Background: Exercise-Induced Bronchospasm (EIB) is an inflammatory condition characterized by severe airway constriction following the mobilization of inflammatory cells and interleukin-6 (IL-6). When severe, EIB can ...Background: Exercise-Induced Bronchospasm (EIB) is an inflammatory condition characterized by severe airway constriction following the mobilization of inflammatory cells and interleukin-6 (IL-6). When severe, EIB can require the use of pressurized salbutamol to treat athletes. This study investigated the nature of the systemic changes in inflammatory cells and post-exercise IL-6 concentrations after salbutamol treatment in EIB-susceptible distance runners. Materials and Methods: This was an experimental study that enrolled 12 long-distance runners. In Session A, the participants completed a treadmill exercise test, and those who had a maximum expiratory volume per second (FEV1) that was decreased by at least 10% compared to their base value were placed in the EIB-susceptible group (EIB+) (n = 6). Those whose FEV1 did not meet this criterion were placed in the nonresponsive (EIB?) group (n = 6). Before the Session B exercise, athletes in the BIE+ group inhaled two puffs of salbutamol (EIB+ Salb), while their EIB? counterparts received no treatment. Spirometry was performed before and after the exercise using a Spirobank G portable spirometer. Blood samples were taken before, immediately after and 2 hours after the stress test. Results: The mean post-exercise FEV1 values were not significantly different (p > 0.05) between the EIB+ Salb group and the EIB? group. The systemic changes in inflammatory cells and IL-6 concentrations in the EIB+ runners after salbutamol treatment were similar to those observed in their EIB? counterparts. Conclusion: Salbutamol pretreatment improved the systemic immune status of EIB-susceptible athletes.展开更多
Objective:To study the influence of budesonide and salbutamol atomization inhalation on Th17/Treg balance in patients with bronchial asthma and its correlation with airway remodeling.Methods:A total of 90 patients wit...Objective:To study the influence of budesonide and salbutamol atomization inhalation on Th17/Treg balance in patients with bronchial asthma and its correlation with airway remodeling.Methods:A total of 90 patients with bronchial asthma who received systemic treatment in our hospital between July 2013 and April 2016 were divided into control group (n=45) and observation group (n=45) according to random number table. Patients in the control group were treated with salbutamol atomization inhalation alone while those in observation group were treated with budesonide and salbutamol atomization inhalation. The Th17/Treg ratio in peripheral blood as well as serum contents of airway remodeling-related indicators was compared between two groups before and after treatment. The correlation between Th17/Treg balance and airway remodeling in patients with bronchial asthma was detected by Pearson test. Results:Before treatment, the differences in peripheral blood Th17/Treg ratio as well as serum contents of inflammatory mediators, growth factor indexes and collagen metabolism indexes were not statistically significant between two groups of patients. After treatment, peripheral blood Th17/Treg ratio in observation group was lower than that in control group, serum CRP, IL-8, IL-13 and TNF- contents in observation group were lower than those in control group, serum PDGF-BB, b-FGF and VEGF contents in observation group were lower than those in control group, and serum HA, PCⅢ and LN contents in observation group were lower than those in control group. The Th17/Treg ratio in patients with bronchial asthma after treatment was positively correlated with the levels of airway remodeling-related indexes.Conclusion:Budesonide combined with salbutamol atomization inhalation can optimize the Th17/Treg balance in patients with bronchial asthma, and Th17/Treg is directly correlated to the degree of airway remodeling.展开更多
