A new method of prefetching data blocks from the NVCache to the page cache in main memory and cascading prefetching n-blocks from a hard disk to the NVCache together was proposed to reduce the spin-up frequency of a h...A new method of prefetching data blocks from the NVCache to the page cache in main memory and cascading prefetching n-blocks from a hard disk to the NVCache together was proposed to reduce the spin-up frequency of a hybrid hard disk drive and thus enhance I/O performance.The proposed method consists of three steps:1) Analyzing the pattern of read requests in block units;2) Determining the number of blocks prefetched to the NVCache;3) Replacing blocks in the NVCache according to the block replacement policy.The proposed method can reduce the latency time of a hybrid hard disk and optimize the power consumption of an IPTV set-top box.Experimental results show that the proposed method provides better average response time compared to an existing adaptive multistream prefetching(AMP) method by 25.17%.It also reduces by 20.83% the average power consumption over that of the existing external caching in energy saving storage system(EXCES) method.展开更多
Digital broadcasting is a novel paradigm for the next generation broadcasting. Its goal is to provide not only better quality of pictures but also a variety of services that is impossible in traditional airwaves broad...Digital broadcasting is a novel paradigm for the next generation broadcasting. Its goal is to provide not only better quality of pictures but also a variety of services that is impossible in traditional airwaves broadcasting. One of the important factors for this new broadcasting environment is the interoperability among broadcasting applications since the environment is distributed. Therefore the broadcasting metadata becomes increasingly important and one of the metadata standards for a digital broadcasting is TV-Anytime metadata. TV-Anytime metadata is defined using XML schema, so its instances are XML data. In order to fulfill interoperability, a standard query language is also required and XQuery is a natural choice. There are some researches for dealing with broadcasting metadata. In our previous study, we have proposed the method for efficiently managing the broadcasting metadata in a service provider. However, the environment of a Set-Top Box for digital broadcasting is limited such as low-cost and low-setting. Therefore there are some considerations to apply general approaches for managing the metadata into the Set-Top Box. This paper proposes a method for efficiently managing the broadcasting metadata based on the Set-Top Box and a prototype of metadata management system for evaluating our method. Our system consists of a storage engine to store the metadata and an XQuery engine to search the stored metadata and uses special index for storing and searching. Our two engines are designed independently with hardware platform therefore these engines can be used in any low-cost applications to manage broadcasting metadata.展开更多
消费性电子产品(Consumer Electronics)近来比信息科技产业更引人注目，因为尽管经济景气自2001年起就逐步下滑，消费性电子产品市场仍持续地成长。今日，数字电视(DTV)已成为快速兴起的消费性电子产品之一。我们能利用它的平台功能发...消费性电子产品(Consumer Electronics)近来比信息科技产业更引人注目，因为尽管经济景气自2001年起就逐步下滑，消费性电子产品市场仍持续地成长。今日，数字电视(DTV)已成为快速兴起的消费性电子产品之一。我们能利用它的平台功能发展家庭多媒体平台(multimedia home platform；MHP)，提供个人计算机(PC)之外，另一个能与因特网连接(Internet)的管道，让我们拥有更丰富的多媒体生活。这也意味着庞大的商机。由于DTV接收数据的方式和机上盒(STB)相似，我们可藉由研究STB的架构来了解DTV。展开更多
BACKGROUND Diabetic intracerebral hemorrhage(ICH)is a serious complication of diabetes.The role and mechanism of bone marrow mesenchymal stem cell(BMSC)-derived exosomes(BMSC-exo)in neuroinflammation post-ICH in patie...BACKGROUND Diabetic intracerebral hemorrhage(ICH)is a serious complication of diabetes.The role and mechanism of bone marrow mesenchymal stem cell(BMSC)-derived exosomes(BMSC-exo)in neuroinflammation post-ICH in patients with diabetes are unknown.In this study,we investigated the regulation of BMSC-exo on hyperglycemia-induced neuroinflammation.AIM To study the mechanism of BMSC-exo on nerve function damage after diabetes complicated with cerebral hemorrhage.METHODS BMSC-exo were isolated from mouse BMSC media.This was followed by transfection with microRNA-129-5p(miR-129-5p).BMSC-exo or miR-129-5poverexpressing BMSC-exo were intravitreally injected into a diabetes mouse model with ICH for in vivo analyses and were cocultured with high glucoseaffected BV2 cells for in vitro analyses.The dual luciferase test and RNA immunoprecipitation test verified the targeted binding relationship between miR-129-5p and high-mobility group box 1(HMGB1).Quantitative polymerase chain reaction,western