素、MMP-1、IL-1预测膝骨关节炎合并软骨损伤的价值。结果两组性别构成比、年龄、体重指数、病变部位、合并高血压、高脂血症、糖尿病、饮酒史、吸烟史比较,差异均无统计学意义(P>0.05);合并组MRI不同区域软骨T_(2)值以及血清骨钙素、MMP-1、IL-1水平均显著高于未合并组,差异均有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,MRI不同区域软骨T_(2)值、骨钙素、MMP-1、IL-1是膝骨关节炎患者合并软骨损伤的危险因素(P<0.05)。经ROC分析证实,LF软骨T_(2)值、MF软骨T_(2)值、LT软骨T_(2)值、MT软骨T_(2)值、P软骨T_(2)值、骨钙素、MMP-1、IL-1最佳截断值分别为39.705 ms、44.250 ms、36.855 ms、35.715 ms、38.005 ms、6.655μg/L、7.335μg/L、389.340 pg/mL,曲线下面积分别为0.796、0.840、0.859、0.882、0.728、0.705、0.763、0.721,均有较高预测价值(P<0.05)。结论MRI不同区域软骨T_(2)值、血清骨钙素、MMP-1、IL-1是膝骨关节炎合并软骨损伤的危险因素;同时LF软骨T_(2)值≥39.705 ms、MF软骨T_(2)值≥44.250 ms、LT软骨T_(2)值≥36.855 ms、MT软骨T_(2)值≥35.715 ms、P软骨T_(2)值≥38.005 ms、骨钙素≥6.655μg/L、MMP-1≥7.335μg/L、IL-1≥389.340 pg/mL可用于预测此类患者合并风险。 展开更多
关键词 核磁共振成像 骨钙素 基质金属蛋白酶 白细胞介素-1 膝骨关节炎 软骨损伤 危险因素 预测风险
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胆红素总量/白蛋白比值、听力筛查及MRI-T_(1)WI影像对新生儿急性胆红素脑病的诊断价值
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作者 王粉 王燕 +3 位作者 顾圆 王倩倩 陈志云 田小娟 《中外医学研究》 2024年第4期143-148,共6页
目的:探究胆红素总量/白蛋白比值(B/A)、听力筛查及磁共振成像-T_(1)加权成像(MRI-T_(1)WI)对新生儿急性胆红素脑病(ABE)的诊断价值。方法:选取2013年6月—2023年6月于太仓市第一人民医院接受治疗的136例新生儿高胆红素血症(NHB)患儿作... 目的:探究胆红素总量/白蛋白比值(B/A)、听力筛查及磁共振成像-T_(1)加权成像(MRI-T_(1)WI)对新生儿急性胆红素脑病(ABE)的诊断价值。方法:选取2013年6月—2023年6月于太仓市第一人民医院接受治疗的136例新生儿高胆红素血症(NHB)患儿作为研究对象,根据是否并发ABE分为并发组(n=42)和对照组(n=94)。对比两组的临床资料、B/A水平、听力筛查结果、苍白球T_(1)WI信号强度,对单因素分析有意义的指标进行多因素logistic回归分析,采用ROC曲线分析其对新生儿ABE的诊断价值。结果:并发组总血清胆红素(TSB)峰值、B/A水平均高于对照组,差异有统计学意义(P<0.05)。并发组初筛听力异常率为38.10%,复筛听力异常率为35.71%,均高于对照组的18.09%、8.51%,差异有统计学意义(P<0.05)。并发组苍白球与额叶脑皮质T_(1)WI信号强度比值(G/Gr)水平高于对照组,差异有统计学意义(P<0.05)。logistic回归分析显示,B/A、听力异常和G/Gr水平表达均为影响NHB患儿并发ABE的独立危险因素,差异有统计学意义(P<0.05)。ROC曲线分析显示,B/A、G/Gr、听力异常及三者联合检测NHB患儿并发ABE的AUC值分别为0.773、0.652、0.754、0.863,有较高诊断价值,且联合诊断价值最高(P<0.05)。结论:ABE患儿中B/A、听力异常和G/Gr表达水平明显升高,三者单独和联合检测NHB患儿并发ABE均有较高诊断价值,其中三者联合诊断效果最佳。 展开更多
关键词 急性胆红素脑病 新生儿 胆红素总量/白蛋白比值 听力筛查 磁共振成像-T_(1)加权成像
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基于HJ-1星和GF-1号影像融合特征提取冬小麦种植面积 被引量:1
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作者 张宏 李卫国 +4 位作者 张晓东 卢必慧 张琤琤 李伟 马廷淮 《中国农业科技导报》 CAS CSCD 北大核心 2024年第2期109-119,共11页
为提高基于国产环境与灾害监测预报卫星(HJ-1/CCD)影像大范围提取冬小麦种植面积的精度,以江苏省宿迁市沭阳县为研究区域,对冬小麦拔节期30 m×30 m的HJ-1/CCD多光谱影像和2 m×2 m的高分1号卫星全色影像(GF-1/PMS)进行融合与... 为提高基于国产环境与灾害监测预报卫星(HJ-1/CCD)影像大范围提取冬小麦种植面积的精度,以江苏省宿迁市沭阳县为研究区域,对冬小麦拔节期30 m×30 m的HJ-1/CCD多光谱影像和2 m×2 m的高分1号卫星全色影像(GF-1/PMS)进行融合与面向对象分类研究。将GF-1/PMS全色影像进行8、16和24 m重采样,得到4种空间分辨率(含2 m)的全色影像,分别与HJ-1/CCD多光谱影像利用光谱锐化法(Gram-Schmidt,GS)进行融合。通过对融合影像进行质量评价,选择适合研究区冬小麦种植田块格局的适宜尺度影像。将HJ-1/CCD多光谱影像重采样,得到与适宜尺度融合影像相同尺度的影像,在两景影像中分别选取包含光谱、纹理信息的训练融合影像样本(samples of fused image,SFI)和重采样影像样本(samples of resampling image,SRI),采用面向对象分类方法对适宜尺度融合影像(fused image,FI)和重采样影像(resampling image,RI)进行冬小麦种植面积提取。结果表明,16 m×16 m融合影像的效果优于2 m×2 m、8 m×8 m和24 m×24 m融合影像,其均值、标准差、平均梯度和相关系数分别为161.15、83.01、4.55和0.97。面向对象分类后,SFI对重采样影像RI16m分类的总体精度为92.22%,Kappa系数为0.90。SFI对融合影像FI16m分类的总体精度为94.44%,Kappa系数为0.93。SRI对重采样影像RI16m分类的总体精度为84.44%,Kappa系数为0.80。SFI对融合影像FI16m分类效果最好,说明基于融合影像和融合影像提取样本(SFI)结合的面向对象分类方法能准确提取冬小麦种植面积。另外,重采样影像和融合影像提取样本(SFI)相结合的面向对象分类方法也可较好提取冬小麦种植面积。为利用国产中空间分辨率HJ-1/CCD卫星和高分1号卫星融合影像有效提取大区域冬小麦种植面积信息提供了参考。 展开更多
