Drug-resistant tuberculosis(DR-TB)continues to be a public health concern.In 2019,nearly half a million patients had rifampicin-resistant tuberculosis(RR-TB),with 78%of those having multidrug-resistant TB(MDR-TB).Indi...Drug-resistant tuberculosis(DR-TB)continues to be a public health concern.In 2019,nearly half a million patients had rifampicin-resistant tuberculosis(RR-TB),with 78%of those having multidrug-resistant TB(MDR-TB).India(27%),China(14%),and the Russian Federation(8%)are the three countries with the highest share of the global burden.展开更多
China's annual Central Economic Work Conference was held in Beijing on December 11 and 12.Serving to set the priorities for economic policy in the next year,this year's session was closely watched,as a robust ...China's annual Central Economic Work Conference was held in Beijing on December 11 and 12.Serving to set the priorities for economic policy in the next year,this year's session was closely watched,as a robust rebound in growth in China has significant implications for the rest of the world.展开更多
There have been studies on the structure and properties of segmented polyetherurethane (SPEU)based on polytetramethylene glycol (PTMG)/4, 4′-diphenylmethane diisoeyanate (MDI)/1,4-butandiol (BD). It was shown that on...There have been studies on the structure and properties of segmented polyetherurethane (SPEU)based on polytetramethylene glycol (PTMG)/4, 4′-diphenylmethane diisoeyanate (MDI)/1,4-butandiol (BD). It was shown that only sufficient long hard segment (MDI/BD) domains could crystallize under certain conditions, while the shorter hard domains (hard segment in the SPEU with 1000 n PTMG and mole展开更多
Objective To investigate the independent association of the body mass index(BMI)with serum uric acid among shorter children and adolescent.Methods A cross-sectional study was conducted to collect general clinical data...Objective To investigate the independent association of the body mass index(BMI)with serum uric acid among shorter children and adolescent.Methods A cross-sectional study was conducted to collect general clinical data of 922 subjects with shorter statures.In each case,their information about height,weight,insulin-like growth factor-Ⅰ(IGF-Ⅰ),growth hormone peak,uric acid,and blood lipids were collected,and their BMI and BMI standard deviations score(SDS)were calculated.Smooth curve fitting and multiple piecewise linear regression were used to analyze the relationship between BMI SDS and uric acid.Results Univariate analysis found that serum uric acid was positively correlated with age,height standard deviation score,body weight standard deviation score,BMI SDS,IGF-Ⅰstandard deviation score,growth hormone peak,triglyceride,and creatinine(P<0.05),while negatively correlated with high-density lipoprotein-cholesterol(P<0.01).Female had significantly lower serum uric acid levels than male(P=0.003).The serum uric acid level was significantly increased after puberty(P<0.01).After adjusting for potential confounders,the smooth curve fitting revealed a U-shaped relationship between BMI SDS and uric acid,with a BMI SDS inflection point of-0.7.In the population of BMI SDS<-0.7,for every unit increase of BMI SDS,serum uric acid decreased by 11.78μmol/L(P=0.030).In the population of BMI SDS≥-0.7,uric acid increased by 11.79μmol/L(P<0.01)for every unit increase of BMI SDS.Conclusion Serum uric acid levels seem to be affected by BMI,and increased in population with thinness or obesity.We should pay attention to the measurement of serum uric acid in both thin and obese children.展开更多
这个标题非常触目,标题中的Stature就是“身材”的意思。标题可以四字直译:矮人命短。这并非是对现代人的研究结果,而是一种考古的发现:Therisk of death before age 30 declined as bone length increased。本文的观点之一是:Height is...这个标题非常触目,标题中的Stature就是“身材”的意思。标题可以四字直译:矮人命短。这并非是对现代人的研究结果,而是一种考古的发现:Therisk of death before age 30 declined as bone length increased。本文的观点之一是:Height is an indicator of childhood nutrition,which may have long-lasting effectson health,这个分析站得住脚吗?读者朋友,你信这个“邪”吗?】展开更多
