Objective:To explore the clinical effect of modified treatment after finger replantation and its impact on the survival rate of replantation.Methods:The research was conducted from March 2022 to March 2023.A total of ...Objective:To explore the clinical effect of modified treatment after finger replantation and its impact on the survival rate of replantation.Methods:The research was conducted from March 2022 to March 2023.A total of 58 patients who underwent finger replantation at our hospital were selected.These patients were divided into two groups using the digital table grouping method:the research group(n=29)and the control group(n=29).Patients in the control group received standard treatment following finger replantation,while patients in the study group received modified treatment after the procedure.The incidence of vascular crisis and the survival rate of replantation were compared between the two groups.Results:The incidence of vascular crisis in the study group was lower than that in the control group(P<0.05);the replantation survival rate in the study group was higher than that in the control group(P<0.05).Conclusion:Modified treatment after replantation of severed fingers can reduce the incidence of vascular crisis replantation and improve the survival rate of replantation,so it should be popularized and applied in medical institutions.展开更多
BACKGROUND Acute kidney injury(AKI)is one of the most common acute pancreatitis(AP)-associated complications that has a significant effect on AP,but the factors affecting the AP patients’survival rate remains unclear...BACKGROUND Acute kidney injury(AKI)is one of the most common acute pancreatitis(AP)-associated complications that has a significant effect on AP,but the factors affecting the AP patients’survival rate remains unclear.AIM To assess the influences of AKI on the survival rate in AP patients.METHODS A total of 139 AP patients were included in this retrospective study.Patients were divided into AKI group(n=72)and non-AKI group(n=67)according to the occurrence of AKI.Data were collected from medical records of hospitalized patients.Then,these data were compared between the two groups and further analysis was performed.RESULTS AKI is more likely to occur in male AP patients(P=0.009).AP patients in AKI group exhibited a significantly higher acute physiologic assessment and chronic health evaluation II score,higher Sequential Organ Failure Assessment score,lower Glasgow Coma Scale score,and higher demand for mechanical ventilation,infusion of vasopressors,and renal replacement therapy than AP patients in non-AKI group(P<0.01,P<0.01,P=0.01,P=0.001,P<0.01,P<0.01,respectively).Significant differences were noted in dose of norepinephrine and adrenaline,duration of mechanical ventilation,maximum and mean values of intra-peritoneal pressure(IPP),maximum and mean values of procalcitonin,maximum and mean serum levels of creatinine,minimum platelet count,and length of hospitalization.Among AP patients with AKI,the survival rate of surgical intensive care unit and in-hospital were only 23%and 21%of the corresponding rates in AP patients without AKI,respectively.The factors that influenced the AP patients’survival rate included body mass index(BMI),mean values of IPP,minimum platelet count,and hospital day,of which mean values of IPP showed the greatest impact.CONCLUSION AP patients with AKI had a lower survival rate and worse relevant clinical outcomes than AP patients without AKI,which necessitates further attention to AP patients with AKI in surgical intensive care unit.展开更多
To explore the nest survival rate of Reeves' s pheasant(Syrmaticus reevesii) and the nest-site factors that affect it, we conducted artificial nest experiments with reference to natural nests at Dongzhai National ...To explore the nest survival rate of Reeves' s pheasant(Syrmaticus reevesii) and the nest-site factors that affect it, we conducted artificial nest experiments with reference to natural nests at Dongzhai National Nature Reserve(DNNR), Henan Province and Pingjingguan, Hubei Province from April to June 2014 simulating the situation in its early and later breeding season. We also determined distance characteristics of the nest sites by Arc GIS 10.0. Nest survival models were constructed in Program MARK for data analysis. Results indicated that in the early breeding season, the apparent survival rate(ASR) in DNNR(52.4%) was significantly greater than that in Pingjingguan(13.5%), and the ASR in the later breeding season in DNNR(26.7%) was not indistinctively correlated with Pingjingguan(3.2%). The daily survival rate(DSR) in the later breeding season was 93.8% in DNNR and 92.0% in Pingjingguan, respectively. The DSRs were both negatively correlated with nest distance to forest edges and settlements. The DSR in Pingjingguan was positively correlated with nest distance to paths and negatively correlated with nest distance to water sources. However, the DSR in DNNR was negatively correlated with nest distance to paths but positively correlated with nest distance to water sources.展开更多