关键词 HJ-1/CCD卫星影像 GF-1/PMS卫星影像 冬小麦种植面积 特征提取 影像融合 面向对象分类
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缺血性疾病患者血清lncRNA PVT1和FOXM1表达水平及联合心脏磁共振延迟强化成像与预后的关系
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作者 尹晓翔 赵森 +2 位作者 郭颖 刘梦雯 庄琰 《中国CT和MRI杂志》 2024年第3期73-75,共3页
目的 探讨缺血性疾病患者血清长链非编码RNA浆细胞瘤转化迁移基因1(lncRNA PVT1)和叉头框转录因子M1(FOX M1)表达水平及联合心脏钆对比剂延迟增强磁共振成像(LGE-MRI)与预后的关系。方法 选取2021年2月-2022年2月我院收治的缺血性心脏... 目的 探讨缺血性疾病患者血清长链非编码RNA浆细胞瘤转化迁移基因1(lncRNA PVT1)和叉头框转录因子M1(FOX M1)表达水平及联合心脏钆对比剂延迟增强磁共振成像(LGE-MRI)与预后的关系。方法 选取2021年2月-2022年2月我院收治的缺血性心脏病患者118例即为研究组,随访一年根据随访过程中是否发生主要心脏不良事件(MACE),分为MACE组32例,无MACE组86例。同期选择在我院体检健康的志愿者118例为对照组。实时荧光定量PCR(qRT-PCR)检测血清lncRNA PVT1的相对表达量。采用酶联免疫吸附试验(E LISA)检测FOXM1水平。受试者工作特征(ROC)曲线分析LGE-MRI、血清lncRNA PVT1和FOXM1对缺血性心脏病患者预后发生MACE的预测价值。结果 研究组患者DBP、SBP、TG、TC、 LDL-C、GLU水平与对照组相比显著升高,HDL-C水平显著降低(P<0.05)。与对照组相比,研究组的血清中lncRNA PVT1和FOXM1水平显著升高(P<0.05)。与无MACE组相比,MACE组患者DBP、SBP、TC、LDL-C水平显著升高, HDL-C水平显著降低(P<0.05)。与无MACE组相比,MACE组患者血清中lncRNA PVT1和FOXM1水平显著升高(P<0.05)。MACE组的LGE-MRI阳性数量显著高于无MACE组(P<0.)05。与LGE-MRI、血清lncRNA PVT1和FOXM1单独预测相比,三者联合预测MACE发生的AUC更高(Z=7.221,P<0.001;Z=7.737,P<0.001;Z=7.091,P<0.001)。结论 缺血性心脏病预后发生MACE的患者血清lncRNA PVT1和FOXM1水平呈高表达,二者联合LGE-MRI对MACE的发生有一定的预测价值。 展开更多
关键词 长链非编码RNA浆细胞瘤转化迁移基因1 叉头框转录因子M1 心脏钆对比剂延迟增强磁共振成像 预后 缺血性疾病
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Magnetic resonance imaging focused on the ferritin heavy chain 1 reporter gene detects neuronal differentiation in stem cells 被引量:1
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作者 Xiao-Ya He Yi-Rui Zhou +4 位作者 Tong Mu Yi-Fan Liao Li Jiang Yong Qin Jin-Hua Cai 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第7期1563-1569,共7页
The neuronal differentiation of mesenchymal stem cells offers a new strategy for the treatment of neurological disorders.Thus,there is a need to identify a noninvasive and sensitive in vivo imaging approach for real-t... The neuronal differentiation of mesenchymal stem cells offers a new strategy for the treatment of neurological disorders.Thus,there is a need to identify a noninvasive and sensitive in vivo imaging approach for real-time monitoring of transplanted stem cells.Our previous study confirmed that magnetic resonance imaging,with a focus on the ferritin heavy chain 1 reporter gene,could track the proliferation and differentiation of bone marrow mesenchymal stem cells that had been transduced with lentivirus carrying the ferritin heavy chain 1 reporter gene.However,we could not determine whether or when bone marrow mesenchymal stem cells