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Solid-state NMR of the retinal protonated Schiff base in microbial rhodopsins
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作者 Sari Kumagai Izuru Kawamura 《Magnetic Resonance Letters》 2024年第3期11-18,共8页
Rhodopsin is a seven-helical transmembrane protein with a retinal chromophore covalently bound to a conserved lysine in helix G via a retinal protonated Schiff base(RPSB).Microbial rhodopsins absorb light through chro... Rhodopsin is a seven-helical transmembrane protein with a retinal chromophore covalently bound to a conserved lysine in helix G via a retinal protonated Schiff base(RPSB).Microbial rhodopsins absorb light through chromophore and play a fundamental role in optogenetics.Numerous microbial rhodopsins have been discovered,contributing to diverse functions and colors.Solid-state NMR spectroscopy has been instrumental in elucidating the conformation of chromophores and the three-dimensional structure of microbial rhodopsins.This review focuses on the 15N chemical shift values of RPSB and summarizes recent progress in the field.We displayed the correlation between the 15N isotropic chemical shift values of RPSB and the maximum absorption wavelength of rhodopsin using solid-state NMR spectroscopy. 展开更多
关键词 Membrane proteins Microbial rhodopsin RETINAL solid-state NMR Protonated schiff base
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Synthesis and Characterization of Novel Schiff Base for Enhanced Dye-Sensitized Solar Cell Photo-Response Mechanism
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作者 Raphael Shadai Oguike Hanatu Akanagn Omolara Oni 《Crystal Structure Theory and Applications》 2024年第2期11-20,共10页
The efficient photo-response mechanism is one of the key factors in the commercialization of dye-sensitized solar cells in a bid to satisfy renewable energy demands. Progress in green technology has put solar energy o... The efficient photo-response mechanism is one of the key factors in the commercialization of dye-sensitized solar cells in a bid to satisfy renewable energy demands. Progress in green technology has put solar energy on the front burner as a provider of clean and affordable energy for a sustainable society. We report the synthesis of a novel Schiff base with optical transparency in the visible and near IR region of the solar spectrum that can find application in the DSSCs photo-response mechanism. The synthesized crystal exhibited features that could handle some of the shortcomings of dye-sensitized solar cells which include wide band solar spectrum absorption and capability for swift charge transfer within the photoelectrodes. The synthesized Schiff base was characterized using x-ray diffractometer, UV/Visible spectrometer, Frontier transmission infrared spectrometer and conductometer. XRD data revealed the grown crystal to have an average crystallite size of 2.08 nm with average microstrain value of about 269.43. The FT-IR recorded transmission wave ѵ (CO) at 1207.7 cm<sup>−1</sup> while dominant wave occurred at ѵ1654.9 and ѵ1592.3 cm<sup>−1</sup> relating to ѵ (CN) stretching and ѵ (NH) bending respectively were observed. The IR spectrum revealed the bonding species and a probable molecular structure of 2,6-bis(benzyloxy)pyridine. The UV/Visible spectra convoluted to maximum peak within the near IR region suggesting that 2,6-bis(benzyloxy)pyridine can absorb both the visible and near IR region while its electrical conductivity was determined to be 4.58 µS/cm. The obtained result of the present study revealed promising characteristics of a photosensitizer that can find application in the photo-response mechanism of DSSCs. 展开更多
关键词 Dye-sensitized solar Cell schiff base PHOTOsENsITIZER Optical Transparency BENZIL PYRIDINE
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Synthesis, Characterization and Biological Activity Evaluation of Schiff Bases Derived from 1,8-Diaminonaphtalène
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作者 Niameke Jean Baptiste Kangah Nanou Tiéba Tuo +4 位作者 Daouda Ballo Ahmont Landry Claude Kablan N’goran Etienne Kouame Charles Guillaume Kodjo Nahossé Ziao 《Open Journal of Physical Chemistry》 CAS 2023年第2期29-37,共9页
The compounds have been synthesized and characterized by routine MS, IR and NMR spectrometry methods. The compounds are all active on bacterial strains with the exception of Salmonella typhimirium, with a MIC value of... The compounds have been synthesized and characterized by routine MS, IR and NMR spectrometry methods. The compounds are all active on bacterial strains with the exception of Salmonella typhimirium, with a MIC value of 7.5 mg/mL. They show a percentage of anti-radical activity of 75.476 ± 5.070 for the compound DAN-S and of 68.142 ± 6.539 for the compound DAN-OV. The compounds are sensitive to the two champions used. DAN-S compound is then the most active. 展开更多
关键词 schiff base sPECTROMETRY ANTIOXIDANT Antimicrobial Activity INHIBITION 1 8-Diaminonaphthalene
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5-硝基水杨醛氨基酸Schiff-bases铜配合物与DNA相互作用的研究 被引量:5
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作者 冯莉 顾文 +5 位作者 马小芳 许光军 刘慧 阎世平 廖代正 程鹏 《南开大学学报(自然科学版)》 CAS CSCD 北大核心 2007年第1期27-31,共5页
用电子光谱、荧光淬灭光谱和循环伏安的方法,研究了(苯丙氨酸缩5-硝基水杨醛)铜(1)和(组氨酸缩5-硝基水杨醛)铜(2)与 DNA 的作用.结果表明,配合物均以插入模式与 DNA 作用;配合物与 DNA 作用强弱为:配合物(2)>配合物(1).