Background:The allocation of resources between offspring size and number is a central question of life-history theory.Although several studies have tested the existence of this trade-off,few studies have investigated ...Background:The allocation of resources between offspring size and number is a central question of life-history theory.Although several studies have tested the existence of this trade-off,few studies have investigated how environmental variation influences the allocation of resources to offspring size and offspring number.Additionally,the relationship between population dynamics and the offspring size and number allocation is far less understood.Methods:We investigate whether resource allocation between egg size and clutch size is influenced by the ambient temperature and whether it may be related to apparent nest survival rate.We measured 1548 eggs from 541 nests of two closely related shorebird species,the Kentish Plover(Charadrius alexandrinus)and the White-faced Plover(C.dealbatus)in China,in four populations that exhibit contrasting ambient environments.We weighed females,monitored nest survival,and calculated the variance of ambient temperature.Results:Although we found that egg size and clutch size were all different between the four breeding populations,the reproductive investment(i.e.total clutch volume)was similar between populations.We also found that populations with a high survival rate had relatively larger eggs and a smaller clutch than populations with a low nest survival rate.The latter result is in line with a conservative/diversified bet-hedging strategy.Conclusions:Our findings suggest that plovers may increasing fitness by investing fewer,larger or many,small according local nest survival rate to make a similar investment in reproduction,and thereby may have an impact on population demography.展开更多
Breast cancer is one of the leading diseases that affect women’s lives. It affects their lives in so many ways by denying them the required standard of health needed to carry out all of their daily activities for som...Breast cancer is one of the leading diseases that affect women’s lives. It affects their lives in so many ways by denying them the required standard of health needed to carry out all of their daily activities for some days, weeks, months or years before eventually causing death. This research estimates the survival rate of breast cancer patients and investigates the effects of stage of tumor, gender, age, ethnic group, occupation, marital status and type of cancer upon the survival of patients. Data used for the study were extracted from the case file of patients in the Radiation Oncology Department, University College Hospital, Ibadan using a well-structured pro forma in which 74 observations were censored and 30 events occurred. The Kaplan-Meier estimator was used to estimate the overall survival probability of breast cancer patients following their recruitment into the study and determine the mean and median survival times of breast cancer patients following their time of recruitment into the study. Since there are different groups with respect to the stages of tumor at the time of diagnosis, the log-rank test was used to compare the survival curve of the stages of tumor with considering p-values below 0.05 as statistically significant. Multivariate Cox regression was used to investigate the effects of some variables on the survival of patients. The overall cumulative survival probability obtained is 0.175 (17.5%). The overall estimated mean time until death is 28.751 weeks while the median time between admission and death is 23 weeks. As the p-value (0.000032) of the log-rank test for comparing stages of tumor is less than 0.05, it is concluded that there is significant evidence of a difference in survival times for the stages of tumor. The survival function plot for the stages of tumor shows that patients with stage III tumor are less likely to survive. From the estimated mean time until death for the stages of tumor, it was deduced that stage I tumor patients have an increased chance of survival. Types of cancer, gender, marital status, ethnic group, occupation and patient’s age at entry into the study are not important predictors of chances of survival.展开更多
Objective To investigate the effect of adipose stromal vascular fraction cells(SVFs)on the survival rate of fat ransplantation.Methods 0.5mL autologous fat tissue was mixed with: ① DiI-labeled autologous SVFs (Group ...Objective To investigate the effect of adipose stromal vascular fraction cells(SVFs)on the survival rate of fat ransplantation.Methods 0.5mL autologous fat tissue was mixed with: ① DiI-labeled autologous SVFs (Group A);②展开更多
