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On the Meaning of the Number SEVEN in the Eastern and Western Culture
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作者 涂朝莲 陈坤 《海外英语》 2011年第4X期276-276,284,共2页
This paper interprets the connotation,denotation and the symbolic meaning of SEVEN from the perspective of semiotics.The number SEVEN means samsara,destiny,reincarnation,the ending and a brand new beginning,satisfacti... This paper interprets the connotation,denotation and the symbolic meaning of SEVEN from the perspective of semiotics.The number SEVEN means samsara,destiny,reincarnation,the ending and a brand new beginning,satisfaction after a lot of suffering in the East.While,in the West,besides these,it refers to the magic and holy power of the God,mystery,completeness and perfection,occult,happiness and luck. 展开更多
关键词 the NUMBER seven CULTURE MEANING numerology SEMIOTICS
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Seven-day triple therapy is a better choice for Helicobacter pylori eradication in regions with low antibiotic resistance 被引量:12
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作者 Yue-Feng Tong Jun Lv +8 位作者 Li-Yuan Ying Fang Xu Bo Qin Ming-Tong Chen Fei Meng Miao-Ying Tu Ning-Min Yang You-Ming Li Jian-Zhong Zhang 《World Journal of Gastroenterology》 SCIE CAS 2015年第46期13073-13079,共7页
AIM: To investigate whether 7-d triple therapies are still valid in populations with low levels of resistance.METHODS: A total of 1106 Helicobacter pylori(H. pylori)-positive patients were divided into three groups,ea... AIM: To investigate whether 7-d triple therapies are still valid in populations with low levels of resistance.METHODS: A total of 1106 Helicobacter pylori(H. pylori)-positive patients were divided into three groups,each of which received one type of 7-d triple therapy. Therapeutic outcomes of the patients were assessed by the 13C-urea breath test at 8 wk after treatment. The susceptibility of H. pylori to antibiotics was determined by an agar-dilution method. Data analysis was performed by χ2 tests.RESULTS: The eradication rates in groups A,B and C were 90.71%(332/366),90.46%(313/346) and 90.87%(189/208),respectively(P = 0.986). The resistance rates were 8.91% for clarithromycin,14.78% for levofloxacin and 0% for amoxicillin. The eradication rate was significantly different between clarithromycin-and levofloxacin-resistant patients(P < 0.05) in group A. Patients whose treatment failed in group A also had a higher clarithromycin resistance rate than did successive patients(P = 0.034). However,levofloxacin resistance had no obvious influence on the eradication rate. Furthermore,three main antibiotics(clarithromycin,levofloxacin and amoxicillin) had lower DID(defined daily dose per 1000 inhabitants per day) in this city.CONCLUSION: Clarithromycin resistance is the main reason for the failure of 7-d triple therapy. In populations with low levels of resistance,a 7-d triple therapy is a viable choice. The choice of therapy should not be influenced by conditions in high antibiotic resistance regions. 展开更多
关键词 HELICOBACTER PYLORI seven-day TRIPLE therapy Eradi
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Up-to-seven criteria for hepatocellular carcinoma liver transplantation:A single center analysis 被引量:8
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作者 Jian-Yong Lei Wen-Tao Wang Lu-Nan Yan 《World Journal of Gastroenterology》 SCIE CAS 2013年第36期6077-6083,共7页
AIM:To detect whether the up-to-seven should be used as inclusion criteria for liver transplantation for hepatocellular carcinoma.METHODS:Between April 2002 and July 2008,220hepatocellular carcinoma(HCC)patients who w... AIM:To detect whether the up-to-seven should be used as inclusion criteria for liver transplantation for hepatocellular carcinoma.METHODS:Between April 2002 and July 2008,220hepatocellular carcinoma(HCC)patients who were diagnosed with HCC and underwent liver transplantation(LT)at our liver transplantation center were included.These patients were divided into three groups according to the characteristics of their tumors(tumor diameter,tumor number):the Milan criteria group(Group 1),the in up-to-seven group(Group 2)and the out up-toseven group(Group 3).Then,we compared long-term survival and tumor recurrence of these three groups.RESULTS:The baseline characteristics of transplant recipients were comparable among these three groups,except for the type of liver graft(deceased donor liver transplant or live donor liver transplantation).There were also no significant differences in the pre-operativeα-fetoprotein level.The 1-,3-,and 5-year overall survival and tumor-free survival rate for the Milan criteriagroup were 94.8%,91.4%,89.7%and 91.4%,86.2%,and 86.2%respectively;in the up-to-seven criteria group,these rates were 87.8%,77.8%,and 76.6%and 85.6%,75.6%,and 75.6%respectively(P<0.05).However,the advanced HCC patients’(in the group out of up-to-seven criteria)overall and tumor-free survival rates were much lower,at 75%,53.3%,and 50%and65.8%,42.5%,and 41.7%,respectively(P<0.01).CONCLUSION:Considering that patients in the up-toseven criteria group exhibited a considerable but lower survival rate compared with the Milan criteria group,the up-to-seven criteria should be used carefully and selectively. 展开更多