关键词 氨基酸 schiff 铜配合物 DNA
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固体推进剂用新型Schiff碱类高效键合剂的合成及性能表征
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作者 武卓 赵志坤 +3 位作者 徐爽 李洪旭 杨玉林 庞爱民 《火炸药学报》 EI CAS CSCD 北大核心 2024年第7期649-655,I0004,共8页
为提高丁羟四组元推进剂和CL-20/GAP推进剂的力学性能,解决新的推进剂填料基体界面“脱湿”问题,设计合成了新型Schiff碱键合剂;采用傅里叶红外光谱仪、扫描电子显微镜及万能材料拉伸机等对键合剂的键合效果和推进剂的力学性能进行了表... 为提高丁羟四组元推进剂和CL-20/GAP推进剂的力学性能,解决新的推进剂填料基体界面“脱湿”问题,设计合成了新型Schiff碱键合剂;采用傅里叶红外光谱仪、扫描电子显微镜及万能材料拉伸机等对键合剂的键合效果和推进剂的力学性能进行了表征。结果表明,合成的新型Schiff碱键合剂包含键合剂必备官能团且在AP表面存在明显键合,新型Schiff碱键合剂有望取代有毒MAPO,可明显提高丁羟四组元推进剂的力学性能,使丁羟四组元推进剂常温拉伸强度达到0.7 MPa,常温延伸率大于55%,高温延伸率大于50%,低温延伸率大于60%,并可以明显改善丁羟四组元推进剂的工艺性能;在CL-20/GAP推进剂中,新型Schiff碱键合剂可同时提高推进剂的拉伸强度和延伸率。 展开更多
关键词 材料力学 丁羟推进剂 键合剂 力学性能 schiff 界面脱湿 MAPO
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脱氢枞胺水杨醛类席夫碱(Schiff Bases)对铜离子萃取性能的研究 被引量:4
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作者 姚绪杰 饶小平 +1 位作者 王宗德 宋湛谦 《江西农业大学学报》 CAS CSCD 北大核心 2007年第3期461-465,共5页
合成5种脱氢枞胺水杨醛类Schiff碱,对其萃取铜离子的影响因素进行研究,并与萃取剂N902对电镀废水中铜离子的萃取性能进行了比较。结果表明:萃取温度和萃取时间对铜离子萃取率的影响不明显,萃取温度在20~30℃、萃取时间为2 h就能达到萃... 合成5种脱氢枞胺水杨醛类Schiff碱,对其萃取铜离子的影响因素进行研究,并与萃取剂N902对电镀废水中铜离子的萃取性能进行了比较。结果表明:萃取温度和萃取时间对铜离子萃取率的影响不明显,萃取温度在20~30℃、萃取时间为2 h就能达到萃取平衡;大部分Schiff碱在低pH范围内对铜离子的萃取效果不理想,在高pH范围内有较好的萃取性能。DHAA 2,3,4-三羟基苯甲醛的萃取效果与N902相当。 展开更多
关键词 脱氢枞胺 schiff 溶剂萃取 铜离子
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Schiff bases及配合物的研究进展 被引量:8
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作者 焦元红 张前 《黄石理工学院学报》 2007年第3期38-41,共4页
希夫碱配体及与后过渡金属元素所形成的配合物,以其多样的结构和广泛的用途愈来愈受到人们的重视。文章综述了Schiff base配体及配合物的发展状况以及在生物化学、催化化学、分析化学、材料化学等方面的研究与应用,并指出了它的美好前景。
关键词 schiff base 配体 金属配合物
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Flexible,thermal processable,self-healing,and fully bio-based starch plastics by constructing dynamic imine network
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作者 Xiaoqian Zhang Haishan Zhang +2 位作者 Guowen Zhou Zhiping Su Xiaohui Wang 《Green Energy & Environment》 SCIE EI CAS CSCD 2024年第10期1610-1618,共9页
The serious environmental threat caused by petroleum-based plastics has spurred more researches in developing substitutes from renewable sources.Starch is desirable for fabricating bioplastic due to its abundance and ... The serious environmental threat caused by petroleum-based plastics has spurred more researches in developing substitutes from renewable sources.Starch is desirable for fabricating bioplastic due to its abundance and renewable nature.However,limitations such as brittleness,hydrophilicity,and thermal properties restrict its widespread application.To overcome these issues,covalent adaptable network was constructed to fabricate a fully bio-based starch plastic with multiple advantages via Schiff base reactions.This strategy