[Objectives]To explore the antidepressant effect of Shenwei Ningyu Tablet,a new antidepressant traditional Chinese medicine,on rat chronic stress depression model and mouse tail suspension models.[Methods]Rat chronic ...[Objectives]To explore the antidepressant effect of Shenwei Ningyu Tablet,a new antidepressant traditional Chinese medicine,on rat chronic stress depression model and mouse tail suspension models.[Methods]Rat chronic stress model:except for the normal group,the rats in other groups were given corresponding chronic stress,and administered by gavage 1 h before modeling,for a total of 21 d.The changes of each indicator before and after the experiment were observed through the body weight change,the sugar water test,and open field test.The relevant hormone levels were detected by radioimmunoassay.Mouse tail suspension depression model:after continuous administration for 7 d,the activity times was recorded with the mouse automatic recorder,and the mouse immobility time was recorded after tail suspension,to explore the effects of each administration group on the tail suspension immobility time of mice.[Results]Chronic stress depression model:21 d after modeling,compared with the normal group,rats in the model group exhibited significantly reduced body weight,sucrose preference index,and horizontal and vertical movement scores(P<0.05).Compared with the model group,the low-dose Shenwei Ningyu Tablets group had significant differences in the sugar water test,horizontal and vertical movement scores(P<0.05).In addition,all three dose groups of Shenwei Ningyu Tablets could effectively reduce the content of CRF in chronic stress model rats,and the low dose group could significantly reduce the ACTH level in model rats(P<0.05).Mouse tail suspension depression model:the immobility time after tail suspension in each administration group was significantly different from that in the model group(P<0.05).[Conclusions]Shenwei Ningyu Tablets has a certain anti-depression effect on both the rat chronic stress depression model and the mouse tail suspension depression model.展开更多
申威26010高性能众核处理器在多核处理器申威1600基础上,采用片上系统(system on chip,SoC)技术,在单芯片内集成4个运算控制核心和256个运算核心,采用自主设计的64位申威RISC(reduced instruction set computer)指令系统,支持256位SIMD(...申威26010高性能众核处理器在多核处理器申威1600基础上,采用片上系统(system on chip,SoC)技术,在单芯片内集成4个运算控制核心和256个运算核心,采用自主设计的64位申威RISC(reduced instruction set computer)指令系统,支持256位SIMD(single instruction multiple data)整数和浮点向量加速运算,单芯片双精度浮点峰值性能达3.168TFLOPS.申威26010处理器基于28nm工艺流片,芯片die面积超过500mm\+2,芯片260个核心稳定运行频率达1.5GHz.申威26010处理器从结构级、微结构级到电路级,综合采用多种低功耗设计技术,峰值能效比达10.559GFLOPS/W.芯片运行频率和能效比均超过同时期国际同类型处理器.申威26010通过在高频率设计、稳定可靠性设计和成品率设计等方面的技术创新,有效解决了芯片在实现高性能目标中所遇到的高频率目标、功耗墙、稳定可靠性和成品率等难题,成功大规模应用于国产10万万亿次超级计算机系统“神威·太湖之光”,有效满足了科学与工程应用的计算需求.展开更多
基金National Major Scientific and Technological Special Project for"Significant New Drugs Development"(2019ZX09301-005).
文摘[Objectives]To explore the antidepressant effect of Shenwei Ningyu Tablet,a new antidepressant traditional Chinese medicine,on rat chronic stress depression model and mouse tail suspension models.[Methods]Rat chronic stress model:except for the normal group,the rats in other groups were given corresponding chronic stress,and administered by gavage 1 h before modeling,for a total of 21 d.The changes of each indicator before and after the experiment were observed through the body weight change,the sugar water test,and open field test.The relevant hormone levels were detected by radioimmunoassay.Mouse tail suspension depression model:after continuous administration for 7 d,the activity times was recorded with the mouse automatic recorder,and the mouse immobility time was recorded after tail suspension,to explore the effects of each administration group on the tail suspension immobility time of mice.[Results]Chronic stress depression model:21 d after modeling,compared with the normal group,rats in the model group exhibited significantly reduced body weight,sucrose preference index,and horizontal and vertical movement scores(P<0.05).Compared with the model group,the low-dose Shenwei Ningyu Tablets group had significant differences in the sugar water test,horizontal and vertical movement scores(P<0.05).In addition,all three dose groups of Shenwei Ningyu Tablets could effectively reduce the content of CRF in chronic stress model rats,and the low dose group could significantly reduce the ACTH level in model rats(P<0.05).Mouse tail suspension depression model:the immobility time after tail suspension in each administration group was significantly different from that in the model group(P<0.05).[Conclusions]Shenwei Ningyu Tablets has a certain anti-depression effect on both the rat chronic stress depression model and the mouse tail suspension depression model.
文摘申威26010高性能众核处理器在多核处理器申威1600基础上,采用片上系统(system on chip,SoC)技术,在单芯片内集成4个运算控制核心和256个运算核心,采用自主设计的64位申威RISC(reduced instruction set computer)指令系统,支持256位SIMD(single instruction multiple data)整数和浮点向量加速运算,单芯片双精度浮点峰值性能达3.168TFLOPS.申威26010处理器基于28nm工艺流片,芯片die面积超过500mm\+2,芯片260个核心稳定运行频率达1.5GHz.申威26010处理器从结构级、微结构级到电路级,综合采用多种低功耗设计技术,峰值能效比达10.559GFLOPS/W.芯片运行频率和能效比均超过同时期国际同类型处理器.申威26010通过在高频率设计、稳定可靠性设计和成品率设计等方面的技术创新,有效解决了芯片在实现高性能目标中所遇到的高频率目标、功耗墙、稳定可靠性和成品率等难题,成功大规模应用于国产10万万亿次超级计算机系统“神威·太湖之光”,有效满足了科学与工程应用的计算需求.
