期刊文献+
共找到265,608篇文章
< 1 2 250 >
每页显示 20 50 100
Exploring the Implications of Patient Advocacy Outcomes among Practicing Nurses within the Hospital Context: A Qualitative Research
1
作者 Comfort Nsiah Paul Kukye-Ayiri Ninnoni +1 位作者 Mate Siakwa Francis Nsiah 《Open Journal of Nursing》 2023年第12期855-874,共20页
Background: Nurses are expected by their international code of ethics to advocate for patients to enhance safety and quality care. However, there is a limited understanding regarding the implications of specific patie... Background: Nurses are expected by their international code of ethics to advocate for patients to enhance safety and quality care. However, there is a limited understanding regarding the implications of specific patient advocacy outcomes experienced by nurses who advocate for patients in the hospital context. Purpose: This study explored the implications of patient advocacy outcomes experienced among practicing nurses in the hospital context. Methods: A qualitative, descriptive study design was utilized. Data was collected through purposive sampling and an in-depth semi-structured interview of 25 Registered Nurses in an acute care hospital. An inductive qualitative content analysis method was used, and the SRQR guidelines for reporting qualitative studies were followed. Results: This study revealed that nurses who succeeded in advocating for patients experienced feelings of happiness, increased confidence levels, increased work output, and job satisfaction. However, nurses who failed to succeed in advocating for patients experienced physical, emotional, and psychological consequences, which contributed negatively to the quality of patient care. Therapeutic communication and nurses’ commitment to intervene for patients emerged as vital qualities and skills required to succeed in the patient advocacy process. Conclusions: This study showed that patient advocacy has advantages. However, when nurses fail to succeed in their attempt to advocate for patients in clinical practice, the outcomes can negatively affect their own well-being and the quality of patient care delivery. These study results could promote awareness and help nurses to develop strategies for improving patient advocacy activities based on their experiences. Additionally, nurses can seek help, including psychological counseling, when necessary to enhance their optimal well-being as they care for their patients. Nursing educational institutions and hospital managers can support, train, and equip nurses with the required skills for enhancing positive advocacy outcomes. . 展开更多
关键词 IMPLICATIONS Patient Advocacy Nurses Advocacy Outcomes qualitative research
下载PDF
Self-experience of buried seeds at auricular points in depressive patients with sleep disorder: a qualitative research 被引量:1
2
作者 XIAO Aixiang YU Lin +3 位作者 YE Junrong LI Sijue WEI Hongmei WANG Chen 《中西医结合护理(中英文)》 2017年第12期1-5,共5页
Objective To explore the self-experience of burying seeds at auricular points in depressive patients with sleep disorder,so as to seek possible approaches to improve the quality of care.Methods Eleven patients involve... Objective To explore the self-experience of burying seeds at auricular points in depressive patients with sleep disorder,so as to seek possible approaches to improve the quality of care.Methods Eleven patients involved in a three-week randomized controlled clinical trial were purposefully interviewed by the experienced,qualified counselor.The process of thematic analysis was applied in this study,the self-experience was discussed and recorded,transcribed,and analyzed accordingly.Results Four themes related to self-experience were extracted,these included the deficiency in relevant support,passive acceptance,distrust,expectation and further advice.Conclusion There was an urgent demand of humane care and emotional support,which might improve compliance of the treatment to some extent in terms of health education.Additionally,medical practitioners should provide the patient with comprehensive support,professional health education,as well as standardize training program for TCM operator and control the operation’s quality. 展开更多
关键词 buried seeds in auricular point DEPRESSION qualitative research self experience
下载PDF
Factors influencing the degree of participation in surgical decision-making among Chinese patients with prostate cancer:A qualitative research
3
作者 Jie Cao Chunxue Peng +2 位作者 Xiaoying Lu Lingjun Zhou Jing Wu 《Asian Journal of Urology》 CSCD 2022年第2期177-185,共9页