endowed starch plastic with excellent thermal processability,as evidenced by a low glass transition temperature(T_(g)=20.15℃).Through introducing Priamine with long carbon chains,the starch plastic demonstrated superior flexibility(elongation at break=45.2%)and waterproof capability(water contact angle=109.2°).Besides,it possessed a good thermal stability and self-adaptability,as well as solvent resistance and chemical degradability.This work provides a promising method to fabricate fully bio-based plastics as alternative to petroleum-based plastics. 展开更多
关键词 Bioplastic Covalent adaptable networks schiff base chemistry Thermal processability sELF-HEALING
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1-苯基-3-(1-环己胺)-丙烯Schiff碱缓蚀剂在盐酸溶液中对J55钢的缓蚀效果
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作者 方晓君 卜晓阳 《油田化学》 CAS CSCD 北大核心 2024年第2期315-321,共7页
为改善酸化压裂施工造成的腐蚀问题,以肉桂醛和环己胺为原料合成了Schiff碱酸化缓蚀剂1-苯基-3-(1-环己胺)-丙烯(PCP),通过红外光谱和气相色谱-质谱联用对其结构进行表征,并采用失重法、电化学(极化曲线、阻抗谱、噪声)及分子动力学模... 为改善酸化压裂施工造成的腐蚀问题,以肉桂醛和环己胺为原料合成了Schiff碱酸化缓蚀剂1-苯基-3-(1-环己胺)-丙烯(PCP),通过红外光谱和气相色谱-质谱联用对其结构进行表征,并采用失重法、电化学(极化曲线、阻抗谱、噪声)及分子动力学模拟等方法评价了PCP的缓蚀效果。结果表明,合成产物即为目标产物PCP。在15%HCl、90℃的条件下,随着PCP浓度增加,J55钢的失重腐蚀速率及腐蚀电流密度显著减小,缓释率逐渐增大。不同PCP加量下的缓释率均可达到99%以上,缓蚀效果较好。在PCP加量达到0.15%时,腐蚀速率及缓释率随着缓蚀剂浓度的增加整体变化不大,即缓蚀剂在J55钢表面的吸附浓度已达到临界胶束浓度,吸附量不再发生变化。PCP同时抑制了阴极析氢和阳极溶解反应,为混合型缓蚀剂。随着PCP浓度的增加,容抗弧半径、极化电阻及噪声电阻由小到大的排序均为:空白﹤0.05%﹤0.10%﹤0.15%﹤0.20%;低频的白噪声水平在电流PSD图中随着PCP浓度的增加而减小,即J55钢的腐蚀速率不断减小,与失重法及极化曲线反应的规律一致。当PCP分子与金属发生吸附并达到平衡时,整个缓蚀剂分子处于同一平面,平行吸附在J55钢表面,达到完全覆盖,从而有效减缓了腐蚀介质的侵入。 展开更多
关键词 schiff 缓蚀剂 金属腐蚀 失重法 电化学 分子动力学
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对羟基苯甲醛Schiff碱的合成、表征及生物活性
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作者 吴江萌 刘泽含 +6 位作者 杨雪丽 段旺达 陈宣博 吴蕙臣 张叶松 任思梦 许瑞波 《合成化学》 CAS 2024年第10期874-880,共7页
Schiff是优良配体,并具有抑菌、抗氧化和抗肿瘤等生物活性。以对羟基苯甲醛为原料,分别与4-甲基、5-甲基-2-氨基吡啶反应,合成了2个对羟基苯甲醛Schiff碱,即对羟基苯甲醛缩4-甲基-2-氨基吡啶(1)和对羟基苯甲醛缩5-甲基-2-氨基吡啶(2)。... Schiff是优良配体,并具有抑菌、抗氧化和抗肿瘤等生物活性。以对羟基苯甲醛为原料,分别与4-甲基、5-甲基-2-氨基吡啶反应,合成了2个对羟基苯甲醛Schiff碱,即对羟基苯甲醛缩4-甲基-2-氨基吡啶(1)和对羟基苯甲醛缩5-甲基-2-氨基吡啶(2)。采用熔点、红外光谱、紫外可见光谱、核磁共振氢谱和碳谱以及高分辨质谱等对产物结构进行了全面表征。利用微量肉汤稀释法研究其抑菌活性,结果标明:化合物1和化合物2对大肠杆菌、金黄色葡萄球菌和枯草芽孢杆菌的最小抑菌浓度(MIC)为0.500 mg/mL,对溶藻性弧菌、副溶血性弧菌的MIC为0.250 mg/mL。采用DPPH·法研究了化合物1的抗氧化活性,发现其对DPPH·自由基清除率为68.1%。 展开更多
关键词 对羟基苯甲醛schiff 2-氨基吡啶 水杨醛schiff 抑菌作用 抗氧化活性
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Coordination and Photoisomerization of Azobenzene-Amino Acid Schiff Base Copper(II) Complexes to Lysozyme
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作者 Yuto Kuroda Ryotaro Miyazaki +2 位作者 Daiki Shimonishi Daisuke Nakane Takashiro Akitsu 《Journal of Materials Science and Chemical Engineering》 CAS 2023年第3期34-44,共11页