The present work deals with the development of controlled release tablets of salbutamol sulphate(SS)using graft copolymers of methyl methacrylate(St-g-PMMA and Ast-g-PMMA)on starch and acetylated starch.Formulations w...The present work deals with the development of controlled release tablets of salbutamol sulphate(SS)using graft copolymers of methyl methacrylate(St-g-PMMA and Ast-g-PMMA)on starch and acetylated starch.Formulations were evaluated for physical characteristics like hardness,friability,drug release,drug content and weight variations,which fulfilled all the official requirements of tablet dosage form.The release rates from formulated matrix tablets were studied at SGF(pH 1.2)followed by SIF(pH 6.8).Drug release from the graft copolymer based tablets was found to be sustained upto the 14 h with>75%drug release.The in-vitro release study showed that the graft copolymer based matrix formulations(F3&F4)exhibited highest correlation value(r2)for higuchi kinetic model and Korsmeyer's model with n values between 0.61 and 0.67 proved that release mechanisms were governed by both diffusion and erosion mechanism.There was no significant difference in the pharmacokinetic parameters(tmax,Cmax,AUC,Ke,and t1/2)of the graft copolymers matrices and HPMC K100M matrix tablets,indicating their comparable sustained release effect.The potential of graft copolymers to sustain the drug release is well supported by in-vivo pharmacokinetic studies and their adequate physicochemical properties make them promising excipients for controlled drug delivery system.展开更多
Salbutamol is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm such as asthma and chronic obstructive pulmonary disease (COPD). It is mostly taken through an inhaler device. The compa...Salbutamol is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm such as asthma and chronic obstructive pulmonary disease (COPD). It is mostly taken through an inhaler device. The comparative toxicity assessment between two salbutamol sulfate preparations containing hydrofluoroalkane (HFA) metered dose inhalers with 100 μg per puff was evaluated in selected patients with asthma and COPD after prescribing. An open label, non-randomized, non-interventional observational study was designed. A large cohort of patients with asthma or related respiratory disorder of the general population from Dhaka and Chittagong of Bangladesh were recruited and treated with prescribed generic preparation Azmasol inhaler and brand preparation Ventolin Evohaler. Total 508 patients with asthma and minor obstructive airway disease were selected by the general medical practitioners in Bangladesh those who visited out patient consultation center in hospitals and physicians’ chambers and reported any adverse side effects of inhaled medications. There were no significant differences between the metered dose generic preparation Azmasol inhaler and Ventolon Evohaler among the patients treated with the medicines in asthma and related respiratory diseases in terms of adverse effects like immune system problem,dizziness,tremor,headache,nervousness,diarrhea,nausea,vomiting,heartburn,palpitation,skin rash,hypertension and taste feeling. It is concluded that Azmasol Inhaler, the generic salbutamol sulphate metered dose preparation containing HFA was as safe as the Ventolin Evohaler,a salbutamol sulfate brand preparation containing HFA when given to the patients in primary care after their physicians’ visits. Both the preparations have shown the similar safety profiles after regular use.展开更多
