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Recent developments of fluorescence imaging technology in the second near-infrared window
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作者 Shu-Tong Wu Lin Chen +6 位作者 Wei-Wei Kang Qin Liu Meng-Ting Gao Dong-Sheng Li Yao Li Rong Dai Zi-Liang Zheng 《Biomedical Engineering Communications》 2022年第1期8-23,共16页
Background:Fluorescence bio-imaging in the second near-infrared window(NIR-II FL,1000-1700nm)has great potential in clinical theranostics,which is of great importance providing precise locations of lesions and molecul... Background:Fluorescence bio-imaging in the second near-infrared window(NIR-II FL,1000-1700nm)has great potential in clinical theranostics,which is of great importance providing precise locations of lesions and molecular dynamic actions simultaneously in a single nanoprobe.Methods:T here has been an upsurge of multidisciplinary research focusing on developing functional types of inorganic and organic nanoprobes that can be used for NIR-II FL with the high spatiotemporal resolution,deep tissue penetration,and negligible auto-fluorescence.Results:In this mini-review,we summarize recent progress in inorganic/organic NIR-II FL nanoprobes.We introduce the design and properties of inorganic and organic nanoprobes,in the order of single-walled carbon nanotubes,quantum dots,rare-earth-doped nanoparticles,metal nanoclusters and organic fluorophores,expect to realize precise diagnosis and efficient image-guided therapy.Conclusion:Meanwhile,to elucidate the problems and perspectives,we aim to offer diverse biological applications of inorganic/organic NIR-II FL nanoprobes and accelerate the clinical transformation progress. 展开更多
关键词 second near-infrared biowindow NIR-II fluorescence bio-imaging organic nanoprobes inorganic nanoprobes imaging performance
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Tunable femtosecond near-infrared source based on a Yb:LYSO-laser-pumped optical parametric oscillator 被引量:2
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作者 田文龙 王兆华 +1 位作者 朱江峰 魏志义 《Chinese Physics B》 SCIE EI CAS CSCD 2016年第1期616-619,共4页
We demonstrate a widely tunable near-infrared source from 767 nm to 874 nm generated by the intracavity second harmonic generation (SHG) in an optical parametric oscillator pumped by a Yb:LYSO solid-state laser. Th... We demonstrate a widely tunable near-infrared source from 767 nm to 874 nm generated by the intracavity second harmonic generation (SHG) in an optical parametric oscillator pumped by a Yb:LYSO solid-state laser. The home-made Yb:LYSO oscillator centered at 1035 nm delivers an average power of 2 W and a pulse duration as short as 351 fs. TWo MgO doped periodically poled lithium niobates (MgO:PPLN) with grating periods of 28.5-31.5 μm in steps of 0.5 μm and 19.5-21.3μm in steps of 0.2 μm are used for the OPO and intracavity SHG, respectively. The maximum average output power of 180 mW at 798 nm was obtained and the output pulses have pulse duration of 313 fs at 792 nm if a sech2-pulse shape was assumed. In addition, tunable signal femtosecond pulses from 1428 nm to 1763 nm are also realized with the maximum average power of 355 mW at 1628 nm. 展开更多
关键词 femtosecond optical parametric oscillator intracavity second harmonic generation periodically-poled lithium niobate Yb:LYSO solid-state laser
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Functional near-infrared spectroscopy in non-invasive neuromodulation 被引量:3
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作者 Congcong Huo Gongcheng Xu +6 位作者 Hui Xie Tiandi Chen Guangjian Shao Jue Wang Wenhao Li Daifa Wang Zengyong Li 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第7期1517-1522,共6页