Objective:There was increasingly demand of participation in surgical decision-making among Chinese patients with prostate cancer.However,due to the complex healthcare system and advanced care settings,it is quite chal... Objective:There was increasingly demand of participation in surgical decision-making among Chinese patients with prostate cancer.However,due to the complex healthcare system and advanced care settings,it is quite challenging for the patients to gain sufficient support from the institute and the government.This research aimed to investigate the factors that impact the degree of participation in surgical decision-making among Chinese prostate cancer patients.Methods:A phenomenological approach of qualitative research based on the results of semi-structured interviews was adopted,to explore the influencing factors which hinder the participation in surgical decision-making.Consolidated Criteria for Reporting Qualitative Research were utilized.Up to 160 post-operative patients who had undergone radical prostatectomy along with 68 medical and nursing staffs,were purposively recruited in this research.This retrospective study was carried out from September 2018 to August 2019.After recording and transcribing the interviews,the interview materials were evaluated via the Colaizzi's seven step approach and the NVivo Version 10 software to analyze the interview content.Results:According to the analysis and summary of the interviews,there were three factors affecting the degree of participation in surgical decision-making.Firstly,insufficient information was provided by medical and nursing staffs because of their lack of time,proper communication skills,and career experience,as well as difficulties in the development of patient decision aid and inconsistent resource availability.Secondly,the cognitive level of decision-making among patients was relatively low due to poor psychological endurance,insufficient amount of education,senility,and less knowledge and information demand.Ultimately,decisions were constantly made by family members with/without patients.Conclusions:The degree of participation of Chinese prostate cancer patients in the surgical decision-making had much space for improvement. 展开更多
关键词 Prostate cancer PARTICIPATION DECISION-MAKING SURGERY Influence factors qualitative research
下载PDF
A qualitative research of idiopathic granulomatous mastitis patients
4
作者 WANG Fengjuan CHEN Sujin +1 位作者 YAN Yahong CHEN Yuezhi 《中西医结合护理》 2021年第7期164-172,共9页
Objective To thoroughly investigate the genuine emotional experience of patients with idiopathic granulomatous mastitis(IGM)pre-and post-treatment.Methods A purposive sampling method was adopted to select 13 patients ... Objective To thoroughly investigate the genuine emotional experience of patients with idiopathic granulomatous mastitis(IGM)pre-and post-treatment.Methods A purposive sampling method was adopted to select 13 patients with idiopathic granulomatous mastitis(IGM)as study objects during Feb to Dec 2016 who were all from the Department of Breast Surgery,the first affiliated hospital of Xiamen University.In addition,hermeneutic phenomenological method was performed in different ways including face-to-face interview,semi-structured interview,indepth interview,live recording and subject analysis of these collected data in hermeneutics rota⁃tion principle.Results The genuine emotional experience of patients with idiopathic granuloma⁃tous mastitis(IGM)pre-and post-treatment could be summarized into six subjects,through the thoroughly analysis of interview data,including change of sleep state,fatigue,lack of knowledge of disease,difficult to adapt to treatment state,worries and fears,and positive views of prosthesis implantation.Conclusion Lifestyle change among patient was prevalent pre-idiopathic granulo⁃matous mastitis,and patient always suffered from negative emotions and lack of disease knowl⁃edge once developed it.Therefore,it would demand medical staff to be committed to health edu⁃cation,communication with patients,and discovery problems in the first time.Moreover,posi⁃tive pertinent measures were appealed to improve confidence to overcome the suffering,and to ease or eliminate the negative emotion for recovery promotion. 展开更多
关键词 idiopathic granulomatous mastitis qualitative research systematic health education continuous nursing
下载PDF
Bibliometric analysis of qualitative researches in nursing in China from 2013 to 2019
5
作者 Wen-Jiao Li Hui-Min Zhang +1 位作者 Xue-Chao Liu Chang-De Jin 《TMR Integrative Nursing》 2020年第6期176-182,共7页
Aims:To analyze the research status and development trend of nursing qualitative research in China from 2013 to 2019.Method:China national knowledge infrastructure(CNKI),Wanfang Data and VIP database were researched t... Aims:To analyze the research status and development trend of nursing qualitative research in China from 2013 to 2019.Method:China national knowledge infrastructure(CNKI),Wanfang Data and VIP database were researched to include all related articles which were published from 2013 to 2019 about nursing qualitative research literature.NoteExpress literature management software and Excel were used to organize literature from annual distribution region,organization,core periodical,as well as the research object,research methods,data