The origin of 5-HMF (5-hydroxymethyl-2-furaldehyde) in a Shengmaiyin decoction was investigated by the RP-HPLC method below. A C18 column (250 mm×4.6 mm, i.d. 5 μm) with a column temperature of 25 °C was us...The origin of 5-HMF (5-hydroxymethyl-2-furaldehyde) in a Shengmaiyin decoction was investigated by the RP-HPLC method below. A C18 column (250 mm×4.6 mm, i.d. 5 μm) with a column temperature of 25 °C was used. The mobile phase was a mixture of ultra-pure water-acetonitrile (95:5, V/V) and the flow rate was 1.0 ml/min. The detection wavelength was 280 nm. The injection volume was 1 μl and the running time was about 20 min. The addition of Schisandra was regulated to assess the contribution of an acid environment to the production of 5-HMF. In order to confirm the role of saccharides in the production of 5-HMF, different amount of fructose was used. The 5-HMF level in decoctions of processed and unprocessed Schisandra was investigated in order to determine the origin of 5-HMF. The results showed that 5-HMF was derived mainly from the decoction of Schisandra only and not the mixed decoction of Ophionpogon and Schisandra. The appearance of 5-HMF is not simply the result of the decomposition of saccharides under the acid environment created by Schisandra, but the processing procedure plays an important role in the production of 5-HMF.展开更多
目的观察生脉饮联合辅酶Q10片治疗心律失常的临床疗效。方法将120例心律失常患者随机分为观察组和对照组,各60例。对照组采用常规治疗加用生脉饮注射液20 m L+5%葡萄糖注射液200 m L,每日1次,静脉滴注;观察组在对照组基础上加用辅酶Q10...目的观察生脉饮联合辅酶Q10片治疗心律失常的临床疗效。方法将120例心律失常患者随机分为观察组和对照组,各60例。对照组采用常规治疗加用生脉饮注射液20 m L+5%葡萄糖注射液200 m L,每日1次,静脉滴注;观察组在对照组基础上加用辅酶Q10片口服,每次20 mg,每日3次。两组均持续治疗60 d。观察两组患者的临床疗效、室性早搏及房性早搏次数、不良反应发生情况。结果观察组总有效率为93.33%,显著高于对照组的88.33%(P<0.05);室性早搏及房性早搏次数两组均有显著改善(P<0.05),且治疗组改善效果更佳(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论生脉饮联合辅酶Q10片治疗心律失常疗效好,值得临床推广。展开更多
基金Project (No. 2004CCA05500) supported by the Ministry of Science and Technology, China
文摘The origin of 5-HMF (5-hydroxymethyl-2-furaldehyde) in a Shengmaiyin decoction was investigated by the RP-HPLC method below. A C18 column (250 mm×4.6 mm, i.d. 5 μm) with a column temperature of 25 °C was used. The mobile phase was a mixture of ultra-pure water-acetonitrile (95:5, V/V) and the flow rate was 1.0 ml/min. The detection wavelength was 280 nm. The injection volume was 1 μl and the running time was about 20 min. The addition of Schisandra was regulated to assess the contribution of an acid environment to the production of 5-HMF. In order to confirm the role of saccharides in the production of 5-HMF, different amount of fructose was used. The 5-HMF level in decoctions of processed and unprocessed Schisandra was investigated in order to determine the origin of 5-HMF. The results showed that 5-HMF was derived mainly from the decoction of Schisandra only and not the mixed decoction of Ophionpogon and Schisandra. The appearance of 5-HMF is not simply the result of the decomposition of saccharides under the acid environment created by Schisandra, but the processing procedure plays an important role in the production of 5-HMF.
文摘目的观察生脉饮联合辅酶Q10片治疗心律失常的临床疗效。方法将120例心律失常患者随机分为观察组和对照组,各60例。对照组采用常规治疗加用生脉饮注射液20 m L+5%葡萄糖注射液200 m L,每日1次,静脉滴注;观察组在对照组基础上加用辅酶Q10片口服,每次20 mg,每日3次。两组均持续治疗60 d。观察两组患者的临床疗效、室性早搏及房性早搏次数、不良反应发生情况。结果观察组总有效率为93.33%,显著高于对照组的88.33%(P<0.05);室性早搏及房性早搏次数两组均有显著改善(P<0.05),且治疗组改善效果更佳(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论生脉饮联合辅酶Q10片治疗心律失常疗效好,值得临床推广。
