Objective To investigate the relationship between connective tissue growth factor(CTGF)rs9399005 gene polymorphism and serum CTGF level,coronary heart disease(CHD).Methods The serum CTGF levels were de-tected by enzym...Objective To investigate the relationship between connective tissue growth factor(CTGF)rs9399005 gene polymorphism and serum CTGF level,coronary heart disease(CHD).Methods The serum CTGF levels were de-tected by enzyme linked immunosorbent assay in 214 cases of CHD and 64 cases of normal control group.CTGF gene rs9399005 single nucleotide polymorphism(SNP)was analyzed by Sanger method.Baseline clinical data,serum CTGF and genotype distribution frequencies展开更多
Most of the progress in the development of single scale mathematical and computational models for the study of infectious disease dynamics which now span over a century is build on a body of knowledge that has been de...Most of the progress in the development of single scale mathematical and computational models for the study of infectious disease dynamics which now span over a century is build on a body of knowledge that has been developed to address particular single scale descriptions of infectious disease dynamics based on understanding disease transmission process.Although this single scale understanding of infectious disease dynamics is now founded on a body of knowledge with a long history,dating back to over a century now,that knowledge has not yet been formalized into a scientific theory.In this article,we formalize this accumulated body of knowledge into a scientific theory called the transmission mechanism theory of disease dynamics which states that at every scale of organization of an infectious disease system,disease dynamics is determined by transmission as the main dynamic disease process.Therefore,the transmission mechanism theory of disease dynamics can be seen as formalizing knowledge that has been inherent in the study of infectious disease dynamics using single scale mathematical and computational models for over a century now.The objective of this article is to summarize this existing knowledge about single scale modelling of infectious dynamics by means of a scientific theory called the transmission mechanism theory of disease dynamics and highlight its aims,assumptions and limitations.展开更多
文摘Objective To investigate the relationship between connective tissue growth factor(CTGF)rs9399005 gene polymorphism and serum CTGF level,coronary heart disease(CHD).Methods The serum CTGF levels were de-tected by enzyme linked immunosorbent assay in 214 cases of CHD and 64 cases of normal control group.CTGF gene rs9399005 single nucleotide polymorphism(SNP)was analyzed by Sanger method.Baseline clinical data,serum CTGF and genotype distribution frequencies
基金financial support from South Africa National Research Foundation(NRF)Grant No.IPRR(UID 132608).
文摘Most of the progress in the development of single scale mathematical and computational models for the study of infectious disease dynamics which now span over a century is build on a body of knowledge that has been developed to address particular single scale descriptions of infectious disease dynamics based on understanding disease transmission process.Although this single scale understanding of infectious disease dynamics is now founded on a body of knowledge with a long history,dating back to over a century now,that knowledge has not yet been formalized into a scientific theory.In this article,we formalize this accumulated body of knowledge into a scientific theory called the transmission mechanism theory of disease dynamics which states that at every scale of organization of an infectious disease system,disease dynamics is determined by transmission as the main dynamic disease process.Therefore,the transmission mechanism theory of disease dynamics can be seen as formalizing knowledge that has been inherent in the study of infectious disease dynamics using single scale mathematical and computational models for over a century now.The objective of this article is to summarize this existing knowledge about single scale modelling of infectious dynamics by means of a scientific theory called the transmission mechanism theory of disease dynamics and highlight its aims,assumptions and limitations.
