目的:对比分析18F-Na F PET/CT与99m Tc-MDP SPECT/CT诊断前列腺癌骨转移灶的临床价值。方法:回顾性分析32例前列腺癌患者(2013年9月至2015年3月)骨转移灶。32例患者均在我科接受了18F-Na F PET/CT与99m Tc-MDP SPECT/CT检查,两种检查...目的:对比分析18F-Na F PET/CT与99m Tc-MDP SPECT/CT诊断前列腺癌骨转移灶的临床价值。方法:回顾性分析32例前列腺癌患者(2013年9月至2015年3月)骨转移灶。32例患者均在我科接受了18F-Na F PET/CT与99m Tc-MDP SPECT/CT检查,两种检查最长间隔不超过一周,以病理学结果或随访结果对显像进行分析。结果:18F-Na F PET/CT骨扫描探测到32例患者中31人存在骨转移灶,其中20处骨骼病灶性质待定。99mTc-MDP SPECT/CT骨显像探测到32例患者中30人存在骨转移灶,18处骨骼病灶性质待定。18F-Na F PET/CT骨显像图像的质量及分辨率均优于99m Tc-MDP SPECT/CT骨显像。18F-Na F PET/CT骨显像和99m Tc-MDP SPECT/CT骨显像诊断前列腺癌骨转移灶的灵敏度分别为97.2%和61%;特异度分别为100%和100%;两种显像方法的阳性预测值分别为100%和100%,而阴性预测值为95.4%和59.7%。结论:18F-Na F PET/CT骨显像评价前列腺癌骨转移灶较99m Tc-MDP SPECT/CT骨显像灵敏度、阴性预测值高,在临床上有更好的应用价值。展开更多
The proposed phantom is designed for the quality control of micro-SPECT/CT and micro-PET/CT systems. However, it is an assembly of six patterns stored in a cylindrical box enabling to control both micro-SPECT unit in ...The proposed phantom is designed for the quality control of micro-SPECT/CT and micro-PET/CT systems. However, it is an assembly of six patterns stored in a cylindrical box enabling to control both micro-SPECT unit in terms of uniformity, spatial linearity and spatial resolution and micro-CT unit in terms of uniformity, spatial linearity, spatial resolution, diffusion rate, low contrast detectability, Hounsfield unit linearity and slice thickness. The construction material is Plexiglas. As for the implementation, it was made on a micro-SPECT/CT machine of the type “speCZT eXplore CT 120”. Compared to the NEMA NU 4-2008 image quality phantom, this phantom offers micro-CT quality control and is more efficient in control of spatial resolution for micro-SPECT and micro- PET systems.展开更多
ObjectiveTo investigate the diagnostic value of 18F-fluorodeoxyglucose positron emission tomography （18F-FDG PET） in the as-sessment of myocardial viability in patients with known coronary artery disease （CAD） whe...ObjectiveTo investigate the diagnostic value of 18F-fluorodeoxyglucose positron emission tomography （18F-FDG PET） in the as-sessment of myocardial viability in patients with known coronary artery disease （CAD） when compared to99mTc single photon emission computed tomography （SPECT） and echocardiography, with invasive coronary angiography as the gold standard.MethodsThirty patients with diagnosed CAD met the selection criteria, with 10 of them （9 men, mean age 59.5 ± 10.5 years） undergoing all of these imaging proce-dures consisting of SPECT and PET, echocardiography and invasive angiography. Diagnostic sensitivity of these less invasive modalities for detection of myocardial viability was compared to invasive coronary angiography. Inter- and intra-observer agreement was assessed for di-agnostic performance of SPECT and PET.ResultsOf all patients with proven CAD, 50% had triple vessel disease. Diagnostic sensitivity of SPECT, PET and echocardiography was 90%, 100% and 80% at patient-based assessment, respectively. Excellent agreement was achieved between inter-observer and intra-observer agreement of the diagnostic value of SPECT and PET in myocardial viability （k= 0.9）. Conclusion18F-FDG PET has high diagnostic value in the assessment of myocardial viability in patients with known CAD when com-pared to SPECT and echocardiography. Further studies based on a large cohort with incorporation of18F-FDG PET into patient management are warranted.展开更多
Coronary artery disease remains a major cause of mortality. Presence of atherosclerotic plaques in the coronary artery is responsible for lu-men stenosis which is often used as an indicator for determining the severit...Coronary artery disease remains a major cause of mortality. Presence of atherosclerotic plaques in the coronary artery is responsible for lu-men stenosis which is often used as an indicator for determining the severity of coronary artery disease. However, the degree of coronary lumen stenosis is not often related to compromising myocardial blood flow, as most of the cardiac events that are caused by atherosclerotic plaques are the result of vulnerable plaques which are prone to rupture. Thus, identification of vulnerable plaques in coronary arteries has become increas-ingly important to assist identify patients with high cardiovascular risks. Molecular imaging with use of positron emission tomography （PET） and single photon emission computed tomography （SPECT） has fulfilled this goal by providing functional information about plaque activity which enables accurate assessment of plaque stability. This review article provides an overview of diagnostic applications of molecular imaging tech-niques in the detection of plaques in coronary arteries with PET and SPECT. New radiopharmaceuticals used in the molecular imaging of coro-nary plaques and diagnostic applications of integrated PET/CT and PET/MRI in coronary plaques are also discussed.展开更多