collection method and sampling method for metrology analysis.Results:2194 articles met the inclusion criteria,the number of articles is increasing year by year.Most of them come from Shanghai,Beijing,zhejiang and other developed areas.The top three institutions were the Huazhong University of Science and Technology,Tongji Medical College,Affiliated Union Hospital,Fudan university and Shanghai jiao tong university.And 835 of them were published in core journals.Research object are mainly divided into patient,nurses,nursing managers,etc.The included literature mainly adopts phenomenological research methods.Interview is the mainly data collection methods,and Colaizzi method is the mainly data analysis methods.Most articles use the method of purpose sampling.Conclusion:The qualitative research is becoming more and more attention by researchers in China.Qualitative research has covered clinical nursing,nursing education,nursing management,nursing psychology and other different nursing field.However,the selection of qualitative research methods,data analysis methods and related reports need to be further improved and standardized. 展开更多
关键词 qualitative research NURSING Bibliometrics analysis Literature analysis
下载PDF
A Qualitative Research on the Relationship between Prior Success and Motivation of Chinese EFL Readers
6
作者 李艳 《海外英语》 2014年第12X期234-235,263,共3页
In this study the author will pay attention to the relationship between the prior success of Chinese EFL readers and their motivation of reading. This essay is to investigate the question about whether prior success h... In this study the author will pay attention to the relationship between the prior success of Chinese EFL readers and their motivation of reading. This essay is to investigate the question about whether prior success has a positive effect on Chinese EFL readers' motivation. 展开更多
关键词 qualitative research SUCCESS MOTIVATION EFL
下载PDF
Qualitative Research on Learner's Beliefs about Learning English
7
作者 王熙 《海外英语》 2016年第21期60-64,共5页
In the ESOL/SLA field, qualitative studies try to explain the language learning process not merely from psychological points of view, but also from social and cultural perspectives. In this study, a Chinese learner... In the ESOL/SLA field, qualitative studies try to explain the language learning process not merely from psychological points of view, but also from social and cultural perspectives. In this study, a Chinese learner's perceptions of mainstream English instruction in China has been investigated through the interview, and the problem was explained from social and cultural perspectives. 展开更多
关键词 quantitative researches qualitative approaches learner’s beliefs
下载PDF
Qualitative Research and Narrative Sources in the Context of Critical and Renal Cares
8
作者 José Siles-González Carmen Solano-Ruiz 《Open Journal of Nursing》 2014年第6期385-401,共17页
The objective of this study is to clarify the relevance of qualitative research in the context of critical care and renal dialysis requires using narrative sources. Also specific objectives are to identify the phases ... The objective of this study is to clarify the relevance of qualitative research in the context of critical care and renal dialysis requires using narrative sources. Also specific objectives are to identify the phases or cultural moments that are distinguished in these processes. Research Question: How can the narrative materials contribute to the study of the processes of critical care and/or qualitative research in nephrology? Method and Sources: There have been studies focusing on the narrative of patients who have written their experiences building a literature experience ill (Siles et al., 1997, 1999, 2000). Sources have been used to extract testimony retrospective autobiographies written by people who have experienced the experiences of different diseases (Allué, 1996, 1997, Zorn, 1991, Gilbert, 1993;Comas, 2009;Gracia Armendáriz, 2010;Sampedro, 1996, Sacks, 2010). The analysis was developed by categorizing units of meaning, meaning families and networks. To identify the cultural moments we have followed the criteria established by Siles and Solano (2009): Multiculturalism, interculturalism and transculturalism. To identify rites of passage and liminality states have followed the principles outlined by Van Gennep (2013) and Turner (1990, 2008). Results: We identified cultural moments and characteristic states of liminality in critical care and kidney. Conclusions: narrative sources are effective for analyzing the meanings and experiences of patients in critical care and nephrology tool. 展开更多
关键词 NURSING NARRATIVE ANTHROPOLOGY of Care qualitative research CRITICAL and RENAL Cares
下载PDF
Practical Experience in Home Care of Nursing Interns: A Qualitative Research
9
作者 Lin Wang Meijuan Luo +3 位作者 Ruiying Huang Yanying Zhu Zhili Chen Weiju Chen 《Open Journal of Nursing》 2020年第5期526-533,共8页
