<i><span style="font-family:Verdana;">Annona</span></i><span style="font-family:""> <i><span style="font-family:Verdana;">muricata</span&...<i><span style="font-family:Verdana;">Annona</span></i><span style="font-family:""> <i><span style="font-family:Verdana;">muricata</span></i><span style="font-family:Verdana;"> L. (Soursop or Graviola) is a naturally occurring plant seen in Southern part of Africa, traditionally used in Benin to treat various diseases. The present study aimed to investigate phytochemical composition and antioxidant, anti-inflammatory activities of </span><i><span style="font-family:Verdana;">A</span></i><span style="font-family:Verdana;">. </span><i><span style="font-family:Verdana;">muricata</span></i><span style="font-family:Verdana;"> leaves extracts. The secondary metabolites of ethanolic and hemi-ethanolic extracts were analysed by HPLC method. The DPPH and FRAP methods were used to evaluate the antioxidant activity. Inhibition of albumin denaturation method was used to evaluate anti-inflammatory activity of the tested extracts of which larval cytotoxicity was st</span><span><span style="font-family:Verdana;">udied. The major identified compounds were gallic acid, chlorogenic acid, cafeic acid, tannic acid, ferrulic acid, Rutin. Ascorbic acid exhibited the highest inhibition percentage (83.33% ± 0.50%) of DPPH radical with the lowest IC</span><sub><span style="font-family:Verdana;">50</span></sub><span style="font-family:Verdana;"> (45.1 ± 0.28 μg/ml). The inhibition of the ferric ion Fe</span><sup><span style="font-family:Verdana;">3+</span></sup><span style="font-family:Verdana;"> varied (</span><i><span style="font-family:Verdana;">p</span></i><span style="font-family:Verdana;"> = 0.0013) according to the extracts type. IC</span><sub><span style="font-family:Verdana;">50</span></sub><span style="font-family:Verdana;"> values of ferric ion inhibition range from 119.5 ± 3.10 to 250.8 ± 2.13 μg/ml respectively for </span><i><span style="font-family:Verdana;">A</span></i><span style="font-family:Verdana;">. </span><i><span style="font-family:Verdana;">muricata</span></i><span style="font-family:Verdana;"> leaves ethanol and hemi-ethanolic extracts. The hemi-ethanolic extract exhibited the highest anti-inflammatory activity (96.66% </span></span><span style="font-family:Verdana;">± 1.17%). The presence of phenolic compound confers to </span><i><span style="font-family:Verdana;">A</span></i><span style="font-family:Verdana;">. </span><i><span style="font-family:Verdana;">muricata</span></i><span style="font-family:Verdana;"> leaves, through the ethanolic and the hemi-ethanolic extracts, the antioxidant and anti-inflammatory activities.展开更多
文摘<i><span style="font-family:Verdana;">Annona</span></i><span style="font-family:""> <i><span style="font-family:Verdana;">muricata</span></i><span style="font-family:Verdana;"> L. (Soursop or Graviola) is a naturally occurring plant seen in Southern part of Africa, traditionally used in Benin to treat various diseases. The present study aimed to investigate phytochemical composition and antioxidant, anti-inflammatory activities of </span><i><span style="font-family:Verdana;">A</span></i><span style="font-family:Verdana;">. </span><i><span style="font-family:Verdana;">muricata</span></i><span style="font-family:Verdana;"> leaves extracts. The secondary metabolites of ethanolic and hemi-ethanolic extracts were analysed by HPLC method. The DPPH and FRAP methods were used to evaluate the antioxidant activity. Inhibition of albumin denaturation method was used to evaluate anti-inflammatory activity of the tested extracts of which larval cytotoxicity was st</span><span><span style="font-family:Verdana;">udied. The major identified compounds were gallic acid, chlorogenic acid, cafeic acid, tannic acid, ferrulic acid, Rutin. Ascorbic acid exhibited the highest inhibition percentage (83.33% ± 0.50%) of DPPH radical with the lowest IC</span><sub><span style="font-family:Verdana;">50</span></sub><span style="font-family:Verdana;"> (45.1 ± 0.28 μg/ml). The inhibition of the ferric ion Fe</span><sup><span style="font-family:Verdana;">3+</span></sup><span style="font-family:Verdana;"> varied (</span><i><span style="font-family:Verdana;">p</span></i><span style="font-family:Verdana;"> = 0.0013) according to the extracts type. IC</span><sub><span style="font-family:Verdana;">50</span></sub><span style="font-family:Verdana;"> values of ferric ion inhibition range from 119.5 ± 3.10 to 250.8 ± 2.13 μg/ml respectively for </span><i><span style="font-family:Verdana;">A</span></i><span style="font-family:Verdana;">. </span><i><span style="font-family:Verdana;">muricata</span></i><span style="font-family:Verdana;"> leaves ethanol and hemi-ethanolic extracts. The hemi-ethanolic extract exhibited the highest anti-inflammatory activity (96.66% </span></span><span style="font-family:Verdana;">± 1.17%). The presence of phenolic compound confers to </span><i><span style="font-family:Verdana;">A</span></i><span style="font-family:Verdana;">. </span><i><span style="font-family:Verdana;">muricata</span></i><span style="font-family:Verdana;"> leaves, through the ethanolic and the hemi-ethanolic extracts, the antioxidant and anti-inflammatory activities.