Three polyamines(PAs)(spermidine(Spd),spermine(Spm),and putrescine(Put))were used as growth regulators to the marine macroalgae Gracilariopsis lemaneiformis and to female gametophyte and reproductive tissues(cystocarp...Three polyamines(PAs)(spermidine(Spd),spermine(Spm),and putrescine(Put))were used as growth regulators to the marine macroalgae Gracilariopsis lemaneiformis and to female gametophyte and reproductive tissues(cystocarps were constructed),which led to early maturation of cystocarps and spore release.Laboratory cultivation revealed that exogenous PA application accelerated the development of cystocarps,and the mean sporeling growth rate was 20%–50%/d during the initial week of cultivation.The spore count(SC),survival rate(SR),and germination rate(GR)of G.lemaneiformis showed different responses to PA(10-6 mol/L and 10-3 mol/L)treatments under different temperatures(18,26,and 34℃),light intensities(30,60,and 90μmol photons/(m^(2)·s)),salinities(25,30,and 35),and nutrient levels(25꞉2.5,50꞉5.0,and 75꞉7.5μmol/L NH4Cl꞉K2HPO4),and the optimal conditions were 26℃,light intensity of 60μmol/(m^(2)·s),salinity of 35,and nutrient level of 50꞉5.0μmol/L NH4Cl꞉K2HPO4.Under the optimum conditions,the SC per cystocarp increased by 82.38%,and the spore SR and GR increased by 33.07%and 46.44%,respectively.Each experiment lasted for 7 days,with the highest SC on Day 4 and plateauing on Day 7.The results indicate that PAs could promote the early maturation,spore release,survival,and germination of G.lemaneiformis under laboratory conditions.展开更多
Heterosis has been exploited to enhance the yield and adaptability in various shellfish species;however,the molecular basis of it remains unclear.The Pacific oyster Crassostrea gigas is one of the most economically im...Heterosis has been exploited to enhance the yield and adaptability in various shellfish species;however,the molecular basis of it remains unclear.The Pacific oyster Crassostrea gigas is one of the most economically important aquaculture species,and its productive traits can be improved by hybridization.Here,an intraspecific cross between orange shell(O,10th generation)and‘Haida No.1’(H,13th generation)of C.gigas was performed to assess the heterosis of survival trait.Survival rates of hybrid family(OH)and inbred families(HH and OO)were compared at larval stage,and eyed-pediveliger larvae of three families were subjected to transcriptome analysis.The analysis results of best-parent heterosis and mid-parent heterosis showed that the hybrid family exhi-bited a high heterosis in survival relative to the parental families.The OH-M(OH vs.OO)and OH-P(OH vs.HH)had 425 and 512 dif-ferentially expressed genes(DEGs),respectively.Functional enrichment analysis of these DEGs revealed that the significantly enrich-ed genes function in virion binding,C-type lectin receptor signaling pathway,cellular defense response and other immune-related pro-cesses,which involves perlucin-like protein,CD209 antigen-like protein,ZNFX1,caspase-3 and acan genes.These differentially ex-pressed genes in OH-M and OH-P,together with the immune-related processes mentioned above may play an important role in the larval survival of C.gigas.In addition,three genes(CYP450,fucolectin and perlucin-like)are associated with the orange shell and low survival of maternal oyster OO.These findings provide support for the application of hybrid with superior survival and will facilitate the understanding of heterosis formation in the Pacific oyster.展开更多
Background: Restoring a viable population by reintroduction is the ultimate goal of a large number of ex situ conservation projects for endangered animals. However, many reintroductions fail to establish a population ...Background: Restoring a viable population by reintroduction is the ultimate goal of a large number of ex situ conservation projects for endangered animals. However, many reintroductions fail to establish a population in the wild, partly because released animals cannot acclimate to the native environment of the release site, resulting in very low survival rates. Acclimation training is a technique to resolve this problem, although it does not have positive results in all species. We tested whether acclimation training and soft-release could improve the reintroduction success for captive-bred Cabot's Tragopan(Tragopan caboti), an endangered pheasant in southern China.Methods: Reintroduction of captive-bred Cabot's Tragopan was carried out in the Taoyuandong National Nature Reserve, China from 2010 to 2011. We built a soft-release enclosure for acclimation training in the typical montane habitat of this pheasant. Nine birds were acclimated to the environment of this release site in this cage for more than 50 days before release("trained birds"), while 11 birds remained only in the cage for 3 days prior to release("untrained birds"). Released birds were tagged with a collar radio-transmitter.Results: Post-release monitoring revealed that the survival rate of trained birds was higher than that of untrained birds after 50 days(trained: 85.7%; untrained: 20.0%). Cox regression analysis showed that there was a significant difference in the mortality rates between the trained and untrained birds. In addition, a survey of the habitat of the experimental and the control groups showed significant differences in habitat selection between the groups.Conclusion: Our study suggests that pre-release acclimatization training is an important factor that can lead to improved survival and habitat selection of captive-bred reintroduced tragopans.展开更多