Purpose: To explore practical experience in home care of nursing interns. Methods: The phenomenological method for qualitative research was to interview 15 nursing interns in a semi-structured way, and then the collec... Purpose: To explore practical experience in home care of nursing interns. Methods: The phenomenological method for qualitative research was to interview 15 nursing interns in a semi-structured way, and then the collected data were analyzed and summarized by using the Colaizzi analysis method. Results: Interviewing results showed that there were five recurring themes, including: 1) personalized care;2) health education;3) humanistic care;4) solid professional foundation and sense of responsibility;5) expanded vision. Conclusion: Through home care practice, nursing interns deepened their cognitions of nursing connotation, stimulated their love for nursing and motivation of continuous learning, and improved their sense of identity to nursing career. In general, the practice of home care had a positive impact on nursing interns. 展开更多
关键词 NURSING Interns HOME CARE PRACTICAL EXPERIENCE qualitative research
下载PDF
Qualitative Research on Emergency Medicine Physicians: A Literature Review
10
作者 Charlotte Paltved Peter Musaeus 《International Journal of Clinical Medicine》 2012年第7期772-789,共18页
Aim: This study aims to review the qualitative research studying Emergency Medicine (EM) physicians in Emergency Departments (ED). Background: Qualitative research aims to study complex social phenomena by other means... Aim: This study aims to review the qualitative research studying Emergency Medicine (EM) physicians in Emergency Departments (ED). Background: Qualitative research aims to study complex social phenomena by other means than quantification often through verbal or observational investigation. EM is a highly complex medical and social environment that has been investigated through qualitative methodologies. A literature review is needed to show what qualitative studies illuminate about EM and why this work is important to develop EM as a complex organizational and communicative practice. Methods: Electronic databases of English peer-reviewed articles were searched from 1971 to 2012 using Medline through PubMed and PsychINFO. This search was supplemented with hand-searches of Academic Emergency Medicine and Emergency Medicine Journal from 1999 to 2012 and cross references were reviewed. The key words used were emergency medicine, qualitative, ethnography, observation, interview, video, anthropology, simulation, and simulation-based. Results: 820 papers were identified and 46 studies were included in this review. This literature review found that the reviewed qualitative studies on EM physicians were designed using the following strategies of inquiry: Ethnography, mixed methods, action research, grounded theory, phenomenology, content analysis, discourse analysis, and critical incident analysis. The reviewed studies were categorized into four main themes: Education and training, communication, professional roles, and organizational factors, and into 12 sub-themes. Conclusion: The strength of qualitative research is its ability to grasp and operationalize complex relations within EM. Although qualitative research methodologies have gained in rigor in recent years and few researchers would question their value in studying complex medical and social phenomena, rigorous design in qualitative studies is needed. Qualitative research studies that stick with one strategy of inquiry that they follow closely are likely to yield more valid studies. 展开更多
关键词 EMERGENCY MEDICINE EMERGENCY DEPARTMENT Review qualitative research INTERVIEW Observation
下载PDF
An Exploration of the Relationships between Data and Theory in Qualitative Research
11
作者 周刚 《中国校外教育》 2009年第10期58-59,共2页
This article has explored the relationships between data and theory in qualitative research from an enthnographic perspective. It has also explicated the discovery of theory from data systematically obtained from enth... This article has explored the relationships between data and theory in qualitative research from an enthnographic perspective. It has also explicated the discovery of theory from data systematically obtained from enthnographic research, the Participant Observation approach based on inductive logic, that is, grounded theory. 展开更多
关键词 英语 数据 理论 定性研究
下载PDF
Qualitative Research Methods in Spatial Urban Development: A Methodological Investigation of Approaches into Urban Development Based on Centralities in the Context of a Medium-Sized European City
12
作者 Martin Brabant 《Journal of Civil Engineering and Architecture》 2016年第11期1288-1296,共9页
关键词 城市空间发展 城市发展 方法论 欧洲 生活方式 城市核心 城市环境 空间分析
下载PDF
Nurse anesthetists’perceptions and experiences of managing emergence delirium:A qualitative study
13
作者 Yi Xin Fu-Cai Lin +5 位作者 Chen Huang Bin He Ya-Ling Yan Shuo Wang Guang-Ming Zhang Rui Li 《World Journal of Psychiatry》 SCIE 2024年第4期553-562,共10页
