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Correlation between genotypes of Orientia tsutsugamushi and clinical characteristics of patients with scrub typhus in Guangzhou,China
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作者 Jiali Long Ziyi Zeng +8 位作者 Haiyan Chen Xia Tao Xinwei Wu Shouyi Chen Liqun Fang Xiuqing Zhang Jianxiong Xu Lin Zhang Yuehong Wei 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2024年第7期299-309,I0008,I0009,共13页
Objective:To explore the correlation between genotypes of Orientia(O.)tsutsugamushi and clinical characteristics of scrub typhus patients.Methods:Clinical data of patients with scrub typhus admitted to different types... Objective:To explore the correlation between genotypes of Orientia(O.)tsutsugamushi and clinical characteristics of scrub typhus patients.Methods:Clinical data of patients with scrub typhus admitted to different types of medical institutions in Guangzhou from September 2012 to December 2016 were collected using medical records.Demographic data,clinical manifestations,as well as hematological and biochemical indicators of patients infected with different genotypes were analyzed and compared.Results:A total of 192 patients were included in this study,including 121 patients with Karp genotype of O.tsutsugamushi infection(63.0%),36 patients with Gilliam genotype(19.0%),23 patients with Kato genotype(12.0%),and 12 patients with TA763 genotype(6.0%)infection.The median value of albumin in patients with Karp genotype infection was significantly lower than that of Gilliam-infected patients(P=0.032).Patients with Karp genotype infection had a significantly longer hospital stay(9 days)than those with Gilliam genotype(7 days)(P=0.009)and Kato genotype infection(6 days)(P=0.005).Karp-infected patients also represented for the largest number of patients with complicated organ involvement(88/133,66.2%).Furthermore,Karp-infected patients had higher risk of developing multiple organ dysfunction syndrome(18.2%)and requiring intensive care unit treatment(15.9%).Besides,patients with Gilliam genotype(8 days)and TA763 genotype infection(7.5 days)had shorter fever duration than those with Karp genotype(9 days)and Kato genotype(9 days)infection,respectively.Conclusions:Genotypes of Orientia tsutsugamushi were associated with varying clinical manifestations,organ involvement,and treatment outcomes,suggesting that genotypes ranged in virulence. 展开更多
关键词 scrub typhus Orientia tsutsugamushi GENOTYPE Clinical characteristics
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Real-world utility of serological tests in patients with suspected scrub typhus in the Republic of Korea:A single-center,retrospective,observational study
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作者 Seulki Kim A Reum Kim +2 位作者 Seungjin Lim Su Jin Lee Moonsuk Bae 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2024年第6期273-280,I0004,I0005,共10页
Objective:Serological tests are widely used for scrub typhus diagnosis;however,their limitations are evident.This study aims to assess their practical value in clinical settings.Methods:We analyzed the data of adult p... Objective:Serological tests are widely used for scrub typhus diagnosis;however,their limitations are evident.This study aims to assess their practical value in clinical settings.Methods:We analyzed the data of adult patients with suspected scrub typhus who visited a tertiary care hospital in the Republic of Korea from September to December from 2019 to 2021.The included patients had an acute fever and at least one of the following ten secondary findings:myalgia,skin rash,eschar,headache,thrombocytopenia,increased liver enzyme levels,lymphadenopathy,hepatomegaly,splenomegaly,and pleural effusion.The diagnoses were grouped as scrub typhus or other diseases by two infectious disease physicians.Results:Among 136 patients who met the eligibility criteria,109 had scrub typhus and 27 had different diseases.Single and paired total antibodies using immunofluorescence assay(IFA),and total antibodies using immunochromatography-based rapid diagnostic testing(ICT)were measured in 98%,22%,and 75%of all patients,respectively.Confirmation using paired samples for scrub typhus was established at a median of 11[interquartile range(IQR)10-16]days following the first visit.Among the 82 admitted patients,the median admission time was 9(IQR 7-13)days.According to IFA,58(55%)patients with scrub typhus had total immunoglobulin titers≥1:320,while 23(85%)patients with other disease had titers<1:320.Positive ICT results were observed in 64(74%)patients with scrub typhus and 10(67%)patients with other diseases showed negative ICT results.Conclusions:Serological testing for scrub typhus is currently insufficient for decision-making in clinical practice. 展开更多
