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Unraveling the efficacy network: A network meta-analysis of adjuvant external beam radiation therapy methods after hepatectomy
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作者 Gao-Yuan Yang Zhi-Wei He +7 位作者 Yong-Chang Tang Feng Yuan Ming-Bo Cao Yu-Peng Ren Yu-Xuan Li Xiao-Rui Su Zhi-Cheng Yao Mei-Hai Deng 《World Journal of Gastrointestinal Surgery》 SCIE 2024年第1期205-214,共10页
BACKGROUND Primary liver cancer is a malignant tumor with a high recurrence rate that significantly affects patient prognosis.Postoperative adjuvant external radiation therapy(RT)has been shown to effectively prevent ... BACKGROUND Primary liver cancer is a malignant tumor with a high recurrence rate that significantly affects patient prognosis.Postoperative adjuvant external radiation therapy(RT)has been shown to effectively prevent recurrence after liver cancer resection.However,there are multiple RT techniques available,and the differ-ential effects of these techniques in preventing postoperative liver cancer re-currence require further investigation.AIM To assess the advantages and disadvantages of various adjuvant external RT methods after liver resection based on overall survival(OS)and disease-free survival(DFS)and to determine the optimal strategy.METHODS This study involved network meta-analyses and followed the PRISMA guidelines.The data of qualified studies published before July 10,2023,were collected from PubMed,Embase,the Web of Science,and the Cochrane Library.We included relevant studies on postoperative external beam RT after liver resection that had OS and DFS as the primary endpoints.The magnitudes of the effects were determined using risk ratios with 95%confidential intervals.The results were analyzed using R software and STATA software.RESULTS A total of 12 studies,including 1265 patients with hepatocellular carcinoma(HCC)after liver resection,were included in this study.There was no significant heterogeneity in the direct paired comparisons,and there were no significant differences in the inclusion or exclusion criteria,intervention measures,or outcome indicators,meeting the assumptions of heterogeneity and transitivity.OS analysis revealed that patients who underwent stereotactic body radiotherapy(SBRT)after resection had longer OS than those who underwent intensity modulated radiotherapy(IMRT)or 3-dimensional conformal RT(3D-CRT).DFS analysis revealed that patients who underwent 3D-CRT after resection had the longest DFS.Patients who underwent IMRT after resection had longer OS than those who underwent 3D-CRT and longer DFS than those who underwent SBRT.CONCLUSION HCC patients who undergo liver cancer resection must consider distinct advantages and disadvantages when choosing between SBRT and 3D-CRT.IMRT,a RT technique that is associated with longer OS than 3D-CRT and longer DFS than SBRT,may be a preferred option. 展开更多
关键词 Primary liver cancer Hepatocellular carcinoma Network meta-analysis external beam radiation therapy Stereotactic body radiotherapy Intensity modulated radiotherapy
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The feasibility and safety of high-intensity focused ultrasound combined with low-dose external beam radiotherapy as supplemental therapy for advanced prostate cancer following hormonal therapy 被引量:3
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作者 Rui-Yi Wu Guo-Min Wang +4 位作者 Lei Xu Bo-Heng Zhang Ye-Qing Xu Zhao-Chong Zeng Bing Chen 《Asian Journal of Andrology》 SCIE CAS CSCD 2011年第3期499-504,515,共7页
The aim of this study was to investigate the feasibility and safety of high-intensity focused ultrasound (HIFU) combined with (+) low-dose external beam radiotherapy (LRT) as supplemental therapy for advanced p... The aim of this study was to investigate the feasibility and safety of high-intensity focused ultrasound (HIFU) combined with (+) low-dose external beam radiotherapy (LRT) as supplemental therapy for advanced prostate cancer (PCa) following hormonal therapy (HT). Our definition of HIFU+LRT refers to treating primary tumour lesions with HIFU in place of reduced field boost irradiation to the prostate, while retaining four-field box irradiation to the pelvis in conventional-dose external beam radiotherapy (CRT). We performed a prospective, controlled and non-randomized study on 120 patients with advanced PCa after HT who received HIFU, CRT, HIFU+LRT and HT alone, respectively. CT/MR imaging showed the primary tumours and pelvic lymph node metastases visibly shrank or even disappeared after HIFU +LRT treatment. There were significant differences among four groups with regard to overall survival (OS) and disease-specific survival (DSS) curves (P=0.018 and 0.015). Further comparison between each pair of groups suggested that the long-term DSS of the H IFU + LRT group was higher than those of the other three groups, but there was no significant difference between the HIFU+LRT group and the CRT group. Multivariable Cox's proportional hazard model showed that both HIFU+LRT and CRT were independently associated with DSS (P=0.001 and 0.035) and had protective effects with regard to the risk of death. Compared with CRT, HIFU +LRT significantly decreased incidences of radiation-related late gastrointestinal (GI) and genitourinary (GU) toxicity grade ≥ II. In conclusion, long-term survival of patients with advanced PCa benefited from strengthening local control of primary tumour and reRional lymph node metastases after HT. As an alternative to CRT, HIFU+LRT showed Rood efficacy and better safety. 展开更多