An immunomagnetic bead kit to separate and enrich salbutamol was prepared through the reaction between salbutamol and 4-aminobenzoic acid.The kit had a catch of 20 ng/ml to salbutamol in samples,and showed no cross re...An immunomagnetic bead kit to separate and enrich salbutamol was prepared through the reaction between salbutamol and 4-aminobenzoic acid.The kit had a catch of 20 ng/ml to salbutamol in samples,and showed no cross reaction with competitive drugs with structure and function similar to salbutamol: clenbuterol,ractopamine,phenylethanolamine A, bromchlorbuterol, brombuterol, terbutaline, hydroxymethyl salbutamol,cimaterol,tulobuterol,mapenterol,cimbuterol,clenpenterol,zilpaterol,penbutolol,clenproperol,mabuterol and clorprenaline.展开更多
Salbutamol sulfate was coordinated with Cu2+ when pH was 10, and the characteristic absorption peak of the complex was generated at 334 nm. The absorption intensity of the complex was in linear relation with the conce...Salbutamol sulfate was coordinated with Cu2+ when pH was 10, and the characteristic absorption peak of the complex was generated at 334 nm. The absorption intensity of the complex was in linear relation with the concentration of salbutamol sulfate. The regression equation was A=0.011 ρsalbutamol sulfate-0.123 0, correlation coefficient r=0.999 5, and the detection limit was 4.6 μg/ml. It was used for the determination of salbutamol sulfate samples successfully. The recovery rate was 100.5%-103.0%, and the RSD was 1.5%.展开更多
Salbutamol,which increases the muscle mass and decreases the adipose tissue,is misused as nutrient repartitioning agent in the livestock.The novelty of this work is the determination of salbutamol in the livestock mea...Salbutamol,which increases the muscle mass and decreases the adipose tissue,is misused as nutrient repartitioning agent in the livestock.The novelty of this work is the determination of salbutamol in the livestock meat via new bonded-phases bearing eight derivatives of p-tert-calix[4]arene in partial-cone conformation.The new synthesized bonded-phases were characterized and optimized.The bonding interactions of solute and stationary-phases were examined and the main interactions were reported.The salbutamol levels in six samples of livestock meat were analyzed and the results reveal that for the best bonded-phases,the limit of detection(LOD) and limit of quantitation(LOQ) were 0.02 and 0.06 μg/mL,respectively.展开更多
Ultrasonic speeds of 4-aminobutyric acid in 0.0041,0.0125 and 0.0207 mol·kg-1 aqueous salbutamol sulphate(SBS) solutions are measured at 308.15,313.15 and 318.15 K.Isentropic compressibility kS,change in isentrop...Ultrasonic speeds of 4-aminobutyric acid in 0.0041,0.0125 and 0.0207 mol·kg-1 aqueous salbutamol sulphate(SBS) solutions are measured at 308.15,313.15 and 318.15 K.Isentropic compressibility kS,change in isentropic compressibility△k S,relative change in isentropic compressibility( 0 S S △k /k) ,apparent molal compressibility kφ,limiting apparent molal compressibility k0 φ,transfer limiting apparent molal compressibility k0 φ,hydration number nH,pair and triplet interaction parameters kAS,kASS are estimated.The above parameters are used to interpret the solute-solute and solute-solvent interactions of 4-aminobutyric acid in the aqueous salbutamol sulphate solutions.展开更多
Enantiomeric separation of epinephrine and salbutamol was investigated by micellar electrokinetic chromatography employing β-cyclodextrin as chiral additive in ammonium chloride-ammonia solution. The analytes were de...Enantiomeric separation of epinephrine and salbutamol was investigated by micellar electrokinetic chromatography employing β-cyclodextrin as chiral additive in ammonium chloride-ammonia solution. The analytes were detected by electrochemistry using gold microelectrode at +0.65 V versus SCE reference electrode. The effects of detection potential, concentration of β-cyclodextrin, concentration of sodium dodecyl sulfate, pH value of electrolyte and applied voltage were discussed.展开更多