关键词 scrub typhus Serological test Immunofluorescence assay IMMUNOCHROMATOGRAPHY Rapid detecting test
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Longitudinally extensive transverse myelitis associated with scrub typhus:A case report
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作者 Amit Kumar Rajesh Chetiwal Shweta Tanwar 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2024年第8期375-378,共4页
Rationale:Longitudinally extensive transverse myelitis(LETM)is a rare inflammatory demyelinating disease predominantly associated with autoimmune and inflammatory disorders.Scrub typhus can cause a variety of neurolog... Rationale:Longitudinally extensive transverse myelitis(LETM)is a rare inflammatory demyelinating disease predominantly associated with autoimmune and inflammatory disorders.Scrub typhus can cause a variety of neurological complications,which may result in poor recovery and long-term disability.This report reveals a rare linkage between LETM and scrub typhus.Patient concerns:A 24-year-old female presented with a history of fever for 10 days associated with progressive quadriparesis.Physical examination revealed bilateral lower limb weakness(grade 0/5)and bilateral upper limb weakness(grade 2/5)with reduced sensation below the T3 dermatome.Diagnosis:Scrub typhus presenting with longitudinally extensive transverse myelitis.Interventions:Steroid pulse therapy with antibiotics supported by early intensive rehabilitation.Outcomes:Complete recovery was achieved.Lessons:This case report highlights the importance of considering scrub typhus as a potential cause of LETM in endemic regions,particularly in patients presenting with febrile illness and neurological symptoms. 展开更多
关键词 Longitudinally extensive transverse myelitis scrub typhus Orientia tsutsugamushi Case report
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Omadacycline in the treatment of scrub typhus:Three case reports
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作者 Xue-Mei Lang Yun Qiu +3 位作者 Ya-Juan Jia Hong Sun Su-Min Gao Hong-Mei Zhao 《World Journal of Clinical Cases》 SCIE 2024年第25期5832-5838,共7页
BACKGROUND Scrub typhus is a naturally occurring acute infectious disease that is primarily transmitted through the bites of chiggers or larval mites infected by Orientia tsutsugamushi(O.tsutsugamushi).Omadacycline,a ... BACKGROUND Scrub typhus is a naturally occurring acute infectious disease that is primarily transmitted through the bites of chiggers or larval mites infected by Orientia tsutsugamushi(O.tsutsugamushi).Omadacycline,a novel tetracycline,exhibits potent antibacterial efficacy against both typical bacteria and atypical pathogens.However,omadacycline application in the treatment of scrub typhus remains limited.CASE SUMMARY In the present work,we report several cases of scrub typhus,with the main clinical symptoms being fever,the formation of eschars or ulcers,local or systemic lymphadenopathy,headache,myalgia and rash.Blood samples were collected before omadacycline was administered,and O.tsutsugamushi infection was confirmed through targeted next-generation sequencing(tNGS).After two days of treatment,the patients’symptoms,including fever,were alleviated,with no adverse drug reactions.CONCLUSION tNGS is an effective method for diagnosing scrub typhus.Omadacycline can be considered an alternative option for antiinfective therapy in patients with O.tsutsugamushi infections. 展开更多
关键词 Omadacycline scrub typhus Orientia tsutsugamushi Targeted nextgeneration sequencing ESCHAR Case report
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Myositis and rhabdomyolysis in scrub typhus infection: A case report 被引量:1
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作者 Tukaram Bolla Sushmita Bhattarai +3 位作者 Harpreet Singh Vikas Suri Ashish Bhalla Debajyoti Chatterjee 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2023年第4期187-189,共3页
