AIM：To detect the impact of insulin-like growth factor-1（IGF-1）and other risk factors for the early prediction of retinopathy of prematurity（ROP）and to establish a scoring system for ROP prediction by using clini...AIM：To detect the impact of insulin-like growth factor-1（IGF-1）and other risk factors for the early prediction of retinopathy of prematurity（ROP）and to establish a scoring system for ROP prediction by using clinical criteria and serum IGF-1 levels.METHODS：The study was conducted with 127 preterm infants.IGF-1 levels in the 1st day of life,1st,2nd,3rd and4th week of life was analyzed.The score was established after logistic regression analysis,considering the impact of each variable on the occurrences of any stage ROP.A validation cohort containing 107 preterm infants was included in the study and the predictive ability of ROP score was calculated.RESULTS：Birth weights（BW）,gestational weeks（GW）and the prevalence of breast milk consumption were lower,respiratory distress syndrome（RDS）,bronchopulmonarydysplasia（BPD）and necrotizing enterocolitis（NEC）were more frequent,the duration of mechanical ventilation and oxygen supplementation was longer in patients with ROP（P〈0.05）.Initial serum IGF-1 levels tended to be lower in newborns who developed ROP.Logistic regression analysis revealed that low BW（〈1250 g）,presence of intraventricular hemorrhage（IVH）and formula feeding increased the risk of ROP.Afterwards,the scoring system was validated on 107 infants.The negative predictive values of a score less than 4 were 84.3%,74.7%and 79.8%while positive predictive values were 76.3%,65.5%and71.6%respectively.CONCLUSION：In addition to BW〈1250 g and IVH,formula consumption was detected as a risk factor for the development of ROP.Breastfeeding is important for prevention of ROP in preterm infants.展开更多
OBJECTIVE: To study the value of serum insulin-like growth factor binding protein-3 (IGFBP-3) levels in differential diagnosis of growth hormone deficiency (GHD). METHODS: To measure serum IGFBP-3 levels by RIA in nor...OBJECTIVE: To study the value of serum insulin-like growth factor binding protein-3 (IGFBP-3) levels in differential diagnosis of growth hormone deficiency (GHD). METHODS: To measure serum IGFBP-3 levels by RIA in normal children and adolescents, GHD children and short-stature children without GHD. RESULTS: Serum level of IGFBP-3 in 129 children with untreated GHD and with no pubertal development was 1.6 +/- 0.9 mg/L, which was less than that in normal group of the same age, but overlapped with the normal children in Tanner stage I. After six-month treatment with recombinant human growth hormone (rhGH), serum level of IGFBP-3 in 59 GHD significantly increased from 1.3 +/- 0.7 mg/L to 2.7 +/- 0.9 mg/L, accompanied by an increase of body heights, growth velocities and serum level of IGF-1. Serum level of IGFBP-3 in 55 short-stature children without GHD was 3.3 +/- 2.2 mg/L, which was not significantly different from that in normal group. CONCLUSION: Serum IGFBP-3 level can reflect the status of GH secretion in children with GHD and is a useful marker for differential diagnosis of GHD.展开更多
目的进行维生素D联合门冬胰岛素对妊娠期糖尿病患者血清指标及分娩结局影响分析。方法选取医院2019年8月—2020年7月收治的妊娠期糖尿病患者86例,按照随机法分为两组,对照组43例患者采用门冬胰岛素治疗,观察组43例患者采用门冬胰岛素联...目的进行维生素D联合门冬胰岛素对妊娠期糖尿病患者血清指标及分娩结局影响分析。方法选取医院2019年8月—2020年7月收治的妊娠期糖尿病患者86例,按照随机法分为两组,对照组43例患者采用门冬胰岛素治疗,观察组43例患者采用门冬胰岛素联合维生素D治疗。根据Toll样受体4(TLR4)、血管细胞黏附分子1(VCAM-1)对比两组治疗前后血清指标。根据空腹血糖(FPG)、餐后2 h血糖(2 h PG)及糖化血红蛋白(HbA1c)水平对比两组治疗前后血糖水平。根据巨大儿、呼吸窘迫、黄疸及早产儿发生率对比两组患者妊娠结局。结果治疗前两组患者TLR4、VCAM-1水平的差异无统计学意义(P>0.05),治疗后观察组TLR4、VCAM-1水平显著降低对照组,组间差异有统计学意义(P<0.05)。治疗前两组FPG、2 h PG及HbA1c等水平的差异无统计学意义(P>0.05),治疗后观察组FPG、2 h PG及HbA1c等水平均优于对照组,组间差异有统计学意义(P<0.05)。观察组不良妊娠结局总发生率均低于对照组,组间差异有统计学意义(P<0.05)。结论采用维生素D联合门冬胰岛素对妊娠期糖尿病患者治疗,显著降低患者各项血清指标及血糖水平,改善患者妊娠结局。展开更多