1.Introduction For athletes,the quality and quantity of sleep are essential elements for optimizing recovery and subsequent performance.1 Unfortunately,athletes frequently face challenges getting sufficient,high-quali...1.Introduction For athletes,the quality and quantity of sleep are essential elements for optimizing recovery and subsequent performance.1 Unfortunately,athletes frequently face challenges getting sufficient,high-quality sleep.2 A recent systematic review and meta-analysis of 81 studies involving 1830 athletes concluded that compared to healthy non-athletes,athletes'sleep duration was shorter with poorer sleep efficiency.展开更多
Background The evidence regarding the association between leucocyte telomere length(LTL)and brain health is sparse and inconclusive.Aims To investigate the associations of LTL with brain structure and the risk of deme...Background The evidence regarding the association between leucocyte telomere length(LTL)and brain health is sparse and inconclusive.Aims To investigate the associations of LTL with brain structure and the risk of dementia based on a large-scale prospective study.Methods LTL in the peripheral blood was measured by the quantitative polymerase chain reaction(qPCR)assay from 439961 individuals in the UK Biobank recruited between 2006 and 2010 and followed up until 2020.Electronic health records were used to record the incidence of dementia,including Alzheimer’s disease(AD)and vascular dementia(VD).The brain structure,including total and regional brain volume,of 38740 participants was then assessed by magnetic resonance imaging(MRI).Results During a median follow-up of 11.6 years,a total of 5820(1.3%)dementia cases were documented.The restricted cubic spline model showed significant overall associations between LTL and the risk of dementia and AD(p for overall<0.05).The multivariable adjusted hazard ratios(HRs)for the lowest LTL tertile compared with the highest LTL tertile were 1.14(95%confidence interval(CI):1.06 to 1.21)for dementia,1.28(95%CI:1.12 to 1.46)for AD and 1.18(95%CI:0.98 to 1.42)for VD.Furthermore,we found that shorter LTL was associated with smaller total brain volume(β=−0.0128,p=0.003),white matter volume(β=−0.0224,p<0.001),hippocampus volume(β=−0.0172,p<0.001),thalamus volume(β=−0.0239,p<0.001)and accumbens(β=−0.0155,p=0.001).Conclusions Shorter LTL is associated with total and regional brain structure and a higher risk of incident dementia and AD,implying the potential of telomere length as a predictive biomarker of brain health.展开更多
BACKGROUND Many studies have been developed with a focus on surgical techniques and drugs,but few that address the importance of rehabilitation in the pre and postoperative period,and the specific benefits for each su...BACKGROUND Many studies have been developed with a focus on surgical techniques and drugs,but few that address the importance of rehabilitation in the pre and postoperative period,and the specific benefits for each surgical procedure or type of neoplasm,aiming to minimize respiratory complications in the postoperative period.AIM To compare the strength of the respiratory muscles in the pre and postoperative periods of hepatectomy by laparotomy and to verify the incidence of postoperative pulmonary complications among the groups studied.METHODS Prospective,randomized,clinical trial study that compared the inspiratory muscle training group(GTMI)with the control group(CG).After the collection of sociodemographic and clinical data,in both groups,preoperatively,on the first and fifth postoperative days,vital signs and pulmonary mechanics were evaluated and recorded.Albumin and bilirubin values were recorded for the albumin-bilirubin(ALBI)score.After randomization and allocation of participants,those in the CG underwent conventional physical therapy and those in the GTMI underwent