关键词 Up-to-seven CRITERIA Liver transplantation Outcome HEPATOCELLULAR carcinoma RECURRENCE
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On Cultural Differences between English and Chinese --From the Aspect of Seven Types of Meaning
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作者 刘海萍 《陕西师范大学学报(哲学社会科学版)》 CSSCI 北大核心 2002年第S1期312-314,共3页
This paper analyzes cultural differences of English and Chinese in terms of Seven Types of Meaning . It proceeds from the theory of Leech’s Seven Types of meaning , then comparatively illustrates with analysis of eac... This paper analyzes cultural differences of English and Chinese in terms of Seven Types of Meaning . It proceeds from the theory of Leech’s Seven Types of meaning , then comparatively illustrates with analysis of each type of meaning and cultural differences. And concludes with the cause of cultural differences and problems of it in cross-cultural communication with the hope that Chinese student could avoid Chinglish in learning and both Chinese and foreigners could avoid cultural shock when communicating with each other. 展开更多
关键词 cultural differences Chinese English seven types of meaning
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Studies on the Total Synthesis of Pseudolaric Acid A Stereocontrolled Synthesis of the Seven-membered Lactone
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作者 You Hong HU Li Gong OU +1 位作者 Xi Lu WANG Dong Lu BAI(Shanghai Institute of Materia Medica,Chinese Academy of Sciences. 294 Taiyuan Road, Shanghai 200031) 《Chinese Chemical Letters》 SCIE CAS CSCD 1999年第4期281-284,共4页
The lactone 16 was obtained stereo- and regioselectively by a reaction sequence of 9 steps in 21% overall yield.
关键词 Pseudplaric ACID A stereocontrl SYNTHESIS seven-membered LACTONE
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THERAPEUTIC EFFECT OF SEVEN-STAR NEEDLE ACUPUNCTURE IN PATIENTS OF PEDIATRIC CEREBRAL PALSY
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作者 袁清顺 《World Journal of Acupuncture-Moxibustion》 1995年第3期3-7,共5页
In this paper the therapeutic results of the seven-star acupuncture combined with bodyacupuncture in 260 patients of pediatric cerebral palsy are reported and the author claims that the cere-bral palsy is not an incur... In this paper the therapeutic results of the seven-star acupuncture combined with bodyacupuncture in 260 patients of pediatric cerebral palsy are reported and the author claims that the cere-bral palsy is not an incurable disease and an ideal therapeutic result can be obtained if the treatmentcan be started early and continued persistently through a good co0peration between the patients andthe physicians. 展开更多
关键词 Cerebral PALSY MUSCULAR SPASM DYSKINESIA seven-star NEEDLE
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Hawthorne's Puritanism in The House of the Seven Gables
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作者 常青 魏蕊 +1 位作者 卢晓敏 刘晓希 《中国校外教育》 2017年第3期115-116,共2页
Impacted by the family background and social trend,Hawthorne frequently got perplexed.At the same time,he also criticized the extremism in traditional Puritanism and insisted on a more tolerant attitude towards the di... Impacted by the family background and social trend,Hawthorne frequently got perplexed.At the same time,he also criticized the extremism in traditional Puritanism and insisted on a more tolerant attitude towards the dissidents.So Hawthorne established his own Puritanism,which is based on the traditional Puritanism and influenced by Transcendentalism and personal experience.As a result,Hawthorne’s fictions are filled with his own concept of Puritanism and The House of the Seven Gablesreveals his Puritanism as can be seen from the characters and the use of symbolism. 展开更多
关键词 英语学习 学习方法 阅读知识 阅读材料
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Improving the Construction Industry Quality Using the Seven Basic Quality Control Tools
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作者 Mohamed Abdel-Hamid Hanaa Mohamed Abdelhaleem 《Journal of Minerals and Materials Characterization and Engineering》 2019年第6期412-420,共9页
