Gastric cancer is one of the most common malignancies of the digestive system,and the number of deaths continues to increase.The standardized management of the diagnosis and treatment of gastric cancer is challenging ...Gastric cancer is one of the most common malignancies of the digestive system,and the number of deaths continues to increase.The standardized management of the diagnosis and treatment of gastric cancer is challenging due to the great differences in the diagnosis and treatment of gastric cancer in different regions.The Gastric Cancer Expert Committee of the National Cancer Quality Control Center(NCQCC)identified a lack of authoritative quality control standards as an opportunity to utilize its multidisciplinary membership to improve the standardized diagnosis and treatment of gastric cancer.The Gastric Cancer Expert Committee of the NCQCC aims to promote quality control and national standardization,uniformity,and normalization of gastric cancer diagnosis and treatment,which ultimately improved the survival rate and quality of life of gastric cancer patients.A panel of experts with gastrointestinal cancer surgery,gastrointestinal cancer medicine,medical imaging,pathology and radiotherapy were drawn together and determined the quality control standards for the standardized diagnosis and treatment of gastric cancer.The authors then utilized a modified Delphi approach to generate consensus recommendations.展开更多
Autoimmune hepatitis is a rare chronic inflammatory liver disease,affecting all ages,characterised by elevated transaminase and immunoglobulin G levels,positive autoantibodies,interface hepatitis at liver histology an...Autoimmune hepatitis is a rare chronic inflammatory liver disease,affecting all ages,characterised by elevated transaminase and immunoglobulin G levels,positive autoantibodies,interface hepatitis at liver histology and good response to immunosuppressive treatment. If untreated,it has a poor prognosis. The aim of this review is to summarize the evidence for standard treatment and to provide a systematic review on alternative treatments for adults and children. Standard treatment is based on steroids and azathioprine,and leads to disease remission in 80%-90% of patients. Alternative first line treatment has been attempted with budesonide or cyclosporine,but their superiority compared to standard treatment remains to be demonstrated. Second-line treatments are needed for patients not responding or intolerant to standard treatment. No randomized controlled trials have been performed for second-line options. Mycophenolate mofetil is the most widely used second-line drug,and has good efficacy particularly for patients intolerant to azathioprine,but has the major disadvantage of being teratogenic. Only few and heterogeneous data on cyclosporine,tacrolimus,everolimus and sirolimus are available. More recently,experience with the anti-tumour necrosis factoralpha infliximab and the anti-CD20 rituximab has been published,with ambivalent results; these agents may have severe side-effects and their use should be restricted to specialized centres. Clinical trials with new therapeutic options are ongoing.展开更多
This review focuses on techniques for achieving very low concentration of TN and TP in water.The 1970 Clean Water Act in the US and the Urban Waste Water Treatment Directive in Europe now provide the benchmark standar...This review focuses on techniques for achieving very low concentration of TN and TP in water.The 1970 Clean Water Act in the US and the Urban Waste Water Treatment Directive in Europe now provide the benchmark standards for TN and TP levels.Arden and Lockett discovered activated sludge in the 1910’s.Since then,many improvements have been made to the biological treatment process to provide various configurations that have the ability to deliver effluent concentrations between 6-8mg TN/L and 0.5-1.0mg TP/L,without external carbon addition.Typically,however,additional advanced nutrient removal technologies are used in tertiary treatment to meet more stringent effluent quality requirements.One advanced technology that has been successfully implemented in the US is denitrifying filters.For TP removal,tests showed that the BlueP RO and CoM ag systems both reliably met an effluent target as low as 0.04 mg TP/L.However,the establishment of stringent TN and TP effluent limits will dramatically increase the capital and operational costs of wastewater treatment plants.A more promising nutrient capturing process is based on the assimilation of nutrients(both N and P)during heterotrophic growth which uses a carbon source for energy.Laboratory trials of the single step process by Reach Green suggest that concentrations as low as 0.5 mg TN/L and 0.02mg TP/L are readily achievable.展开更多
基金supported by“Beijing Municipal Administration of Hospitals Incubating Program”(No.PX2018043)。
文摘Gastric cancer is one of the most common malignancies of the digestive system,and the number of deaths continues to increase.The standardized management of the diagnosis and treatment of gastric cancer is challenging due to the great differences in the diagnosis and treatment of gastric cancer in different regions.The Gastric Cancer Expert Committee of the National Cancer Quality Control Center(NCQCC)identified a lack of authoritative quality control standards as an opportunity to utilize its multidisciplinary membership to improve the standardized diagnosis and treatment of gastric cancer.The Gastric Cancer Expert Committee of the NCQCC aims to promote quality control and national standardization,uniformity,and normalization of gastric cancer diagnosis and treatment,which ultimately improved the survival rate and quality of life of gastric cancer patients.A panel of experts with gastrointestinal cancer surgery,gastrointestinal cancer medicine,medical imaging,pathology and radiotherapy were drawn together and determined the quality control standards for the standardized diagnosis and treatment of gastric cancer.The authors then utilized a modified Delphi approach to generate consensus recommendations.
文摘Autoimmune hepatitis is a rare chronic inflammatory liver disease,affecting all ages,characterised by elevated transaminase and immunoglobulin G levels,positive autoantibodies,interface hepatitis at liver histology and good response to immunosuppressive treatment. If untreated,it has a poor prognosis. The aim of this review is to summarize the evidence for standard treatment and to provide a systematic review on alternative treatments for adults and children. Standard treatment is based on steroids and azathioprine,and leads to disease remission in 80%-90% of patients. Alternative first line treatment has been attempted with budesonide or cyclosporine,but their superiority compared to standard treatment remains to be demonstrated. Second-line treatments are needed for patients not responding or intolerant to standard treatment. No randomized controlled trials have been performed for second-line options. Mycophenolate mofetil is the most widely used second-line drug,and has good efficacy particularly for patients intolerant to azathioprine,but has the major disadvantage of being teratogenic. Only few and heterogeneous data on cyclosporine,tacrolimus,everolimus and sirolimus are available. More recently,experience with the anti-tumour necrosis factoralpha infliximab and the anti-CD20 rituximab has been published,with ambivalent results; these agents may have severe side-effects and their use should be restricted to specialized centres. Clinical trials with new therapeutic options are ongoing.
文摘This review focuses on techniques for achieving very low concentration of TN and TP in water.The 1970 Clean Water Act in the US and the Urban Waste Water Treatment Directive in Europe now provide the benchmark standards for TN and TP levels.Arden and Lockett discovered activated sludge in the 1910’s.Since then,many improvements have been made to the biological treatment process to provide various configurations that have the ability to deliver effluent concentrations between 6-8mg TN/L and 0.5-1.0mg TP/L,without external carbon addition.Typically,however,additional advanced nutrient removal technologies are used in tertiary treatment to meet more stringent effluent quality requirements.One advanced technology that has been successfully implemented in the US is denitrifying filters.For TP removal,tests showed that the BlueP RO and CoM ag systems both reliably met an effluent target as low as 0.04 mg TP/L.However,the establishment of stringent TN and TP effluent limits will dramatically increase the capital and operational costs of wastewater treatment plants.A more promising nutrient capturing process is based on the assimilation of nutrients(both N and P)during heterotrophic growth which uses a carbon source for energy.Laboratory trials of the single step process by Reach Green suggest that concentrations as low as 0.5 mg TN/L and 0.02mg TP/L are readily achievable.