文摘目的:对比分析18F-Na F PET/CT与99m Tc-MDP SPECT/CT诊断前列腺癌骨转移灶的临床价值。方法:回顾性分析32例前列腺癌患者(2013年9月至2015年3月)骨转移灶。32例患者均在我科接受了18F-Na F PET/CT与99m Tc-MDP SPECT/CT检查,两种检查最长间隔不超过一周,以病理学结果或随访结果对显像进行分析。结果:18F-Na F PET/CT骨扫描探测到32例患者中31人存在骨转移灶,其中20处骨骼病灶性质待定。99mTc-MDP SPECT/CT骨显像探测到32例患者中30人存在骨转移灶,18处骨骼病灶性质待定。18F-Na F PET/CT骨显像图像的质量及分辨率均优于99m Tc-MDP SPECT/CT骨显像。18F-Na F PET/CT骨显像和99m Tc-MDP SPECT/CT骨显像诊断前列腺癌骨转移灶的灵敏度分别为97.2%和61%;特异度分别为100%和100%;两种显像方法的阳性预测值分别为100%和100%,而阴性预测值为95.4%和59.7%。结论:18F-Na F PET/CT骨显像评价前列腺癌骨转移灶较99m Tc-MDP SPECT/CT骨显像灵敏度、阴性预测值高,在临床上有更好的应用价值。
文摘The proposed phantom is designed for the quality control of micro-SPECT/CT and micro-PET/CT systems. However, it is an assembly of six patterns stored in a cylindrical box enabling to control both micro-SPECT unit in terms of uniformity, spatial linearity and spatial resolution and micro-CT unit in terms of uniformity, spatial linearity, spatial resolution, diffusion rate, low contrast detectability, Hounsfield unit linearity and slice thickness. The construction material is Plexiglas. As for the implementation, it was made on a micro-SPECT/CT machine of the type “speCZT eXplore CT 120”. Compared to the NEMA NU 4-2008 image quality phantom, this phantom offers micro-CT quality control and is more efficient in control of spatial resolution for micro-SPECT and micro- PET systems.
文摘ObjectiveTo investigate the diagnostic value of 18F-fluorodeoxyglucose positron emission tomography （18F-FDG PET） in the as-sessment of myocardial viability in patients with known coronary artery disease （CAD） when compared to99mTc single photon emission computed tomography （SPECT） and echocardiography, with invasive coronary angiography as the gold standard.MethodsThirty patients with diagnosed CAD met the selection criteria, with 10 of them （9 men, mean age 59.5 ± 10.5 years） undergoing all of these imaging proce-dures consisting of SPECT and PET, echocardiography and invasive angiography. Diagnostic sensitivity of these less invasive modalities for detection of myocardial viability was compared to invasive coronary angiography. Inter- and intra-observer agreement was assessed for di-agnostic performance of SPECT and PET.ResultsOf all patients with proven CAD, 50% had triple vessel disease. Diagnostic sensitivity of SPECT, PET and echocardiography was 90%, 100% and 80% at patient-based assessment, respectively. Excellent agreement was achieved between inter-observer and intra-observer agreement of the diagnostic value of SPECT and PET in myocardial viability （k= 0.9）. Conclusion18F-FDG PET has high diagnostic value in the assessment of myocardial viability in patients with known CAD when com-pared to SPECT and echocardiography. Further studies based on a large cohort with incorporation of18F-FDG PET into patient management are warranted.
文摘Coronary artery disease remains a major cause of mortality. Presence of atherosclerotic plaques in the coronary artery is responsible for lu-men stenosis which is often used as an indicator for determining the severity of coronary artery disease. However, the degree of coronary lumen stenosis is not often related to compromising myocardial blood flow, as most of the cardiac events that are caused by atherosclerotic plaques are the result of vulnerable plaques which are prone to rupture. Thus, identification of vulnerable plaques in coronary arteries has become increas-ingly important to assist identify patients with high cardiovascular risks. Molecular imaging with use of positron emission tomography （PET） and single photon emission computed tomography （SPECT） has fulfilled this goal by providing functional information about plaque activity which enables accurate assessment of plaque stability. This review article provides an overview of diagnostic applications of molecular imaging tech-niques in the detection of plaques in coronary arteries with PET and SPECT. New radiopharmaceuticals used in the molecular imaging of coro-nary plaques and diagnostic applications of integrated PET/CT and PET/MRI in coronary plaques are also discussed.
