This Bombesin (BBN), a tetradecapeptide analog of human gastrin-releasing peptide (GRP) with a high binding affinity for GRP receptors (GRPR), is over- expressed in early stages of androgen-dependent prostate carcinom...This Bombesin (BBN), a tetradecapeptide analog of human gastrin-releasing peptide (GRP) with a high binding affinity for GRP receptors (GRPR), is over- expressed in early stages of androgen-dependent prostate carcinomas, but not in advanced stages. Therefore, there is a need to develop effective tracers for the accurate and specific detection of this disease. The objective of this study was to evaluate Lys<sup>1</sup>, Lys<sup>3</sup>-DOTA-BBN (1,14) analog with the radiolabeled positron emitter [<sup>68</sup>Ga]-Ga-BBN for receptor imaging with PET, and to determine its biodistribution and radiation dosimetry using whole-body (WB) PET scans in healthy volunteers. The highest uptake was in the pancreas, followed by urinary bladder. The critical organ was pancreas with a mean absorbed dose of 206 ± 0.7, 210 ± 0.7, 120 ± 0.9, 390.23 ± 0.6 μGy/MBq and the effective doses were estimated as 73.2 ± 0.6, 49.8 ± 0.3 μGy/MBq (women and men, respectively).展开更多
BNCT is finally becoming ＂a new option against cancer＂. The difficulties for its development progress of that firstly is to improve the performance of boron compounds, secondly, it is the requirements of quantificat...BNCT is finally becoming ＂a new option against cancer＂. The difficulties for its development progress of that firstly is to improve the performance of boron compounds, secondly, it is the requirements of quantification and accuracy upon radiation dosimetry evaluation in clinical trials. Furthermore, that is long anticipation on hospital base neutron sources. It includes dedicated new NCT reactor, accelerator based neutron sources, and isotope source facilities. In ad- dition to reactors, so far, the technology of other types of sources for clinical trials is not yet completely proven. The In- Hospital Neutron lrradiator specially designed for NCT, based on the MNSR successfully developed by China, can be installed inside or near the hospital and operated directly by doctors. The Irradiator has two neutron beams for respective treatment of the shallow and deep tumors. It is expected to initiate operation in the end of this year. It would provide a safe, low cost, and effective treatment tool for the NCT routine application in near future.展开更多
45 P_(2)O_(5)-15 BaO-25 ZnO-15 B2O_(3)glasses doped with different concentrations(0 mol%,0.1 mol%,0.25 mol%,0.5 mol%,and 0.75 mol%)of Gd^(3+)were prepared by a melt-quenching method and treated to fabricate glass-cera...45 P_(2)O_(5)-15 BaO-25 ZnO-15 B2O_(3)glasses doped with different concentrations(0 mol%,0.1 mol%,0.25 mol%,0.5 mol%,and 0.75 mol%)of Gd^(3+)were prepared by a melt-quenching method and treated to fabricate glass-ceramics containing BaZn_(2)(PO_(4))_(2)crystals by controllable crystallization.The structural,optical,and dosimetric properties were investigated.FTIR spectra indicate that the glasses are composed of[PO_(4)],[BO_(3)],and[BO_(4)]basic structural units.The XRD pattern analysis indicates that the samples contain BaZn_(2)(PO_(4))_(2)crystals.In the photoluminesce nce(PL)spectra,two emission bands are observed at 307 and 313 nm due to the^(6)P_(5/2)→^(8)S_(7/2)and^(6)P_(7/2)→^(8)S_(7/2)transitions of Gd^(3+),respectively.The OSL dosimetric properties of glass-ceramics were studied further under beta radiation of90Sr.The optimal Gd^(3+)doping concentration of 0.5 mol%was determined.The fading of the OSL signal shows that the CW-OSL signal of Gd^(3+)-doped BaZn_(2)(PO_(4))_(2)glass-ceramics decays by about 58.95%within120 h,and the intensity remains stable thereafter.The thermoluminescence(TL)curve has three peaks at 164,240,and 344℃.Minimum detectable dose(MDD)of the 0.5 mol%Gd^(3+)-doped BaZn_(2)(PO_(4))_(2)glass-ceramics was calculated as 0.675 mGy.The samples also exhibit good signal reusability and a broad linear dose-response range(0.3-500 Gy).Results show the excellent dosimetric properties of Gd^(3+)-doped BaZn_(2)(PO_(4))_(2)glass-ceramics and their potential application in radiation dosimetry.展开更多