关键词 COMPLICATION high-intensity focused ultrasound hormonal therapy low-dose external beam radiotherapy prostate cancer survival rate
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Real-time dosimetry in external beam radiation therapy
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作者 Ramachandran Prabhakar 《World Journal of Radiology》 CAS 2013年第10期352-355,共4页
With growing complexity in radiotherapy treatment delivery,it has become mandatory to check each and every treatment plan before implementing clinically.This process is currently administered by an independent seconda... With growing complexity in radiotherapy treatment delivery,it has become mandatory to check each and every treatment plan before implementing clinically.This process is currently administered by an independent secondary check of all treatment parameters and as a pre-treatment quality assurance (QA) check for intensity modulated radiation therapy (IMRT) and volumetric modulated arc therapy treatment plans.Although pre-treatment IMRT QA is aimed to ensure the correct dose is delivered to the patient,it does not necessarily predict the clinically relevant patient dose errors.During radiotherapy,treatment uncertainties can affect tumor control and may increase complications to surrounding normal tissues.To combat this,image guided radiotherapy is employed to help ensure the plan conditions are mimicked on the treatment machine.However,it does not provide information on actual delivered dose to the tumor volume.Knowledge of actual dose delivered during treatment aid in confirming the prescribed dose and also to replan/reassess the treatment in situations where the planned dose is not delivered as expected by the treating physician.Major accidents in radiotherapy would have been averted if real time dosimetry is incorporated as part of the routine radiotherapy procedure.Of late real-time dosimetry is becoming popular with complex treatments in radiotherapy.Realtime dosimetry can be either in the form of point doses or planar doses or projected on to a 3D image dataset to obtain volumetric dose.They either provide entrance dose or exit dose or dose inside the natural cavities of a patient.In external beam radiotherapy,there are four different established platforms whereby the delivered dose information can be obtained:(1)Collimator;(2)Patient;(3)Couch;and(4)Electronic Portal Imaging Device.Current real-time dosimetric techniques available in radiotherapy have their own advantages and disadvantages and a combination of one or more of these methods provide vital information about the actual dose delivered to radiotherapy patients. 展开更多
关键词 CANCER radiotherapy external beam DOSIMETRY REAL-TIME
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Dose escalation of external beam radiotherapy for high-risk prostate cancerdImpact of multiple high-risk factor
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作者 Rei Umezawa Koji Inaba +12 位作者 Satoshi Nakamura Akihisa Wakita Hiroyuki Okamoto Keisuke Tsuchida Tairo Kashihara Kazuma Kobayashi Ken Harada Kana Takahashi Naoya Murakami Yoshinori Ito Hiroshi Igaki Keiichi Jingu Jun Itami 《Asian Journal of Urology》 CSCD 2019年第2期192-199,共8页
Objective:To retrospectively investigate the treatment outcomes of external beam radiotherapy with androgen deprivation therapy(ADT)in high-risk prostate cancer in three radiotherapy dose groups.Methods:Between 1998 a... Objective:To retrospectively investigate the treatment outcomes of external beam radiotherapy with androgen deprivation therapy(ADT)in high-risk prostate cancer in three radiotherapy dose groups.Methods:Between 1998 and 2013,patients with high-risk prostate cancer underwent threedimensional conformal radiotherapy or intensity-modulated radiotherapy of 66 Gy,72 Gy,or 78 Gy with ADT.Prostate-specific antigen(PSA)relapse was defined using the Phoenix definition.PSA relapse-free survival(PRFS)was evaluated in each radiotherapy dose group.Moreover,high-risk patients were divided into H-1(patients with multiple high-risk factors)and H-2(patients with a single high-risk factor)as risk subgroups.Results:Two hundred and eighty-nine patients with a median follow-up period of 77.3 months were analyzed in this study.The median duration of ADT was 10.1 months.Age,Gleason score,T stage,and radiotherapy dose influenced PRFS with statistical significance both in univariate and multivariate analyses.The 4-year PRFS rates in Group-66 Gy,Group-72 Gy and Group-78 Gy were 72.7%,81.6%and 90.3%,respectively.PRFS rates in the H-1 subgroup differed with statistical significance with an increasing radiotherapy dose having a more favorable PRFS,while PRFS rates in H-2 subgroup did not differ with increase in radiotherapy dose.Conclusion:Dose escalation for high-risk prostate cancer in combination with ADT improved PRFS.PRFS for patients in the H-1 subgroup was poor,but dose escalation in those patients was beneficial,while dose escalation in the H-2 subgroup was not proven to be effective for improving PRFS. 展开更多
关键词 Prostate cancer external beam radiotherapy Dose escalation Biochemical control
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Adjuvant External Beam Radiotherapy ±Brachytherapy in Endometrial Cancer: A Retrospective Study from Faculty of Medicine, Chiang Mai University
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作者 Ekkasit Tharavichitkul Sukon Prasitwattanaseree +6 位作者 Patrinee Traisathit Cholthicha Thipmate Somvilai Chakrabandhu Pitchayaponne Klunklin Wimrak Onchan Razvan M. Galalae Imjai Chitapanarux 《Journal of Cancer Therapy》 2015年第2期115-121,共7页