Red osier dogwood(Cornus sericea L.),widely distributed throughout North America,is essential for wildlife,thus biodiversity.It is recommended for reclamation or revegetation of sites disturbed by oil and gas extracti...Red osier dogwood(Cornus sericea L.),widely distributed throughout North America,is essential for wildlife,thus biodiversity.It is recommended for reclamation or revegetation of sites disturbed by oil and gas extraction because it tolerates a wide range of soil types and high pH levels.Since germination of this species is extremely difficult with long stratification requirements and poor germination,cuttings facilitate propagation.In this study,to develop techniques to propagate the species from stem cuttings,four concentrations of indole-3-butyric acid(IBA)and two cutting ages previous year’s growth(PYG)and current year’s growth(CYG)were investigated for survival and growth.After 4 months,survival rate,height growth,and shoot biomass from PYG cuttings were enhanced with IB A.In contrast,IB A did not affect these parameters in CYG cuttings.Root morphology was significantly affected by IB A concentration and cutting age.IBA,at higher concentrations,increased root surface and length.Total root surface area and length of PYG cuttings were increased,which may facilitate the absorption of essential resources and consequently increase growth.The results indicate that increasing the concentration of IB A may be an effective way to have better plant survival and growth of previous year’s cuttings in red osier dogwood.展开更多
BACKGROUND Recurrent hepatocellular carcinoma(rHCC)is a common outcome after curative treatment.Retreatment for rHCC is recommended,but no guidelines exist.AIM To compare curative treatments such as repeated hepatecto...BACKGROUND Recurrent hepatocellular carcinoma(rHCC)is a common outcome after curative treatment.Retreatment for rHCC is recommended,but no guidelines exist.AIM To compare curative treatments such as repeated hepatectomy(RH),radiofrequency ablation(RFA),transarterial chemoembolization(TACE)and liver transplantation(LT)for patients with rHCC after primary hepatectomy by conducting a network meta-analysis(NMA).METHODS From 2011 to 2021,30 articles involving patients with rHCC after primary liver resection were retrieved for this NMA.The Q test was used to assess heterogeneity among studies,and Egger’s test was used to assess publication bias.The efficacy of rHCC treatment was assessed using disease-free survival(DFS)and overall survival(OS).RESULTS From 30 articles,a total of 17,11,8,and 12 arms of RH,RFA,TACE,and LT subgroups were collected for analysis.Forest plot analysis revealed that the LT subgroup had a better cumulative DFS and 1-year OS than the RH subgroup,with an odds ratio(OR)of 0.96(95%CI:0.31-2.96).However,the RH subgroup had a better 3-year and 5-year OS compared to the LT,RFA,and TACE subgroups.Hierarchic step diagram of different subgroups measured by the Wald test yielded the same results as the forest plot analysis.LT had a better 1-year OS(OR:1.04,95%CI:0.34-03.20),and LT was inferior to RH in 3-year OS(OR:10.61,95%CI:0.21-1.73)and 5-year OS(OR:0.95,95%CI:0.39-2.34).According to the predictive P score evaluation,the LT subgroup had a better DFS,and RH had the best OS.However,meta-regression analysis revealed that LT had a better DFS(P<0.001)as well as 3-year OS(P=0.881)and 5-year OS(P=0.188).The differences in superiority between DFS and OS were due to the different testing methods used.CONCLUSION According to this NMA,RH and LT had better DFS and OS for rHCC than RFA and TACE.However,treatment strategies should be determined by the recurrent tumor characteristics,the patient’s general health status,and the care program at each institution.展开更多
This review will describe the global patterns and trends of colorectal cancer survival,using data from the population-based studies or cancer registration.We performed a systematic search of China National Knowledge I...This review will describe the global patterns and trends of colorectal cancer survival,using data from the population-based studies or cancer registration.We performed a systematic search of China National Knowledge Infrastructure(CNKI),Wanfang Data,PubMed,Web of Science,EMBASE,and SEER and collected all population-based survival studies of colorectal cancer(up to June 2020).Estimates of observed and relative survival rates of colorectal cancer by sex,period,and country were extracted from original studies to describe the temporal patterns and trends from the late 1990s to the early 21st century.Globally,5-year observed survival rates were higher in Seoul,Republic of Korea(1993–1997;56.8%and 54.3%for colon and rectum cancers,respectively),Zhejiang province(2005–2010;52.9%for colon cancer),Tianjin(1991–1999;52.5%for colon cancer),Shanghai(2002–2006;50.0%for rectum cancer)of China,and in Japan(1993–1996,59.6%for colorectal cancer).Five-year relative survival rates of colorectal cancer in the Republic of Korea(2010–2014),Queensland,Australia(2005–2012),and the USA(2005–2009)ranked at relatively higher positions compared to other countries.In general,colorectal cancer survival rates are improving over time worldwide.Sex disparities in survival rates were also observed in the colon,rectum,and colorectal cancers in most countries or regions.The poorest age-specific 5-year relative survival rate was observed in patients>75 years of age.In conclusion,over the past 3 decades,colorectal cancer survival has gradually improved.Geographic variations,sex differences,and age gradients were also observed globally in colorectal cancer survival.Further studies are therefore warranted to investigate the prognostic factors of colorectal cancer.展开更多