文摘This Bombesin (BBN), a tetradecapeptide analog of human gastrin-releasing peptide (GRP) with a high binding affinity for GRP receptors (GRPR), is over- expressed in early stages of androgen-dependent prostate carcinomas, but not in advanced stages. Therefore, there is a need to develop effective tracers for the accurate and specific detection of this disease. The objective of this study was to evaluate Lys<sup>1</sup>, Lys<sup>3</sup>-DOTA-BBN (1,14) analog with the radiolabeled positron emitter [<sup>68</sup>Ga]-Ga-BBN for receptor imaging with PET, and to determine its biodistribution and radiation dosimetry using whole-body (WB) PET scans in healthy volunteers. The highest uptake was in the pancreas, followed by urinary bladder. The critical organ was pancreas with a mean absorbed dose of 206 ± 0.7, 210 ± 0.7, 120 ± 0.9, 390.23 ± 0.6 μGy/MBq and the effective doses were estimated as 73.2 ± 0.6, 49.8 ± 0.3 μGy/MBq (women and men, respectively).
文摘BNCT is finally becoming ＂a new option against cancer＂. The difficulties for its development progress of that firstly is to improve the performance of boron compounds, secondly, it is the requirements of quantification and accuracy upon radiation dosimetry evaluation in clinical trials. Furthermore, that is long anticipation on hospital base neutron sources. It includes dedicated new NCT reactor, accelerator based neutron sources, and isotope source facilities. In ad- dition to reactors, so far, the technology of other types of sources for clinical trials is not yet completely proven. The In- Hospital Neutron lrradiator specially designed for NCT, based on the MNSR successfully developed by China, can be installed inside or near the hospital and operated directly by doctors. The Irradiator has two neutron beams for respective treatment of the shallow and deep tumors. It is expected to initiate operation in the end of this year. It would provide a safe, low cost, and effective treatment tool for the NCT routine application in near future.
基金Project supported by the National Natural Science Foundation of China(11675260)。
文摘45 P_(2)O_(5)-15 BaO-25 ZnO-15 B2O_(3)glasses doped with different concentrations(0 mol%,0.1 mol%,0.25 mol%,0.5 mol%,and 0.75 mol%)of Gd^(3+)were prepared by a melt-quenching method and treated to fabricate glass-ceramics containing BaZn_(2)(PO_(4))_(2)crystals by controllable crystallization.The structural,optical,and dosimetric properties were investigated.FTIR spectra indicate that the glasses are composed of[PO_(4)],[BO_(3)],and[BO_(4)]basic structural units.The XRD pattern analysis indicates that the samples contain BaZn_(2)(PO_(4))_(2)crystals.In the photoluminesce nce(PL)spectra,two emission bands are observed at 307 and 313 nm due to the^(6)P_(5/2)→^(8)S_(7/2)and^(6)P_(7/2)→^(8)S_(7/2)transitions of Gd^(3+),respectively.The OSL dosimetric properties of glass-ceramics were studied further under beta radiation of90Sr.The optimal Gd^(3+)doping concentration of 0.5 mol%was determined.The fading of the OSL signal shows that the CW-OSL signal of Gd^(3+)-doped BaZn_(2)(PO_(4))_(2)glass-ceramics decays by about 58.95%within120 h,and the intensity remains stable thereafter.The thermoluminescence(TL)curve has three peaks at 164,240,and 344℃.Minimum detectable dose(MDD)of the 0.5 mol%Gd^(3+)-doped BaZn_(2)(PO_(4))_(2)glass-ceramics was calculated as 0.675 mGy.The samples also exhibit good signal reusability and a broad linear dose-response range(0.3-500 Gy).Results show the excellent dosimetric properties of Gd^(3+)-doped BaZn_(2)(PO_(4))_(2)glass-ceramics and their potential application in radiation dosimetry.