Purpose: To report the retrospective study of external beam radiotherapy (EBRT) ± intravaginal brachytherapy (IVBT) as adjuvant treatment for endometrial cancer. Materials and Methods: From 2001-2009, 152 patient... Purpose: To report the retrospective study of external beam radiotherapy (EBRT) ± intravaginal brachytherapy (IVBT) as adjuvant treatment for endometrial cancer. Materials and Methods: From 2001-2009, 152 patients received complete surgical staging for endometrial carcinoma and were designed by a multidisciplinary team to receive EBRT ± IVBT. The treatment results and late toxicities were evaluated and recorded. Results: At the median follow-up time of 43 months, the disease-free survival, metastasis-free survival and overall survival rates were 96.9%, 96.9% and 96.9%, respectively. Stage and age showed the statistical significance with the p-value of less than 0.001. From five to ten percent of patients developed Grades 1-2 late gastrointestinal and genitourinary toxicities, respectively. Conclusion: The using of adjuvant EBRT ± IVBT for endometrial?carcinoma yielded treatment results and acceptable toxicities. 展开更多
关键词 ENDOMETRIAL Cancer ADJUVANT Treatment external beam radiotherapy
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Application of Statistical Process Control for Setting Action Thresholds as Quality Assurance of Dose Verifications in External Beam Radiotherapy
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作者 Philip Kioko Ndonye Samuel Nii Adu Tagoe 《International Journal of Medical Physics, Clinical Engineering and Radiation Oncology》 2022年第1期22-35,共14页
Purpose: To test the concept of Statistical Process Control (SPC) as a Quality Assurance (QA) procedure for dose verifications in external beam radiation therapy in conventional and 3D Conformal Radiotherapy (3D-CRT) ... Purpose: To test the concept of Statistical Process Control (SPC) as a Quality Assurance (QA) procedure for dose verifications in external beam radiation therapy in conventional and 3D Conformal Radiotherapy (3D-CRT) treatment of cervical cancer. Materials and Methods: A study of QA verification of target doses of 198 cervical cancer patients undergoing External Beam Radiotherapy (EBRT) treatments at two different cancer treatment centers in Kenya was conducted. The target doses were determined from measured entrance doses by the diode in vivo dosimetry. Process Behavior Charts (PBC) developed by SPC were applied for setting Action Thresholds (AT) on the target doses. The AT set was then proposed as QA limits for acceptance or rejection of verified target doses overtime of the EBRT process. Result and Discussion: Target doses for the 198 patients were calculated and SPC applied to test whether the action limits set by the Process Behavior Charts could be applied as QA for verified doses in EBRT. Results for the two sub-groups of n = 3 and n = 4 that were tested produced action thresholds which are within clinical dose specifications for both conventional AP/PA and 3D-CRT EBRT treatment techniques for cervical cancer. Conclusion: Action thresholds set by SPC were within the clinical dose specification of ±5% uncertainty for both conventional AP/PA and 3D-CRT EBRT treatment techniques for cervical cancer. So the concept of SPC could be applied in setting QA action limits for dose verifications in EBRT. 展开更多
关键词 Quality Assurance Statistical Process Control Action Thresholds Dose Verification external beam radiation Therapy
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Linear Accelerator Based External Beam Radiotherapy in Glomus Jugulare Tumour: A Retrospective Review from a Tertiary Cancer Hospital in Kenya
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作者 Vijayakumar Narayanan Asmeeta Patel James Mbogo 《Case Reports in Clinical Medicine》 2022年第4期122-132,共11页
Objective: Tumours originating from jugular bulb, carotid bifurcation, Vagus nerve are collectively called Paragangliomas. They are slow growing, essentially benign tumours, but can be detrimental if untreated. There ... Objective: Tumours originating from jugular bulb, carotid bifurcation, Vagus nerve are collectively called Paragangliomas. They are slow growing, essentially benign tumours, but can be detrimental if untreated. There is limited evidence on the effectiveness of fractionated radiotherapy in the management ofs Glomus jugulare tumours. The aim of this study is to determine the efficacy of Linear accelerator based fractionated external beam radiotherapy on unilateral inoperable Glomus jugulare paragangliomas. Method: This is a retrospective analysis of all the 12 cases of inoperable, unilateral Glomus jugulare tumours treated during the period 2011-2016 at a tertiary cancer centre in Kenya. Minimum follow up duration was 3 years. Patient characteristics, disease staging, immediate complications and therapeutic efficacy were analysed from the case files. Results: The 12 patients diagnosed with inoperable Glomus jugulare tumours reported in this period were treated with external beam radiotherapy to a tumour dose of 54 Gy in 30 fractions over a period of 6 weeks using IMRT technique in 6 MV Linear accelerator. 2/3<sup>rd </sup>of the patients were females in 5<sup>th</sup> and 6<sup>th</sup> decade of life. Onset of first symptom to initiation of treatment was found to be 1.7 years. Headache, earache, and tinnitus were the main complaints. No major side effects were recorded during therapy. Mean length of the tumour in its maximum dimension at the time of diagnosis was 4.5 cm. At the end of one-year post therapy, a mean reduction of 6.5 mm in the tumour length was observed, (Range: 0 - 15 mm). Tumour size remained static for a year and thereafter a slow growth pattern of 1mm per year was observed. Conclusion: Fractionated external beam radiotherapy is an effective and non-invasive treatment for advanced, inoperable Glomus jugulare paragangliomas. Clinical stability through tumour control was observed. Though newer radiation techniques like Cyberknife, Proton therapy offer better tumour control, conventional external beam radiotherapy is an effective tool in disease containment in resource limited countries. 展开更多