Non-invasive cerebral neuromodulation technologies are essential for the reorganization of cerebral neural networks,which have been widely applied in the field of central neurological diseases,such as stroke,Parkinson... Non-invasive cerebral neuromodulation technologies are essential for the reorganization of cerebral neural networks,which have been widely applied in the field of central neurological diseases,such as stroke,Parkinson’s disease,and mental disorders.Although significant advances have been made in neuromodulation technologies,the identification of optimal neurostimulation paramete rs including the co rtical target,duration,and inhibition or excitation pattern is still limited due to the lack of guidance for neural circuits.Moreove r,the neural mechanism unde rlying neuromodulation for improved behavioral performance remains poorly understood.Recently,advancements in neuroimaging have provided insight into neuromodulation techniques.Functional near-infrared spectroscopy,as a novel non-invasive optical brain imaging method,can detect brain activity by measuring cerebral hemodynamics with the advantages of portability,high motion tole rance,and anti-electromagnetic interference.Coupling functional near-infra red spectroscopy with neuromodulation technologies offe rs an opportunity to monitor the cortical response,provide realtime feedbac k,and establish a closed-loop strategy integrating evaluation,feedbac k,and intervention for neurostimulation,which provides a theoretical basis for development of individualized precise neuro rehabilitation.We aimed to summarize the advantages of functional near-infra red spectroscopy and provide an ove rview of the current research on functional near-infrared spectroscopy in transcranial magnetic stimulation,transcranial electrical stimulation,neurofeedback,and braincomputer interfaces.Furthermore,the future perspectives and directions for the application of functional near-infrared spectroscopy in neuromodulation are summarized.In conclusion,functional near-infrared spectroscopy combined with neuromodulation may promote the optimization of central pellral reorganization to achieve better functional recovery form central nervous system diseases. 展开更多
关键词 brain-computer interface cerebral neural networks functional near-infrared spectroscopy neural circuit NEUROFEEDBACK neurological diseases NEUROMODULATION non-invasive brain stimulation transcranial electrical stimulation transcranial electrical stimulation
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Near-infrared spectroscopy in schizophrenia:A bibliometric perspective
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作者 Xin-Xing Fei Shi-Qi Wang +4 位作者 Ji-Yang Li Zhang-Yu Xu Jian-Xiong Wang Ya-Qian Gao Yue Hu 《World Journal of Psychiatry》 SCIE 2024年第11期1755-1765,共11页
BACKGROUND Compared with current methods used to assess schizophrenia,near-infrared spectroscopy(NIRS)has the advantages of providing noninvasive and real-time monitoring of functional activities of the brain and prov... BACKGROUND Compared with current methods used to assess schizophrenia,near-infrared spectroscopy(NIRS)has the advantages of providing noninvasive and real-time monitoring of functional activities of the brain and providing direct and objective assessment information.AIM To explore the research field of NIRS in schizophrenia from the perspective of bibliometrics.METHODS The Web of Science Core Collection was used as the search tool,and the last search date was April 21,2024.Bibliometric indicators,such as the numbers of publications and citations,were recorded.Bibliometrix and VOS viewer were used for visualization analysis.RESULTS A total of 355 articles from 105 journals were included in the analysis.The overall trend of the number of research publications increased.Schizophrenia Research was identified as an influential journal in the field.Kasai K was one of the most influential and productive authors in this area of research.The University of Tokyo and Japan had the highest scientific output for an institution and a country,respectively.The top ten keywords were“schizophrenia”,“activation”,“near-infrared spectroscopy”,“verbal fluency task”,“cortex”,“brain,performance”,“workingmemory”,“brain activation”,and“prefrontal cortex”.CONCLUSION Our study reveals the evolution of knowledge and emerging trends in the field of NIRS in schizophrenia.the research focus is shifting from underlying disease characteristics to more in-depth studies of brain function and physiological mechanisms. 展开更多
关键词 near-infrared spectroscopy SCHIZOPHRENIA BIBLIOMETRICS Bibliometrix VOS viewer
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A highly sensitive ratiometric near-infrared nanosensor based on erbium-hyperdoped silicon quantum dots for iron(Ⅲ) detection
