Rh(Ⅲ) and Ir(Ⅲ) were separated satisfactorily in Tween80 (NH 4) 2SO 4 H 2O system by the liquid solid extraction in form of complexes with stannous chloride.
Rh(Ⅲ)-catalyzed, chelation-assisted oxidative C-H imidation of arenes with N-H imide have been realized using PhI(OAc)2 as an oxidant. This transformation exhibits a broad substrate scope and tolerates various functi...Rh(Ⅲ)-catalyzed, chelation-assisted oxidative C-H imidation of arenes with N-H imide have been realized using PhI(OAc)2 as an oxidant. This transformation exhibits a broad substrate scope and tolerates various functional groups. The reaction proceeded via in situ generation of an iodine(Ⅲ) imido. DFT calculations suggest that this oxidative imidaton system proceeds via a Rh(Ⅲ)-Rh(Ⅴ)-Rh(Ⅲ) pathway.展开更多
Heterocycle-braced cyclic peptides have demonstrated enhanced metabolic stability,increased potency and selectivity.Here,we present a rapid synthesis method for constructing Trp(C7)-alkene(E)-crosslinked cyclic peptid...Heterocycle-braced cyclic peptides have demonstrated enhanced metabolic stability,increased potency and selectivity.Here,we present a rapid synthesis method for constructing Trp(C7)-alkene(E)-crosslinked cyclic peptides with potent anti-proliferative activities against cancer cells,through C-H alkenylation and macrolactamization.This report addresses critical challenges associated with the installation and removal of the directing group N-Piv,configuration selectivity of the olefin,and intramolecular cyclization.No-tably,this method exhibits mild reaction conditions,traceless removal of the directing group,and high configuration selectivity.展开更多
The construction of N-fused polycyclic compounds at room temperature via the combination of transition-metal catalyst and photocatalyst has been reported.This novel work has successfully realized LED irradiated C—H a...The construction of N-fused polycyclic compounds at room temperature via the combination of transition-metal catalyst and photocatalyst has been reported.This novel work has successfully realized LED irradiated C—H activation of iodonium ylides.The strategy shows wide substrate scope and ideal functional group tolerance.Our work would be useful for the construction of various heterocyclic compounds.展开更多
A new Rh(Ⅲ)-catalyzed aldehydic C-H activation/[4+3]annulation cascade of N-sulfonyl-2-aminobenzaldehydes with gem-difluorocyclopropenes is reported for the first time,and used to produce a range of hitherto unreport...A new Rh(Ⅲ)-catalyzed aldehydic C-H activation/[4+3]annulation cascade of N-sulfonyl-2-aminobenzaldehydes with gem-difluorocyclopropenes is reported for the first time,and used to produce a range of hitherto unreported precedentedβ-monofluorinated benzo[b]azepin-5-ones with good yields and complete regioselectivity.This approach features a broad substrate scope,good functional group tolerance,and high regioselectivity,which may include Rh(Ⅲ)-catalyzed aldehydic C-H activation,tandem site-/regioselective insertion,defluorinated ring-scission,and 1,2-elimination.展开更多
文摘Rh(Ⅲ) and Ir(Ⅲ) were separated satisfactorily in Tween80 (NH 4) 2SO 4 H 2O system by the liquid solid extraction in form of complexes with stannous chloride.
基金supported by Shanghai Municipal Natural Science Foundation,China(15ZR1447800)the Chinese Postdoctoral Science Foundation(2012M511158,2013T60477,2014M560363)~~
文摘Rh(Ⅲ)-catalyzed, chelation-assisted oxidative C-H imidation of arenes with N-H imide have been realized using PhI(OAc)2 as an oxidant. This transformation exhibits a broad substrate scope and tolerates various functional groups. The reaction proceeded via in situ generation of an iodine(Ⅲ) imido. DFT calculations suggest that this oxidative imidaton system proceeds via a Rh(Ⅲ)-Rh(Ⅴ)-Rh(Ⅲ) pathway.
基金the National Key R&D Program of China(No.2022YFA1302900 to H.Liu)National Natural Science Foundation of China(Nos.82130105,22337003,82121005 to H.Liu+2 种基金and Nos.22177124,82322063 to J.Wang)Program of Shang-hai Academic Research Leader(No.23XD1460300 to J.Wang)the Lingang Laboratory(No.LG-GG-202204-02 to J.Wang)for supporting this work.We would like to acknowledge Shanghai Highline Therapeutics.
文摘Heterocycle-braced cyclic peptides have demonstrated enhanced metabolic stability,increased potency and selectivity.Here,we present a rapid synthesis method for constructing Trp(C7)-alkene(E)-crosslinked cyclic peptides with potent anti-proliferative activities against cancer cells,through C-H alkenylation and macrolactamization.This report addresses critical challenges associated with the installation and removal of the directing group N-Piv,configuration selectivity of the olefin,and intramolecular cyclization.No-tably,this method exhibits mild reaction conditions,traceless removal of the directing group,and high configuration selectivity.
基金the support from Sichuan Science and Technology Program(No.2020YJ0221).
文摘The construction of N-fused polycyclic compounds at room temperature via the combination of transition-metal catalyst and photocatalyst has been reported.This novel work has successfully realized LED irradiated C—H activation of iodonium ylides.The strategy shows wide substrate scope and ideal functional group tolerance.Our work would be useful for the construction of various heterocyclic compounds.
基金financial support from the schoollevel research projects of Yancheng Institute of Technology(No.xjr2020044)the National Natural Science Foundation of China(Nos.22101151 and 21971090)。
文摘A new Rh(Ⅲ)-catalyzed aldehydic C-H activation/[4+3]annulation cascade of N-sulfonyl-2-aminobenzaldehydes with gem-difluorocyclopropenes is reported for the first time,and used to produce a range of hitherto unreported precedentedβ-monofluorinated benzo[b]azepin-5-ones with good yields and complete regioselectivity.This approach features a broad substrate scope,good functional group tolerance,and high regioselectivity,which may include Rh(Ⅲ)-catalyzed aldehydic C-H activation,tandem site-/regioselective insertion,defluorinated ring-scission,and 1,2-elimination.