关键词 Glomus Jugulare PARAGANGLIOMAS external beam radiotherapy
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Combined cryotherapy and external beam radiation therapy for the treatment of intermediate-risk localized prostate cancer: A case series
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作者 Peter Qi Matvey Tsivian +1 位作者 Zeljko Vujaskovic Thomas J. Polascik 《Case Reports in Clinical Medicine》 2014年第1期47-51,共5页
Introduction: Routine PSA screening for prostate cancer (PCa) has increased the detection of intermediate-risk, localized disease. Conventional treatments for localized PCa include surgery, brachytherapy, cryotherapy ... Introduction: Routine PSA screening for prostate cancer (PCa) has increased the detection of intermediate-risk, localized disease. Conventional treatments for localized PCa include surgery, brachytherapy, cryotherapy or external beam radiotherapy (EBRT). However, for intermediate risk patients, rates of recurrence are moderately high and a multi-modal treatment approach for these patients may be necessary. We treated patients with a combination of cryotherapy and low dose EBRT to assess the safety and feasibility of this combinatory approach as well as to evaluate early oncological outcomes. Case Presentation: Men with intermediate risk (PSA = 10-20 ng/ml and/or Gleason = 7 and/or clinical T2b) localized PCa were prospectively enrolled in this study. Patients underwent cryotherapy and then 39 Gy EBRT 4-6 weeks after surgery. After completing EBRT, the men were followed every 3 months for 2 years. Adverse events, PSA, urinary and erectile function were assessed during each follow-up. Three patients completed the study. Preoperative PSA ranged from 3.5 to 7.9 ng/ml. There were no intraoperative complications and the treatment was well tolerated. Following cryotherapy and EBRT, all patients were pad-free within 6 months and remained continent for the duration of the study. Bother index remained stable throughout the study for all patients. No urethral strictures or rectal toxicities were observed. PSA remained undetectable for all patients. Conclusions: In this prospective study, cryotherapy combined with low dose EBRT was a safe approach for the treatment of intermediate-risk, localized PCa. Early oncological outcomes appeared to be favorable with all patients having undetectable PSA during the 2-year follow-up period. Further studies are warranted to confirm these preliminary results. 展开更多
关键词 external beam radiation CRYOTHERAPY LOCALIZED PROSTATE Cancer INTERMEDIATE RISK
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Californium-252 neutron brachytherapy combined with external pelvic radiotherapy plus concurrent chemotherapy for cervical cancer: a retrospective clinical study 被引量:3
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作者 Shen Qian Ling Ye +9 位作者 Yun-Hong Tian Li-Gen Wang Zuo-Ping Huang Feng Li Bing Hou Ni Song Juan Chen Ying Liu Xiao Liu Tao Zhou 《Chinese Journal of Cancer》 SCIE CAS CSCD 2017年第4期193-201,共9页
Background:Cervical cancer is the sixth most common cancer in Chinese women.A standard treatment modal?ity for cervical cancer is the combination of surgery,chemotherapy,external?beam radiotherapy and intracavitary br... Background:Cervical cancer is the sixth most common cancer in Chinese women.A standard treatment modal?ity for cervical cancer is the combination of surgery,chemotherapy,external?beam radiotherapy and intracavitary brachytherapy.The aim of this study was to retrospectively assess the long?term treatment outcomes of patients with cervical cancer who were treated with californium?252 neutron brachytherapy combined with external?beam radio?therapy plus concurrent chemotherapy.Methods:We retrospectively analyzed the medical records of 150 patients with primary stages IB?IVB cervical cancer who received neutron brachytherapy combined with external?beam radiotherapy concurrently with cisplatin chemo?therapy.All patients were followed up.Using an actuarial analysis,patient outcomes and treatment?related adverse effects were evaluated and compared.Results:The median overall survival(OS)was 33.2 months.The 3?year progression?free survival rates for patients with stages I–II,III,and IV diseases were 81.0%(68/84),65.0%(39/60),and 0%(0/6),respectively;the 3?year OS rates were 90.5%(76/84),85.0%(51/60),and 16.7%(1/6),respectively.Vaginal bleeding was controlled within the median time of4.0 days.One month after treatment,97.3%of patients achieved short?term local control.The local recurrence rates for patients with stages I–II,III,and IV disease were 4.8%(4/84),11.7%(7/60),and 33.3%(2/6),respectively,and the occurrence rates of distant metastasis were 16.7%(14/84),25.0%(15/60),and 100.0%(6/6),respectively.Cancer stage,tumor size,and lymph node metastasis were identified as prognostic risk factors,but only lymph node metastasis was found to be an independent prognostic factor.The most common adverse effects during treatment were grades 1 and 2 irradiation?related proctitis and radiocystitis.Conclusion:For patients with cervical cancer,neutron brachytherapy combined with external?beam radiotherapy plus concurrent chemotherapy produces a rapid response and greatly improves local control and long?term survival rates with tolerable adverse effects. 展开更多
