As one of the possible technologies to improve the oral absorption of poorly water-soluble drugs, supersaturable formulation, which enables to dissolve the drug to the higher concentration than their equilibrium solub...As one of the possible technologies to improve the oral absorption of poorly water-soluble drugs, supersaturable formulation, which enables to dissolve the drug to the higher concentration than their equilibrium solubility, is now attracting the attention (1)This include salt-formation, soliddispersion, co-crystallization or the use of amorphous form.Since supersaturation is a thermodynamically metastable state,supersaturated solution has a high potential to precipitate. Some pharmaceutical excipients.展开更多
The morphology and kinetics evolution of the γ’(Ni3 Al)phase during re-dissolution are studied in Ni-15 at% Al alloy,the changes of volume fraction and average particle radius of theγ’phase were clarified with pha...The morphology and kinetics evolution of the γ’(Ni3 Al)phase during re-dissolution are studied in Ni-15 at% Al alloy,the changes of volume fraction and average particle radius of theγ’phase were clarified with phasefield simulation.During isothermal aging,the interdistance of the neighboringγ’phase affects the interface concentration gradient of Al,which dominates the growth or redissolution of the γ’phase particle.After isothermal aging at 700 K,the alloy is continuously heated to 900 K with different heating rates,the re-dissolution lag happens,meaning the coalescence coarsening of adjacent γ’phase particles still proceeds at the initial heating stage.The predissolution of γ’phase with cubic shape is re-dissolved firstly at the edges and corners,in continuous heating to 900 K or by second-order aging from 700 to 900 K.Different from continuous heating,in the second-order aging process,the connected particles with band shape are broken initially by re-dissolving.At different heating rates,the similar dynamic relationships are abstracted for the volume fraction and the heating rates,and the average particle radius and the heating rates.展开更多
文摘As one of the possible technologies to improve the oral absorption of poorly water-soluble drugs, supersaturable formulation, which enables to dissolve the drug to the higher concentration than their equilibrium solubility, is now attracting the attention (1)This include salt-formation, soliddispersion, co-crystallization or the use of amorphous form.Since supersaturation is a thermodynamically metastable state,supersaturated solution has a high potential to precipitate. Some pharmaceutical excipients.
基金supported by the National Natural Science Foundation of China(No.51571122)the Fundamental Research Funds for the Central Universities(No 30916015107)。
文摘The morphology and kinetics evolution of the γ’(Ni3 Al)phase during re-dissolution are studied in Ni-15 at% Al alloy,the changes of volume fraction and average particle radius of theγ’phase were clarified with phasefield simulation.During isothermal aging,the interdistance of the neighboringγ’phase affects the interface concentration gradient of Al,which dominates the growth or redissolution of the γ’phase particle.After isothermal aging at 700 K,the alloy is continuously heated to 900 K with different heating rates,the re-dissolution lag happens,meaning the coalescence coarsening of adjacent γ’phase particles still proceeds at the initial heating stage.The predissolution of γ’phase with cubic shape is re-dissolved firstly at the edges and corners,in continuous heating to 900 K or by second-order aging from 700 to 900 K.Different from continuous heating,in the second-order aging process,the connected particles with band shape are broken initially by re-dissolving.At different heating rates,the similar dynamic relationships are abstracted for the volume fraction and the heating rates,and the average particle radius and the heating rates.