In this study, we exhibited an amino acid (arginine and threonine) derivative Schiff base copper(II) complexes incorporating an azobenzene moiety as a photoresponsive site and conjugated it to egg white lysozyme, a we... In this study, we exhibited an amino acid (arginine and threonine) derivative Schiff base copper(II) complexes incorporating an azobenzene moiety as a photoresponsive site and conjugated it to egg white lysozyme, a well-known protein, to change ligand conformation under binding to lysozyme. Among several spectroscopic investigations, ESR clearly showed that the nitrogen atom of the amino acid residue of lysozyme was bound to the paramagnetic copper(II) ion of the complex, and UV light irradiation confirmed photoisomerization of the azobenzene moiety of the ligand to cis-form. The binding mode was considered by means of spectroscopic as well as computational methods, whereas complete crystallographic verification was still a preliminary stage. 展开更多
关键词 AZOBENZENE schiff base Copper Amino Acid LYsOZYME Artificial Metalloprotein
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Synthesis and Characterisation of Cr(III) and Co(II) Schiff Base Complexes
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作者 Fatin M. Elmagbari Ahmed N. Hammouda +2 位作者 Hamdi A. M. Bennour Rashd M. EL-Ferjani Younis O. Ben Amer 《Materials Sciences and Applications》 CAS 2023年第2期53-62,共10页
Co(II) and Cr(III) metal complexes of Schiff bases were synthesized from the condensation reaction between 4-(dimethylamino)benzaldehyde and 4-amino-3-hydroxy-naphthalene-1-sulfonic acid. Their structures were investi... Co(II) and Cr(III) metal complexes of Schiff bases were synthesized from the condensation reaction between 4-(dimethylamino)benzaldehyde and 4-amino-3-hydroxy-naphthalene-1-sulfonic acid. Their structures were investigated by elemental analysis, molar conductance measurements, infrared spectroscopy, electronic spectroscopy, and 1HNMR spectroscopy. The elemental analysis data suggested a 1:1 [M:L] ratio for the complexes. The molar conductance measurements of the complexes indicate their electrolytic nature in DMSO as a solvent. The absorption bands in the electronic spectra verified an octahedral environment around the metal ions in the complexes. 展开更多
关键词 schiff base Ligand Complexes <sup>1sup>HNMR spectra
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Synthesis of New Schiff Bases Containing Thiophene Moiety 被引量:5
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作者 Zhu Wan-ren, Hu Pei-zhi, Li Mei-ying, Huang Xiao-ling, Wu Cheng-taiCollege of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072,Hubei, China 《Wuhan University Journal of Natural Sciences》 CAS 2003年第02A期433-436,共4页