Enantioseparation of salbutamol solute was carried out in liquid-supported membrane by using a polyvinylidene fluoride hollow-fiber module. The enantioselective transport of solute was facilitated by combinatorial chi...Enantioseparation of salbutamol solute was carried out in liquid-supported membrane by using a polyvinylidene fluoride hollow-fiber module. The enantioselective transport of solute was facilitated by combinatorial chiral selectors, which were dissolved in toluene organic solvent. The effects of molar concentration ratios of salbutamol to combinatorial chiral selectors, and the pH value of buffer solution on enantioseparation were investigated. The results show that when the molar concentration ratio is 2∶1∶1, the maximum separation factor and enantiomer excess are 1.49 and 19.74%, respectively, and the R-enantiomer flux is more than S-enantiomer; the pH value of buffer solution influences the performances of enantioseparartion obviously, and the appropriate range of pH value is 7.07.2.展开更多
目的分析肺部康复训练在沙丁胺醇治疗重度支气管哮喘急性发作患儿中对气道炎症因子和肺功能的影响,为临床治疗重度支气管哮喘急性发作提供治疗依据。方法选取郑州大学第三附属医院2021年9月至2023年2月收治的102例重度支气管哮喘急性发...目的分析肺部康复训练在沙丁胺醇治疗重度支气管哮喘急性发作患儿中对气道炎症因子和肺功能的影响,为临床治疗重度支气管哮喘急性发作提供治疗依据。方法选取郑州大学第三附属医院2021年9月至2023年2月收治的102例重度支气管哮喘急性发作患儿进行前瞻性研究,采用随机数字表法将其分为两组(参照组、治疗组),每组51例。参照组男32例、女19例;年龄5~12(7.32±1.85)岁;病程2~18(12.30±1.28)个月;体质量12~27(21.65±2.08)kg。治疗组男28例、女23例;年龄6~13(7.94±1.16)岁;病程2~17(11.89±2.31)个月;体质量11~28(22.32±2.17)kg。入院后两组患儿均予以布地奈德抗感染治疗,参照组采用沙丁胺醇治疗,治疗组采用沙丁胺醇联合肺部康复训练,两组患儿治疗周期均为1个月。比较两组患儿临床效果,临床症状(呼吸困难、咳嗽、喘息、哮鸣音、湿啰音)消失时间,治疗前及治疗后1个月炎症因子水平[白细胞介素-4(interleukin-4,IL-4)、IL-18、IL-1β、嗜酸性粒细胞(eosinophils,EOS)]、肺功能[用力呼出50%肺活量时的瞬间呼气流量(forced expiratory flow at 50%,FEF50%)、呼气峰值流量(peak expiratory flow,PEF)、第1秒用力呼气容积(forced expiratory volume in the first second,FEV1)、用力肺活量(forced vital capacity,FVC)]。统计学方法采用t检验、χ^(2)检验。结果治疗组经治疗后临床总有效率比参照组高[96.08%(49/51)比82.35%(42/51)](χ^(2)=4.993,P<0.05)。与参照组[(5.23±1.03)d、(4.32±1.30)d、(2.36±0.26)d、(6.22±1.63)d、(5.89±1.07)d]比较,治疗组呼吸困难、咳嗽、喘息、哮鸣音、湿啰音消失时间[(2.25±0.69)d、(2.03±0.85)d、(2.23±0.32)d、(5.63±1.10)d、(3.62±1.04)d]均较短,差异均有统计学意义(t=17.166、10.529、2.252、2.143、10.864,均P<0.05)。治疗1个月后,治疗组血清IL-4、IL-18、IL-1β、EOS水平均比参照组低[(25.30±3.96)ng/L比(28.30±3.47)ng/L,(92.03±7.36)ng/L比(100.65±8.66)ng/L,(2.03±0.26)ng/L比(2.89±0.32)ng/L,(1.06±0.39)%比(2.84±0.52)%],差异均有统计学意义(t=4.069、5.417、14.896、19.557,均P<0.05)。治疗1个月后,治疗组FEF50%、PEF、FEV1、FVC水平均比参照组高,差异均有统计学意义(均P<0.05)。结论重度支气管哮喘急性发作患儿在沙丁胺醇治疗时采用肺部康复训练可使临床效果得到提升,缩短临床呼吸困难、咳嗽等症状消失时间,缓解气道炎症反应,促进患儿肺功能恢复,从而加快患儿康复。展开更多
文摘Background: Exercise-Induced Bronchospasm (EIB) is an inflammatory condition characterized by severe airway constriction following the mobilization of inflammatory cells and interleukin-6 (IL-6). When severe, EIB can require the use of pressurized salbutamol to treat athletes. This study investigated the nature of the systemic changes in inflammatory cells and post-exercise IL-6 concentrations after salbutamol treatment in EIB-susceptible distance runners. Materials and Methods: This was an experimental study that enrolled 12 long-distance runners. In Session A, the participants completed a treadmill exercise test, and those who had a maximum expiratory volume per second (FEV1) that was decreased by at least 10% compared to their base value were placed in the EIB-susceptible group (EIB+) (n = 6). Those whose FEV1 did not meet this criterion were placed in the nonresponsive (EIB?) group (n = 6). Before the Session B exercise, athletes in the BIE+ group inhaled two puffs of salbutamol (EIB+ Salb), while their EIB? counterparts received no treatment. Spirometry was performed before and after the exercise using a Spirobank G portable spirometer. Blood samples were taken before, immediately after and 2 hours after the stress test. Results: The mean post-exercise FEV1 values were not significantly different (p > 0.05) between the EIB+ Salb group and the EIB? group. The systemic changes in inflammatory cells and IL-6 concentrations in the EIB+ runners after salbutamol treatment were similar to those observed in their EIB? counterparts. Conclusion: Salbutamol pretreatment improved the systemic immune status of EIB-susceptible athletes.
