BACKGROUND Corneal neovascularization(CoNV)is the second major cause of blindness.Vascular endothelial growth factor(VEGF)inhibitors,e.g.,bevacizumab,have been used to prevent CoNV.AIM We conducted an updated systemat...BACKGROUND Corneal neovascularization(CoNV)is the second major cause of blindness.Vascular endothelial growth factor(VEGF)inhibitors,e.g.,bevacizumab,have been used to prevent CoNV.AIM We conducted an updated systematic review and meta-analysis of clinical trials to examine the efficacy and safety of anti-VEGF in CoNV.METHODS A literature search was conducted using three electronic databases.Mean difference(MD),standard mean difference(SMD),and relative risk(RR)are used to estimate the effect size.RESULTS Nine randomized controlled and three non-randomized trials were obtained.The pooled results demonstrated a significant reduction of CoNV area/Length(SMD=-1.17,95%CI:-1.58 to-0.75),best corrected visual acuity(MD=-0.54,95%CI:-0.91 to-0.17),and graft rejection(RR=0.44,95%CI:0.24 to 0.8)and failure(RR=0.39,95%CI:0.19 to 0.78)rates in the anti-VEGF group than the placebo group.A non-significant reduction of the epithelial defect was also observed in the bevacizumab group compared with the placebo(RR=0.56,95%CI:0.30 to 1.06).Compared with a placebo,the unsynthesizable trials also support that bevacizumab improves visual acuity,CoNV,graft rejection,and failure rates.Trials reporting other comparisons revealed the superiority of combined remedy with bevacizumab compared to other treatments in reducing CoNV.CONCLUSION Anti-VEGF agents,mainly bevacizumab,are an effective and safe treatment for CoNV of all causes and prevent corneal graft rejection and failure in corneal transplantation.展开更多
BACKGROUND Pleural effusions occur for various reasons,and their diagnosis remains challenging despite the availability of different diagnostic modalities.Medical thoracoscopy(MT)can be used for both diagnostic and th...BACKGROUND Pleural effusions occur for various reasons,and their diagnosis remains challenging despite the availability of different diagnostic modalities.Medical thoracoscopy(MT)can be used for both diagnostic and therapeutic purposes,especially in patients with undiagnosed pleural effusion.AIM To assess the diagnostic efficacy and safety of MT in patients with pleural effusion of different causes.METHODS Between January 1,2012 and April 30,2021,patients with pleural effusion underwent MT in the Department of Respiratory Medicine,The Second Affiliated Hospital of Xi’an Jiaotong University(Shaanxi,China).According to the discharge diagnosis,patients were divided into malignant pleural effusion(MPE),tuberculous pleural effusion(TBPE),and inflammatory pleural effusion(IPE)groups.General information,and tuberculosis-and effusion-related indices of the three groups were analyzed.The diagnostic yield,diagnostic accuracy,performance under thoracoscopy,and complications of patients were compared among the three groups.Then,the significant predictive factors for diagnosis between the MPE and TBPE groups were analyzed.RESULTS Of the 106 patients enrolled in this 10-year study,67 were male and 39 female,with mean age of 57.1±14.184 years.Among the 74 thoracoscopy-confirmed patients,41(38.7%)had MPE,21 had(19.8%)TBPE,and 32(30.2%)were undiagnosed.Overall diagnostic yield of MT was 69.8%(MPE:75.9%,TBPE:48.8%,and IPE:75.0%,with diagnostic accuracies of 100%,87.5%,and 75.0%,respectively).Under thoracoscopy,single or multiple pleural nodules were observed in 81.1%and pleural adhesions in 34.0%with pleural effusions.The most common complication was chest pain(41.5%),followed by chest tightness(11.3%)and fever(10.4%).Multivariate logistic regression analyses showed effusion appearance[odds ratio(OR):0.001,95%CI:0.000-0.204;P=0.010]and carcinoembryonic antigen(OR:0.243,95%CI:0.081-0.728;P=0.011)as significant for differentiating MPE and TBPE,with area under the receiver operating characteristic curve of 0.977(95%CI:0.953-1.000;P<0.001).CONCLUSION MT is an effective,safe,and minimally invasive procedure with high diagnostic yield for pleural effusion of different causes.展开更多