had undergone neuronal differentiation based on changes in the magnetic resonance imaging signal.To solve this problem,we identified a neuron-specific enolase that can be differentially expressed before and after neuronal differentiation in stem cells.In this study,we successfully constructed a lentivirus carrying the neuron-specific enolase promoter and expressing the ferritin heavy chain 1 reporter gene;we used this lentivirus to transduce bone marrow mesenchymal stem cells.Cellular and animal studies showed that the neuron-specific enolase promoter effectively drove the expression of ferritin heavy chain 1 after neuronal differentiation of bone marrow mesenchymal stem cells;this led to intracellular accumulation of iron and corresponding changes in the magnetic resonance imaging signal.In summary,we established an innovative magnetic resonance imaging approach focused on the induction of reporter gene expression by a neuron-specific promoter.This imaging method can be used to noninvasively and sensitively detect neuronal differentiation in stem cells,which may be useful in stem cell-based therapies. 展开更多
关键词 ferric ammonium citrate ferritin heavy chain 1 gene magnetic resonance imaging mesenchymal stem cells molecular imaging neuronal differentiation neuron-like cells NEURONS neuron-specific enolase PROMOTER
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Performances of conventional fusion methods evaluated for inland water body observation using GF-1 image 被引量:3
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作者 Yong Du Xiaoyu Zhang +1 位作者 Zhihua Mao Jianyu Chen 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2019年第1期172-179,共8页
Satellite remote sensing of inland water body requires a high spatial resolution and a multiband narrow spectral resolution, which makes the fusion between panchromatic(PAN) and multi-spectral(MS) images particularly ... Satellite remote sensing of inland water body requires a high spatial resolution and a multiband narrow spectral resolution, which makes the fusion between panchromatic(PAN) and multi-spectral(MS) images particularly important. Taking the Daquekou section of the Qiantang River as an observation target, four conventional fusion methods widely accepted in satellite image processing, including pan sharpening(PS), principal component analysis(PCA), Gram-Schmidt(GS), and wavelet fusion(WF), are utilized to fuse MS and PAN images of GF-1.The results of subjective and objective evaluation methods application indicate that GS performs the best,followed by the PCA, the WF and the PS in the order of descending. The existence of a large area of the water body is a dominant factor impacting the fusion performance. Meanwhile, the ability of retaining spatial and spectral informations is an important