目的 本研究旨在分析瘢痕子宫再次妊娠时血栓弹力图(thromboelasmography,TEG)及红细胞分布宽度变异系数(red blood cell distribution width coefficient of variation,RDW-CV)、中性粒细胞/淋巴细胞比值(neutrophil to lymphocyte rat...目的 本研究旨在分析瘢痕子宫再次妊娠时血栓弹力图(thromboelasmography,TEG)及红细胞分布宽度变异系数(red blood cell distribution width coefficient of variation,RDW-CV)、中性粒细胞/淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)、单核细胞/淋巴细胞比值(monocyte lymphocyte ratio,MLR)以及全身免疫炎症指数(systemic immune-inflammation index,SII)等指标的变化情况,探讨凝血相关指标及炎症相关指标对瘢痕子宫再次妊娠风险预测价值。方法 回顾2021年3月1日至2024年3月1日在延安市人民医院产科住院的孕妇临床资料168例。比较瘢痕子宫不同妊娠阶段TEG及RDW-CV、NLR、MLR、SII等炎症指标的变化;比较瘢痕子宫孕妇与健康孕妇TEG及RDW-CV、NLR、MLR、SII等炎症指标的变化情况。结果 瘢痕子宫孕妇中,与中孕组相比,晚孕组孕妇TEG中的R值增加,Angle角、MA值减少(均P<0.05);NLR、MLR增高(P<0.05)。瘢痕子宫孕妇与健康孕妇相比,瘢痕子宫TEG中的R值、K值、Angle角、MA值的差异无统计学意义(均P>0.05);NLR、MLR差异有统计学意义(P<0.05)。结论 瘢痕子宫再次妊娠对TEG及部分炎症指标有影响,随着孕周数增加TEG指标与炎症指标有所变化;TEG及炎症指标联合检测可对瘢痕子宫再次妊娠风险作出预测。展开更多
Paraneoplastic neurological syndrome refers to certain malignant tumors that have affected the distant nervous system and caused corresponding dysfunction in the absence of tumor metastasis.Patients with this syndrome...Paraneoplastic neurological syndrome refers to certain malignant tumors that have affected the distant nervous system and caused corresponding dysfunction in the absence of tumor metastasis.Patients with this syndrome produce multiple antibodies,each targeting a different antigen and causing different symptoms and signs.The CV2/collapsin response mediator protein 5(CRMP5)antibody is a major antibody of this type.It damages the nervous system,which often manifests as limbic encephalitis,chorea,ocular manifestation,cerebellar ataxia,myelopathy,and peripheral neuropathy.Detecting CV2/CRMP5 antibody is crucial for the clinical diagnosis of paraneoplastic neurological syndrome,and anti-tumor and immunological therapies can help to alleviate symptoms and improve prognosis.However,because of the low incidence of this disease,few repo rts and no reviews have been published about it so far.This article intends to review the research on CV2/CRMP5antibody-associated paraneoplastic neurological syndrome and summarize its clinical features to help clinicians comprehensively understand the disease.Additionally,this review discusses the curre nt challenges that this disease poses,and the application prospects of new detection and diagnostic techniques in the field of paraneoplastic neurological syndrom e,including CV2/CRMP5-associated paraneoplastic neurological syndrome,in recent years.展开更多
[Objectives]To optimize the solid-state fermentation process of Flos Sophorae Immaturus by Penicillium with Sophora japonica cv.jinhuai as raw material.[Methods]The fermentation conditions were optimized by single fac...[Objectives]To optimize the solid-state fermentation process of Flos Sophorae Immaturus by Penicillium with Sophora japonica cv.jinhuai as raw material.[Methods]The fermentation conditions were optimized by single factor experiment and response surface methodology with quercetin content as the dependent variable.[Results]According to the established model,the optimal fermentation process of Flos Sophorae Immaturus was obtained as follows:temperature 29.97℃,time 6.88 d,rotation speed 180.86 rpm,inoculation amount 3.93 mL,and the expected content of quercetin was 34.8053 mg/g.Based on this,the fermentation parameters were adjusted,and the actual content was 33.67 mg/g,which was close to the predicted value.[Conclusions]The optimization of fermentation process of Flos Sophorae Immaturus by response surface methodology provides a reference for the development and utilization of this medicinal material.展开更多