The study took place at Bangladesh Agricultural Research Institute’s Olericulture Division’s research farm from March 2021 to February 2022 (BARI). In a protected net house, we investigated the impact of five differ...The study took place at Bangladesh Agricultural Research Institute’s Olericulture Division’s research farm from March 2021 to February 2022 (BARI). In a protected net house, we investigated the impact of five different types of vegetables on various maturation stages, including tomato, broccoli, sweet pepper, cucumber, and netted melon. Vegetables cultivated under protected conditions in a transparent poly-film net house can improve quality, maturity, fruit size, and yield. When fruits and vegetables are picked before they are fully mature, they may stay green for longer, but they may not ripen to a satisfactory color and flavor, resulting in a loss of consumer confidence. Furthermore, because fruit continues to grow until the harvest, immature fruit will be smaller than mature fruit, reducing harvest yield. We tried to determine the right maturation stages in order to avoid product loss during our investigation. The tomato was found to be an appropriate size (6.5 cm length and 6.2 cm diameter), weight (84 g), TSS (4.5 percent), pH (4.3), “turning red”, and “tasty” at the week 5 stage, while the broccoli was found to be an appropriate size (12.0 cm length and 13.0 cm diameter), weight (360 g), and “green” color at the week 5 stage. At the week 6 stage, the nettled melon was found to be of appropriate size (15.2 cm length and 14.5 cm diameter), weight (800 g), TSS (10.8 percent), pH (6.3), “net fully developed” on the fruit skin and “much tasty,” while cucumber was found to be of appropriate size (8.8 - 10.8 cm length and 2.2 - 2.9 cm diameter), weight (61 - 88 g), TSS (3.8 - 4.1 percent), pH (6.3), “less powdery”. As a result, establishing the optimal maturity of our research will benefit both consumers and growers.展开更多
The study was undertaken to identify the suitable mulch paper for different high-value vegetables during the winter season of November 2019 to March 2020 at the Olericulture research field of Bangladesh Agricultural R...The study was undertaken to identify the suitable mulch paper for different high-value vegetables during the winter season of November 2019 to March 2020 at the Olericulture research field of Bangladesh Agricultural Research Institute, Gazipur, Bangladesh. The study was a randomized complete block design with 3 replications. Four vegetable varieties viz., tomato, brinjal, capsicum and broccoli and 3 mulch treatments viz., T1 = Silver over black mulch;T2 = Black mulch;T3 = No mulch were included in this study. Different vegetables responded differently with the changes of mulches irrespective of different characters. it was clear that fruit number, average fruit weight, fruit length, fruit diameter were strongly related to soil moisture content. The effect of different plastic mulches on fruit weight per plant and yield (t/ha) was significant. Mulching produced higher fruit yield per plant and fruit yield per hectare than for the control, indicating that the mulch had a positive effect in generating increased fruit yield. Silver over black plastic mulch produced the highest fruit yield viz., 98.05 t/ha (tomato), 54.11 t/ha (brinjal), 34.33 t/ha (capsicum), 26.09 t/ha (broccoli) followed by black and no mulches, while the control plot produced the lowest fruit yield.展开更多
This paper is concerned with the relationship between beliefs and economic performance and explains the differences of country performance in global economic growth over the past two decades based on the composite bel...This paper is concerned with the relationship between beliefs and economic performance and explains the differences of country performance in global economic growth over the past two decades based on the composite belief index comprising the beliefs on trust,social justice,competition and work-leisure.By influencing personal motivations,beliefs shape society and the institutions and policies of a country in the form of collective ideology.Beliefs demonstrate great differences across countries and change with time,which helps explain the country and intertemporal differences of growth.This paper also found that China s composite belief index is very high,which helps explain China's economic growth miracle.展开更多
In the rapid development of technology and knowledge-based economy against the background of the times, the IPR of enterprises participating in the process of value creation has been the key issues in the business wor...In the rapid development of technology and knowledge-based economy against the background of the times, the IPR of enterprises participating in the process of value creation has been the key issues in the business world. The resulting growth in the value chain of IP is a complicated process of evolution, and non-linear dynamics, and self-organizing system. This paper explores the intellectual property value chain from its conditions, mechanisms and dynamics as well as the inspiration for the enterprises.展开更多