BACKGROUND This study employs a descriptive phenomenological approach to investigate the challenges anesthesia nurses face in managing emergence delirium(ED),a common and complex postoperative complication in the post... BACKGROUND This study employs a descriptive phenomenological approach to investigate the challenges anesthesia nurses face in managing emergence delirium(ED),a common and complex postoperative complication in the post-anesthesia care unit.The role of nurses in managing ED is critical,yet research on their understanding and management strategies for ED is lacking.AIM To investigate anesthetic nurses’cognition and management experiences of ED in hopes of developing a standardized management protocol.METHODS This study employed a descriptive phenomenological approach from qualitative research methodologies.Purposeful sampling was utilized to select 12 anesthetic nurses from a tertiary hospital in Shanghai as research subjects.Semi-structured interviews were conducted,and the data were organized and analyzed using Colaizzi’s seven-step analysis method,from which the final themes were extracted.RESULTS After analyzing the interview content,four main themes and eight subthemes were distilled:Inefficient cognition hinders the identification of ED(conceptual ambiguity,empirical identification),managing diversity and challenges(patientcentered safe care,low level of medical-nursing collaboration),work responsibilities and pressure coexist(heavy work responsibilities,occupational risks and stress),demand for high-quality management(expecting the construction of predictive assessment tools and prevention strategies,and pursuing standardized management processes to enhance management effectiveness).CONCLUSION Nursing managers should prioritize the needs and suggestions of nurses in order to enhance their nursing capabilities and provide guidance for standardized management processes. 展开更多
关键词 Anesthetic nurse Emergence delirium Postoperative complications COGNITION Disease management qualitative research
下载PDF
Global trends in diabetic eye disease research from 2012 to 2021
14
作者 Yuan Yuan Shangli Ji +4 位作者 Yali Song Zhaodi Che Lu Xiao Shibo Tang Jia Xiao 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第10期2310-2320,共11页
Diabetic eye disease refers to a group of eye complications that occur in diabetic patients and include diabetic retinopathy, diabetic macular edema, diabetic cataracts, and diabetic glaucoma. However, the global epid... Diabetic eye disease refers to a group of eye complications that occur in diabetic patients and include diabetic retinopathy, diabetic macular edema, diabetic cataracts, and diabetic glaucoma. However, the global epidemiology of these conditions has not been well characterized. In this study, we collected information on diabetic eye disease-related research grants from seven representative countries––the United States, China, Japan, the United Kingdom, Spain, Germany, and France––by searching for all global diabetic eye disease journal articles in the Web of Science and Pub Med databases, all global registered clinical trials in the Clinical Trials database, and new drugs approved by the United States, China, Japan, and EU agencies from 2012 to 2021. During this time period, diabetic retinopathy accounted for the vast majority(89.53%) of the 2288 government research grants that were funded to investigate diabetic eye disease, followed by diabetic macular edema(9.27%). The United States granted the most research funding for diabetic eye disease out of the seven countries assessed. The research objectives of grants focusing on diabetic retinopathy and diabetic macular edema differed by country. Additionally, the United States was dominant in terms of research output, publishing 17.53% of global papers about diabetic eye disease and receiving 22.58% of total citations. The United States and the United Kingdom led international collaborations in research into diabetic eye disease. Of the 415 clinical trials that we identified, diabetic macular edema was the major disease that was targeted for drug development(58.19%). Approximately half of the trials(49.13%) pertained to angiogenesis. However, few drugs were approved for ophthalmic(40 out of 1830;2.19%) and diabetic eye disease(3 out of 1830;0.02%) applications. Our findings show that basic and translational research related to diabetic eye disease in the past decade has not been highly active, and has yielded few new treatment methods and newly approved drugs. 展开更多
关键词 clinical trials diabetic cataracts diabetic eye disease diabetic glaucoma diabetic macular edema diabetic retinopathy drug development global research PUBLICATION research grant
下载PDF
Global Scientific Trends in Research Related to Diabetic Sarcopenia from 1993 to 2023: A Bibliometric Analysis
15