Rationale:Fever with myositis and rhabdomyolysis is a medical emergency requiring prompt diagnosis and management.Scrub typhus associated myositis with rhabdomyolysis is rare.Patient concerns:A 36-year-old female pres... Rationale:Fever with myositis and rhabdomyolysis is a medical emergency requiring prompt diagnosis and management.Scrub typhus associated myositis with rhabdomyolysis is rare.Patient concerns:A 36-year-old female presented with intermittent fever up to 38.6℃,jaundice and progressive weakness of all four limbs.Diagnosis:Scrub typhus associated myositis and rhabdomyolysis.Intervention:Doxycycline 100 mg twice daily and injection of ceftriaxone 1 gm twice daily along with continuous intravenous fluids.Outcome:Fever resolved with normalization of liver function and recovery of muscle power.Lessons:Presence of myositis and rhabdomyolysis is uncommon in scrub typhus;high clinical suspicion should be kept in patients with atypical manifestations of scrub typhus. 展开更多
关键词 scrub typhus MYOSITIS RHABDOMYOLYSIS DOXYCYCLINE Transaminitis VASCULITIS
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Epidemiology and clinico-laboratory manifestations of scrub typhus in Hadoti region of Rajasthan,India:A cross-sectional study 被引量:1
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作者 Pankaj Jain Manoj Sharma +1 位作者 Manoj Seval Pramod Meena 《Journal of Acute Disease》 2023年第2期57-60,共4页
Objective:To study epidemiology,clinical manifestations,and laboratory parameters of scrub typhus in Hadoti region of Rajasthan,India.Methods:A cross-sectional study was conducted on 50 patients with scrub typhus betw... Objective:To study epidemiology,clinical manifestations,and laboratory parameters of scrub typhus in Hadoti region of Rajasthan,India.Methods:A cross-sectional study was conducted on 50 patients with scrub typhus between August 2022 and November 2022.Scrub typhus was diagnosed by ELISA IgM scrub typhus antibody.The data about demography,vital parameters,and lab investigations were collected and analyzed.Results:Ninety-two percent of the patients were from a rural background(92%),86% were farmers and the majority were females.Most patients were 40-60 years old.The major complaints were fever(100%),myalgia(100%),headache(82%),and body swelling(80%).Major complications were pneumonia(68%),multiple organ dysfunction syndrome(62%),hepatitis(44%),and acute kidney injury(42%).Triglyceride levels were>200 mg/dL in 80% of patients,albumin<3.5 g/dL in 98% and eschar mark was present in 24%of patients.Conclusions:Scrub typhus is a serious acute febrile illness that can lead to multi-organ dysfunction and is associated with significant mortality.Increasing awareness regarding disease in endemic regions,early screening of patients,and treatment as early as possible could help prevent the patient from severe life-threatening complications. 展开更多
关键词 scrub typhus EPIDEMIOLOGY Eschar mark Multiple organ dysfunction syndrome
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A review of the epidemic and clinical study on scrub typhus in China(2010-2020)
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作者 XIE Xiao-fei WANG Gao-yu +6 位作者 HUANG Yi TANG Chuan-ning PENG Ruo-yan HU Xiao-yuan DU Jiang QIN Ai-ping YIN Fei-fei 《Journal of Hainan Medical University》 CAS 2023年第19期57-61,共5页
Scrub typhus is an acute febrile vector-borne zoonotic disease caused by the obligate intracellular growth bacterium Orientia tsutsugamushi(Ot).Mites are the primary vectors and rodents play a pivotal role in the tran... Scrub typhus is an acute febrile vector-borne zoonotic disease caused by the obligate intracellular growth bacterium Orientia tsutsugamushi(Ot).Mites are the primary vectors and rodents play a pivotal role in the transmission of scrub typhus.Due to the climate warming,increased human activity and other factors,cases of scrub typhus have been increased sharply during the past decade in China,especially in the northern China.To understand the incidence trend,epidemic pattern,clinical sign,diagnosis and therapy of this diseases as well as genotype evolution of Orientia tsutsugamushi,we summarized and analyzed the current knowledge of scrub typhus in China from 2010 to 2020.The data indicated that the