Seven new Schiff bases, which are 4,4,4-trifluo-ro-1-(2-thienyl)-1-butanone-3-Z, Z =-thioseraicarbazone (a); -thiocarbohydrazone (b),-benzoic hydrazone (c), -( o-hydroxyphenyl) imine (d) ,-nicotinic hydrazone (e),-sal... Seven new Schiff bases, which are 4,4,4-trifluo-ro-1-(2-thienyl)-1-butanone-3-Z, Z =-thioseraicarbazone (a); -thiocarbohydrazone (b),-benzoic hydrazone (c), -( o-hydroxyphenyl) imine (d) ,-nicotinic hydrazone (e),-salicylic hydrazone (f), and -(p-fluoro-m-chlorophenyl) imine (g), have been synthesized by reaction of 4, 4, 4-trifluoro-1-(2-thienyl)-1,3-butanedione (TFTBD) with corresponding hy-drazides or anilines, acetic acid or p-toluence sulfonic acid as catalyst, and characterized by Elemental analysis, IR, UV-Vis,1H NMR and MS. The MS spectra confirmed that the -C3=O condensed with primary amino group. Tauto-merism of the compounds is discussed. 展开更多
关键词 thiophene moiety schiff base synthsis tau-tomerism
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Dioxygen Affinity and Catalytic Performance of Bis-(furaldehyde) Schiff Bases Co(II) Complexes in Cyclohexene Oxidation 被引量:4
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作者 Sun, B Chen, JR +1 位作者 Hu, JY Li, XJ 《Chinese Chemical Letters》 SCIE CAS CSCD 2001年第11期1043-1046,共4页
Oxygenation constants and thermodynamic parameters DeltaH degrees and DeltaS degrees of cobalt (II) complexes with bis-(furaldehyde) Schiff bases (1, 2, 3, 4)were obtained by mearsuring saturated dioxygen uptake of th... Oxygenation constants and thermodynamic parameters DeltaH degrees and DeltaS degrees of cobalt (II) complexes with bis-(furaldehyde) Schiff bases (1, 2, 3, 4)were obtained by mearsuring saturated dioxygen uptake of these complexes in pyridine at different temperature. These complexes could activate molecular oxygen and were used as catalysts in cyclohexene oxidation. The influence of ligand structure on the dioxygen affinity and catalytic activity of the complexes were discussed. 展开更多
关键词 schiff base cobalt (II) complex OXYGENATION catalytic oxidation CYCLOHEXENE
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Reaction of Nitrosonium (NO^+) with Schiff Bases 被引量:3
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作者 YuLuZHOU CongDeHUO ShuMIAO LongMinWU 《Chinese Chemical Letters》 SCIE CAS CSCD 2004年第7期801-804,共4页
The reaction of nitrosonium (NO+) with Schiff bases produced diazonium salts and aldehydes in good yield. The reaction is assumed to be an electrophilic reaction of nitrosonium with imines via a four-member ring inter... The reaction of nitrosonium (NO+) with Schiff bases produced diazonium salts and aldehydes in good yield. The reaction is assumed to be an electrophilic reaction of nitrosonium with imines via a four-member ring intermediate. 展开更多
关键词 NITROsONIUM schiff bases electrophilic.