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作者 Kun Wang Wenxuan Lai +2 位作者 Zhenyi Ni Deren Yang Xiaodong Pi 《Journal of Semiconductors》 EI CAS CSCD 2024年第8期49-58,共10页
Ratiometric fluorescent detection of iron(Ⅲ)(Fe^(3+))offers inherent self-calibration and contactless analytic capabilities.However,realizing a dual-emission near-infrared(NIR)nanosensor with a low limit of detection... Ratiometric fluorescent detection of iron(Ⅲ)(Fe^(3+))offers inherent self-calibration and contactless analytic capabilities.However,realizing a dual-emission near-infrared(NIR)nanosensor with a low limit of detection(LOD)is rather challenging.In this work,we report the synthesis of water-dispersible erbium-hyperdoped silicon quantum dots(Si QDs:Er),which emit NIR light at the wavelengths of 810 and 1540 nm.A dual-emission NIR nanosensor based on water-dispersible Si QDs:Er enables ratiometric Fe^(3+)detection with a very low LOD(0.06μM).The effects of pH,recyclability,and the interplay between static and dynamic quenching mechanisms for Fe^(3+)detection have been systematically studied.In addition,we demonstrate that the nanosensor may be used to construct a sequential logic circuit with memory functions. 展开更多
关键词 erbium-hyperdoped silicon quantum dots dual-emission near-infrared nanosensor Fe^(3+)detection sequential logic circuit
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Cortical activity in patients with high-functioning ischemic stroke during the Purdue Pegboard Test:insights into bimanual coordinated fine motor skills with functional near-infrared spectroscopy
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作者 Siyun Chen Mengchai Mao +4 位作者 Guangyue Zhu Yufeng Chen Yuqi Qiu Bin Ye Dongsheng Xu 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第5期1098-1104,共7页
After stroke,even high-functioning individuals may experience compromised bimanual coordination and fine motor dexterity,leading to reduced functional independence.Bilateral arm training has been proposed as a promisi... After stroke,even high-functioning individuals may experience compromised bimanual coordination and fine motor dexterity,leading to reduced functional independence.Bilateral arm training has been proposed as a promising intervention to address these deficits.However,the neural basis of the impairment of functional fine motor skills and their relationship to bimanual coordination performance in stroke patients remains unclear,limiting the development of more targeted interventions.To address this gap,our study employed functional near-infrared spectroscopy to investigate cortical responses in patients after stroke as they perform functional tasks that engage fine motor control and coordination.Twenty-four high-functioning patients with ischemic stroke(7 women,17 men;mean age 64.75±10.84 years)participated in this cross-sectional observational study and completed four subtasks from the Purdue Pegboard Test,which measures unimanual and bimanual finger and hand dexterity.We found significant bilateral activation of the sensorimotor cortices during all Purdue Pegboard Test subtasks,with bimanual tasks inducing higher cortical activation than the assembly subtask.Importantly,patients with better bimanual coordination exhibited lower cortical activation during the other three Purdue Pegboard Test subtasks.Notably,the observed neural response patterns varied depending on the specific subtask.In the unaffected hand task,the differences were primarily observed in the ipsilesional hemisphere.In contrast,the bilateral sensorimotor cortices and the contralesional hemisphere played a more prominent role in the bimanual task and assembly task,respectively.While significant correlations were found between cortical activation and unimanual tasks,no significant correlations were observed with bimanual tasks.This study provides insights into the neural basis of bimanual coordination and fine motor skills in high-functioning patients after stroke,highlighting task-dependent neural responses.The findings also suggest that patients who exhibit better bimanual performance demonstrate more efficient cortical activation.Therefore,incorporating bilateral arm training in post-stroke rehabilitation is important for better outcomes.The combination of functional near-infrared spectroscopy with functional motor paradigms is valuable for assessing skills and developing targeted interventions in stroke rehabilitation. 展开更多