dominate genotypes of scrub typhus in China were Karp,Kato and Gilliam.Although the disease was distributed national wide,Yunnan,Guangzhou and Fujian showed the highest incidence rate.The main vector of scrub typhus in southwest,middle east and southeast of China appeared a geographic preference respectively.Seasonal timing,age and occupation were the key factors that relate to the peak incidence of scrub typhus.Notably,farmer was the occupation with the highest risk of Ot infection.Further study on the epidemic characteristics,risk factors,diagnosis and treatments of scrub typhus will be of benefit to a comprehensive guideline for prevention and control of this ancient disease. 展开更多
关键词 scrub typhus Orientia tsutsugamushi Epidemic region TREND Clinical study
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基于Scrubbing的空间SRAM型FPGA抗单粒子翻转系统设计 被引量:12
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作者 马寅 安军社 +1 位作者 王连国 孙伟 《空间科学学报》 CAS CSCD 北大核心 2012年第2期270-276,共7页
基于SRAM工艺的FPGA在空间环境下容易受到单粒子翻转(Single Event Upsets,SEU)的影响而导致信息丢失或功能中断.在详细讨论三模冗余(Triple Modular Redundancy,TMR)和刷新(Scrubbing)的重要原理及实现细节的基础上,实现了一种高可靠性... 基于SRAM工艺的FPGA在空间环境下容易受到单粒子翻转(Single Event Upsets,SEU)的影响而导致信息丢失或功能中断.在详细讨论三模冗余(Triple Modular Redundancy,TMR)和刷新(Scrubbing)的重要原理及实现细节的基础上,实现了一种高可靠性、TMR+Scrubbing+Reload的容错系统设计,用反熔丝型FPGA对SRAM型FPGA的配置数据进行毫秒级周期刷新,同时对两个FPGA均做TMR处理.该容错设计已实际应用于航天器电子系统,可为高可靠性电子系统设计提供参考. 展开更多
关键词 单粒子翻转(SEU) 三模冗余(TMR) 刷新(scrubbing) FPGA容错
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Scrub typhus:pathophysiology,clinical manifestations and prognosis 被引量:14
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作者 Senaka Rajapakse Chaturaka Rodrigo Deepika Fernando 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2012年第4期261-264,共4页
Scrub typhus is a zoonosis caused by the pathogen Orientia tsutsugamushi(O.tsvtsugamushi). The disease has significant prevalence in eastern and Southeast Asia.Usually presenting as an acute febrile illness,the diagno... Scrub typhus is a zoonosis caused by the pathogen Orientia tsutsugamushi(O.tsvtsugamushi). The disease has significant prevalence in eastern and Southeast Asia.Usually presenting as an acute febrile illness,the diagnosis is often missed because of similarities with oilier tropical febrile infections.Many unusual manifestations are present,and these are described in this review,together with an outline of current knowledge of pathophysiology.Awareness of these unusual clinical manifestations will help the clinician to arrive at an early diagnosis,resulting in early administration of appropriate antibiotics.Prognostic indicators for severe disease have not yet been clearly established. 展开更多
关键词 scrub TYPHUS Orientia TSUTSUGAMUSHI Clinical MANIFESTATIONS
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Comparison of a rapid diagnostic test and microimmunofluorescence assay for detecting antibody to Orientia tsutsugamushi in scrub typhus patients in China 被引量:2
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作者 Lijuan Zhang Si He +5 位作者 Shiwen Wang Huilan Yu Xuemei Li Derong Zhang Lei Pan Qiang Yu 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2011年第8期666-668,共3页
Objective:To evaluate the detection of IgM and IgG antibodies to Orientia tsutsugamushi(O. tsutsugamushi) by rapid diagnostic test(RDT) and microimmunofluorescence assay(ml FA). Methods:RDT using a mixture of recombin... Objective:To evaluate the detection of IgM and IgG antibodies to Orientia tsutsugamushi(O. tsutsugamushi) by rapid diagnostic test(RDT) and microimmunofluorescence assay(ml FA). Methods:RDT using a mixture of recombinant 56-kDa proteins of O.tsutsugamushi and mIFA assay were performed on 20 patients from Fujian and 13 patients from Yunnan Province,and 82 sera samples from healthy farmers in Anhui Province and Beijing City in 2009.Comparison of the RDT and mIFA assay was performed by using X test and the P level of 【0.05 was considered to be significance.Results:Among these 82 normal sera samples,the specificity of RDT was 100%for both IgM and IgG tests.In 33 samples from patients with scrub typhus,5 cases were positively detected earlier by RDT than by mIFA in IgM test,and 2 cases were positive in IgG test.Sensitivities of RDT were 93.9%and 90.9%for IgM and IgG,respectively.The sensitivity of combination lest of IgM and IgG was 100%.Geometric mean titer diluted sera from confirmed cases by IFA and RDT assay were 1:37 vs.1:113(P【0.001) in IgM test and 1:99 vs.1:279 (P【0.05) in IgG test.Conclusions:RDT is more sensitivite than mIFA in the early diagnosis of scrub typhus and it is particularly applicable in rural areas. 展开更多