conventional physical therapy plus inspiratory muscle,in both groups for five postoperative days.RESULTS Of 76 subjects met eligibility criteria.The collection of 41 participants was completed:20 in the CG and 21 in the GTMI.The most frequent diagnosis was 41.5%with liver metastasis,followed by 26.8%with hepatocellular carcinoma.As for respiratory complications in the GTMI,there was no incidence.In the CG,there were three respiratory complications.Patients in the CG classified as ALBI score 3 presented,statistically,a higher energy value compared to patients classified as ALBI score 1 and 2(P=0.0187).Respiratory variables,measured preoperatively and on the first postoperative day,had a significant drop in both groups from the preoperative to the first postoperative day(P≤0.0001).When comparing the preoperative period and the fifth postoperative day between the GTMI and the CG,the maximal inspiratory pressure variable in the GTMI was statistically significant(P=0.0131).CONCLUSION All respiratory measures showed a reduction in the postoperative period.Respiratory muscle training using the Powerbreathe?device increased maximal inspiratory pressure and this may have contributed to a shorter hospital stay and better clinical outcome.展开更多
The paradox of our time in history is that: We have taller buildings, but shorter tempers; Wider freeways, but narrower viewpoints ; We spend more, but have less; We buy more, but enjoy it less; We have bigger houses ...The paradox of our time in history is that: We have taller buildings, but shorter tempers; Wider freeways, but narrower viewpoints ; We spend more, but have less; We buy more, but enjoy it less; We have bigger houses and smaller families ; More conveniences, but less time; We have more degrees, but less sense;展开更多
AIM: To evaluate the impact of thrombus aspiration(TA) on procedural outcomes in a real-world ST-segment elevation myocardial infarction(STEMI) registry.METHODS: From May 2006 to August 2008, 542 consecutive STEMI pat...AIM: To evaluate the impact of thrombus aspiration(TA) on procedural outcomes in a real-world ST-segment elevation myocardial infarction(STEMI) registry.METHODS: From May 2006 to August 2008, 542 consecutive STEMI patients referred for primary or rescue percutaneous coronary intervention were enrolled and the angiographic results and stent implantation characteristics were compared according to the performance of manual TA.RESULTS: A total of 456 patients were analyzable and categorized in TA group(156 patients; 34.2%) and non-TA(NTA) group(300 patients; 65.8%). Patientstreated with TA had less prevalence of multivessel disease(39.7% vs 54.7%, P = 0.003) and higher prevalence of initial thrombolysis in myocardial infarction flow < 3(P < 0.001) than NTA group. There was a higher rate of direct stenting(58.7% vs 45.5%, P = 0.009), with shorter(24.1 ± 11.8 mm vs 26.9 ± 15.7 mm, P = 0.038) and larger stents(3.17 ± 0.43 mm vs 2.93 ± 0.44 mm, P < 0.001) in the TA group as compared to NTA group. The number of implanted stents(1.3 ± 0.67 vs 1.5 ± 0.84, P = 0.009) was also lower in TA group. CONCLUSION: In an "all-comers" STEMI population, the use of TA resulted in more efficient procedure leading to the implantation of less number of stents per lesion of shorter lengths and larger sizes.展开更多
文摘Drug-resistant tuberculosis(DR-TB)continues to be a public health concern.In 2019,nearly half a million patients had rifampicin-resistant tuberculosis(RR-TB),with 78%of those having multidrug-resistant TB(MDR-TB).India(27%),China(14%),and the Russian Federation(8%)are the three countries with the highest share of the global burden.
文摘China's annual Central Economic Work Conference was held in Beijing on December 11 and 12.Serving to set the priorities for economic policy in the next year,this year's session was closely watched,as a robust rebound in growth in China has significant implications for the rest of the world.