关键词 bilateral arm training bimanual coordination cortical activity fine motor dexterity functional near-infrared spectroscopy(fNIRS) high-functioning Purdue Pegboard Test stroke
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Rapid Determination of Hemicellulose Content in Corn Stalks by Near-infrared Spectroscopy Based on Dung Beetle Optimizer
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作者 Baihong TONG Jinming LIU Jianfei SHI 《Agricultural Biotechnology》 2024年第5期83-85,92,共4页
Corn stalks are a kind of common organic fertilizer and feed material in agriculture in China,as well as an important source of modern biomass energy and new materials.Hemicellulose is an important component in corn s... Corn stalks are a kind of common organic fertilizer and feed material in agriculture in China,as well as an important source of modern biomass energy and new materials.Hemicellulose is an important component in corn stalks,and it is very important to determine its content in corn stalks.In this paper,the feasibility of near-infrared spectroscopy(NIRS)combined with chemometrics for rapid detection of hemicellulose content in corn stalks was studied.In order to improve the accuracy of NIRS detection,a new intelligent optimization algorithm,dung beetle optimizer(DBO),was applied to select characteristic wavelengths of NIRS.Its modeling performance was compared with that based on characteristic wavelength selection using genetic algorithm(GA)and binary particle swarm optimization(BPSO),and it was found that the characteristic wavelength selection performance of DBO was excellent,and the regression accuracy of hemicellulose quantitative detection model established by its preferred characteristic wavelengths was better than the above two intelligent optimization algorithms. 展开更多
关键词 HEMICELLULOSE near-infrared spectrum Characteristic wavelength selection Intelligent optimization algorithm Dung beetle algorithm
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Near-infrared cholangiography with intragallbladder indocyanine green injection in minimally invasive cholecystectomy
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作者 Savvas Symeonidis Ioannis Mantzoros +9 位作者 Elissavet Anestiadou Orestis Ioannidis Panagiotis Christidis Stefanos Bitsianis Vasiliki Bisbinas Konstantinos Zapsalis Trigona Karastergiou Dimitra Athanasiou Stylianos Apostolidis Stamatios Angelopoulos 《World Journal of Gastrointestinal Surgery》 SCIE 2024年第4期1017-1029,共13页
Laparoscopic cholecystectomy(LC)remains one of the most commonly performed procedures in adult and paediatric populations.Despite the advances made in intraoperative biliary anatomy recognition,iatrogenic bile duct in... Laparoscopic cholecystectomy(LC)remains one of the most commonly performed procedures in adult and paediatric populations.Despite the advances made in intraoperative biliary anatomy recognition,iatrogenic bile duct injuries during LC represent a fatal complication and consist an economic burden for healthcare systems.A series of methods have been proposed to prevent bile duct injury,among them the use of indocyanine green(ICG)fluorescence.The most commonly reported method of ICG injection is the intravenous administration,while literature is lacking studies investigating the direct intragallbladder ICG injection.This narrative mini-review aims to assess the potential applications,usefulness,and limitations of intragallbladder ICG fluorescence in LC.Authors screened the available international literature to identify the reports of intragallbladder ICG fluorescence imaging in minimally invasive cholecystectomy,as well as special issues regarding its use.Literature search retrieved four prospective cohort studies,three case-control studies,and one case report.In the three case-control studies selected,intragallbladder near-infrared cholangiography(NIRC)was compared with standard LC under white light,with intravenous administration of ICG for NIRC and with standard intraoperative cholangiography(IOC).In total,133 patients reported in the literature have been administered intragallbladder ICG administration for biliary mapping during LC.Literature includes several reports of intragallbladder ICG administration,but a standardized technique has not been established yet.Published data suggest that NIRC with intragallbladder ICG injection is a promising method to achieve biliary mapping,overwhelming limitations of IOC including intervention and radiation exposure,as well as the high hepatic parenchyma signal and time interval needed in intravenous ICG fluorescence.Evidence-based guidelines on the role of intragallbladder ICG fluorescence in LC require the assessment of further studies and multicenter data collection into large registries. 展开更多