文摘AIM：To detect the impact of insulin-like growth factor-1（IGF-1）and other risk factors for the early prediction of retinopathy of prematurity（ROP）and to establish a scoring system for ROP prediction by using clinical criteria and serum IGF-1 levels.METHODS：The study was conducted with 127 preterm infants.IGF-1 levels in the 1st day of life,1st,2nd,3rd and4th week of life was analyzed.The score was established after logistic regression analysis,considering the impact of each variable on the occurrences of any stage ROP.A validation cohort containing 107 preterm infants was included in the study and the predictive ability of ROP score was calculated.RESULTS：Birth weights（BW）,gestational weeks（GW）and the prevalence of breast milk consumption were lower,respiratory distress syndrome（RDS）,bronchopulmonarydysplasia（BPD）and necrotizing enterocolitis（NEC）were more frequent,the duration of mechanical ventilation and oxygen supplementation was longer in patients with ROP（P〈0.05）.Initial serum IGF-1 levels tended to be lower in newborns who developed ROP.Logistic regression analysis revealed that low BW（〈1250 g）,presence of intraventricular hemorrhage（IVH）and formula feeding increased the risk of ROP.Afterwards,the scoring system was validated on 107 infants.The negative predictive values of a score less than 4 were 84.3%,74.7%and 79.8%while positive predictive values were 76.3%,65.5%and71.6%respectively.CONCLUSION：In addition to BW〈1250 g and IVH,formula consumption was detected as a risk factor for the development of ROP.Breastfeeding is important for prevention of ROP in preterm infants.
文摘OBJECTIVE: To study the value of serum insulin-like growth factor binding protein-3 (IGFBP-3) levels in differential diagnosis of growth hormone deficiency (GHD). METHODS: To measure serum IGFBP-3 levels by RIA in normal children and adolescents, GHD children and short-stature children without GHD. RESULTS: Serum level of IGFBP-3 in 129 children with untreated GHD and with no pubertal development was 1.6 +/- 0.9 mg/L, which was less than that in normal group of the same age, but overlapped with the normal children in Tanner stage I. After six-month treatment with recombinant human growth hormone (rhGH), serum level of IGFBP-3 in 59 GHD significantly increased from 1.3 +/- 0.7 mg/L to 2.7 +/- 0.9 mg/L, accompanied by an increase of body heights, growth velocities and serum level of IGF-1. Serum level of IGFBP-3 in 55 short-stature children without GHD was 3.3 +/- 2.2 mg/L, which was not significantly different from that in normal group. CONCLUSION: Serum IGFBP-3 level can reflect the status of GH secretion in children with GHD and is a useful marker for differential diagnosis of GHD.
文摘目的进行维生素D联合门冬胰岛素对妊娠期糖尿病患者血清指标及分娩结局影响分析。方法选取医院2019年8月—2020年7月收治的妊娠期糖尿病患者86例,按照随机法分为两组,对照组43例患者采用门冬胰岛素治疗,观察组43例患者采用门冬胰岛素联合维生素D治疗。根据Toll样受体4(TLR4)、血管细胞黏附分子1(VCAM-1)对比两组治疗前后血清指标。根据空腹血糖(FPG)、餐后2 h血糖(2 h PG)及糖化血红蛋白(HbA1c)水平对比两组治疗前后血糖水平。根据巨大儿、呼吸窘迫、黄疸及早产儿发生率对比两组患者妊娠结局。结果治疗前两组患者TLR4、VCAM-1水平的差异无统计学意义(P>0.05),治疗后观察组TLR4、VCAM-1水平显著降低对照组,组间差异有统计学意义(P<0.05)。治疗前两组FPG、2 h PG及HbA1c等水平的差异无统计学意义(P>0.05),治疗后观察组FPG、2 h PG及HbA1c等水平均优于对照组,组间差异有统计学意义(P<0.05)。观察组不良妊娠结局总发生率均低于对照组,组间差异有统计学意义(P<0.05)。结论采用维生素D联合门冬胰岛素对妊娠期糖尿病患者治疗,显著降低患者各项血清指标及血糖水平,改善患者妊娠结局。