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Synthesis, Structural Features and Evaluation of Antibacterial Activities of Two Schiff Bases Derived from 3,4-Dihydroxybenzhydrazide 被引量:3
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作者 刁云鹏 钟民涛 +6 位作者 张厚利 黄珊珊 刘欣 李传勋 郑泽宝 林原 黄敏 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2010年第11期1684-1688,共5页
A new Schiff base compound (I), (E)-N'-(2-hydroxy-3-methoxybenzylidene)-3,4-dihydroxybenzohydrazide-ethanol-water (1/1/1), has been synthesized and characterized by elemental analysis, IR spectra, and single-... A new Schiff base compound (I), (E)-N'-(2-hydroxy-3-methoxybenzylidene)-3,4-dihydroxybenzohydrazide-ethanol-water (1/1/1), has been synthesized and characterized by elemental analysis, IR spectra, and single-crystal X-ray diffraction. The crystal belongs to monoclinic, space group P21/n with a = 7.459(4), b = 18.316(10), c = 13.638(7), β = 101.585(9)o, V = 1825.2(17)3, Z = 4, μ = 0.104 mm-1, Dc = 1.333 g/cm3, F(000) = 776, the final R = 0.0635 and wR = 0.1302 for 3216 observed reflections with I 〉 2σ(I). Another compound (Ⅱ), (E)-N'-(2,5-dimethoxybenzylidene)-3,4-dihydroxybenzohydrazide-ethanol-water (1/1/1), has been synthesized and reported before. The antibacterial activities of these two compounds against seven bacteria were first evaluated, and one compound showed considerable antibacterial activity against S. aureus. 展开更多
关键词 schiff base crystal structure ANTIBACTERIAL
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Synthesis of Schiff bases of naphtha[1,2-d]thiazol-2-amine and metal complexes of 2-(2'-hydroxy)benzylideneaminonaphthothiazole as potential antimicrobial agents 被引量:4
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作者 AZAM Faizul SINGH Satendra +1 位作者 KHOKHRA Sukhbir Lal PRAKASH Om 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2007年第6期446-452,共7页
Objective: A series of 2-benzylideneaminonaphthothiazoles were designed and synthesized incorporating the lipophilic naphthalene ring to render them more capable of penetrating various biomembranes. Methods: Schiff ... Objective: A series of 2-benzylideneaminonaphthothiazoles were designed and synthesized incorporating the lipophilic naphthalene ring to render them more capable of penetrating various biomembranes. Methods: Schiff bases were synthesized by the reaction of naphtha[1,2-d]thiazol-2-amine with various substituted aromatic aldehydes. 2-(2'-Hydroxy)ben- zylideneaminonaphthothiazole was converted to its Co(Ⅱ), Ni(Ⅱ) and Cu(Ⅱ) metal complexes upon treatment with metal salts in ethanol. All the compounds were evaluated for their antibacterial activities by paper disc diffusion method with Gram positive Staphylococcus aureus and Staphylococcus epidermidis and Gram negative Escherichia coli and Pseudomonas aeruginosa bacteria. The minimum inhibitory concentrations of all the Schiff bases and metal complexes were determined by agar streak dilution method. Results: All the compounds moderately inhibited the growth of Cram positive and Gram negative bacteria. In the present study among all Schiff bases 2-(2'-hydroxy)benzylideneaminonaphthothiazole showed maximum inhibitory activity and among metal complexes Cu(Ⅱ) metal complex was found to be most potent. Conclusion: The results obtained validate the hypothesis that Schiff bases having substitution with halogens, hydroxyl group and nitro group at phenyl ring are required for the antibacterial activity while methoxy group at different positions in the aromatic ring has minimal role in the inhibitory activity. The results also indicated that the metal complexes are better antibacterial agents as compared to the Schiff bases. 展开更多
关键词 schiff bases Metal complexes ANTIMICROBIAL
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Synthesis of Pyridyl Polyheterocyclic Oxime-ether Schiff Bases Containing s-Triazole and Oxadiazole Subunits 被引量:1