关键词 Minimally invasive cholecystectomy Laparoscopic cholecystectomy Biliary tract mapping Indocyanine green near-infrared fluorescent cholangiography Intracystic indocyanine green Intragallbladder indocyanine green Bile duct injury
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Rational Design and Application of an Indolium-Derived Heptamethine Cyanine with Record-Long Second Near-Infrared Emission 被引量:3
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作者 Xiaoxie Ma Yurou Huang +9 位作者 Syed Ali Abbas Abedi Heejeong Kim Tan Teck Boon Davin Xiaogang Liu Wen-Chao Yang Yao Sun Sheng Hua Liu Jun Yin Juyoung Yoon Guang-Fu Yang 《CCS Chemistry》 CAS 2022年第6期1961-1976,共16页
Heptamethine cyanine dyes,typified by indocyanine green,have been extensively employed as bioimaging indicators and theranostic agents.Significant efforts have been made to develop functional heptamethine cyanine dyes... Heptamethine cyanine dyes,typified by indocyanine green,have been extensively employed as bioimaging indicators and theranostic agents.Significant efforts have been made to develop functional heptamethine cyanine dyes with outstanding bioimaging and theranostic utilities.In this work,we rationally designed and successfully developed a novel indolium-like heptamethine cyanine dye by installing indolium-derived polycyclic aromatic hydrocarbons on the terminal ends of a conjugated polyene backbone.This dye showed excellent photostability and showed bright fluorescent emission in the second near-infrared(NIR-Ⅱ)window with a peak at approximately 1120 nm.Such long wavelength emission prompted a superior bioimaging resolution in vivo.In particular,this NIR-Ⅱ dye had the remarkable capability of marking the blood vessels of the hindlimbs,abdomens,and brains of mice.More significantly,this dye involved a typical indolium-like heptamethine skeleton and exhibited two strong absorption bands in the 700–1300 nm NIR range,which endowed it with an intrinsic tumor-targeting capability and a high photothermal conversion efficiency(up to 68.2%),serving for the photothermal therapy of tumors under the guidance of NIR-Ⅱ fluorescence imaging.This work provides an efficient design strategy for achieving indolium-like heptamethine cyanine dyes with further NIR-Ⅱ emission. 展开更多
关键词 fluorescent probe heptamethine cyanine second near-infrared emission molecular design biological application
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Fusing Thienoisoindigo to the Conjugated Ribbons with Strong Absorption in the Second Near-Infrared Window 被引量:1
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作者 Yu Jiang Yaogang Zhang +7 位作者 Yunfeng Deng Shaoqiang Dong Bo Li Yuanping Yi Zebing Zeng Hanjiao Chen Hao Luo Yanhou Geng 《CCS Chemistry》 CAS 2022年第11期3497-3504,共8页
Organic dyes with strong absorption in the second near-infrared(NIR-II)window(1000-1700 nm)have multiple applications.However,the design and synthesis of stable NIR-II absorbing organic dyes are very challenging and c... Organic dyes with strong absorption in the second near-infrared(NIR-II)window(1000-1700 nm)have multiple applications.However,the design and synthesis of stable NIR-II absorbing organic dyes are very challenging and constantly defy our synthetic ability.In this work,we have successfully synthesized a series of soluble and stable fused thienoisoindigo(nThIID)ribbons.The absorption maximum(λ_(max))of the ribbons increases from 644 nm of 1ThIID to 1252 nm of 6ThIID.Importantly,nThIIDs with n≥4 all display strong absorption in the NIR-II window with molar extinction coefficients(ε_(max))greater than 105 L mol^(−1)cm^(−1)atλmax.These molecules are promising photothermal conversion dyes with photothermal conversion efficiencies of ca.60%under 1064 nm laser irradiation. 展开更多
