A case of dilated cardiomyopathy was reported,including the course of onset and long-term application of Qilan Qiangxin Capsule combined with a new anti-heart failure drug,Sakubatril Valsartan,in order to improve the ...A case of dilated cardiomyopathy was reported,including the course of onset and long-term application of Qilan Qiangxin Capsule combined with a new anti-heart failure drug,Sakubatril Valsartan,in order to improve the symptoms of heart failure,increase the LVEF(left ventricular ejection fraction),and reduce the plasma NT-proBNP(N-terminal B-type natriuretic peptide)level.The effect of improving ventricular remodeling is obvious,and the quality of life of patients is improved.展开更多
文摘A case of dilated cardiomyopathy was reported,including the course of onset and long-term application of Qilan Qiangxin Capsule combined with a new anti-heart failure drug,Sakubatril Valsartan,in order to improve the symptoms of heart failure,increase the LVEF(left ventricular ejection fraction),and reduce the plasma NT-proBNP(N-terminal B-type natriuretic peptide)level.The effect of improving ventricular remodeling is obvious,and the quality of life of patients is improved.
文摘目的 观察芪苈强心胶囊对慢性心(chronic heart failure,CHF)衰后认知功能障碍的干预作用并探讨其相关机制。方法 SD大鼠建立心梗后心衰大鼠模型,分为假手术组、模型组、芪苈组和缬沙坦组。Morris水迷宫检测大鼠认知功能,超声心动图和血流动力学检测心功能,HE染色观察心脏结构,尼氏染色观察海马神经元,ELISA法检测血浆和海马血管紧张素(angiotensin,Ang)Ⅱ、海马β淀粉样蛋白(amyloid-β,Aβ)42浓度。结果 与假手术组比较,模型组大鼠的左心室舒张末压(left ventricular end diastolic pressure,LVEDP)、海马Aβ42、血浆和海马AngⅡ浓度显著升高(P<0.05),穿台次数、心室射血分数(ejection fraction,EF)、心室缩短分数(fractional shortening,FS)、左心室收缩压(left ventricular systolic pressure,LVSP)、左心室内压最大上升速率(the maximal rate of increase of left ventricular pressure,+dp/dt max)和最大下降速率(the maximal rate of decrease of left ventricular pressure,-dp/dt max)显著降低(P<0.05),心肌细胞结构模糊,有明显炎性细胞浸润,海马神经元数量减少且染色较浅。与模型组比较,芪苈组大鼠的海马Aβ42、血浆和海马AngⅡ浓度明显降低(P<0.05),穿台次数、EF、FS、LVSP显著增加(P<0.05),心肌和海马染色结果均有改善。结论芪苈强心胶囊可能通过抑制外周和海马AngⅡ及脑内Aβ42水平,改善慢性心衰大鼠心功能和认知功能障碍。