文摘Objective:To study the influence of budesonide and salbutamol atomization inhalation on Th17/Treg balance in patients with bronchial asthma and its correlation with airway remodeling.Methods:A total of 90 patients with bronchial asthma who received systemic treatment in our hospital between July 2013 and April 2016 were divided into control group (n=45) and observation group (n=45) according to random number table. Patients in the control group were treated with salbutamol atomization inhalation alone while those in observation group were treated with budesonide and salbutamol atomization inhalation. The Th17/Treg ratio in peripheral blood as well as serum contents of airway remodeling-related indicators was compared between two groups before and after treatment. The correlation between Th17/Treg balance and airway remodeling in patients with bronchial asthma was detected by Pearson test. Results:Before treatment, the differences in peripheral blood Th17/Treg ratio as well as serum contents of inflammatory mediators, growth factor indexes and collagen metabolism indexes were not statistically significant between two groups of patients. After treatment, peripheral blood Th17/Treg ratio in observation group was lower than that in control group, serum CRP, IL-8, IL-13 and TNF- contents in observation group were lower than those in control group, serum PDGF-BB, b-FGF and VEGF contents in observation group were lower than those in control group, and serum HA, PCⅢ and LN contents in observation group were lower than those in control group. The Th17/Treg ratio in patients with bronchial asthma after treatment was positively correlated with the levels of airway remodeling-related indexes.Conclusion:Budesonide combined with salbutamol atomization inhalation can optimize the Th17/Treg balance in patients with bronchial asthma, and Th17/Treg is directly correlated to the degree of airway remodeling.
文摘The present work deals with the development of controlled release tablets of salbutamol sulphate(SS)using graft copolymers of methyl methacrylate(St-g-PMMA and Ast-g-PMMA)on starch and acetylated starch.Formulations were evaluated for physical characteristics like hardness,friability,drug release,drug content and weight variations,which fulfilled all the official requirements of tablet dosage form.The release rates from formulated matrix tablets were studied at SGF(pH 1.2)followed by SIF(pH 6.8).Drug release from the graft copolymer based tablets was found to be sustained upto the 14 h with>75%drug release.The in-vitro release study showed that the graft copolymer based matrix formulations(F3&F4)exhibited highest correlation value(r2)for higuchi kinetic model and Korsmeyer's model with n values between 0.61 and 0.67 proved that release mechanisms were governed by both diffusion and erosion mechanism.There was no significant difference in the pharmacokinetic parameters(tmax,Cmax,AUC,Ke,and t1/2)of the graft copolymers matrices and HPMC K100M matrix tablets,indicating their comparable sustained release effect.The potential of graft copolymers to sustain the drug release is well supported by in-vivo pharmacokinetic studies and their adequate physicochemical properties make them promising excipients for controlled drug delivery system.
文摘Salbutamol is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm such as asthma and chronic obstructive pulmonary disease (COPD). It is mostly taken through an inhaler device. The comparative toxicity assessment between two salbutamol sulfate preparations containing hydrofluoroalkane (HFA) metered dose inhalers with 100 μg per puff was evaluated in selected patients with asthma and COPD after prescribing. An open label, non-randomized, non-interventional observational study was designed. A large cohort of patients with asthma or related respiratory disorder of the general population from Dhaka and Chittagong of Bangladesh were recruited and treated with prescribed generic preparation Azmasol inhaler and brand preparation Ventolin Evohaler. Total 508 patients with asthma and minor obstructive airway disease were selected by the general medical practitioners in Bangladesh those who visited out patient consultation center in hospitals and physicians’ chambers and reported any adverse side effects of inhaled medications. There were no significant differences between the metered dose generic preparation Azmasol inhaler and Ventolon Evohaler among the patients treated with the medicines in asthma and related respiratory diseases in terms of adverse effects like immune system problem,dizziness,tremor,headache,nervousness,diarrhea,nausea,vomiting,heartburn,palpitation,skin rash,hypertension and taste feeling. It is concluded that Azmasol Inhaler, the generic salbutamol sulphate metered dose preparation containing HFA was as safe as the Ventolin Evohaler,a salbutamol sulfate brand preparation containing HFA when given to the patients in primary care after their physicians’ visits. Both the preparations have shown the similar safety profiles after regular use.