The organizations used quality tools to develop their processes and gain satisfaction from the customers. The main objective of this study is to develop levels of quality in the construction industry through the use o... The organizations used quality tools to develop their processes and gain satisfaction from the customers. The main objective of this study is to develop levels of quality in the construction industry through the use of the seven basic quality control tools. Such tools are extremely crucial tools which are used worldwide in the industries for continual improvement. The seven basic quality tools are Check Sheet, Histogram, Pareto Chart, Fishbone Diagram, Control Chart, Flowchart and Scatter Diagram. They were implemented in various steps of the process in order to define the problems, measure its impacts, find out its root causes and solve these problems to ensure the production of non-defective items. The study shows how the seven basic tools of quality are very useful and effective in identifying and removal of defects from the manufacturing process. These tools are helpful in every stage of the defect removal process. This study was conducted on Cleopatra Group Company. This company succeeded to serve the public and private projects in the Egyptian construction sectors. 展开更多
关键词 QUALITY IMPROVEMENT seven Basic QUALITY Control TOOLS Construction INDUSTRY
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Study on the Effects of Extreme Precipitation for Seven Growth Stages of Winter Wheat in Northern Weihe Loess Plateau, China
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作者 Ouk Sereyrorth Baowen Yan +2 位作者 Khem Chunpanha Porn Lybun Pich Linvolak 《Journal of Water Resource and Protection》 2020年第4期358-380,共23页
The research on the characteristic frequency of precipitation is a great significance for guiding regional agricultural planning, water conservancy project designs, and drought and flood control. Droughts and floods o... The research on the characteristic frequency of precipitation is a great significance for guiding regional agricultural planning, water conservancy project designs, and drought and flood control. Droughts and floods occurred in northern Weihe Loess Plateau, affecting growing and yield of winter wheat in the area. Based on the daily precipitation data of 29 meteorological stations from 1981 to 2012, this study is to address the analysis of three different frequencies of annual precipitation at 5%, 50%, and 95%, and to determine the amount of rainfall excess and water shortage during seven growth stages of winter wheat at 5%, 10%, and 20% frequencies, respectively. Pearson type III curve was selected for this study to analyze the distribution frequency of annual rainfall and rainfall amount following seven growth stages of winter wheat crop in 29 stations of Northern Weihe loess plateau. As a result of our study, annual precipitation is gradually increasing from southwest to northeast of Northern Weihe loess plateau. The highest amount of annual precipitation occurred in the Baoji area and the lowest precipitation covered by the northwest area of Northern Weihe loess plateau. Moreover, the amount of rainfall of seven growth stages indicates that excessive rainfall occurs not only in the first stage (sowing to tillering) and seventh stage (flowering to ripening) but also in second stage (tillering to wintering). In the seventh stage, a large amount of excessive rainfall occurred in Changwu, Bin, Qianyang, Fengxiang, Baojiqu, and Baojixian. Moreover, water shortage is distributed in the third stage (from wintering to greening), the fourth stage (from greening to jointing), the fifth stage (from jointing to heading), and the sixth stage (from heading to flowering). Furthermore, the worst water shortages occurred in Hancheng, Heyang, Chengcheng, Pucheng, Dali, Tongchuan, and Fuping in the fourth stage (greening to jointing stage). Even though we study the crop water requirement under extreme rainfall conditions, the amount of rainwater still supply inadequate in some parts of the winter wheat growth stage. Therefore, this study provides main clues for the next step to study the irrigation water needs of winter wheat crops and to reduce agricultural risks in 29 counties in the northern loess plateau and other regions. 展开更多
关键词 Extreme PRECIPITATION Annual PRECIPITATION seven Growth Stages Winter Wheat Crop Rainfall Excess Water SHORTAGE NORTHERN Weihe Loess Plateau
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Translation of Images in Seven-character Quatrains Based on the “Aesthetic Level of Translation”