factor affecting the fusion performance of different fusion methods. The fundamental difference of reflectivity information acquisition between water and land is the reason for the failure of conventional fusion methods for land observation such as the PS to be used in the presence of the large water body. It is suggested that the adoption of the conventional fusion methods in the observing water body as the main target should be taken with caution. The performances of the fusion methods need re-assessment when the large-scale water body is present in the remote sensing image or when the research aims for the water body observation. 展开更多
关键词 GF-1 satellite image FUSION methods FUSION evaluation INLAND water body
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Two-photon live imaging of direct glia-to-neuron conversion in the mouse cortex 被引量:1
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作者 Zongqin Xiang Shu He +13 位作者 Rongjie Chen Shanggong Liu Minhui Liu Liang Xu Jiajun Zheng Zhouquan Jiang Long Ma Ying Sun Yongpeng Qin Yi Chen Wen Li Xiangyu Wang Gong Chen Wenliang Lei 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第8期1781-1788,共8页
Over the past decade,a growing number of studies have reported transcription factor-based in situ reprogramming that can directly conve rt endogenous glial cells into functional neurons as an alternative approach for ... Over the past decade,a growing number of studies have reported transcription factor-based in situ reprogramming that can directly conve rt endogenous glial cells into functional neurons as an alternative approach for n euro regeneration in the adult mammalian central ne rvous system.Howeve r,many questions remain regarding how a terminally differentiated glial cell can transform into a delicate neuron that forms part of the intricate brain circuitry.In addition,concerns have recently been raised around the absence of astrocyte-to-neuron conversion in astrocytic lineage-tra cing mice.In this study,we employed repetitive two-photon imaging to continuously capture the in situ astrocyte-to-neuron conversion process following ecto pic expression of the neural transcription factor NeuroD1 in both prolife rating reactive astrocytes and lineage-tra ced astrocytes in the mouse cortex.Time-lapse imaging over several wee ks revealed the ste p-by-step transition from a typical astrocyte with numero us short,tapered branches to a typical neuro n with a few long neurites and dynamic growth cones that actively explored the local environment.In addition,these lineage-converting cells were able to migrate ra dially or to ngentially to relocate to suitable positions.Furthermore,two-photon Ca2+imaging and patch-clamp recordings confirmed that the newly generated neuro ns exhibited synchronous calcium