基金Supported by Beijing Training Project for the Leading Talents in S&T(Z171100001117158)
文摘An immunomagnetic bead kit to separate and enrich salbutamol was prepared through the reaction between salbutamol and 4-aminobenzoic acid.The kit had a catch of 20 ng/ml to salbutamol in samples,and showed no cross reaction with competitive drugs with structure and function similar to salbutamol: clenbuterol,ractopamine,phenylethanolamine A, bromchlorbuterol, brombuterol, terbutaline, hydroxymethyl salbutamol,cimaterol,tulobuterol,mapenterol,cimbuterol,clenpenterol,zilpaterol,penbutolol,clenproperol,mabuterol and clorprenaline.
基金Supported by School-level Project of Guangxi University of Chinese Medicine(YB140004)The 2017 Basic Ability Improving Project of Young and Middleaged Teachers by the Education Department of Guangxi(2017KY0284)
文摘Salbutamol sulfate was coordinated with Cu2+ when pH was 10, and the characteristic absorption peak of the complex was generated at 334 nm. The absorption intensity of the complex was in linear relation with the concentration of salbutamol sulfate. The regression equation was A=0.011 ρsalbutamol sulfate-0.123 0, correlation coefficient r=0.999 5, and the detection limit was 4.6 μg/ml. It was used for the determination of salbutamol sulfate samples successfully. The recovery rate was 100.5%-103.0%, and the RSD was 1.5%.
基金Supported by the Project of Islamic Azad University(Shahreza Branch)the Iran Nanotechnology Initiative Council
文摘Salbutamol,which increases the muscle mass and decreases the adipose tissue,is misused as nutrient repartitioning agent in the livestock.The novelty of this work is the determination of salbutamol in the livestock meat via new bonded-phases bearing eight derivatives of p-tert-calix[4]arene in partial-cone conformation.The new synthesized bonded-phases were characterized and optimized.The bonding interactions of solute and stationary-phases were examined and the main interactions were reported.The salbutamol levels in six samples of livestock meat were analyzed and the results reveal that for the best bonded-phases,the limit of detection(LOD) and limit of quantitation(LOQ) were 0.02 and 0.06 μg/mL,respectively.
文摘Ultrasonic speeds of 4-aminobutyric acid in 0.0041,0.0125 and 0.0207 mol·kg-1 aqueous salbutamol sulphate(SBS) solutions are measured at 308.15,313.15 and 318.15 K.Isentropic compressibility kS,change in isentropic compressibility△k S,relative change in isentropic compressibility( 0 S S △k /k) ,apparent molal compressibility kφ,limiting apparent molal compressibility k0 φ,transfer limiting apparent molal compressibility k0 φ,hydration number nH,pair and triplet interaction parameters kAS,kASS are estimated.The above parameters are used to interpret the solute-solute and solute-solvent interactions of 4-aminobutyric acid in the aqueous salbutamol sulphate solutions.
文摘Enantiomeric separation of epinephrine and salbutamol was investigated by micellar electrokinetic chromatography employing β-cyclodextrin as chiral additive in ammonium chloride-ammonia solution. The analytes were detected by electrochemistry using gold microelectrode at +0.65 V versus SCE reference electrode. The effects of detection potential, concentration of β-cyclodextrin, concentration of sodium dodecyl sulfate, pH value of electrolyte and applied voltage were discussed.
基金Supported by the National High Technology Research and Development Program of China （2001AA218061） and the National Natural Science Foundation of China （20236020）.