关键词 CERVICAL cancer Californium-252 NEUTRON BRACHYTHERAPY external-beam radiotherapy
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Efficacy and safety of intraoperative radiotherapy in rectal cancer:A systematic review and meta-analysis 被引量:2
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作者 Bin Liu Long Ge +6 位作者 Jing Wang Ya-Qiong Chen Shi-Xun Ma Pei-Lan Ma Yun-Qiang Zhang Ke-Hu Yang Hui Cai 《World Journal of Gastrointestinal Oncology》 SCIE 2021年第1期69-86,共18页
BACKGROUND In recent years,intraoperative radiotherapy(IORT)has been increasingly used for the treatment of rectal cancer.However,the efficacy and safety of IORT for the treatment of rectal cancer are still controvers... BACKGROUND In recent years,intraoperative radiotherapy(IORT)has been increasingly used for the treatment of rectal cancer.However,the efficacy and safety of IORT for the treatment of rectal cancer are still controversial.AIM To evaluate the value of IORT for patients with rectal cancer.METHODS We searched PubMed,Embase,Cochrane Library,Web of Science databases,and conference abstracts and included randomized controlled trials and observational studies on IORT vs non-IORT for rectal cancer.Dichotomous variables were evaluated by odds ratio(OR)and 95%confidence interval(CI),hazard ratio(HR)and 95%CI was used as a summary statistic of survival outcomes.Statistical analyses were performed using Stata V.15.0 and Review Manager 5.3 software.RESULTS In this study,3 randomized controlled studies and 12 observational studies were included with a total of 1460 patients,who are mainly residents of Europe,the United States,and Asia.Our results did not show significant differences in 5-year overall survival(HR=0.80,95%CI=0.60-1.06;P=0.126);5-year disease-free survival(HR=0.94,95%CI=0.73-1.22;P=0.650);abscess(OR=1.10,95%CI=0.67-1.80;P=0.713),fistulae(OR=0.79,95%CI=0.33-1.89;P=0.600);wound complication(OR=1.21,95%CI=0.62-2.36;P=0.575);anastomotic leakage(OR=1.09,95%CI=0.59-2.02;P=0.775);and neurogenic bladder dysfunction(OR=0.69,95%CI=0.31-1.55;P=0.369).However,the meta-analysis of 5-year local control was significantly different(OR=3.07,95%CI=1.66-5.66;P=0.000).CONCLUSION The advantage of IORT is mainly reflected in 5-year local control,but it is not statistically significant for 5-year overall survival,5-year disease-free survival,and complications. 展开更多
关键词 Intraoperative radiotherapy Rectal cancer Systematic review external beam radiation therapy Randomized controlled trials META-ANALYSIS
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Current role of spacers for prostate cancer radiotherapy 被引量:2
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作者 Michael Pinkawa 《World Journal of Clinical Oncology》 CAS 2015年第6期189-193,共5页
Radiotherapy is an established curative treatment method for prostate cancer. Optimal tumor control rates can only be achieved with high local doses,associated with a considerable risk of rectal toxicity. Apart from a... Radiotherapy is an established curative treatment method for prostate cancer. Optimal tumor control rates can only be achieved with high local doses,associated with a considerable risk of rectal toxicity. Apart from already widely adapted technical advances,as intensitymodulated radiation therapy,the application of spacers placed between the prostate and rectum has been increasingly used in the last years. Biodegradable spacers,including hydrogel,hyaluronic acid,collagen or an implantable balloon,can be injected or inserted in a short procedure under transrectal ultrasound guidance via a transperineal approach. A distance of about 1.0-1.5 cm is usually achieved between the rectum and prostate,excluding the rectal wall from the high isodoses. Several studies have shown well tolerated injection procedures and treatments. Apart from considerable reduction of rectal irradiation,a prospective randomized trial demonstrated a reduction of rectal toxicity after hydrogel injection in men undergoing prostate image-guided intensity-modulated radiation therapy. The results are encouraging for continuing evaluation in dose escalation,hypofractionation,stereotactic radiotherapy or re-irradiation trials in the future. 展开更多
关键词 external-beam radiotherapy Intensitymodulated radiotherapy BRACHYTHERAPY SPACER Hydrogel Biodegradable BALLOON Hyaluronic acid Collagen PROSTATE cancer Toxicity
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A Longitudinal Study of Clinical Benefits with Implementation of the Deep Inspiration Breath-Hold Technique in Post-Operative Radiotherapy for Left-Sided Breast Cancer
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作者 Chunhui Han Nayana Vora +2 位作者 Sean Zhang An Liu Jeffrey Y. C. Wong 《International Journal of Medical Physics, Clinical Engineering and Radiation Oncology》 2019年第3期151-162,共12页