关键词 scrub TYPHUS Orientia TSUTSUGAMUSHI Rapid DIAGNOSTIC test Microimmunofluorescence ASSAY
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A PRELIMINARY STUDY ON TRE ZONE OF ALPINE SCRUB AND MEADOW OF QINGHAI-XIZANG (TIBETAN) PLATEAU 被引量:3
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作者 Zheng Du(Institute of Geography, CAS, Beijing 100101People’s Republic of China) 《Journal of Geographical Sciences》 SCIE CSCD 1996年第3期28-38,共11页
The zone of alpine scrub and meadow, characterized by highlandsubpolar humid/subhumid climate, is a transitional area from deep gorges to theplateau proper.The natural zone is unique in physical environments and natur... The zone of alpine scrub and meadow, characterized by highlandsubpolar humid/subhumid climate, is a transitional area from deep gorges to theplateau proper.The natural zone is unique in physical environments and naturalecosystems, and could not be found at the lowlands elsewhere on the earth.Thepredominant type of vegeation is alpine meadow, including Kobresia meadow,herbaceous meadow and swampy meadow. It is an important pasturelands ofanimal husbandry for Tibetan on the plateau. Main vegetion types, animal groups,characteristics of alpine meadow soils, the altitudinal belt and the horizontalzonality of the natural zone, as well as utilization and management of the grasslandsare discussed in the present paper. 展开更多
关键词 natural zone alpine scrub and meadow Qinghai-Xizang Plateau
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Pancreatic abscess following scrub typhus associated with multiorgan failure 被引量:3
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作者 Sun Young Yi Jung Hyun Tae 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第25期3523-3525,共3页
Clinical severity of scrub typhus ranges from mild to fatal. Acute pancreatitis with abscess formation is a rare complication among patients with scrub typhus. This paper reports a case of scrub typhus in a 75 years o... Clinical severity of scrub typhus ranges from mild to fatal. Acute pancreatitis with abscess formation is a rare complication among patients with scrub typhus. This paper reports a case of scrub typhus in a 75 years old man with acute pancreatitis with abscess formation and multiorgan failure. Abdominal computed tomography showed multiple infected pancreatic pseudocysts with periopancreatic infiltration. Multiorgan failure was successfully treated with doxycycline, ceftriaxone, and supportive management. The pancreatic abscess was successfully drained percutaneously and the sizes of pseudocysts decreased remarkably. 展开更多
关键词 scrub typhus PANCREATITIS Pancreaticabscess Multiorgan failure
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Neglected scrub typhus:An updated review with a focus on omics technologies 被引量:3
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作者 Dixit Sharma Ankita Sharma +2 位作者 Birbal Singh Sunil Kumar Shailender Kumar Verma 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2022年第12期531-541,共11页
Scrub typhus is a neglected disease and one of the most serious health problems in the Asia-Pacific region.The disease is caused by an obligate intracellular bacteria Orientia tsutsugamushi,which is transmitted by chi... Scrub typhus is a neglected disease and one of the most serious health problems in the Asia-Pacific region.The disease is caused by an obligate intracellular bacteria Orientia tsutsugamushi,which is transmitted by chigger bites or larval mite bites.Scrub typhus is a threat to billions of people worldwide causing different health complications and acute encephalitis in infants and growing children.The disease causes multiple organ failure and mortality rates may reach up to 70%due to a lack of appropriate healthcare.Currently available genome and proteome databases,and bioinformatics methods are valuable tools to develop novel therapeutics to curb the pathogen.This review discusses the state-of-the-art of information about Orientia tsutsugamushi-mediated scrub typhus and delineates the role of omics technologies to develop drugs against the pathogen.The role of proteome-wide in silico approaches for the identification of therapeutic targets is also highlighted. 展开更多