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作者 Guo Qiang HU Sheng LI Wen Long HUANG 《Chinese Chemical Letters》 SCIE CAS CSCD 2006年第7期899-902,共4页
4-Amino-5-pyridin-4-yl-s-triazole-3-thiol (1) was sequentally reacted with 3-chloro-1- phenylpropan-1-one to afford 3-(4-amino-5-pyridin-4-yl-s-triazole-3-sulfanyl)-1-phenylpropan-1- one (2) followed by oximatio... 4-Amino-5-pyridin-4-yl-s-triazole-3-thiol (1) was sequentally reacted with 3-chloro-1- phenylpropan-1-one to afford 3-(4-amino-5-pyridin-4-yl-s-triazole-3-sulfanyl)-1-phenylpropan-1- one (2) followed by oximation with hydroxylamine hydrochloride and etherification with 5-aryl-[13,4]oxadiazole-2-cbloromethanes to the corresponding oxime (3) and oxime-ethers (4a-e), respectively. The condensation of compounds 4 with salicylaldehyde gave the title compounds (5a-e). The antibacterial activity in vitro against Gram-postive (G^+) and Gram negative (G) bacteria was primarily evaluated. 展开更多
关键词 Pyridine triazole OXADIAZOLE oxime-ether schiff base antibacterial activity.
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Antioxidative Effect of Schiff Bases with o-Hydroxybenzylidene Groupon Free Radical Induced Hemolysis of Human Red Blood Cell 被引量:1
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作者 LUO Xu yang ZHAO Jian zhang +1 位作者 LIN Ying jie LIU Zai qun 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2002年第3期287-289,共3页
The hemolysis of human red blood cells was initiated by a water soluble free radical initiator, 2,2′ azobis (2 amidinopropane hydrochloride)(AAPH), at 37 ℃ in phosphate buffered saline(pH=7.4). The respective additi... The hemolysis of human red blood cells was initiated by a water soluble free radical initiator, 2,2′ azobis (2 amidinopropane hydrochloride)(AAPH), at 37 ℃ in phosphate buffered saline(pH=7.4). The respective addition of 1 [ N (o hydroxybenzylidene)amino]tetradecane(TDCA), 1,2 di[ N (o hydroxybenzylidene)amino]cyclohexane(DACH), 4 [ N (o hydroxybenzylidene)amino]benzoic acid(PABA), 4 nitro[ N (o hydroxybenzylidene)]aniline(APNA) or N (o hydroxybenzylidene)aniline(APA) can all prolong the inhibition period of hemolysis, indicating that the above Schiff bases play an antioxidative role in free radical induced hemolysis. It can be concluded that Schiff base with an alkyl group or a conjugated system in the molecule protect red blood cells against free radical induced hemolysis efficiently. This information may be useful for antioxidant drug design. 展开更多
关键词 Red blood cell HEMOLYsIs schiff base Free radical
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Synthesis and Characterization of New Schiff Bases Formed by Condensation of 2,9-Phenathroline-1,10-dialdehyde with Sulfur-Containing Amines 被引量:2
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作者 Md. Arifuzzaman Mohammad R. Karim +2 位作者 Tasneem A. Siddiquee Aminul H. Mirza Mohamad A. Ali 《International Journal of Organic Chemistry》 2013年第1期81-86,共6页
Four new Schiff bases of 1,10-phenanthroline-2,9-dicarboxaldehyde with sulfur-containing amines such as 2-mercaptoaniline, S-alkyl/aryl dithiocarbazates and thiosemicarbazide have been synthesized and characterized by... Four new Schiff bases of 1,10-phenanthroline-2,9-dicarboxaldehyde with sulfur-containing amines such as 2-mercaptoaniline, S-alkyl/aryl dithiocarbazates and thiosemicarbazide have been synthesized and characterized by spectroscopic and X-ray crystallographic techniques. A comparative study of the methods of synthesis has been made using both traditional and microwave techniques. A significant reduction in reaction time has been observed when the microwave method was used. In some of the reactions, the yields also increased significantly. 展开更多
关键词 PHENANTHROLINE schiff base Dithiocarbazide sulfur-Containing Antibaterial
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