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作者 韩畅畅 《海外英语》 2014年第20期189-190,共2页
Image is a term that mainly embodies in the composition of classical Chinese poetry(CCP). Effective translation of images is crucial to the grasp of original meanings in a poem. As aesthetic beauty is the primary conc... Image is a term that mainly embodies in the composition of classical Chinese poetry(CCP). Effective translation of images is crucial to the grasp of original meanings in a poem. As aesthetic beauty is the primary concern in poetry,the conveyance of beauty in image has a direct impact in translation. To analyze translation strategies of imagery beauty,the theory of"translation levels"by Xu Jun is adopted as a criterion in comparing variant English versions of CCP in the aesthetic level. Images are selected from Seven-character quatrains typified for abundant sources of images,and features of images are put forward at the aesthetic level. Through the analysis,images are rendered by recreation of the sensuous and emotional beauty. 展开更多
关键词 IMAGE TRANSLATION AESTHETIC LEVEL seven-character
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On the Themes of Innocence and Resolution——A study of Wordsworth’s We Are Seven and Resolution and Independence
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作者 蒋歌 《海外英语》 2019年第20期239-240,共2页
As a leading figure of the romantic poetry,Wordsworth has a deep love for nature and this special love further leads his love for common working people as they live in nature and they are the closest to nature.As a re... As a leading figure of the romantic poetry,Wordsworth has a deep love for nature and this special love further leads his love for common working people as they live in nature and they are the closest to nature.As a result,the sources of his poetry often come from ordinary people's life and his poems in turn encourage common people to face misfortune and overcome hardships of life.In his We Are Seven,the poet demonstrates different attitudes towards death between a sophisticated adult and an innocent child,expressing the idea that being innocent can help people understand death in a natural way;in Resolution and Independence,the poor old man's strong resolution and firm mind give the poet great power and courage to face hardships of life.The themes of these two poems—innocence and resolution reveal Wordsworth's response to death and hardships of life. 展开更多
关键词 Wordsworth nature INNOCENCE RESOLUTION We Are seven Resolution and Independence
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Supercontinuum generation in seven-core photonic crystal fiber pumped by a broadband picosecond pulsed fiber amplifier 被引量:2
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作者 苏宁 李平雪 +4 位作者 肖坤 王晓晓 刘建国 邵月 苏盟 《Chinese Physics B》 SCIE EI CAS CSCD 2017年第7期134-139,共6页
We report a supercontinuum source generated in seven-core photonic crystal fibers(PCFs) pumped by a self-made all-fiber picosecond pulsed broadband fiber amplifier. The amplifier's output average power is 60 W at ... We report a supercontinuum source generated in seven-core photonic crystal fibers(PCFs) pumped by a self-made all-fiber picosecond pulsed broadband fiber amplifier. The amplifier's output average power is 60 W at 1150 nm with spectral width of 260 nm, and its repetition rate is 8.47 MHz with pulse width of 221 ps. With two different lengths of seven-core PCF, different output powers and spectra are obtained. When a 10 m long seven-core PCF is chosen, the output supercontinuum covers the wavelength range from 620 nm to 1700 nm, with the output power of 11.7 W. With only 2 m long seven-core PCF used in the same experiment, the wavelength of the supercontinuum spans from 680 nm to 1700 nm,with the output power of 20.4 W. The results show that the pulse width is 385 ps in the 10 m long seven-core PCF and 255 ps in the 2 m long one, respectively, due to the normal dispersion of the PCF. 展开更多
关键词 宽带光纤放大器 光子晶体光纤 超连续谱 皮秒脉冲 泵浦 输出功率 光谱宽度 波长范围
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Synthesis and Crystal Structure of a Seven-coordinate Cadmium(Ⅱ) Complex 被引量:2
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作者 王瑞虎 洪茂椿 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 北大核心 2002年第3期268-272,共5页