Industrial real estate plays an increasingly important role in urban economic development and industrial restructuring.In the process of the development of industrial real estate,both the major investors of industrial...Industrial real estate plays an increasingly important role in urban economic development and industrial restructuring.In the process of the development of industrial real estate,both the major investors of industrial real estate and the value growth patterns of industrial real estate have changed.The increase in the value of industrial real estate has contributed to the promotion of urban economic upgrading,social development,and industrial restructuring.In this paper,the investment model of industrial real estate from a single government investment to a diversified model was analyzed,and the value growth patterns of industrial real estate under these two models were elaborated.It is concluded that value growth patterns under the diversification model are more diverse.This paper divided the driving factors of diversified industrial real estate value growth into two types:source factors and secondary factors,used the analytic hierarchy process(AHP) to quantify the driving factors,reached the conclusion that four factors including the industrial real estate market size and the level of independent technology of the enterprise had a major impact on the value growth of industrial real estate,and put forward suggestions for the rapid development of industrial real estate.展开更多
To provide genetic information and materials for breeding hybrid japonica rice with wide adaptability and strong competitive advantage of yield,elite alleles and their carrier varieties of growth duration (GD) and pro...To provide genetic information and materials for breeding hybrid japonica rice with wide adaptability and strong competitive advantage of yield,elite alleles and their carrier varieties of growth duration (GD) and productive panicle number per plant (PN) were detected.A natural population composed of 94 japonica varieties was phenotyped for the GD,PN and plant height (PH) in two environments.The conditional phenotypic data were transferred by the linear model method in software QGAStation 1.0,and association mapping based on the unconditional and conditional phenotype values of GD and PN was analyzed by using general linear model in software TASSEL.A total of 34 simple sequence repeat (SSR) marker loci associated with GD and PN were detected in the two environments.Among them,15 were associated with GD,and 19 were associated with PN.Four elite alleles of RM8095-120bp,RM7102-176bp,RM72-170bp and RM72-178bp were associated with GD,and their carrier varieties were Hongmangshajing,Nipponbare,Hongmangshajing and Nannongjing 62401,respectively.These elite alleles from the carrier varieties can shorten GD by 2.03 9.93 d when they were introduced into improved materials.RM72-182bp associated with PN was an elite allele,and its carrier variety was Xiaoqingzhong.It can increase PN by three when introduced into improved materials.Moreover,these elite alleles can be used to improve target traits without influencing another two traits.展开更多
Aiming at the deficiency of exterminating measures of Chinese firm safety management, a simulation model of Chinese firm's safety management capability based on the organizational learning theory, in which the sim...Aiming at the deficiency of exterminating measures of Chinese firm safety management, a simulation model of Chinese firm's safety management capability based on the organizational learning theory, in which the simulation method of system dynamics is utilized. The level variable and rate variable are designed based on the practical situation and change situation of corresponding variables of firm's safety management capability. Simulation firms are built with accident case groups of the oil industry, chemical industry, machine industry, coal mining industry, and weapon industry. Through analyzing the simulation result, the growth law of Chinese firm's safety management capability is obtained as follows: the accumulating and the coupling of safety knowledge should be emphasized at the same time; the balance of learning behavior of individual, group and organization should be considered together; different types of Chinese firm should take different safety policies according to their practical situations.展开更多
