Objective To explore the relationship between risk of stroke and calcaneal quantitative ultrasound(QUS)T score under-2.5.Methods 5 847 subjects over the age of 40 from Yunyan District,Guiyang City were investigated wi...Objective To explore the relationship between risk of stroke and calcaneal quantitative ultrasound(QUS)T score under-2.5.Methods 5 847 subjects over the age of 40 from Yunyan District,Guiyang City were investigated with questionnaire,physical examination,blood lipids,other metabolic indexes and calcaneus bone展开更多
In the world,nonalcoholic fatty liver disease(NAFLD)accounts for majority of diffuse hepatic diseases.Notably,substantial liver fat accumulation can trigger and accelerate hepatic fibrosis,thus contributing to disease...In the world,nonalcoholic fatty liver disease(NAFLD)accounts for majority of diffuse hepatic diseases.Notably,substantial liver fat accumulation can trigger and accelerate hepatic fibrosis,thus contributing to disease progression.Moreover,the presence of NAFLD not only puts adverse influences for liver but is also associated with an increased risk of type 2 diabetes and cardiovascular diseases.Therefore,early detection and quantified measurement of hepatic fat content are of great importance.Liver biopsy is currently the most accurate method for the evaluation of hepatic steatosis.However,liver biopsy has several limitations,namely,its invasiveness,sampling error,high cost and moderate intraobserver and interobserver reproducibility.Recently,various quantitative imaging techniques have been developed for the diagnosis and quantified measurement of hepatic fat content,including ultrasound-or magnetic resonancebased methods.These quantitative imaging techniques can provide objective continuous metrics associated with liver fat content and be recorded for comparison when patients receive check-ups to evaluate changes in liver fat content,which is useful for longitudinal follow-up.In this review,we introduce several imaging techniques and describe their diagnostic performance for the diagnosis and quantified measurement of hepatic fat content.展开更多
Noninvasive diagnosis of bone density and mechanical properties using non-radiation imaging modality is an emerging area with promising in early prediction of osteopenia and treatment effectiveness in the clinic and f...Noninvasive diagnosis of bone density and mechanical properties using non-radiation imaging modality is an emerging area with promising in early prediction of osteopenia and treatment effectiveness in the clinic and functional disuse,i.e.,long-term bedrest and space mission.Advances in quantitative ultrasound have shown advantages in measuring both bone density and mechanical strength,non-radiation,imaging capability,and easy to use.The challenge that remained is the poor penetration of ultrasound signals passing through trabecular and cortical bones and acoustic energy scattering.A new scanning confocal ultrasound technology is developed in this lab to detect the alteration of bone to provide diagnostic results in bone density and structure properties.A software-controlled flexible ultrasound system with 2-D dual array transducer is developed and proposed for the purpose of noninvasive bone density diagnosis and assessment of bone loss.Transmitting(Tx)transducer elements are divided into sub-blocks to excite the ultrasound signals in sequence to decrease the system complexity while maintaining beam pattern properties by the signal processing procedure at receiving(Rx)side.Apodization is also applied to reduce acoustic side lobes and to make the resolution in the ultrasound field of view(FOV)more uniform.This study may provide basic understanding of modulated confocal ultrasound beam forming for tissue characterization,such as trabecular bone structual and strength properties.展开更多
文摘Objective To explore the relationship between risk of stroke and calcaneal quantitative ultrasound(QUS)T score under-2.5.Methods 5 847 subjects over the age of 40 from Yunyan District,Guiyang City were investigated with questionnaire,physical examination,blood lipids,other metabolic indexes and calcaneus bone
文摘In the world,nonalcoholic fatty liver disease(NAFLD)accounts for majority of diffuse hepatic diseases.Notably,substantial liver fat accumulation can trigger and accelerate hepatic fibrosis,thus contributing to disease progression.Moreover,the presence of NAFLD not only puts adverse influences for liver but is also associated with an increased risk of type 2 diabetes and cardiovascular diseases.Therefore,early detection and quantified measurement of hepatic fat content are of great importance.Liver biopsy is currently the most accurate method for the evaluation of hepatic steatosis.However,liver biopsy has several limitations,namely,its invasiveness,sampling error,high cost and moderate intraobserver and interobserver reproducibility.Recently,various quantitative imaging techniques have been developed for the diagnosis and quantified measurement of hepatic fat content,including ultrasound-or magnetic resonancebased methods.These quantitative imaging techniques can provide objective continuous metrics associated with liver fat content and be recorded for comparison when patients receive check-ups to evaluate changes in liver fat content,which is useful for longitudinal follow-up.In this review,we introduce several imaging techniques and describe their diagnostic performance for the diagnosis and quantified measurement of hepatic fat content.
基金This work is kindly supported by the National Institute of Health(R01 AR52379 and R01 AR61821)the National Space Biomedical Research Institute through a NASA contract NCC 9-58.
文摘Noninvasive diagnosis of bone density and mechanical properties using non-radiation imaging modality is an emerging area with promising in early prediction of osteopenia and treatment effectiveness in the clinic and functional disuse,i.e.,long-term bedrest and space mission.Advances in quantitative ultrasound have shown advantages in measuring both bone density and mechanical strength,non-radiation,imaging capability,and easy to use.The challenge that remained is the poor penetration of ultrasound signals passing through trabecular and cortical bones and acoustic energy scattering.A new scanning confocal ultrasound technology is developed in this lab to detect the alteration of bone to provide diagnostic results in bone density and structure properties.A software-controlled flexible ultrasound system with 2-D dual array transducer is developed and proposed for the purpose of noninvasive bone density diagnosis and assessment of bone loss.Transmitting(Tx)transducer elements are divided into sub-blocks to excite the ultrasound signals in sequence to decrease the system complexity while maintaining beam pattern properties by the signal processing procedure at receiving(Rx)side.Apodization is also applied to reduce acoustic side lobes and to make the resolution in the ultrasound field of view(FOV)more uniform.This study may provide basic understanding of modulated confocal ultrasound beam forming for tissue characterization,such as trabecular bone structual and strength properties.