Purpose/Objectives: We aimed to report clinical effects on critical organ dose and cardiac toxicity from implementation of the deep inspiration breath-hold (DIBH) technique in post-operative extern-beam radiotherapy o... Purpose/Objectives: We aimed to report clinical effects on critical organ dose and cardiac toxicity from implementation of the deep inspiration breath-hold (DIBH) technique in post-operative extern-beam radiotherapy of patients with left-sided breast cancer, using longitudinal clinical data. Materials/Methods: We retrieved three groups of patients who received post-operative radiotherapy of left-sided breast cancer in our institution in recent years: Groups A and B consist of patients whose treatment did not include internal mammary nodes (IMN) and who were treated with the free breathing technique and with the DIBH technique, respectively, and Group C consists of patients whose radiotherapy included internal mammary nodes with the DIBH technique. Dose parameters for the heart and left lung were retrieved from the treatment plans. Radiation-induced cardiac risks were estimated using existing risk models. Results: The average heart dose was 2.65 ± 0.98 Gy, 1.10 ± 0.29 Gy, and 1.26 ± 0.25 Gy in Groups A, B, and C, respectively. The average heart volumes receiving at least 25 Gy were 7.10 ± 9.79 cc in Group A, 0.07 ± 0.22 cc in Group B, and 0.03 ± 0.08 cc in Group C. On average, the excessive risk of having ischemic heart disease was estimated to be 19.6%, 8.1%, and 9.3% in Groups A, B, and C, respectively. The mean left lung doses were 5.73 ± 1.86 Gy, 5.93 ± 1.55 Gy, and 9.13 ± 1.57 Gy in Groups A, B, and C, respectively. Conclusion: Implementation of the DIBH technique significantly lowered heart dose and decreased the ischemic heart disease risk in patients receiving post-operative radiotherapy for left-sided breast cancer, without significant increase in left lung dose. 展开更多
关键词 BREAST Cancer Heart TOXICITY BREATH HOLD Extern-beam radiotherapy
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Outcomes of External-Beam Radiation Therapy Boost with Conventional Fractionation in Cervical Cancer: A Retrospective Analysis about 133 Cases
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作者 Evrard Narcisse Séka Bertrand Ghislain Compaoré +7 位作者 Bassané Alain Wilfried Mossé Siham Jaba Kouadio Davy N’chiépo Maroua Benlemlih Hasnae Bouhia Mohammed Adnane Tazi Sanae El Majjaoui Noureddine Benjaafar 《Journal of Cancer Therapy》 2020年第9期547-560,共14页
<strong>Introduction:</strong> <span style="font-family:""><span style="font-family:Verdana;">External-beam radiation therapy boost is a treatment option in cervical ca... <strong>Introduction:</strong> <span style="font-family:""><span style="font-family:Verdana;">External-beam radiation therapy boost is a treatment option in cervical cancer when brachytherapy is not feasible. Though less effective than brachytherapy, some encouraging results have been reported from some institutions experiences. We conducted this study to assess outcomes of EBRT boost for our patients at National Institute of Oncology in Rabat. </span><b><span style="font-family:Verdana;">Patients and Methods: </span></b><span style="font-family:Verdana;">We collected data from patients treated for cervical cancer between January 2012 and December 2015. Patients, tumor and treatment characteristics were collected. Overall survival (OS), disease-free survival (DFS) and prognostic factors influencing DFS were assessed. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> One hundred and thirty-three patients were enrolled. Median age was 52 years. Patient haemoglobin level ranged from 3.9 to 15.5</span></span><span style="font-family:""> </span><span style="font-family:Verdana;">g/dl [mean: 11.2 g/dl]. Most tumors were classified stage III/IVA (63.2%) according to the FIGO classification. Regional lymph node metastases (pelvic and or para-aortic) were observed in 45.1%. Median total dose to tumor was 69.6 Gy (ranging from 66 to 70 Gy). Overall treatment time was protracted, with a median of 60 days. Most of patients received concurrent chemotherapy (94.7%) and the number of cycle ranged from 2 to 7 (median</span><span style="font-family:""> </span><span style="font-family:Verdana;">=</span><span style="font-family:""> </span><span style="font-family:Verdana;">5). The follow-up median was 31.3 months, ranging from 6.2 to 96.8 months. At the first visit, most patients achieved complete response (80.5%). Five years OS and DFS were 47% and 44% respectively. In univariate and multivariate analysis, regional lymph nodes metastasis (presence or absence) and haemoglobin level (≤11</span><span style="font-family:""> </span><span style="font-family:Verdana;">g/dl and >11</span><span style="font-family:""> </span><span style="font-family:Verdana;">g/dl) were the two significant and independent prognostic factors influencing DFS (HR: 1.86;p</span><span style="font-family:""> </span><span style="font-family:Verdana;">=</span><span style="font-family:""> </span><span style="font-family:Verdana;">0.01 for the former) (HR: 0.59;p</span><span style="font-family:""> </span><span style="font-family:Verdana;">=</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">0.03 for the latter). </span><b><span style="font-family:Verdana;">Conclusion: </span></b><span style="font-family:Verdana;">Our study showed that EBRT boost in conventional fractionation was an acceptable treatment option for cervical cancer unamenable to brachytherapy, especially in the two subgroups of patients that are those without pelvic and/or para-aortic lymph node metastasis and those with haemoglobin level above 11 g/dl.</span></span> 展开更多
关键词 Cervical Cancer external beam radiation Therapy Boost Survival Prognostic Factors
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Radiation Oncology and Medical Devices( Part 1)
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作者 岳宁 陈霆 邹薇 《中国医疗设备》 2014年第1期1-9,共9页