目的探究有腹部手术史病人应用安全性关键视角(critical view of safety,CVS)技术理念行急诊腹腔镜胆囊切除术(LC)的应用价值。方法回顾性分析既往有腹部手术史接受急诊LC手术患者48例,依据患者手术是否施行CVS理念将患者分为CVS组和非...目的探究有腹部手术史病人应用安全性关键视角(critical view of safety,CVS)技术理念行急诊腹腔镜胆囊切除术(LC)的应用价值。方法回顾性分析既往有腹部手术史接受急诊LC手术患者48例,依据患者手术是否施行CVS理念将患者分为CVS组和非CVS组。其中CVS组28例,非CVS组20例,分析患者手术时间、术中出血量、术中胆管损伤、临近脏器损伤、胃肠功能恢复时间、总住院时间、术后腹腔引流量、术后拔管时间、总住院费用、术后出血、术后胆漏发生率等情况。结果所有患者均顺利完成手术,两组患者术中出血量、术后胃肠功能恢复时间、术后出血、总住院费用、总住院时间等无明显差异;CVS组手术时间稍长于非CVS组,而术后腹腔引流量、术后拔管时间CVS组显著低于非CVS组,差异有统计学意义(P<0.05);此外,CVS组发生胆管损伤、临近脏器损伤、术后胆漏等并发症发生率显著低于非CVS组,差异有统计学意义(P<0.05)。结论CVS技术理念的应用可有效提高有腹部手术史患者LC手术的安全性,尤其对于急诊手术患者,可显著降低术后并发症发生率,该理念的应用有助于促进患者康复、提高手术安全性。展开更多
基金National Natural Science Foundation of China,No.U1604181Henan Province Key R&D and Promotion Special Project (Science and Technology Tackle),No.212102310834+1 种基金Henan Medical Education Research Project,No.Wjlx2020531the Joint project of Medical Science and Technology Research Program of Henan Province,No.LHGJ20190078 (all to JW)。
文摘Paraneoplastic neurological syndrome refers to certain malignant tumors that have affected the distant nervous system and caused corresponding dysfunction in the absence of tumor metastasis.Patients with this syndrome produce multiple antibodies,each targeting a different antigen and causing different symptoms and signs.The CV2/collapsin response mediator protein 5(CRMP5)antibody is a major antibody of this type.It damages the nervous system,which often manifests as limbic encephalitis,chorea,ocular manifestation,cerebellar ataxia,myelopathy,and peripheral neuropathy.Detecting CV2/CRMP5 antibody is crucial for the clinical diagnosis of paraneoplastic neurological syndrome,and anti-tumor and immunological therapies can help to alleviate symptoms and improve prognosis.However,because of the low incidence of this disease,few repo rts and no reviews have been published about it so far.This article intends to review the research on CV2/CRMP5antibody-associated paraneoplastic neurological syndrome and summarize its clinical features to help clinicians comprehensively understand the disease.Additionally,this review discusses the curre nt challenges that this disease poses,and the application prospects of new detection and diagnostic techniques in the field of paraneoplastic neurological syndrom e,including CV2/CRMP5-associated paraneoplastic neurological syndrome,in recent years.
基金Supported by Guilin Scientific Research and Technology Development Program(20210202-1,2020011203-1,2020011203-2)Open Project of Guangxi Key Laboratory of Cancer Immunology and Microenvironment Regulation(2022KF005)+1 种基金Guangxi Science and Technology Major Project(Guike AA22096020)Fund for Central Guiding Local Science and Technology Development(ZY20230102).
文摘[Objectives]To optimize the solid-state fermentation process of Flos Sophorae Immaturus by Penicillium with Sophora japonica cv.jinhuai as raw material.[Methods]The fermentation conditions were optimized by single factor experiment and response surface methodology with quercetin content as the dependent variable.[Results]According to the established model,the optimal fermentation process of Flos Sophorae Immaturus was obtained as follows:temperature 29.97℃,time 6.88 d,rotation speed 180.86 rpm,inoculation amount 3.93 mL,and the expected content of quercetin was 34.8053 mg/g.Based on this,the fermentation parameters were adjusted,and the actual content was 33.67 mg/g,which was close to the predicted value.[Conclusions]The optimization of fermentation process of Flos Sophorae Immaturus by response surface methodology provides a reference for the development and utilization of this medicinal material.
文摘目的探究有腹部手术史病人应用安全性关键视角(critical view of safety,CVS)技术理念行急诊腹腔镜胆囊切除术(LC)的应用价值。方法回顾性分析既往有腹部手术史接受急诊LC手术患者48例,依据患者手术是否施行CVS理念将患者分为CVS组和非CVS组。其中CVS组28例,非CVS组20例,分析患者手术时间、术中出血量、术中胆管损伤、临近脏器损伤、胃肠功能恢复时间、总住院时间、术后腹腔引流量、术后拔管时间、总住院费用、术后出血、术后胆漏发生率等情况。结果所有患者均顺利完成手术,两组患者术中出血量、术后胃肠功能恢复时间、术后出血、总住院费用、总住院时间等无明显差异;CVS组手术时间稍长于非CVS组,而术后腹腔引流量、术后拔管时间CVS组显著低于非CVS组,差异有统计学意义(P<0.05);此外,CVS组发生胆管损伤、临近脏器损伤、术后胆漏等并发症发生率显著低于非CVS组,差异有统计学意义(P<0.05)。结论CVS技术理念的应用可有效提高有腹部手术史患者LC手术的安全性,尤其对于急诊手术患者,可显著降低术后并发症发生率,该理念的应用有助于促进患者康复、提高手术安全性。