BACKGROUND The prognosis of gastric cancer in an advanced stage remains poor. The exact efficacy of the use of intraoperative sustained-release chemotherapy with 5-fluorouracil(5-FU) in advanced-stage gastric cancer i...BACKGROUND The prognosis of gastric cancer in an advanced stage remains poor. The exact efficacy of the use of intraoperative sustained-release chemotherapy with 5-fluorouracil(5-FU) in advanced-stage gastric cancer is still unelucidated.AIM To explore the long-term survival benefit of using sustained-release 5-FU implants in stage Ⅱ and stage Ⅲ gastric cancer patients.METHODS Patients with gastric cancer in a locally advanced stage and who underwent an R0 radical resection between Jan 2014, to Dec 2016, in this single institution were included. Patients with pathological diagnoses other than adenocarcinoma were excluded. All included patients were grouped according to whether intraoperative sustained-release(SR) chemotherapy with 5-FU was used or not(NSR). The primary end-point was 5-year overall survival. Kaplan–Meier method with logrank test was used to analyze the overall survival of patients and Cox analysis was used to analyze prognosis factors of these patients.RESULTS In total, there were 563 patients with gastric cancer with locally advanced stage, who underwent an R0 radical resection. 309 patients were included in the final analysis. 219(70.9%) were men, with an average age of 58.25 years. Furthermore, 56(18.1%) received neoadjuvant chemotherapy, and 191(61.8%) were in TNM stage Ⅲ. In addition, 158 patients received intraoperative sustainedrelease chemotherapy with 5-FU and were included in the SR group, while the other 161 patients were included in the NSR group. The overall complication rate was 12.94% in the whole group and 10.81%, 16.46% in SR and NSR groups, respectively. There were no significant differences between the two groups in overall survival and complication rate(P > 0.05). The multivariate cox analysis indicated that only N Stage and neoadjuvant therapy were independent influencing factors of survival.CONCLUSION Intraoperative sustained-release chemotherapy usage with 5-FU, did not improve the survival of patients who underwent an R0 radical resection in locally advanced stage of gastric cancer.展开更多
Mechanized transplanting of rapeseed(Brassica napus L.)blanket seedling is an innovative cultivation technology.Cultivating high quality blanket seedling to ensure high survival rate of seedling after transplanting is...Mechanized transplanting of rapeseed(Brassica napus L.)blanket seedling is an innovative cultivation technology.Cultivating high quality blanket seedling to ensure high survival rate of seedling after transplanting is the key of the technology.The effects of different uniconazole rates of 0,0.5,1.0,1.5 and 2.0 mg/tray,spraying at one leaf and one heart stage,on selected agronomic traits,physiological indexes and survival rate of two rapeseed cultivars(‘Qinyou 100 and’Yangyou 90)were investigated in 2018 and 2019.Our results showed that the plant height decreased significantly with the increase of uniconazole rate.However,the collar diameter increased significantly with the increase of uniconazole rate up to 1.5 mg/tray,and the leaf area,dry weights of root and shoot increased with increased uniconazole rate up to 1.0 mg/tray.The root to shoot ratios,N concentrations of root and shoot with the uniconazole rates of 1.0 and 1.5 mg/tray were higher than those with other treatments.As uniconazole rate increasing,gibberellin(GA)and auxin(IAA)concentrations of root and shoot decreased,while abscisic acid(ABA)concentrations increased,and cytokinin(CTK)concentrations topped at uniconazole rate of 1.0 mg/tray and decreased thereafter.The seedling survival rates with 1.0 and 1.5 mg/tray were greatly higher than those in other treatments.Regression analysis suggested plant survival rate was positively related to CTK concentrations and negatively to GA concentrations of root and shoot.To achieve high survival rate after mechanized transplanting,our study revealed that the uniconazole applied at a rate of 1.0 mg/tray was recommended as the best,followed by 1.5 mg/tray.The findings would help to enhance qualities of rapeseed blanket seedling and to promote popularization of mechanized transplanting of rapeseed production.展开更多