作者 Qing Yang Yuan Zhao +2 位作者 Han Lu Yaolei Cha Lijie Yang 《Journal of Biosciences and Medicines》 2024年第3期204-222,共19页
Objectives: In this study, bibliometric approach was used to explore the literature in the field of research related to Diabetic Myasthenia Gravis in order to identify the current research progress in Diabetic Myasthe... Objectives: In this study, bibliometric approach was used to explore the literature in the field of research related to Diabetic Myasthenia Gravis in order to identify the current research progress in Diabetic Myasthenia Gravis related research and to help the researchers to predict the future hotspots in the field of research and to provide reference for the research. Methods: Literature related to diabetic sarcopenia published from 1993 to 2023 since the inception of the repository was extracted from the Web of Science Core Collection (WoSCC) and bibliometric analyses were performed. We have analysed the published literature of the last approximately almost 30 years, as well as publication and citation analyses from different countries, institutions, journals and authors. For keywords, we performed co-occurrence, clustering, timeline view and citation burst analysis. Results: On the basis of 1564 publications, we found a continuous increase in the number of publications and citations, especially in the last six years. The United States is the most representative country, and Seoul National University (SNU) is the most representative institution. The most popular journal in the field is Diabetes Care;Fukui, Michiaki is the most prolific author, leading many studies related to diabetic sarcopenia. The most frequently cited reference was a revised European consensus on the definition and diagnosis of sarcopenia;the most cited keywords were related to physiological factors of diabetes, sarcopenia and related conditions, such as “insulin resistance”, “skeletal muscle”, “body composition”, “risk” and “prevalence”. Conclusion: With more and more studies on the relationship between diabetic sarcopenia, this study presents the current status and trend of research related to diabetic sarcopenia over the past nearly 30 years through the visualization software CiteSpace. It can help researchers identify potential collaborators and partner institutions, hotspots and research frontiers in the field of diabetic sarcopenia. However, our work is only based on the English language literature in the WoSCC database, and for future studies, we recommend that researchers explore the literature from multiple databases to enhance the scope of their research. 展开更多
关键词 DIABETES SARCOPENIA BIBLIOMETRICS research Trends Citespace
下载PDF
Enhancing competency of clinical research nurses:A comprehensive training and evaluation framework
16
作者 Yang-Xi Liu Yi Xu 《World Journal of Clinical Cases》 SCIE 2024年第7期1378-1381,共4页
The Sun et al's training program for clinical research nurses(CRNs)in the World Journal of Clinical Cases is a comprehensive and scientific approach.It includes structured frameworks for CRN training,aiming to imp... The Sun et al's training program for clinical research nurses(CRNs)in the World Journal of Clinical Cases is a comprehensive and scientific approach.It includes structured frameworks for CRN training,aiming to improve CRN competency.This program emphasizes practical abilities,updates training content,and improves evaluation methods.The cultivation of CRN talents focuses on enhancing the training system,establishing a multifaceted evaluation framework,and continuously refining the training programs.Regular feedback and evalua-tion are essential to improve CRNs'competency in practical settings. 展开更多
关键词 Clinical research nurse Framework NURSE Operations PRACTICE Structure
下载PDF
Qualitative analysis of aromatic compounds via 1D TOCSY techniques
17
作者 Wenbo Dong Qi Zhao +3 位作者 Jiancheng Zhao Jiarong Zhang Yingxiong Wang Yan Qiao 《Magnetic Resonance Letters》 2024年第1期21-27,共7页
The aromatic compounds,including o-xylene,m-xylene,p-xylene,and ethylbenzene,primarily originate from the catalytic reforming of crude oil,and have a wide variety of applications.However,because of similar physical an... The aromatic compounds,including o-xylene,m-xylene,p-xylene,and ethylbenzene,primarily originate from the catalytic reforming of crude oil,and have a wide variety of applications.However,because of similar physical and chemical properties,these compounds are difficult to be identified by gas chromatography(GC)without standard samples.With the development of modern nuclear magnetic resonance(NMR)techniques,NMR has emerged as a powerful and efficient tool for the rapid analysis of complex and crude mixtures without purification.In this study,the parameters of one-dimensional(1D)total correlation spectroscopy(TOCSY)NMR techniques,including 1D selective gradient TOCSY and 1D chemicalshift-selective filtration(CSSF)with TOCSY,were optimized to obtain comprehensive molecular structure information.The results indicate that the overlapped signals in NMR spectra of nonpolar aromatic compounds(including o-xylene,m-xylene,p-xylene and ethylbenzene),polar aromatic compounds(benzyl alcohol,benzaldehyde,benzoic acid),and aromatic compounds with additional conjugated bonds(styrene)can be resolved in 1D TOCSY.More importantly,full molecular structures can be clearly distinguished by setting appropriate mixing time in 1D TOCSY.This approach simplifies the NMR spectra,provides structural information of entire molecules,and can be applied for the analysis of other structural isomers. 展开更多