In this paper, we study higher order elliptic partial differential equations with variable growth, and obtain the existence of solutions in the setting of Wm,p（x） spaces by means of an abstract result for variationa...In this paper, we study higher order elliptic partial differential equations with variable growth, and obtain the existence of solutions in the setting of Wm,p（x） spaces by means of an abstract result for variational inequalities obtained by Gossez and Mustonen. Our result generalizes the corresponding one of Kováik and Rákosník.展开更多
文摘BACKGROUND Corneal neovascularization(CoNV)is the second major cause of blindness.Vascular endothelial growth factor(VEGF)inhibitors,e.g.,bevacizumab,have been used to prevent CoNV.AIM We conducted an updated systematic review and meta-analysis of clinical trials to examine the efficacy and safety of anti-VEGF in CoNV.METHODS A literature search was conducted using three electronic databases.Mean difference(MD),standard mean difference(SMD),and relative risk(RR)are used to estimate the effect size.RESULTS Nine randomized controlled and three non-randomized trials were obtained.The pooled results demonstrated a significant reduction of CoNV area/Length(SMD=-1.17,95%CI:-1.58 to-0.75),best corrected visual acuity(MD=-0.54,95%CI:-0.91 to-0.17),and graft rejection(RR=0.44,95%CI:0.24 to 0.8)and failure(RR=0.39,95%CI:0.19 to 0.78)rates in the anti-VEGF group than the placebo group.A non-significant reduction of the epithelial defect was also observed in the bevacizumab group compared with the placebo(RR=0.56,95%CI:0.30 to 1.06).Compared with a placebo,the unsynthesizable trials also support that bevacizumab improves visual acuity,CoNV,graft rejection,and failure rates.Trials reporting other comparisons revealed the superiority of combined remedy with bevacizumab compared to other treatments in reducing CoNV.CONCLUSION Anti-VEGF agents,mainly bevacizumab,are an effective and safe treatment for CoNV of all causes and prevent corneal graft rejection and failure in corneal transplantation.
基金Supported by Shaanxi Science and Technology Research Plan Program,Shaanxi,China,No. 2020SF-106
文摘BACKGROUND Pleural effusions occur for various reasons,and their diagnosis remains challenging despite the availability of different diagnostic modalities.Medical thoracoscopy(MT)can be used for both diagnostic and therapeutic purposes,especially in patients with undiagnosed pleural effusion.AIM To assess the diagnostic efficacy and safety of MT in patients with pleural effusion of different causes.METHODS Between January 1,2012 and April 30,2021,patients with pleural effusion underwent MT in the Department of Respiratory Medicine,The Second Affiliated Hospital of Xi’an Jiaotong University(Shaanxi,China).According to the discharge diagnosis,patients were divided into malignant pleural effusion(MPE),tuberculous pleural effusion(TBPE),and inflammatory pleural effusion(IPE)groups.General information,and tuberculosis-and effusion-related indices of the three groups were analyzed.The diagnostic yield,diagnostic accuracy,performance under thoracoscopy,and complications of patients were compared among the three groups.Then,the significant predictive factors for diagnosis between the MPE and TBPE groups were analyzed.RESULTS Of the 106 patients enrolled in this 10-year study,67 were male and 39 female,with mean age of 57.1±14.184 years.Among the 74 thoracoscopy-confirmed patients,41(38.7%)had MPE,21 had(19.8%)TBPE,and 32(30.2%)were undiagnosed.Overall diagnostic yield of MT was 69.8%(MPE:75.9%,TBPE:48.8%,and IPE:75.0%,with diagnostic accuracies of 100%,87.5%,and 75.0%,respectively).Under thoracoscopy,single or multiple pleural nodules were observed in 81.1%and pleural adhesions in 34.0%with pleural effusions.The most common complication was chest pain(41.5%),followed by chest tightness(11.3%)and fever(10.4%).Multivariate logistic regression analyses showed effusion appearance[odds ratio(OR):0.001,95%CI:0.000-0.204;P=0.010]and carcinoembryonic antigen(OR:0.243,95%CI:0.081-0.728;P=0.011)as significant for differentiating MPE and TBPE,with area under the receiver operating characteristic curve of 0.977(95%CI:0.953-1.000;P<0.001).CONCLUSION MT is an effective,safe,and minimally invasive procedure with high diagnostic yield for pleural effusion of different causes.