Modern radiation treatments have become fairly complex and involve in utilizing a variety of medical devices to achieve the goal of providing conformal radiation dose coverage to the tumor target(s)while maximizing th... Modern radiation treatments have become fairly complex and involve in utilizing a variety of medical devices to achieve the goal of providing conformal radiation dose coverage to the tumor target(s)while maximizing the sparing of normal organ structures.Recently,different forms of linear accelerators/radioactive source based machines have been invented and developed with the aim of providing improved treatments and more treatment options.Besides linear accelerators(Linac)that have been undergoing constant improvement and advancement and can deliver fairly complicated dose distribution patterns,imaging systems,computer information and calculation systems have been more and more integrated into radiotherapy processes.To bring radiotherapy to a potentially higher level,many institutions have either acquired or started to consider particle therapy,especially proton therapy.The complexity of modern radiotherapy demands in-depth understanding of radiation physics and machine engineering as well as computer information systems.This paper is intended to provide an introductory description of radiation oncology and related procedures,and to provide an overview of the current status of medical devices in radiotherapy in the United States of America.This paper covers the radiation delivery systems,imaging systems,treatment planning systems,record and verify systems,and QA systems. 展开更多
关键词 radiation oncology radiotherapy external beam radiotherapy BRACHYTHERAPY intensity modulated radiotherapy SRS SBRT LINAC treatment planning system record and verify system 3DCRT simulator
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Radiation Oncology and Medical Devices(Part 2)
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作者 Ning J.Yue Ting Chen Wei Zou 《中国医疗设备》 2014年第2期1-10,共10页
Radiation oncology is one of the three major treatment modalities to manage cancer patient cares,and is a discipline mainly driven by technology and medical devices.Modern radiation treatments have become fairly compl... Radiation oncology is one of the three major treatment modalities to manage cancer patient cares,and is a discipline mainly driven by technology and medical devices.Modern radiation treatments have become fairly complex and involve in utilizing a variety of medical devices to achieve the goal of providing conformal radiation dose coverage to the tumor target(s)while maximizing the sparing of normal organ structures.Recently,different forms of linear accelerators/radioactive source based machines have been invented and developed with the aim of providing improved treatments and more treatment options.Besides linear accelerators(Linac)that have been undergoing constant improvement and advancement and can deliver fairly complicated dose distribution patterns,imaging systems,computer information and calculation systems have been more and more integrated into radiotherapy processes.To bring radiotherapy to a potentially higher level,many institutions have either acquired or started to consider particle therapy,especially proton therapy.The complexity of modern radiotherapy demands in-depth understanding of radiation physics and machine engineering as well as computer information systems.This paper is intended to provide an introductory description of radiation oncology and related procedures,and to provide an overview of the current status of medical devices in radiotherapy in the United States of America.This paper covers the radiation delivery systems,imaging systems,treatment planning systems,record and verify systems,and QA systems. 展开更多
关键词 radiation oncology radiotherapy external beam radiotherapy BRACHYTHERAPY intensity modulated radiotherapy SRS SBRT LINAC treatment planning system record and verify system 3DCRT Simulator
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Nanoparticles for targeted cancer radiotherapy
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作者 Roger M.Pallares Rebecca J.Abergel 《Nano Research》 SCIE EI CAS CSCD 2020年第11期2887-2897,共11页
Radiotherapy,where ionizing radiation is locally delivered either through an external beam or by surgically implanting radionuclide-based seeds in the tumor,is one of the gold standard treatments for cancer.Due to the... Radiotherapy,where ionizing radiation is locally delivered either through an external beam or by surgically implanting radionuclide-based seeds in the tumor,is one of the gold standard treatments for cancer.Due to the non-selective nature of radiation,healthy tissue surrounding the cancerous region is usually affected by the treatment.Hence,new strategies,including targeted alpha therapy,are being studied to improve the selectivity of the treatment and minimize side effects.Several challenges,however,limit the current development of targeted radiotherapy,such as the functionalization of the therapeutic agent with targeting vectors and controlling the release of recoiling daughters.Nanoparticles offer unique opportunities as drug delivery vehicles,since they are biocompatible,enhance the cellular uptake of drugs,and are easily functionalized with targeting molecules.In this review,we examine how nanoparticles can be used for targeted radiotherapy,either as sensitizers of external beams or as delivery vehicles for therapeutic radionuclides.We describe the clinical relevance of different types of nanoparticles,followed by an analysis of how these nanoconstructs can solve some of the main limitations of conventional radiotherapy.Finally,we critically discuss the current situation of nanoparticle-based radiotherapy in clinical settings and challenges that need to be overcome in the future for further development of the field. 展开更多
