BACKGROUND: Sushi suffocation is relatively uncommon, and it is an unignorable cause of sudden death; however, no reports on sushi suffocation have been published.METHODS: A 60-year-old man was referred to our hospita...BACKGROUND: Sushi suffocation is relatively uncommon, and it is an unignorable cause of sudden death; however, no reports on sushi suffocation have been published.METHODS: A 60-year-old man was referred to our hospital for post resuscitative intensive care. He had choked on sushi and collapsed in the dining room of a mental hospital. A nursing assistant summoned a physician who attempted to extract the sushi. External cardiac massage was initiated after 7 minutes had elapsed and followed by endotracheal intubation. Return of spontaneous circulation was achieved after 7 minutes of resuscitation. A bronchoscopy demonstrated a large amount of shari in the trachea and right bronchus, which was removed with alligator forceps and a wire basket.RESULTS: Neurological recovery was evident on day 2 of admission. He was transferred back to the mental hospital with no neurological complications.CONCLUSION: Emergency physicians should consider sushi suffocation, including its clinical features and management.展开更多
Septic shock is caused by Gram-negative bacterial infection. Lipopolysaccharide （LPS） is the bioactive molecule present on the outer membrane of the Gram-negative bacteria. It is generally thought that LPS interacts...Septic shock is caused by Gram-negative bacterial infection. Lipopolysaccharide （LPS） is the bioactive molecule present on the outer membrane of the Gram-negative bacteria. It is generally thought that LPS interacts with sensors on the host cell membrane to activate the intracellular signaling pathway resulting in the overproduction of cytokines such as TNF-α This causes inflammation and ultimately, septic shock. Lipid A is the pharmacophore of the LPS molecule. Thus, developing bio-molecules which are capable of binding LPS at high affinity, especially to the lipid A moiety is an efficient way to neutralize the LPS toxicity. Factor C, a serine protease in the horseshoe crab ameobocytes, is sensitive to trace levels of LPS. We have derived Sushi peptides from the LPS-binding domains of Factor C. Our earlier study showed that the Sushi peptides inhibit LPS-induced septic shock in mice. Here, we demonstrate that the molecular interaction between LPS and Sushi 1 peptide is supported by the hydrophobic interaction between the lipid tail of LPS and Sushi 1 peptide. Furthermore, in the presence of LPS, the peptide transitions from a random structure into an α-helical conformation and it disrupts LPS aggregates, hence, neutralizing the LPS toxicity.展开更多
The Standardized Usage Statistics Harvesting Initiative(SUSHI)is a protocol developed in response to the need in libraries to collect COUNTER compliant usage statistics automatically.Ten years have passed since SUSHI ...The Standardized Usage Statistics Harvesting Initiative(SUSHI)is a protocol developed in response to the need in libraries to collect COUNTER compliant usage statistics automatically.Ten years have passed since SUSHI became a NISO standard.展开更多
Good news for sushi fans;Shanghai has another exclusive omakase restaurant to its name,joining the legions of Aoki,Sushi Oyama,Naramoto et al.Like many restaurants of this caliber Sushi Yano flaunts a compact interioi...Good news for sushi fans;Shanghai has another exclusive omakase restaurant to its name,joining the legions of Aoki,Sushi Oyama,Naramoto et al.Like many restaurants of this caliber Sushi Yano flaunts a compact interioi;consisting of a central sushi bar flanked by two smaller rooms.Rather than being darkly lit and romantic,Yano is bright and clean,with a distinctly 90s Japanese aesthetic.Upbeat Japanese pop music resounded the tiny space on our visit.展开更多
文摘BACKGROUND: Sushi suffocation is relatively uncommon, and it is an unignorable cause of sudden death; however, no reports on sushi suffocation have been published.METHODS: A 60-year-old man was referred to our hospital for post resuscitative intensive care. He had choked on sushi and collapsed in the dining room of a mental hospital. A nursing assistant summoned a physician who attempted to extract the sushi. External cardiac massage was initiated after 7 minutes had elapsed and followed by endotracheal intubation. Return of spontaneous circulation was achieved after 7 minutes of resuscitation. A bronchoscopy demonstrated a large amount of shari in the trachea and right bronchus, which was removed with alligator forceps and a wire basket.RESULTS: Neurological recovery was evident on day 2 of admission. He was transferred back to the mental hospital with no neurological complications.CONCLUSION: Emergency physicians should consider sushi suffocation, including its clinical features and management.
文摘Septic shock is caused by Gram-negative bacterial infection. Lipopolysaccharide （LPS） is the bioactive molecule present on the outer membrane of the Gram-negative bacteria. It is generally thought that LPS interacts with sensors on the host cell membrane to activate the intracellular signaling pathway resulting in the overproduction of cytokines such as TNF-α This causes inflammation and ultimately, septic shock. Lipid A is the pharmacophore of the LPS molecule. Thus, developing bio-molecules which are capable of binding LPS at high affinity, especially to the lipid A moiety is an efficient way to neutralize the LPS toxicity. Factor C, a serine protease in the horseshoe crab ameobocytes, is sensitive to trace levels of LPS. We have derived Sushi peptides from the LPS-binding domains of Factor C. Our earlier study showed that the Sushi peptides inhibit LPS-induced septic shock in mice. Here, we demonstrate that the molecular interaction between LPS and Sushi 1 peptide is supported by the hydrophobic interaction between the lipid tail of LPS and Sushi 1 peptide. Furthermore, in the presence of LPS, the peptide transitions from a random structure into an α-helical conformation and it disrupts LPS aggregates, hence, neutralizing the LPS toxicity.
文摘The Standardized Usage Statistics Harvesting Initiative(SUSHI)is a protocol developed in response to the need in libraries to collect COUNTER compliant usage statistics automatically.Ten years have passed since SUSHI became a NISO standard.
文摘Good news for sushi fans;Shanghai has another exclusive omakase restaurant to its name,joining the legions of Aoki,Sushi Oyama,Naramoto et al.Like many restaurants of this caliber Sushi Yano flaunts a compact interioi;consisting of a central sushi bar flanked by two smaller rooms.Rather than being darkly lit and romantic,Yano is bright and clean,with a distinctly 90s Japanese aesthetic.Upbeat Japanese pop music resounded the tiny space on our visit.