文摘The study took place at Bangladesh Agricultural Research Institute’s Olericulture Division’s research farm from March 2021 to February 2022 (BARI). In a protected net house, we investigated the impact of five different types of vegetables on various maturation stages, including tomato, broccoli, sweet pepper, cucumber, and netted melon. Vegetables cultivated under protected conditions in a transparent poly-film net house can improve quality, maturity, fruit size, and yield. When fruits and vegetables are picked before they are fully mature, they may stay green for longer, but they may not ripen to a satisfactory color and flavor, resulting in a loss of consumer confidence. Furthermore, because fruit continues to grow until the harvest, immature fruit will be smaller than mature fruit, reducing harvest yield. We tried to determine the right maturation stages in order to avoid product loss during our investigation. The tomato was found to be an appropriate size (6.5 cm length and 6.2 cm diameter), weight (84 g), TSS (4.5 percent), pH (4.3), “turning red”, and “tasty” at the week 5 stage, while the broccoli was found to be an appropriate size (12.0 cm length and 13.0 cm diameter), weight (360 g), and “green” color at the week 5 stage. At the week 6 stage, the nettled melon was found to be of appropriate size (15.2 cm length and 14.5 cm diameter), weight (800 g), TSS (10.8 percent), pH (6.3), “net fully developed” on the fruit skin and “much tasty,” while cucumber was found to be of appropriate size (8.8 - 10.8 cm length and 2.2 - 2.9 cm diameter), weight (61 - 88 g), TSS (3.8 - 4.1 percent), pH (6.3), “less powdery”. As a result, establishing the optimal maturity of our research will benefit both consumers and growers.
文摘The study was undertaken to identify the suitable mulch paper for different high-value vegetables during the winter season of November 2019 to March 2020 at the Olericulture research field of Bangladesh Agricultural Research Institute, Gazipur, Bangladesh. The study was a randomized complete block design with 3 replications. Four vegetable varieties viz., tomato, brinjal, capsicum and broccoli and 3 mulch treatments viz., T1 = Silver over black mulch;T2 = Black mulch;T3 = No mulch were included in this study. Different vegetables responded differently with the changes of mulches irrespective of different characters. it was clear that fruit number, average fruit weight, fruit length, fruit diameter were strongly related to soil moisture content. The effect of different plastic mulches on fruit weight per plant and yield (t/ha) was significant. Mulching produced higher fruit yield per plant and fruit yield per hectare than for the control, indicating that the mulch had a positive effect in generating increased fruit yield. Silver over black plastic mulch produced the highest fruit yield viz., 98.05 t/ha (tomato), 54.11 t/ha (brinjal), 34.33 t/ha (capsicum), 26.09 t/ha (broccoli) followed by black and no mulches, while the control plot produced the lowest fruit yield.
文摘This paper is concerned with the relationship between beliefs and economic performance and explains the differences of country performance in global economic growth over the past two decades based on the composite belief index comprising the beliefs on trust,social justice,competition and work-leisure.By influencing personal motivations,beliefs shape society and the institutions and policies of a country in the form of collective ideology.Beliefs demonstrate great differences across countries and change with time,which helps explain the country and intertemporal differences of growth.This paper also found that China s composite belief index is very high,which helps explain China's economic growth miracle.