signals,repetitive action potentials,and spontaneous synaptic responses,suggesting that they had made functional synaptic connections within local neural circuits.In conclusion,we directly visualized the step-by-step lineage conversion process from astrocytes to functional neurons in vivo and unambiguously demonstrated that adult mammalian brains are highly plastic with respect to their potential for neuro regeneration and neural circuit reconstruction. 展开更多
关键词 astrocyte-to-neuron conversion Ca2+imaging direct lineage conversion GLIA ASTROCYTE in vivo reprogramming lineage-tracing mice NeuroD1 NEURON two-photon imaging
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1型发作性睡病认知功能障碍的研究进展 被引量:1
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作者 刘雨欣 谢亮(综述) 邓丽影(审校) 《中风与神经疾病杂志》 CAS 2024年第3期251-254,F0003,共5页
认知功能障碍是1型发作性睡病(narcolepsy type 1,NT1)的常见症状之一,严重影响患者的学习工作。目前研究表明,NT1患者在注意力、记忆、执行功能等认知领域存在显著障碍。NT1认知功能障碍具体机制不明确,动物研究显示脑脊液食欲素分泌... 认知功能障碍是1型发作性睡病(narcolepsy type 1,NT1)的常见症状之一,严重影响患者的学习工作。目前研究表明,NT1患者在注意力、记忆、执行功能等认知领域存在显著障碍。NT1认知功能障碍具体机制不明确,动物研究显示脑脊液食欲素分泌缺乏与认知障碍密切相关,同时近些年来神经影像学已结合不同的研究方法应用于NT1认知障碍机制的研究,能反映相关结构和功能异常。1型发作性睡病的认知功能障碍治疗至今仍缺乏有循证依据的治疗手段。本文对1型发作性睡病的认知功能障碍进展做一综述。 展开更多
关键词 1型发作性睡病 认知功能 食欲素 功能磁共振
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^(1)H-MRS在脑胶质瘤诊断中的研究进展
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作者 刘璟仪 石莹 +1 位作者 田园 刘鹏飞 《现代肿瘤医学》 CAS 2024年第4期782-786,共5页
脑胶质瘤是中枢神经系统最常见的颅内恶性肿瘤,预后差。磁共振波谱成像作为能够无创检测活体组织内化学物质的磁共振功能成像,可以量化感兴趣区的不同代谢物,为更加准确地早期诊断脑胶质瘤提供帮助。本文就氢质子磁共振波谱成像在脑胶... 脑胶质瘤是中枢神经系统最常见的颅内恶性肿瘤,预后差。磁共振波谱成像作为能够无创检测活体组织内化学物质的磁共振功能成像,可以量化感兴趣区的不同代谢物,为更加准确地早期诊断脑胶质瘤提供帮助。本文就氢质子磁共振波谱成像在脑胶质瘤诊断评估中的研究进展进行综述。 展开更多
关键词 胶质瘤 氢质子磁共振波谱成像 磁共振成像
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基于哨兵1号影像浮冰形状特征的北极内尔斯海峡海冰运动信息提取方法
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作者 杨帆 刘婷婷 雷瑞波 《极地研究》 CAS CSCD 北大核心 2024年第2期169-182,共14页
内尔斯海峡是北极海冰输出的重要通道之一,从海峡流出的海冰对巴芬湾、拉布拉多海深层水的形成以及北极海冰物质平衡具有重要影响。由于海峡入口狭窄和海冰密集度较低,现有海冰运动反演算法较难从卫星影像上获取有效的海冰运动信息,从... 内尔斯海峡是北极海冰输出的重要通道之一,从海峡流出的海冰对巴芬湾、拉布拉多海深层水的形成以及北极海冰物质平衡具有重要影响。由于海峡入口狭窄和海冰密集度较低,现有海冰运动反演算法较难从卫星影像上获取有效的海冰运动信息,从而限制了该区域海冰运动信息的提取。本研究提出了一种基于浮冰形状特征的海冰运动提取算法,该算法主要包括影像分割、浮冰提取和浮冰匹配3个步骤。使用该算法从2019年2月20-27日逐日哨兵1号影像中提取了内尔斯海峡的海冰运动信息,并结合人工制作的验证数据评估了该算法在浮冰提取和匹配过程的精度。结果显示该算法提取的浮冰形状参数平均误差为4.3%~8.48%、浮冰运动矢量的总体正确率为84%、浮冰质心与运动速度的均方根误差分别为0.171km和6.313cm·s^(–1)。对比SIFT,ORB和AKAZE三种基于特征追踪的海冰运动反演算法,该算法结果中海冰运动覆盖面积增加了27.7%,精度提高约39%。该算法不仅有效地提取了内尔斯海峡海冰运动信息,而且可为其他区域(如海冰边缘区)的海冰运动信息提取提供参考。 展开更多
关键词 内尔斯海峡 海冰运动 哨兵1 影像分割 浮冰匹配
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磁共振SWI序列联合血清Id1、IGFBP-3对脑胶质瘤术前分级的评估价值 被引量:1
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作者 刘梦雯 赵森 《中国CT和MRI杂志》 2024年第2期5-7,共3页