The reaction of 4-hydroxybenzoic acid (H2L),4, 4-diaminodiphenylmethane (DADPM) and Cd(NO3)2?H2O in methane/water gave rise to a seven-coordinate Cd(Ⅱ) complex [Cd2(HL)4(H2O)6]?H2O which has been characterized by sin... The reaction of 4-hydroxybenzoic acid (H2L),4, 4-diaminodiphenylmethane (DADPM) and Cd(NO3)2?H2O in methane/water gave rise to a seven-coordinate Cd(Ⅱ) complex [Cd2(HL)4(H2O)6]?H2O which has been characterized by single-crystal X-ray diffraction. The complex crystallizes in the orthorhombic system, space group Pna21 with unit cell parameters: a = 10.3352(3), b = 12.0481(3), c = 28.2016(1) ? V = 3511.65(13) 3, Z = 4, C28H36Cd2O20, Mr = 917.37, Dc = 1.735 g/cm3, F(000) = 1840, (MoK? = 1.29mm-1. The final R and wR are 0.0536 and 0.1086 for 4898 observed reflections with I ≥ 4(I). The Cd(Ⅱ) is seven-coordinated in a distorted pentagonal bipyramidal geometry. The inter-molecular hydrogen bonds lead to the formation of a two-dimensional layer structure. 展开更多
关键词 镉配合物 合成 晶体结构 氢键 X射线衍射
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An Analysis of Li's Prose The Great Goal with Gee's "the Seven Building Tasks"
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作者 Li Binglin Zhan Jing 《学术界》 CSSCI 北大核心 2016年第10期257-264,共8页
This paper,by using the theory of Seven Building Tasks to analyze the Prose The Great Goal2 which was ever analyzed from the perspective of theme and rheme structure,aims to demonstrate the application of the new theo... This paper,by using the theory of Seven Building Tasks to analyze the Prose The Great Goal2 which was ever analyzed from the perspective of theme and rheme structure,aims to demonstrate the application of the new theory Severn Building Tasks to analyzing an essay,and thus provide a fresh theory and approach for English learners to analyze prose and learn the English language. 展开更多
关键词 言谈分析 七个建筑物任务 目标 散文
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Singularity Analysis of 2-DOF Planar Seven-bar MechanismsUsed in Hybrid Actuators
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作者 方新国 邹慧君 梁庆华 《Journal of Donghua University(English Edition)》 EI CAS 2004年第4期118-123,共6页
Based on the Jacobian matrices relating the input speeds with the output speeds of linkages, a general method, which is used for solving the singularities of planar multi-loop multi-DOF linkages, is presented. The fou... Based on the Jacobian matrices relating the input speeds with the output speeds of linkages, a general method, which is used for solving the singularities of planar multi-loop multi-DOF linkages, is presented. The four kinds of singularities of 2-DOF planar seven-bar linkages used in hybrid actuators are analyzed in detail by this method. Its five kinds of singular positions whose characteristics are discussed respectively are discovered. Three approaches are proposed on how to avoid the singular positions of planar multi-loop multi-DOF linkages. Based on the assemblability of planar single-loop N-bar chains or linkages, the geometry conditions are investigated and discovered to avoid the singular positions of the linkages. In order to versify aforementioned conclusions, a case is given in which the singular curves are plotted and simulated. 展开更多
关键词 雅可比行列式 奇异分析 2-DOF 制动器 速度矩阵 装配能力 机械系统
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Cloning and characterization of a novel gene encoding a putative seven-span transmembrane protein localized in endoplasmic reticulum
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作者 王冀姝 杨曦 韩骅 《Journal of Medical Colleges of PLA(China)》 CAS 2004年第1期1-6,共6页
Objective: To clone and analyze the structure of a novel gene, named EST 1 (endoplasmic reticulum localized seven span transmembrane protein 1) and to analyze the expression pattern and intracellular location of EST 1... Objective: To clone and analyze the structure of a novel gene, named EST 1 (endoplasmic reticulum localized seven span transmembrane protein 1) and to analyze the expression pattern and intracellular location of EST 1. Methods: The cDNA library was screened to isolate novel cDNA fragment. The structure of novel gene was analysed by computer software. Expression of EST 1 was analyzed by dot blot and Northern blotting. Intracellular localization was observed after EST 1 enhanced green fluorescence protein (EGFP) fusion gene was transfected into mammalian cells. Results: The full length cDNA of mouse EST 1 was 1 802 bp, with a 1 293 bp open reading frame encoding 431 amino acids. It was predicated that protein encoded by EST 1 contained a signal peptide sequence at the N terminus, seven putative transmembrane domains, and an ER retaining signal at the C terminus. EST 1 EGFP fusion protein showed an ER like intracellular distribution in mammalian cells. Expression pattern analysis showed that EST 1 is expressed in all tissues examined. Conclusion: EST 1 is encoding a putative seven span transmembrane protein localized in endoplasmic reticulum. EST 1 was expressed in all tissues examined, suggesting an essential function of EST 1 in cells. 展开更多
关键词 跨膜蛋白 内质网状组织 克隆 基因表达 EST-1基因 DNA片断