关键词 Orientia tsutsugamushi scrub typhus Therapeutic targets Omics technologies Drug discovery
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Circulatory and hepatic failure at admission predicts mortality of severe scrub typhus patients: A prospective cohort study 被引量:2
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作者 Ashok Kumar Pannu Atul Saroch +3 位作者 Saurabh Chandrabhan Sharda Manoj Kumar Debnath Manisha Biswal Navneet Sharma 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2021年第5期209-213,共5页
Objective:To study the spectrum and outcome of severe scrub typhus in adult patients and to predict the hospital mortality by organ failure on admission.Methods:This was a prospective observational cohort study conduc... Objective:To study the spectrum and outcome of severe scrub typhus in adult patients and to predict the hospital mortality by organ failure on admission.Methods:This was a prospective observational cohort study conducted between July 2017 and October 2020 at the medical emergency centre of PGIMER,Chandigarh,India.One hundred and twenty-six patients aged≥13 years were diagnosed with scrub typhus.Severe disease was defined as the presence of organ failure based on the Sequential Organ Failure Assessment(SOFA)score on admission.Results:About two-thirds of the patients were from geographic regions outside the endemic sub-Himalayan belt.Fever(99.21%)and dyspnea(79.36%)were the most frequent complaints.Respiratory failure(81.75%)was the most common organ failure,followed by hepatic(52.38%),coagulative(47.62%),circulatory(33.33%),renal(21.43%),and cerebral dysfunction(13.49%).The median(Q1,Q3)SOFA score was 8(6,9),and 48.41%of the patients had a quick-SOFA score≥2.Organ supports with invasive ventilation(40.48%),vasopressors(36.51%),and renal replacement therapy(7.14%)were frequently required.The in-hospital mortality was 11.90% and was independently predicted by circulatory and hepatic failures on multivariate logistic regression(OR 11.12,95%CI 1.73-71.31 and OR 8.49,95%CI 1.18-61.41,respectively).Conclusions:Most patients had pulmonary dysfunction;circulatory or hepatic failure on admission strongly predicts death. 展开更多
关键词 scrub typhus Orientia tsutsugamushi Organ failure MORTALITY PROGNOSIS
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Scrub typhus hepatitis confirmed by immunohistochemical staining 被引量:3
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作者 Jong-Hoon Chung Sung-Chul Lim +3 位作者 Na-Ra Yun Sung-Heui Shin Choon-Mee Kim Dong-Min Kim 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第36期5138-5141,共4页
Scrub typhus is an acute febrile disease caused by Orientia tsutsugamushi (0. tsutsugamushi). We report herein the case of a woman who presented with fever and elevated serum levels of liver enzymes and who was defi... Scrub typhus is an acute febrile disease caused by Orientia tsutsugamushi (0. tsutsugamushi). We report herein the case of a woman who presented with fever and elevated serum levels of liver enzymes and who was definitively diagnosed with scrub typhus by his- topathological examination of liver biopsy specimens, serological tests and nested polymerase chain reaction. Immunohistochemical staining using a monoclonal an- ti-O. tsutsugamushi antibody showed focally scattered positive immunoreactions in the cytoplasm of some hepatocytes. This case suggests that scrub typhus hepatitis causes mild focal inflammation due to direct liver damage without causing piecemeal necrosis or interface hepatitis. Thus, scrub typhus hepatitis differs from acute viral hepatitis secondary to liver damage due to host immune responses, which causes severe Iobular disarray with diffuse hepatocytic degeneration, necrosis and apoptosis as well as findings indicative of hepatic cholestasis, such as hepatic bile plugs or brown pigmentation of hepatocytes. 展开更多
关键词 scrub typhus Immunohistochemistry Ori-entia tsutsugamushi
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Massive small bowel bleeding caused by scrub typhus in Korea 被引量:1