文摘There have been studies on the structure and properties of segmented polyetherurethane (SPEU)based on polytetramethylene glycol (PTMG)/4, 4′-diphenylmethane diisoeyanate (MDI)/1,4-butandiol (BD). It was shown that only sufficient long hard segment (MDI/BD) domains could crystallize under certain conditions, while the shorter hard domains (hard segment in the SPEU with 1000 n PTMG and mole
文摘Objective To investigate the independent association of the body mass index(BMI)with serum uric acid among shorter children and adolescent.Methods A cross-sectional study was conducted to collect general clinical data of 922 subjects with shorter statures.In each case,their information about height,weight,insulin-like growth factor-Ⅰ(IGF-Ⅰ),growth hormone peak,uric acid,and blood lipids were collected,and their BMI and BMI standard deviations score(SDS)were calculated.Smooth curve fitting and multiple piecewise linear regression were used to analyze the relationship between BMI SDS and uric acid.Results Univariate analysis found that serum uric acid was positively correlated with age,height standard deviation score,body weight standard deviation score,BMI SDS,IGF-Ⅰstandard deviation score,growth hormone peak,triglyceride,and creatinine(P<0.05),while negatively correlated with high-density lipoprotein-cholesterol(P<0.01).Female had significantly lower serum uric acid levels than male(P=0.003).The serum uric acid level was significantly increased after puberty(P<0.01).After adjusting for potential confounders,the smooth curve fitting revealed a U-shaped relationship between BMI SDS and uric acid,with a BMI SDS inflection point of-0.7.In the population of BMI SDS<-0.7,for every unit increase of BMI SDS,serum uric acid decreased by 11.78μmol/L(P=0.030).In the population of BMI SDS≥-0.7,uric acid increased by 11.79μmol/L(P<0.01)for every unit increase of BMI SDS.Conclusion Serum uric acid levels seem to be affected by BMI,and increased in population with thinness or obesity.We should pay attention to the measurement of serum uric acid in both thin and obese children.
文摘这个标题非常触目,标题中的Stature就是“身材”的意思。标题可以四字直译:矮人命短。这并非是对现代人的研究结果,而是一种考古的发现:Therisk of death before age 30 declined as bone length increased。本文的观点之一是:Height is an indicator of childhood nutrition,which may have long-lasting effectson health,这个分析站得住脚吗?读者朋友,你信这个“邪”吗?】
文摘1.Introduction For athletes,the quality and quantity of sleep are essential elements for optimizing recovery and subsequent performance.1 Unfortunately,athletes frequently face challenges getting sufficient,high-quality sleep.2 A recent systematic review and meta-analysis of 81 studies involving 1830 athletes concluded that compared to healthy non-athletes,athletes'sleep duration was shorter with poorer sleep efficiency.
基金This work was supported by the National Natural Science Foundation of China(grant number 72204071)Zhejiang Provincial Natural Science Foundation of China(grant number LY23G030005)Scientific Research Foundation for Scholars of HZNU(grant number 4265C50221204119)。
文摘Background The evidence regarding the association between leucocyte telomere length(LTL)and brain health is sparse and inconclusive.Aims To investigate the associations of LTL with brain structure and the risk of dementia based on a large-scale prospective study.Methods LTL in the peripheral blood was measured by the quantitative polymerase chain reaction(qPCR)assay from 439961 individuals in the UK Biobank recruited between 2006 and 2010 and followed up until 2020.Electronic health records were used to record the incidence of dementia,including Alzheimer’s disease(AD)and vascular dementia(VD).The brain structure,including total and regional brain volume,of 38740 participants was then assessed by magnetic resonance imaging(MRI).Results During a median follow-up of 11.6 years,a total of 5820(1.3%)dementia cases were documented.The restricted cubic spline model showed significant overall associations between LTL and the risk of dementia and AD(p for overall<0.05).The multivariable adjusted hazard ratios(HRs)for the lowest LTL tertile compared with the highest LTL tertile were 1.14(95%confidence interval(CI):1.06 to 1.21)for dementia,1.28(95%CI:1.12 to 1.46)for AD and 1.18(95%CI:0.98 to 1.42)for VD.Furthermore,we found that shorter LTL was associated with smaller total brain volume(β=−0.0128,p=0.003),white matter volume(β=−0.0224,p<0.001),hippocampus volume(β=−0.0172,p<0.001),thalamus volume(β=−0.0239,p<0.001)and accumbens(β=−0.0155,p=0.001).Conclusions Shorter LTL is associated with total and regional brain structure and a higher risk of incident dementia and AD,implying the potential of telomere length as a predictive biomarker of brain health.