文摘In the rapid development of technology and knowledge-based economy against the background of the times, the IPR of enterprises participating in the process of value creation has been the key issues in the business world. The resulting growth in the value chain of IP is a complicated process of evolution, and non-linear dynamics, and self-organizing system. This paper explores the intellectual property value chain from its conditions, mechanisms and dynamics as well as the inspiration for the enterprises.
基金Sponsored by General Project of Humanities and Social Science in Colleges and Universities in Jiangxi Province(GL1458)National Natural Science Fund of China(51568025)
文摘Industrial real estate plays an increasingly important role in urban economic development and industrial restructuring.In the process of the development of industrial real estate,both the major investors of industrial real estate and the value growth patterns of industrial real estate have changed.The increase in the value of industrial real estate has contributed to the promotion of urban economic upgrading,social development,and industrial restructuring.In this paper,the investment model of industrial real estate from a single government investment to a diversified model was analyzed,and the value growth patterns of industrial real estate under these two models were elaborated.It is concluded that value growth patterns under the diversification model are more diverse.This paper divided the driving factors of diversified industrial real estate value growth into two types:source factors and secondary factors,used the analytic hierarchy process(AHP) to quantify the driving factors,reached the conclusion that four factors including the industrial real estate market size and the level of independent technology of the enterprise had a major impact on the value growth of industrial real estate,and put forward suggestions for the rapid development of industrial real estate.
基金supported by the Program of National High Technology Research and Development,Ministry of Science and Technology,China(Grant No.2010AA101301)the Program of Introducing Talents of Discipline to University in China(Grant No.B08025)+1 种基金the Program of Introducing International Advanced Agricultural Science and Technology in China(Grant No.2006-G8[4]-31-1)the Program of Science-Technology Basis and Conditional Platform in China(Grant No.505005)
文摘To provide genetic information and materials for breeding hybrid japonica rice with wide adaptability and strong competitive advantage of yield,elite alleles and their carrier varieties of growth duration (GD) and productive panicle number per plant (PN) were detected.A natural population composed of 94 japonica varieties was phenotyped for the GD,PN and plant height (PH) in two environments.The conditional phenotypic data were transferred by the linear model method in software QGAStation 1.0,and association mapping based on the unconditional and conditional phenotype values of GD and PN was analyzed by using general linear model in software TASSEL.A total of 34 simple sequence repeat (SSR) marker loci associated with GD and PN were detected in the two environments.Among them,15 were associated with GD,and 19 were associated with PN.Four elite alleles of RM8095-120bp,RM7102-176bp,RM72-170bp and RM72-178bp were associated with GD,and their carrier varieties were Hongmangshajing,Nipponbare,Hongmangshajing and Nannongjing 62401,respectively.These elite alleles from the carrier varieties can shorten GD by 2.03 9.93 d when they were introduced into improved materials.RM72-182bp associated with PN was an elite allele,and its carrier variety was Xiaoqingzhong.It can increase PN by three when introduced into improved materials.Moreover,these elite alleles can be used to improve target traits without influencing another two traits.
基金the National Social Science Foundation of China (07BJY080)
文摘Aiming at the deficiency of exterminating measures of Chinese firm safety management, a simulation model of Chinese firm's safety management capability based on the organizational learning theory, in which the simulation method of system dynamics is utilized. The level variable and rate variable are designed based on the practical situation and change situation of corresponding variables of firm's safety management capability. Simulation firms are built with accident case groups of the oil industry, chemical industry, machine industry, coal mining industry, and weapon industry. Through analyzing the simulation result, the growth law of Chinese firm's safety management capability is obtained as follows: the accumulating and the coupling of safety knowledge should be emphasized at the same time; the balance of learning behavior of individual, group and organization should be considered together; different types of Chinese firm should take different safety policies according to their practical situations.
文摘In this paper, we study higher order elliptic partial differential equations with variable growth, and obtain the existence of solutions in the setting of Wm,p（x） spaces by means of an abstract result for variational inequalities obtained by Gossez and Mustonen. Our result generalizes the corresponding one of Kováik and Rákosník.