blotting,and enzyme-linked immunosorbent assay were conducted to assess the levels of some inflammation factors,such as HMGB1,interleukin 6,interleukin 1β,toll-like receptor 4,and tumor necrosis factorα.Brain water content,neural function deficit score,and Evans blue were used to measure the neural function of mice.RESULTS Our findings indicated that BMSC-exo can promote neuroinflammation and functional recovery.MicroRNA chip analysis of BMSC-exo identified miR-129-5p as the specific microRNA with a protective role in neuroinflammation.Overexpression of miR-129-5p in BMSC-exo reduced the inflammatory response and neurological impairment in comorbid diabetes and ICH cases.Furthermore,we found that miR-129-5p had a targeted binding relationship with HMGB1 mRNA.CONCLUSION We demonstrated that BMSC-exo can reduce the inflammatory response after ICH with diabetes,thereby improving the neurological function of the brain.展开更多
MADS-box转录因子广泛存在于植物中,在生长发育和次生代谢过程中发挥重要作用。为探究MADS-box转录因子家族在辣椒素不同积累时期的表达情况。利用辣椒素不同积累时期转录组数据,鉴定辣椒MADS-box转录因子家族成员,并进行亚细胞定位、...MADS-box转录因子广泛存在于植物中,在生长发育和次生代谢过程中发挥重要作用。为探究MADS-box转录因子家族在辣椒素不同积累时期的表达情况。利用辣椒素不同积累时期转录组数据,鉴定辣椒MADS-box转录因子家族成员,并进行亚细胞定位、保守基序、系统进化树和染色体定位分析,对其功能进行初步分析。结果表明,在辣椒转录组数据中共鉴定出95个MADS-box转录因子;含有105~395个氨基酸;分子质量为11.55~44.46 ku;理论等电点为5.16~10.01;主要在细胞核表达,均含有MADS保守结构域,系统发育分析表明,MADS蛋白可分为8个亚家族。有73条CaMADS家族成员定位到12条染色体上。差异表达的MADS-box基因有26个,其中6个基因在C1 vs C2时期上调,在C2 vs C3时期下调。基于KEGG富集和蛋白互作预测到CaMADS13可能参与辣椒中木质素的合成。CaMADS24可能参与辣椒素和木质素合成前体香豆酰辅酶A的合成。利用生物信息学分析,鉴定了辣椒MADS-box家族转录因子,为深入研究辣椒素次生代谢中的分子调控机制提供理论基础。展开更多
基金supported in part by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2011-0004114)in part by the Ministry of Knowledge Economy (MKE) and Korea Institute for Advancement in Technology (KIAT) through the Workforce Development Program in Strategic Technology in part by the MKE (The Ministry of Knowledge Economy), Korea, under the CITRC (Convergence Information Technology Research Center) support program (NIPA-2012-C6150-1201-0001) supervised by the NIPA (National IT Industry Promotion Agency)
文摘A new method of prefetching data blocks from the NVCache to the page cache in main memory and cascading prefetching n-blocks from a hard disk to the NVCache together was proposed to reduce the spin-up frequency of a hybrid hard disk drive and thus enhance I/O performance.The proposed method consists of three steps:1) Analyzing the pattern of read requests in block units;2) Determining the number of blocks prefetched to the NVCache;3) Replacing blocks in the NVCache according to the block replacement policy.The proposed method can reduce the latency time of a hybrid hard disk and optimize the power consumption of an IPTV set-top box.Experimental results show that the proposed method provides better average response time compared to an existing adaptive multistream prefetching(AMP) method by 25.17%.It also reduces by 20.83% the average power consumption over that of the existing external caching in energy saving storage system(EXCES) method.
文摘Digital broadcasting is a novel paradigm for the next generation broadcasting. Its goal is to provide not only better quality of pictures but also a variety of services that is impossible in traditional airwaves broadcasting. One of the important factors for this new broadcasting environment is the interoperability among broadcasting applications since the environment is distributed. Therefore the broadcasting metadata becomes increasingly important and one of the metadata standards for a digital broadcasting is TV-Anytime metadata. TV-Anytime metadata is defined using XML schema, so its instances are XML data. In order to fulfill interoperability, a standard query language is also required and XQuery is a natural choice. There are some researches for dealing with broadcasting metadata. In our previous study, we have proposed the method for efficiently managing the broadcasting metadata in a service provider. However, the environment of a Set-Top Box for digital broadcasting is limited such as low-cost and low-setting. Therefore there are some considerations to apply general approaches for managing the metadata into the Set-Top Box. This paper proposes a method for efficiently managing the broadcasting metadata based on the Set-Top Box and a prototype of metadata management system for evaluating our method. Our system consists of a storage engine to store the metadata and an XQuery engine to search the stored metadata and uses special index for storing and searching. Our two engines are designed independently with hardware platform therefore these engines can be used in any low-cost applications to manage broadcasting metadata.