关键词 organic dyes second near-infrared window low bandgap thienoisoindigo conjugated molecules
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Integrating the second near-infrared fluorescence imaging with clinical techniques for multimodal cancer imaging by neodymiumdoped gadolinium tungstate nanoparticles
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作者 Xujiang Yu Aodenggerile +4 位作者 Zhao Jiang Jianliang Shen Zhiqiang Yan Wanwan Li Huibin Qiu 《Nano Research》 SCIE EI CSCD 2021年第7期2160-2170,共11页
Second near-infrared(NIR-II)fluorescence imaging is a recently emerged technique and is highly useful for accurate diagnosis of cancer.Although a diverse array of fluorescent nanomaterials have been developed to enabl... Second near-infrared(NIR-II)fluorescence imaging is a recently emerged technique and is highly useful for accurate diagnosis of cancer.Although a diverse array of fluorescent nanomaterials have been developed to enable NIR-II fluorescence in various situations,they normally fail to unify the clinical techniques,such as computed tomography(CT)and magnetic resonance imaging(MRI).Therefore,exploiting multimodal agents to integrate the newly emerged NIR-II fluorescence and traditional clinical techniques would be of key significance.Here,we report a rational fabrication of neodymium(Nd)-doped gadolinium tungstate nanoparticles(NPs)that are subsequentially decorated with a hydrophilic layer and demonstrate that they can achieve the harmonious integration of NIR-II fluorescence imaging,CT,and MRI.The NIR-II fluorescence emission was activated by an incident light with discrete wavelength ranging from 250 to 810 nm.NIR-II fluorescence-CT-MRI associated trimodal imaging was subsequently demonstrated for breast cancer by an 808 nm laser,along with the estimation of NIR-II fluorescence imaging for cervical cancer.The integration of newly emerged and traditional clinical imaging techniques highlights the huge potential of rare-earth-doped NPs for multimodal imaging of different types of cancer. 展开更多
关键词 rare-earth-doped nanoparticles(NPs) second near-infrared fluorescence multimodal imaging cancer
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Second Near-Infrared Photothermal Therapy with Superior Penetrability through Skin Tissues
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作者 Yanji Chu Shenglong Liao +5 位作者 Hongguang Liao Yang Lu Xiaodong Geng Di Wu Jian Pei Yapei Wang 《CCS Chemistry》 CAS 2022年第9期3002-3013,共12页
Photothermal therapy(PTT)triggered by second near-infrared(NIR-II)light(1000–1400 nm)has shown great potential in tumor ablation because of its good tissue penetrability.However,NIR-II PTT still cannot treat tumors u... Photothermal therapy(PTT)triggered by second near-infrared(NIR-II)light(1000–1400 nm)has shown great potential in tumor ablation because of its good tissue penetrability.However,NIR-II PTT still cannot treat tumors underneath skin because of the light scattering effect of skin components.This research aims to promote the NIR-II penetrability of skin tissue by weakening the light scattering effect from the refractive index inhomogeneity among skin constituents. 展开更多
关键词 second near-infrared light photothermal therapy conjugated polymers tissue penetration light scattering
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Second near-infrared window persistent luminescence nanomaterials for in vivo bioimaging
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作者 Yuliang Zhao 《Science China Chemistry》 SCIE EI CSCD 2021年第9期1439-1440,共2页
Optical imaging in the second near-infrared(NIR-II,1,000-1,700 nm)window with much reduced tissue scattering plays a crucial role in life sciences due to its high sensitivity and high spatio-temporal resolutions^([1])... Optical imaging in the second near-infrared(NIR-II,1,000-1,700 nm)window with much reduced tissue scattering plays a crucial role in life sciences due to its high sensitivity and high spatio-temporal resolutions^([1]).Therefore,researchers are committed to developing various types of NIR-II fluorescent probes,such as organic dyes. 展开更多
关键词 second near-infrared window persistent luminescence nanomaterials for in vivo bioimaging