文摘salbutamol 硫酸盐(SS ) 的极其细小的粒子的准备与一条反应降水小径， salbutamol 和硫的酸与乙醇的溶剂在被用作反应物被完成。粒子的尺寸上的硫的酸集中，反应温度，激动人心的率，和反应时间的效果被调查。二进制混合物乳糖创作了， SS 被准备评估 SS。结果证明有控制直径在 3 渭 m 和 0.8 渭 m 之间变化并且与狭窄的分布的极其细小的 SS 粒子能被完成。由打的粒子组成的形态学成功地被获得。粒子的纯净上面与紫外察觉到达了 98% 。干燥粉末吸入的剂量被与重新使结晶的乳糖混合粒子获得，它充当了一个搬运人。在呼吸道的药的免职数量用一台成双的 impinger 仪器被估计。与 Shapuer 粉末相比(在市场上购买了) ，结果证明 SS 粒子把更多的数量在模拟的肺减退了。
文摘Enantioseparation of salbutamol solute was carried out in liquid-supported membrane by using a polyvinylidene fluoride hollow-fiber module. The enantioselective transport of solute was facilitated by combinatorial chiral selectors, which were dissolved in toluene organic solvent. The effects of molar concentration ratios of salbutamol to combinatorial chiral selectors, and the pH value of buffer solution on enantioseparation were investigated. The results show that when the molar concentration ratio is 2∶1∶1, the maximum separation factor and enantiomer excess are 1.49 and 19.74%, respectively, and the R-enantiomer flux is more than S-enantiomer; the pH value of buffer solution influences the performances of enantioseparartion obviously, and the appropriate range of pH value is 7.07.2.
文摘目的分析肺部康复训练在沙丁胺醇治疗重度支气管哮喘急性发作患儿中对气道炎症因子和肺功能的影响,为临床治疗重度支气管哮喘急性发作提供治疗依据。方法选取郑州大学第三附属医院2021年9月至2023年2月收治的102例重度支气管哮喘急性发作患儿进行前瞻性研究,采用随机数字表法将其分为两组(参照组、治疗组),每组51例。参照组男32例、女19例;年龄5~12(7.32±1.85)岁;病程2~18(12.30±1.28)个月;体质量12~27(21.65±2.08)kg。治疗组男28例、女23例;年龄6~13(7.94±1.16)岁;病程2~17(11.89±2.31)个月;体质量11~28(22.32±2.17)kg。入院后两组患儿均予以布地奈德抗感染治疗,参照组采用沙丁胺醇治疗,治疗组采用沙丁胺醇联合肺部康复训练,两组患儿治疗周期均为1个月。比较两组患儿临床效果,临床症状(呼吸困难、咳嗽、喘息、哮鸣音、湿啰音)消失时间,治疗前及治疗后1个月炎症因子水平[白细胞介素-4(interleukin-4,IL-4)、IL-18、IL-1β、嗜酸性粒细胞(eosinophils,EOS)]、肺功能[用力呼出50%肺活量时的瞬间呼气流量(forced expiratory flow at 50%,FEF50%)、呼气峰值流量(peak expiratory flow,PEF)、第1秒用力呼气容积(forced expiratory volume in the first second,FEV1)、用力肺活量(forced vital capacity,FVC)]。统计学方法采用t检验、χ^(2)检验。结果治疗组经治疗后临床总有效率比参照组高[96.08%(49/51)比82.35%(42/51)](χ^(2)=4.993,P<0.05)。与参照组[(5.23±1.03)d、(4.32±1.30)d、(2.36±0.26)d、(6.22±1.63)d、(5.89±1.07)d]比较,治疗组呼吸困难、咳嗽、喘息、哮鸣音、湿啰音消失时间[(2.25±0.69)d、(2.03±0.85)d、(2.23±0.32)d、(5.63±1.10)d、(3.62±1.04)d]均较短,差异均有统计学意义(t=17.166、10.529、2.252、2.143、10.864,均P<0.05)。治疗1个月后,治疗组血清IL-4、IL-18、IL-1β、EOS水平均比参照组低[(25.30±3.96)ng/L比(28.30±3.47)ng/L,(92.03±7.36)ng/L比(100.65±8.66)ng/L,(2.03±0.26)ng/L比(2.89±0.32)ng/L,(1.06±0.39)%比(2.84±0.52)%],差异均有统计学意义(t=4.069、5.417、14.896、19.557,均P<0.05)。治疗1个月后,治疗组FEF50%、PEF、FEV1、FVC水平均比参照组高,差异均有统计学意义(均P<0.05)。结论重度支气管哮喘急性发作患儿在沙丁胺醇治疗时采用肺部康复训练可使临床效果得到提升,缩短临床呼吸困难、咳嗽等症状消失时间,缓解气道炎症反应,促进患儿肺功能恢复,从而加快患儿康复。