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作者 Ki Beom Bae Won Hwa Youn +2 位作者 Youn Jae Lee Soo Jin Jung Kwan Hee Hong 《World Journal of Gastrointestinal Surgery》 SCIE CAS 2010年第2期47-50,共4页
A 79-year-old man was diagnosed with scrub typhus based on fever,eschar,skin rash and a markedly elevated serum tsutsugamushi antibody and doxycycline was started.Five days later,hematochezia developed and multiple sm... A 79-year-old man was diagnosed with scrub typhus based on fever,eschar,skin rash and a markedly elevated serum tsutsugamushi antibody and doxycycline was started.Five days later,hematochezia developed and multiple small bowel ulcerations with hemorrhage were seen on colonoscopy.Despite intensive therapy,the massive hematochezia worsened and the distal small bowel was resected.Multiple ulcerated lesions were identified pathologically as vasculitis caused by scrub typhus.This is the first reported case of pathologically proven small bowel involvement in scrub typhus infection. 展开更多
关键词 HEMATOCHEZIA SMALL BOWEL BLEEDING scrub TYPHUS Vasculitis Multiple SMALL BOWEL ULCERATIONS
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Orthogonal Test About Biogas Upgrading by Pressured Water Scrubbing 被引量:1
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作者 HUANG Li JIAO Youzhou +1 位作者 LEI Tingzhou ZHANG Quanguo 《Journal of Northeast Agricultural University(English Edition)》 CAS 2010年第4期50-55,共6页
Biogas is a kind of regenerable energy which is inexpensive and friendly to the environment, but the potential ofbiogas is difficult to develop fully in China, for most biogas have badly qualities and the utilization ... Biogas is a kind of regenerable energy which is inexpensive and friendly to the environment, but the potential ofbiogas is difficult to develop fully in China, for most biogas have badly qualities and the utilization of it is monotonous. The suitable operation term about biogas upgrading by pressurized water scrubbing was researched through the orthogonal test in this study. Two sorts of scrubber packing included the random multidimensional hollow sphere packing and the structured screen packing were also used, and the effects of experiment factors included packing, water temperature, gas flow speed, water flow speed and washing pressure were studied. The results showed that better effect was got when the screen structured packing was used; all the five test factors affected the processing significantly in the arrange as before and had better and better significant effects. 展开更多
关键词 BIOGAS UPGRADING pressured water scrubbing orthogonal test
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Qualitative and Quantitative Characterization of Wood Fibers of Shrubs and Tree Species of the Tamaulipan Thorn Scrub, Northeastern Mexico and Its Possible Relation to Wood Quality and Utilization 被引量:1
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作者 Ratikanta Maiti Humberto G. Rodriguez Aruna Kumari 《American Journal of Plant Sciences》 2016年第7期1046-1057,共12页
The present study was undertaken to determine the variability in fiber cell morphology and its length among wood species of the Tamaulipan Thorn Scrub, Northeastern Mexico, used for various uses such as timber for fur... The present study was undertaken to determine the variability in fiber cell morphology and its length among wood species of the Tamaulipan Thorn Scrub, Northeastern Mexico, used for various uses such as timber for furniture, fence, post, firewood and sources of forage. The results reveal large variability in fiber cell morphology and fiber cell dimensions. The species are classified on the basis of its fiber cell morphology and fiber cell length and recommended for their possible utilization for different purposes. Wood having fibre cells with broad lumen and thin wall could be suitable for the manufacture of paper documented in the literature viz. Acacia farnesciana, Caesalpinia mexicana, Cordia boisiieri, Diospyros palmeri, Forestieria angustifolia, Morus celtifolia, Prosopis laevigata. This technique can be used in preliminary screening of woody species for its utilization for different purposes. Further studies are needed to confirm. 展开更多
关键词 Wood Fiber Cells Characterization VARIABILITY Woody Species Wood Quality Tamualipan Thorn scrub