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Biological imaging without autofluorescence in the second near-infrared region 被引量:14
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作者 Shuo Diao Guosong Hong +4 位作者 Alexander L. Antaris Jeffrey L. Blackbum Kai Cheng Zhen Cheng Hongjie Dai 《Nano Research》 SCIE EI CAS CSCD 2015年第9期3027-3034,共8页
Fluorescence imaging is capable of acquiring anatomical and functional infor- mation with high spatial and temporal resolution. This imaging technique has been indispensable in biological research and disease detectio... Fluorescence imaging is capable of acquiring anatomical and functional infor- mation with high spatial and temporal resolution. This imaging technique has been indispensable in biological research and disease detection/diagnosis. Imaging in the visible and to a lesser degree, in the near-infrared (NIR) regions below 900 nm, suffers from autofluorescence arising from endogenous fluorescent molecules in biological tissues. This autofluorescence interferes with fluorescent molecules of interest, causing a high background and low detection sensitivity. Here, we report that fluorescence imaging in the 1,500-1,700-nm region (termed "NIR-IIb") under 808-nm excitation results in nearly zero tissue autofluorescence, allowing for background-free imaging of fluorescent species in otherwise notoriously autofluorescent biological tissues, including liver. Imaging of the intrinsic fluorescence of individual fluorophores, such as a single carbon nanotube, can be readily achieved with high sensitivity and without autofluorescence background in mouse liver within the 1,500-1,700-nm wavelength region. 展开更多
关键词 FLUORESCENCE imaging second near-infrared nanotechnology AUTOFLUORESCENCE
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Near-infrared spectroscopy method for rapid proximate quantitative analysis of nutrient composition in Pacific oyster Crassostrea gigas 被引量:1
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作者 Zhe LI Haigang QI +4 位作者 Ying YU Cong LIU Rihao CONG Li LI Guofan ZHANG 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2023年第1期342-351,共10页
Glycogen,amino acids,fatty acids,and other nutrient components affect the flavor and nutritional quality of oysters.Methods based on near-infrared reflectance spectroscopy(NIRS)were developed to rapidly and proximatel... Glycogen,amino acids,fatty acids,and other nutrient components affect the flavor and nutritional quality of oysters.Methods based on near-infrared reflectance spectroscopy(NIRS)were developed to rapidly and proximately determine the nutrient content of the Pacific oyster Crassostreagigas.Samples of C.gigas from 19 costal sites were freeze-dried,ground,and scanned for spectral data collection using a Fourier transform NIR spectrometer(Thermo Fisher Scientific).NIRS models of glycogen and other nutrients were established using partial least squares,multiplication scattering correction first-order derivation,and Norris smoothing.The R_(C) values of the glycogen,fatty acids,amino acids,and taurine NIRS models were 0.9678,0.9312,0.9132,and 0.8928,respectively,and the residual prediction deviation(RPD)values of these components were 3.15,2.16,3.11,and 1.59,respectively,indicating a high correlation between the predicted and observed values,and that the models can be used in practice.The models were used to evaluate the nutrient compositions of 1278 oyster samples.Glycogen content was found to be positively correlated with fatty acids and negatively correlated with amino acids.The glycogen,amino acid,and taurine levels of C.gigas cultured in the subtidal and intertidal zones were also significantly different.This study suggests that C.gigas NIRS models can be a cost-effective alternative to traditional methods for the rapid and proximate analysis of various slaughter traits and may also contribute to future genetic and breeding-related studies in Pacific oysters. 展开更多
关键词 Pacific oyster Crassostrea gigas near-infrared reflectance spectroscopy(NIRS) nutrient composition rapid determination
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pH-sensitive and biodegradable charge-transfer nanocomplex for second near-infrared photoacoustic tumor imaging 被引量:3