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Seven amino acid peptide mimic from HVR1 of HCV influences cytokine profile of immune cells
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作者 Song Chunhui Chen Liming Yang Bin Chi Shuping Cheng Yun 《Journal of Medical Colleges of PLA(China)》 CAS 2010年第5期257-266,共10页
Objective:To investigate the actions of cytokine profile in the immune cells by a seven amino acid peptide mimic from HVR1 of HCV (GQTYTSG,named 7P).Methods:The peripheral blood mononuclear cells (PBMCs) from 17 healt... Objective:To investigate the actions of cytokine profile in the immune cells by a seven amino acid peptide mimic from HVR1 of HCV (GQTYTSG,named 7P).Methods:The peripheral blood mononuclear cells (PBMCs) from 17 healthy blood donors were stimulated with 7P,and the cytokine levels in CD4+CD8-,CD4-CD8+ T cells,NK,NKT cells were analyzed by the intracellular cytokine staining.Results:The frequency of cells which secreted interferon-γ (IFN-γ) was found to be significantly increased in all cells,interleukin-10(IL-10) was significantly increased in CD4+CD8-,CD4-CD8+ T cells but decreased in NK,NKT cells,and tumor necrosis factor-α (TNF-α) was decreased in CD4+CD8-,CD4-CD8+ but increased in NK cells.Conclusion:7P could induce a cytokine profile in different immune cells in vitro and there was some difference between the CD4+CD8-,CD4-CD8+ T cells which represented the adaptive immunity cells and NK,NKT cells which represented the innate immunity cells.This kind of variation of cytokine profile might contribute to anti-virus and anti-inflammatory immune reaction. 展开更多
关键词 免疫细胞因子 丙型肝炎病毒 高变区 氨基酸 模拟 外周血单个核细胞 肿瘤坏死因子 白细胞介素10
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Heighten the Study on Factor Seven Activating Protease
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作者 贺石林 陈方平 +1 位作者 张广森 文志斌 《血栓与止血学》 2008年第3期99-100,共2页
Recent studies have showed that factor seven activa-ting protease(FSAP)is a novel serine protease in humanplasma.Immunoreactivity for FSAP has been observed invascular endothelial cells,epithelial cells and macropha-g... Recent studies have showed that factor seven activa-ting protease(FSAP)is a novel serine protease in humanplasma.Immunoreactivity for FSAP has been observed invascular endothelial cells,epithelial cells and macropha-ges but FSAP-specific mRNA expression only exists inthe former two cells.FSAP has three epidermal growthfactor(EGF)domains,a kringle domain and a serineprotease domain.It circulates in the plasma as an inac-tive zymogen and undergoes autoactivation from a 展开更多
关键词 蛋白酶 上皮细胞 内皮细胞 核糖核酸
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On Nathaniel Hawthorne's Cultural-Political Views in Light of the Psychological Descriptions in The House of the Seven Gables
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作者 DENG Jian-hua CHEN Xin-ying 《Sino-US English Teaching》 2013年第5期404-411,共8页
关键词 心理活动 政治 房子 文化 观光 形成影响 现代人
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The E3 ubiquitin ligase seven in absentia homolog 1 may be a potential new therapeutic target for Parkinson's disease
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作者 Zeng-lin Cai Jing Xu +6 位作者 Shou-ru Xue Yuan-yuan Liu Yong-jin Zhang Xin-zhi Zhang Xuan Wang Fang-ping Wu Xiao-min Li 《Neural Regeneration Research》 SCIE CAS CSCD 2015年第8期1286-1291,共6页
In this study, we investigated the effect of an antibody against E3 ubiquitin ligase seven in absentia homolog 1(SIAH-1) in PC12 cells. 1-Methyl-4-phenylpyridinium(MPP+) treatment increased α-synuclein, E1 and SIAH-1... In this study, we investigated the effect of an antibody against E3 ubiquitin ligase seven in absentia homolog 1(SIAH-1) in PC12 cells. 1-Methyl-4-phenylpyridinium(MPP+) treatment increased α-synuclein, E1 and SIAH-1 protein levels in PC12 cells, and it reduced cell viability; however, there was no significant change in light chain 3 expression. Treatment with an SIAH-1 antibody decreased m RNA expression levels of α-synuclein, light chain 3 and SIAH-1, but increased E1 m RNA expression. It also increased cell viability. Combined treatment with MPP+ and rapamycin reduced SIAH-1 and α-synuclein levels. Treatment with SIAH-1 antibody alone diminished α-synuclein immunoreactivity in PC12 cells, and reduced the colocalization of α-synuclein and light chain 3. These findings suggest that the SIAH-1 antibody reduces the monoubiquitination and aggregation of α-synuclein, promoting its degradation by the ubiquitin-proteasome pathway. Consequently, SIAH-1 may be a potential new therapeutic target for Parkinson's disease. 展开更多
关键词 综合治疗 泛素连接酶 帕金森病 同源物 Α-突触核蛋白 靶点 PC12细胞 泛素-蛋白酶体途径
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