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Spectrum of cardiac manifestations and its relationship to outcomes in patients admitted with scrub typhus infection 被引量:1
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作者 Gunasekaran Karthik Thomas Isaiah Sudarsan +6 位作者 John Victor Peter Thambu Sudarsanam George M Varghese Paul Kundavaram Sowmya Sathyendra Ramya Iyyadurai Kishore Pichamuthu 《World Journal of Critical Care Medicine》 2018年第1期16-23,共8页
AIM To study the spectrum of cardiac manifestations in scrub typhus infection and assess its relationship to outcomes.METHODS Demographic data, electrocardiographic(ECG) changes, left ventricular (LV) systolic and dia... AIM To study the spectrum of cardiac manifestations in scrub typhus infection and assess its relationship to outcomes.METHODS Demographic data, electrocardiographic(ECG) changes, left ventricular (LV) systolic and diastolic function, myocardial injury (defined as troponin T > 14 pg/mL), and pericardial effusion were documented. Myocarditis was diagnosed when myocardial injury was associated with global LV systolic dysfunction. The relationship between myocarditis and outcomes was assessed using logistic regression analysis and expressed as odds ratio(OR) with 95%CI.RESULTS The cohort(n = 81; 35 males) aged 49.4 ± 16.1 years(mean, SD) presented 8.1 ± 3.1 d after symptom onset. The APACHE-Ⅱ score was 15.7 ± 7.0. Fortyeight (59%) patients were ventilated, and 46 (56%) required vasoactive agents. Mortality was 9.9%. ECG changes were non-specific; sinus tachycardia was the most common finding. Myocardial injury was evident in 61.7% of patients and LV systolic dysfunction in 30.9%. A diagnosis of myocarditis was made in 12.3%. In addition, seven patients with regional wall motion abnormalities had LV systolic dysfunction and elevated cardiac enzymes. Mild diastolic dysfunction was observed in 18 (22%) patients. Mild to moderate pericardial effusion was seen in 51%. On multivariate logistic regression analysis, patients with myocarditis tended to be older (OR = 1.04, 95%CI: 0.99-1.09), had shorter symptom duration (OR = 0.69, 95%CI: 0.49-0.98), and tended to stay longer in hospital(OR = 1.17, 95%CI: 0.98-1.40). Myocarditis was not associated with increased mortality.CONCLUSION In scrub typhus infection, cardiac manifestations are frequent and associated with increased morbidity but not mortality. 展开更多
关键词 scrub TYPHUS MYOCARDITIS OUTCOME
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Manifestation of acute peritonitis and pneumonedema in scrub typhus without eschar:A case report
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作者 Xiu-Ling Zhou Qing-Long Ye +2 位作者 Jia-Qian Chen Wei Li Hao-Jian Dong 《World Journal of Clinical Cases》 SCIE 2021年第23期6900-6906,共7页
BACKGROUND Scrub typhus is an acute infectious disease caused by rickettsia infection.The diagnosis is based on eschar,and clinical manifestations can range from asymptomatic to multiorgan dysfunction.CASE SUMMARY We ... BACKGROUND Scrub typhus is an acute infectious disease caused by rickettsia infection.The diagnosis is based on eschar,and clinical manifestations can range from asymptomatic to multiorgan dysfunction.CASE SUMMARY We report the case of a 35-year-old man living in Zhuhai,Guangdong,China,who had repeated high fever with a maximum body temperature of 40.2°C and elevated white blood cells and procalcitonin levels.After 7 d of persistent high fever,the patient developed rash,abdominal pain,and symptoms of peritonitis.Within 24 h after admission,the patient developed diffuse peritonitis and pneumonedema,requiring ventilator support in the intensive care unit.However,there was no eschar on the body,and the first Weil-Felix test was negative.Taking into account that the patient had a history of jungle activities,doxycycline combined with meropenem was selected.The patient improved,healed,and was discharged after a week.The diagnosis of scrub typhus was confirmed by a repeat Weil-Felix test(Oxk 1:640),and pathology of the appendix resected by laparotomy suggests vasculitis.CONCLUSION This rare presentation of peritonitis,pulmonary edema,and pancreatitis caused by scrub typhus reminds physicians to be alert to the possibility of scrub typhus. 展开更多
关键词 scrub typhus PERITONITIS Pneumonedema Pancreatitis MYOCARDITIS VASCULITIS Case report
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