关键词 radiotherapy targeted cancer radiotherapy NANOPARTICLES CANCER targeted alpha therapy external beam
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鼻咽癌放疗头颈部摆位误差及外轮廓变化对放疗剂量的影响
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作者 陈乐康 李楚豪 +2 位作者 曾文杰 蔡曼波 伍海彪 《中国医学物理学杂志》 CSCD 2024年第9期1057-1063,共7页
目的:采用千伏级锥形束CT(CBCT)获取分次间鼻咽癌调强放疗中的外轮廓变化及摆位误差,分析其对靶区及危及器官剂量分布的影响。方法:选取21例鼻咽癌患者,将全部患者的137次CBCT图像与定位CT图像匹配后得到左右、头脚、腹背方向的摆位误... 目的:采用千伏级锥形束CT(CBCT)获取分次间鼻咽癌调强放疗中的外轮廓变化及摆位误差,分析其对靶区及危及器官剂量分布的影响。方法:选取21例鼻咽癌患者,将全部患者的137次CBCT图像与定位CT图像匹配后得到左右、头脚、腹背方向的摆位误差数据。选取颈部3个不同层面,测量其外轮廓横切面宽度,并利用Pearson系数和独立样本t检验分析其对摆位误差的影响。基于CBCT影像制定模拟计划,分析摆位误差和外轮廓变化对放疗剂量的影响,并应用Mann-Whitney秩和检验进行显著性分析。结果:左右、头脚、腹背方向的摆位误差分别为(1.04±0.73)、(1.13±0.87)、(1.38±0.95)mm。A、B、C层面上的头颈部最大外轮廓变化率分别为15.36%、14.94%、14.99%。模拟计划显示GTV D_(98)、CTV1 D_(95)、CTV2 D_(95)靶区的模拟计划的剂量均小于执行的计划剂量,差异有统计学意义(P<0.05);脑干和脊髓的模拟计划D_(max)均大于计划剂量,差异有统计学意义(P<0.05)。结论:通过模拟计划可知,当摆位误差和外轮廓变化等不确定性因素存在时,靶区的剂量变化较大,其中GTV D_(98)最大减小11.49%,CTV1 D_(95)、CTV2 D_(95)最大变化率分别为12.88%、21.64%。除左右晶体和左腮腺之外,其余的危及器官和靶区剂量均有显著性差异,表明实际放疗中摆位误差和外轮廓变化的存在会对剂量分布造成显著影响。 展开更多
关键词 鼻咽癌 调强放疗 锥形束CT 外轮廓 摆位误差
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基于SEER数据库分析直肠癌外放疗后第二原发膀胱癌的发生风险与预后
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作者 张曦 方江 +3 位作者 周宇 傅柳铭 刘硕 罗广承 《现代泌尿生殖肿瘤杂志》 2024年第4期197-202,共6页
目的分析直肠癌(RC)患者围手术期外放疗(EBRT)对第二原发膀胱癌(SPBC)发病风险及预后的影响。方法通过监测、流行病学和最终结果(SEER)数据库回顾性筛选1973年1月1日至2015年12月31日期间病理确诊RC患者51649例。利用SEER*Stat软件,采... 目的分析直肠癌(RC)患者围手术期外放疗(EBRT)对第二原发膀胱癌(SPBC)发病风险及预后的影响。方法通过监测、流行病学和最终结果(SEER)数据库回顾性筛选1973年1月1日至2015年12月31日期间病理确诊RC患者51649例。利用SEER*Stat软件,采用泊松回归计算标准化发病率(SIR)。使用R软件,采用Fine-Gray竞争风险回归分析评估RC患者发生SPBC的累积发生率。最后使用倾向评分匹配Kaplan-Meier法评估SPBC患者的生存结局。结果在51649例RC患者中,15612例患者同时了接受手术和EBRT,而36037例患者仅接受手术治疗。总计随访30年,放疗组(RT组)SPBC的累计发病率为4.50%,无放疗组(NRT组)为2.20%。RT组的SIR高于普通人群(SIR=1.43,95%CI:1.24~1.64,P<0.050)。竞争风险回归分析显示,接受放疗与更高的SPBC发生风险相关(HR=1.49,95%CI:1.13~1.95,P=0.004)。RT组和NRT组经倾向评分匹配后合并的SPBC患者的生存分析结果显示,两组患者10年总生存期的差异有统计学意义(62.8%vs 72.7%,P=0.010)。此外,RT组(27.7%vs 40.4%,P=0.005)和NRT组(24.2%vs 35.1%,P<0.001)合并SPBC患者的10年总生存期均显著低于仅诊断原发膀胱癌患者。结论放疗是RC长期生存患者发生SPBC的重要危险因素,且可能与合并SPBC患者的不良预后有关。 展开更多
关键词 直肠癌 外放疗 第二原发膀胱癌 发生率 总生存期
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Radiotherapy and the cellular DNA damage response: current and future perspectives on head and neck cancer treatment 被引量:2
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作者 Maria Rita Fabbrizi Jason L.Parsons 《Cancer Drug Resistance》 2020年第4期775-790,共16页
Incidences of head and neck squamous cell carcinoma(HNSCC)have been on the rise in the last few decades,with a significant risk factor being human papillomavirus(HPV)type-16/18 infection,particularly in the developmen... Incidences of head and neck squamous cell carcinoma(HNSCC)have been on the rise in the last few decades,with a significant risk factor being human papillomavirus(HPV)type-16/18 infection,particularly in the development of oropharyngeal cancers.Radiotherapy(RT)is an important treatment modality for HNSCC,where it promotes extensive cellular DNA damage leading to the therapeutic effect.It has been well-established that HPV-positive HNSCC display better response rates and improved survival following RT compared to HPV-negative HNSCC.The differential radiosensitivity has been largely associated with altered cellular DNA damage response mechanisms in HPV-positive HNSCC,and particularly with the signaling and repair of DNA double strand breaks.However,other factors,particularly hypoxia present within the solid cancer,have a major impact on relative radioresistance.Consequently,recent approaches aimed at enhancing the radiosensitivity of HNSCC have largely centered on targeting key proteins involved in DNA repair,DNA damage checkpoint activation,and hypoxia signaling.These studies have utilised in vitro and in vivo models of HPV-positive and HPV-negative HNSCC and examined the impact of specific inhibitors against the targets in combination with radiation in suppressing HNSCC cell growth and survival.Here,accumulating evidence has shown that targeting enzymes including poly(ADP-ribose)polymerase,ataxia telangiectasia and Rad-3 related,DNA-dependent protein kinase catalytic subunit,and checkpoint kinase 1 can radiosensitise HNSCC cells which should be taken forward in further preclinical studies,with the goal of optimizing the future effective RT treatment of HNSCC. 展开更多
关键词 DNA damage DNA repair head and neck cancer ionising radiation proton beam therapy RADIOBIOLOGY radiotherapy
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三维后装精准放疗联合体外调强外照射治疗宫颈癌的疗效及安全性
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作者 祁鹏 牛书雷 +3 位作者 王静 李腾 刘苏慧 杨健 《西部医学》 2024年第9期1341-1345,共5页
目的探究宫颈癌采用三维后装精准放疗联合体外调强外照射治疗的疗效及安全性。方法对2018年4月—2021年4月期本院收治84例宫颈癌患者资料进行回顾性分析,患者均接受三维后装精准放疗,将加用体外调强外照射治疗与常规放疗治疗者分别纳入... 目的探究宫颈癌采用三维后装精准放疗联合体外调强外照射治疗的疗效及安全性。方法对2018年4月—2021年4月期本院收治84例宫颈癌患者资料进行回顾性分析,患者均接受三维后装精准放疗,将加用体外调强外照射治疗与常规放疗治疗者分别纳入研究组44例与对照组40例。比较两组患者治疗疗效,治疗前后肿瘤标志物,治疗前后生存质量,药物毒副作用,1年无复发生存率。结果研究组患者缓解率均高于对照组,差异有统计学意义(95.45%vs 77.50%,P<0.05);两组患者治疗后细胞角蛋白19片段抗原21-1(CYFRA21-1)、鳞状细胞癌抗原(SCC)以及恶性肿瘤特异生长因子(TSGF)等肿瘤标志物水平均明显下降(P<0.05),治疗后研究组患者CYFRA21-1、SCC、TSGF水平低于对照组(P<0.05);两组患者治疗后Karnofsky评分均明显上升(P<0.05),治疗后研究组患者Karnofsky评分高于对照组(P<0.05);研究组患者治疗后放射性膀胱炎、消化道反应、放射性直肠炎、肝功能损伤以及骨髓抑制等药物毒副反应发生率均显著低于对照组(P<0.05);研究组与对照组患者1年无复发生存率分别为95.5%与75.0%,差异有统计学意义(χ^(2)=6.797,P<0.001)。结论宫颈癌采用三维后装精准放疗联合体外调强外照射治疗疗效及安全性优异。 展开更多
关键词 三维后装精准放疗 体外调强外照射 宫颈癌 疗效 安全性
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