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作者 Zhimin Wang Paul Kumar Upputuri +11 位作者 Xu Zhen Ruochong Zhang Yuyan Jiang Xiangzhao Ai Zhijun Zhang Ming Hu Zhenyu Meng Yunpeng Lu Yuanjing Zheng Kanyi Pu Manojit Pramanik Bengang Xing 《Nano Research》 SCIE EI CAS CSCD 2019年第1期49-55,共7页
The emerging technique of photoacoustic imaging,especially in the near infra-red(NIR)window,permits high resolution,deep-penetration,clinically reliable sensing.However,few contrast agents are available that can speci... The emerging technique of photoacoustic imaging,especially in the near infra-red(NIR)window,permits high resolution,deep-penetration,clinically reliable sensing.However,few contrast agents are available that can specifically respond to intricate biological environments,and which are biodegradable and biocompatible.Herein,we in troduce a new class of pH-sensitive orga nic photoacoustic con trast age nt that operates in the second NIR window(NIR-II,960-1,700 nm),which is derived from the self-assembled charge-transfer nanocomplex(CTN)by 3,3',5,5'-tetramethylbenzidine(TMB)and its dication structure(TMB++).The unique NIR-ll-responsive CTN can specifically respond to pH change in the physiological range and allows noninvasive and sensitive visualization of the tumor acidic microenvironment(e.g.at pH5)in mice with higher signal-to-noise ratio.The CTN is biodegradable under physiological conditions(e.g.pH 7.4),which alleviates the biosafety concern of nan oparticle accumulati on in vivo.These results clearly show the pote ntial of the TMB/TMB++-based CTN as a promisi ng pH-activated and biodegradable molecular probe for specific tumor photoacoustic imaging in the NIR-II region. 展开更多
关键词 CHARGE-TRANSFER nanocomplex second near-infrared window PHOTOACOUSTIC imaging PH-SENSITIVE BIODEGRADABLE tumor acidic microenvironment
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基于Tv-SECOND的自动驾驶场景下的3D目标检测
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作者 魏海跃 杨奎河 毕江峰 《无线电通信技术》 北大核心 2024年第4期823-830,共8页
针对自动驾驶场景中复杂环境下的3D目标检测任务,特别是远距离和遮挡条件下,为提高模型的检测准确率,在SECOND的基础上提出了Tv-SECOND两阶段算法。该算法提出一种基于Transformer架构的提案框特征提取模块,并在传统体素特征编码基础上... 针对自动驾驶场景中复杂环境下的3D目标检测任务,特别是远距离和遮挡条件下,为提高模型的检测准确率,在SECOND的基础上提出了Tv-SECOND两阶段算法。该算法提出一种基于Transformer架构的提案框特征提取模块,并在传统体素特征编码基础上提出可变形的体素特征编码模块。在KITTI数据集上进行测试,结果显示,所提出的算法相比SECOND在远距离和遮挡严重的情况下分别提高了7.49%、9.72%。同时与其他先进的两阶段方法相比,检测精度有不同程度的提升,证明了Tv-SECOND算法的有效性。新算法能够建立特征之间的依赖关系,聚合周边广域的上下文信息,增强模型的学习推理能力,有效提升了模型在远距离和遮挡的情况下的检测性能。 展开更多
关键词 自动驾驶 3D目标检测 TRANSFORMER second
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Single ultrasmall Mn2+-doped NaNdF4 nanocrystals as multimodal nanoprobes for magnetic resonance and second near-infrared fluorescence imaging 被引量:3
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《Nano Research》 SCIE EI CAS CSCD 2018年第2期1069-1081,共13页
Multimodal imaging probes have attracted wide attention and have potential to diagnose diseases accurately because of the complementary advantages of multiple imaging modalities. However, intractable issues remain wit... Multimodal imaging probes have attracted wide attention and have potential to diagnose diseases accurately because of the complementary advantages of multiple imaging modalities. However, intractable issues remain with regard to their complicated multi-step fabrication for hybrid nanostructure and interference of different modal imaging. In the present stud we present, for the first time, T1 and T2-weighted magnetic resonance imaging (MRI) of ultrasmaU Mn2+-doped NaNdF4 nanocrystals (NCs), which can also be used simultaneously for second near infrared (NIR-U) fluorescence and computed tomography (CT) imaging, thus enabling high-performance multimodal MRI/NIR-II/CT imaging of single NaNdF4:Mn NCs. The NaNdF4:Mn was demonstrated as a nanoprobe for in vitro and in vivo multimodal MRI and NIR-II fluorescence imaging of human mesenchymal stem cells. The results provide a new strategy to simplify the nanostructure and preparation of probes, based on the features of NaNdF4:Mn NCs, which offer highly efficient multimodal MRI/NIR-II/CT imaging. 展开更多
关键词 NaNdF4:Mn ultrasmall nanoprobe magnetic resonanceimaging (MRI) second near infrared(NIR-II) fluorescence multimodal imaging
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