目的分析磁共振磁敏感加权成像(SWI)序列联合血清分化抑制因子1(Id1)、胰岛素样生长因子结合蛋白-3(IGFBP-3)对脑胶质瘤术前分级的评估价值。方法选取2019年12月至2022年6月我院收治的脑胶质瘤患者98例作为此次研究对象,根据恶化情况分... 目的分析磁共振磁敏感加权成像(SWI)序列联合血清分化抑制因子1(Id1)、胰岛素样生长因子结合蛋白-3(IGFBP-3)对脑胶质瘤术前分级的评估价值。方法选取2019年12月至2022年6月我院收治的脑胶质瘤患者98例作为此次研究对象,根据恶化情况分为低级别组(世界卫生组织Ⅰ级和Ⅱ级)46例,高级别组(世界卫生组织Ⅲ级和Ⅳ级)52例;入选患者均进行磁共振SWI序列检查;采用酶联免疫吸附(ELISA)法检测血清Id1、IGFBP-3水平;采用Pearson法分析血清Id1、IGFBP-3水平的相关性;受试者工作特征(ROC)曲线分析Id1、IGFBP-3水平对脑胶质瘤术前分级的临界诊断点;采用四格表分析磁共振SWI序列联合血清Id1、IGFBP-3对脑胶质瘤术前高低级别的诊断价值。结果高级别组ITSS分级显著高于低级别组(P>0.05)。高级别组Id1、IGFBP-3水平均显著高于低级别组(P>0.05)。根据pearson相关性分析得知,脑胶质瘤患者血清Id1、IGFBP-3水平呈正相关(r=0.486,P<0.05)。根据ROC曲线得知,Id1、IGFBP-3诊断脑胶质瘤术前分级的曲线下面积(AUC)分别为0.837、0.861,二者联合诊断脑胶质瘤术前分级的AUC为0.908。磁共振SWI序列在脑胶质瘤术前分级诊断中准确度为83.67%,灵敏度为84.62%,特异度为82.61%;Id1在脑胶质瘤术前分级诊断中准确度为79.59%,灵敏度为80.77%,特异度为78.26%;IGFBP-3在脑胶质瘤术前分级诊断中准确度为81.63%,灵敏度为82.69%,特异度为80.43%;三者联合检测在脑胶质瘤术前分级诊断中准确度为91.84%,灵敏度为92.31%,特异度为91.30%。结论Id1、IGFBP-3在脑胶质瘤患者血清中显著升高,磁共振SWI序列联合血清Id1、IGFBP-3可以提高对脑胶质瘤术前分级的评估价值。 展开更多
关键词 磁共振 磁敏感加权成像 分化抑制因子1 胰岛素样生长因子结合蛋白-3 脑胶质瘤
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The brightness reversal of submarine sand waves in “HJ-1A/B” CCD sun glitter images 被引量:2
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作者 HE Xiekai CHEN Ninghua +1 位作者 ZHANG Huaguo GUAN Weibing 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2015年第1期94-99,共6页
The brightness reversal of submarine sand waves appearing in the small satellite constellation for environ- ment and disaster monitoring and forecasting ("HJ- 1A/B") CCD sun glitter images can affect the observati... The brightness reversal of submarine sand waves appearing in the small satellite constellation for environ- ment and disaster monitoring and forecasting ("HJ- 1A/B") CCD sun glitter images can affect the observation and depth inversion of sand wave topography. The simulations of the normalized sun glitter radiance on the submarine sand waves confirm that the reversal would happen at a specific sensor viewing angle, defined as the critical angle. The difference between the calculated critical angle position and the reversal position in the image is about 1', which is excellent in agreement. Both the simulation and actual image show that sand wave crests would be indistinct at the reversal position, which may cause problems when using these sun glitter images to analyze spatial characteristics and migration of sand waves. When using the sun glitter image to obtain the depth inversion, one should take the advantage of image properties of sand waves and choose the location in between the reversal position and the brightest position. It is also necessary to pay attention to the brightness reversal when using "HI-1A/B" CCD images to analyze other oceanic features, such as internal waves, oil slicks, eddies, and ship wakes. 展开更多
关键词 "HJ-1A/B" CCD sun glitter image submarine sand waves brightness reversal Taiwan Banks
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