关键词 1D TOCSY NMR technologies XYLENES Aromatic compounds Structure information of entire molecular qualitative analysis
下载PDF
Near-Infrared Fluorescence Imaging Contrast Agents for Clinical Research: Limitations and Alternatives
18
作者 Serigne Moussa Badiane Elhadji A. L. Bathily +1 位作者 Fawrou Seye Louis A.D. Diouf 《Open Journal of Biophysics》 2024年第1期73-77,共5页
Introduction: Near-infrared fluorescence imaging is a technique that will establish itself in the short term at the international level because it is recognized for its potential to improve the performance of surgical... Introduction: Near-infrared fluorescence imaging is a technique that will establish itself in the short term at the international level because it is recognized for its potential to improve the performance of surgical interventions, its moderate investment and operating costs and its portability. Although the technology is now mature, there is currently the problem of the availability of contrast agents to be injected IV. The aim of this methodology article is to propose an alternative solution to the need for contrast agents for clinical research, particularly in oncology. Methodology: They consist of coupling a fluorescent marker in the form of an NHS derivative, such as IR DYE manufactured in compliance with GMP, with therapeutic monoclonal antibodies having marketing authorization for molecular imaging. For a given antibody, the marking procedure must be the subject of a validation file on the final preparation filtered on a sterilizing membrane at 0.22 μm. Once the procedure has been validated, it would be unnecessary to repeat the tests before each clinical research examination. A check of the marking by thin-layer chromatography (TLC) and place it in a sample bank at +4˚C for 1 month of each injected formulation would be sufficient for additional tests if necessary. Conclusion: Molecular near-infrared fluorescence imaging is experiencing development, the process of which could be accelerated by greater availability of clinical contrast agents. Alternative solutions are therefore necessary to promote clinical research in this area. These methods must be shared to make it easier for researchers. 展开更多
关键词 Fluorescence Imaging Contrast Agents Clinical research
下载PDF
Research Progress of Measuring Tools for Patient Medication Compliance
19
作者 Chengping Jian Xiangdong Peng +3 位作者 Haiyan Tian Liying Wang Yanan Zhang Defang Cai 《Journal of Biosciences and Medicines》 2024年第2期225-235,共11页
This paper introduced the content, compilation process, reliability and validity, scoring method of the evaluation tool for patients’ medication compliance at home and abroad, and reviewed the research progress of th... This paper introduced the content, compilation process, reliability and validity, scoring method of the evaluation tool for patients’ medication compliance at home and abroad, and reviewed the research progress of the tool. The evaluation method, dimension, scoring method, evaluation content and application scope of the tool were compared, so as to provide reference for nurses to comprehensively and accurately evaluate patients’ medication status. 展开更多
关键词 Medication Compliance Assessment Tool research Progress
下载PDF
Research Progress of Detection Methods for Microplastics
20
作者 Peng WAN Zhen ZHAO +3 位作者 Guoyan WEN Yunshuang FU Cuizhi LI Xiaoli WU 《Asian Agricultural Research》 2024年第3期29-32,共4页
Microplastics are plastic particles or fibers with a diameter of less than 5 mm,and they widely exist in the environment and pose potential risks to the ecosystem and human health.Microplastics detection can provide b... Microplastics are plastic particles or fibers with a diameter of less than 5 mm,and they widely exist in the environment and pose potential risks to the ecosystem and human health.Microplastics detection can provide basic data for formulating effective environmental protection strategies.In this paper,the physical,chemical and biological detection methods of microplastics are reviewed,and the advantages and disadvantages of different methods are analyzed.The problems and challenges encountered in microplastics detection are analyzed,and the future research is discussed. 展开更多
关键词 Microplastics DETECTION METHOD research PROGRESS
下载PDF
上一页 1 2 250 下一页 到第
使用帮助 返回顶部