文摘消费性电子产品(Consumer Electronics)近来比信息科技产业更引人注目，因为尽管经济景气自2001年起就逐步下滑，消费性电子产品市场仍持续地成长。今日，数字电视(DTV)已成为快速兴起的消费性电子产品之一。我们能利用它的平台功能发展家庭多媒体平台(multimedia home platform；MHP)，提供个人计算机(PC)之外，另一个能与因特网连接(Internet)的管道，让我们拥有更丰富的多媒体生活。这也意味着庞大的商机。由于DTV接收数据的方式和机上盒(STB)相似，我们可藉由研究STB的架构来了解DTV。
基金Supported by the National Natural Science Foundation of China,No.81900743Heilongjiang Province Outstanding Young Medical Talents Training Grant Project,China,No.HYD2020YQ0007.
文摘BACKGROUND Diabetic intracerebral hemorrhage(ICH)is a serious complication of diabetes.The role and mechanism of bone marrow mesenchymal stem cell(BMSC)-derived exosomes(BMSC-exo)in neuroinflammation post-ICH in patients with diabetes are unknown.In this study,we investigated the regulation of BMSC-exo on hyperglycemia-induced neuroinflammation.AIM To study the mechanism of BMSC-exo on nerve function damage after diabetes complicated with cerebral hemorrhage.METHODS BMSC-exo were isolated from mouse BMSC media.This was followed by transfection with microRNA-129-5p(miR-129-5p).BMSC-exo or miR-129-5poverexpressing BMSC-exo were intravitreally injected into a diabetes mouse model with ICH for in vivo analyses and were cocultured with high glucoseaffected BV2 cells for in vitro analyses.The dual luciferase test and RNA immunoprecipitation test verified the targeted binding relationship between miR-129-5p and high-mobility group box 1(HMGB1).Quantitative polymerase chain reaction,western blotting,and enzyme-linked immunosorbent assay were conducted to assess the levels of some inflammation factors,such as HMGB1,interleukin 6,interleukin 1β,toll-like receptor 4,and tumor necrosis factorα.Brain water content,neural function deficit score,and Evans blue were used to measure the neural function of mice.RESULTS Our findings indicated that BMSC-exo can promote neuroinflammation and functional recovery.MicroRNA chip analysis of BMSC-exo identified miR-129-5p as the specific microRNA with a protective role in neuroinflammation.Overexpression of miR-129-5p in BMSC-exo reduced the inflammatory response and neurological impairment in comorbid diabetes and ICH cases.Furthermore,we found that miR-129-5p had a targeted binding relationship with HMGB1 mRNA.CONCLUSION We demonstrated that BMSC-exo can reduce the inflammatory response after ICH with diabetes,thereby improving the neurological function of the brain.
文摘MADS-box转录因子广泛存在于植物中,在生长发育和次生代谢过程中发挥重要作用。为探究MADS-box转录因子家族在辣椒素不同积累时期的表达情况。利用辣椒素不同积累时期转录组数据,鉴定辣椒MADS-box转录因子家族成员,并进行亚细胞定位、保守基序、系统进化树和染色体定位分析,对其功能进行初步分析。结果表明,在辣椒转录组数据中共鉴定出95个MADS-box转录因子;含有105~395个氨基酸;分子质量为11.55~44.46 ku;理论等电点为5.16~10.01;主要在细胞核表达,均含有MADS保守结构域,系统发育分析表明,MADS蛋白可分为8个亚家族。有73条CaMADS家族成员定位到12条染色体上。差异表达的MADS-box基因有26个,其中6个基因在C1 vs C2时期上调,在C2 vs C3时期下调。基于KEGG富集和蛋白互作预测到CaMADS13可能参与辣椒中木质素的合成。CaMADS24可能参与辣椒素和木质素合成前体香豆酰辅酶A的合成。利用生物信息学分析,鉴定了辣椒MADS-box家族转录因子,为深入研究辣椒素次生代谢中的分子调控机制提供理论基础。