文摘BACKGROUND Many studies have been developed with a focus on surgical techniques and drugs,but few that address the importance of rehabilitation in the pre and postoperative period,and the specific benefits for each surgical procedure or type of neoplasm,aiming to minimize respiratory complications in the postoperative period.AIM To compare the strength of the respiratory muscles in the pre and postoperative periods of hepatectomy by laparotomy and to verify the incidence of postoperative pulmonary complications among the groups studied.METHODS Prospective,randomized,clinical trial study that compared the inspiratory muscle training group(GTMI)with the control group(CG).After the collection of sociodemographic and clinical data,in both groups,preoperatively,on the first and fifth postoperative days,vital signs and pulmonary mechanics were evaluated and recorded.Albumin and bilirubin values were recorded for the albumin-bilirubin(ALBI)score.After randomization and allocation of participants,those in the CG underwent conventional physical therapy and those in the GTMI underwent conventional physical therapy plus inspiratory muscle,in both groups for five postoperative days.RESULTS Of 76 subjects met eligibility criteria.The collection of 41 participants was completed:20 in the CG and 21 in the GTMI.The most frequent diagnosis was 41.5%with liver metastasis,followed by 26.8%with hepatocellular carcinoma.As for respiratory complications in the GTMI,there was no incidence.In the CG,there were three respiratory complications.Patients in the CG classified as ALBI score 3 presented,statistically,a higher energy value compared to patients classified as ALBI score 1 and 2(P=0.0187).Respiratory variables,measured preoperatively and on the first postoperative day,had a significant drop in both groups from the preoperative to the first postoperative day(P≤0.0001).When comparing the preoperative period and the fifth postoperative day between the GTMI and the CG,the maximal inspiratory pressure variable in the GTMI was statistically significant(P=0.0131).CONCLUSION All respiratory measures showed a reduction in the postoperative period.Respiratory muscle training using the Powerbreathe?device increased maximal inspiratory pressure and this may have contributed to a shorter hospital stay and better clinical outcome.
文摘The paradox of our time in history is that: We have taller buildings, but shorter tempers; Wider freeways, but narrower viewpoints ; We spend more, but have less; We buy more, but enjoy it less; We have bigger houses and smaller families ; More conveniences, but less time; We have more degrees, but less sense;
文摘AIM: To evaluate the impact of thrombus aspiration(TA) on procedural outcomes in a real-world ST-segment elevation myocardial infarction(STEMI) registry.METHODS: From May 2006 to August 2008, 542 consecutive STEMI patients referred for primary or rescue percutaneous coronary intervention were enrolled and the angiographic results and stent implantation characteristics were compared according to the performance of manual TA.RESULTS: A total of 456 patients were analyzable and categorized in TA group(156 patients; 34.2%) and non-TA(NTA) group(300 patients; 65.8%). Patientstreated with TA had less prevalence of multivessel disease(39.7% vs 54.7%, P = 0.003) and higher prevalence of initial thrombolysis in myocardial infarction flow < 3(P < 0.001) than NTA group. There was a higher rate of direct stenting(58.7% vs 45.5%, P = 0.009), with shorter(24.1 ± 11.8 mm vs 26.9 ± 15.7 mm, P = 0.038) and larger stents(3.17 ± 0.43 mm vs 2.93 ± 0.44 mm, P < 0.001) in the TA group as compared to NTA group. The number of implanted stents(1.3 ± 0.67 vs 1.5 ± 0.84, P = 0.009) was also lower in TA group. CONCLUSION: In an "all-comers" STEMI population, the use of TA resulted in more efficient procedure leading to the implantation of less number of stents per lesion of shorter lengths and larger sizes.