Trumpet shell(Charonia lampas sauliae)(Mollusca, Heterogastropoda, Cymatidae) has extensive economic value. Studies on the artificial larval development of C. lampas sauliae for aquaculture utilization have become esp...Trumpet shell(Charonia lampas sauliae)(Mollusca, Heterogastropoda, Cymatidae) has extensive economic value. Studies on the artificial larval development of C. lampas sauliae for aquaculture utilization have become especially important due to the finite natural resources. In the present study, the growth and survival rate of the larvae of C. lampas sauliae broodstocks fed three types of starfish diets, Asterina pectinifera Müller & Troschel 1842, A. amurensis Lütken 1871 and their mixture were compared. The larval size increased gradually between day 10 and day 20 after hatching at 15℃ and 20℃. No difference was found in body size and specific growth rate(SGR)(two-way ANOVA; P > 0.05). However, during transition from trochophore to veliger stage 20 days after hatching, significant increases in larval survival and growth rates were observed. The maximum survival rate was observed on day 10. The mean survival rate was 0.463, 0.730 and 0.515 at 15℃, and 0.369, 0.713 and 0.444 at 20 when ℃ A. pectinifera, A. amurensis and their mixture were fed, respectively. The SGR and survival rate of the larvae were definitely influenced by the diets(P < 0.05), and the effect of A. amurensis alone was higher than that of A. pectinifera alone and their mixture.展开更多
Objective Testicular germ cell tumors(TGCT) are the most common cancer among men aged 15 to 39 years. Previous studies have considered factors related to TGCT survival rate and race/ethnicity, but histological type of...Objective Testicular germ cell tumors(TGCT) are the most common cancer among men aged 15 to 39 years. Previous studies have considered factors related to TGCT survival rate and race/ethnicity, but histological type of the diagnosed cancer has not yet been thoroughly assessed.Methods The data came from 42,854 eligible patients from 1992 to 2015 in the Surveillance Epidemiology and End Results 18. Frequencies and column percent by seminoma and nonseminoma subtypes were determined for each covariates. We used Cox proportional hazard regression to assess the impact of multiple factors on post-diagnostic mortality of TGCT.Results Black males were diagnosed at a later stage, more commonly with local or distant metastases.The incidence of TGCT in black non-seminoma tumors increased most significantly. The difference in survival rates between different ethnic and histological subtypes, overall survival(OS) in patients with non-seminoma was significantly worse than in patients with seminoma. The most important quantitative predictor of death was the stage at the time of diagnosis, and older diagnostic age is also important factor affecting mortality.Conclusion Histological type of testicular germ cell tumor is an important factor in determining the prognosis of testicular cancer in males of different ethnic groups.展开更多
Ridgetail white prawn Exopalaemon carinicauda is an important economic marine species in China.To improve the germplasm quality of cultured E.carinicauda,for the fi rst time,we estimated the heritability of ammonia to...Ridgetail white prawn Exopalaemon carinicauda is an important economic marine species in China.To improve the germplasm quality of cultured E.carinicauda,for the fi rst time,we estimated the heritability of ammonia tolerance and survival of E.carinicauda,covering 263 full-sib families in multiple generations.Analysis models including binary linear animal model(BLA),binary linear sire-dam model(BLSD),probit threshold animal model(PTA),and probit threshold sire-dam model(PTSD)were used.The estimated heritability of tolerance to ammonia in diff erent models ranged from 0.09 to 0.22,and that of survival rate ranged from 0.06 to 0.16.Concerning the tolerance to ammonia,both the PTSD and BLSD models showed comparatively better prediction accuracies(0.48 and 0.47,respectively)than PTA and BLA models(0.40 and 0.26,respectively),while to the survival rate,all four models presented relatively low predictive abilities(0.16-0.26).This study provided important information for the future breeding program of E.carinicauda.展开更多
Characterization of growth and survival of mice displaying early onset hypertonic symptoms is critical as these animals are important for research investigating mechanisms and treatments of pediatric conditions associ...Characterization of growth and survival of mice displaying early onset hypertonic symptoms is critical as these animals are important for research investigating mechanisms and treatments of pediatric conditions associated with hypertonia,such as cerebral palsy.Currently,most animal models of cerebral palsy reproduce risk factors for developing this condition,with most failing to develop the physical symptoms or failing to survive in the postnatal period.The B6.Cg-Glrb spa/J(Gly receptor mutation)transgenic mouse(spa mouse),displays symptoms of early onset hypertonia,though little has been reported on growth and survival,with no reports of growth and survival since genotyping became available.We found that the majority of spa mice display symptoms by P14-P16.Of mice surviving to weaning,only^9%were spa mice.By weaning age,spa mice had significantly lower weights than their heterozygote and wild-type littermates.Of mice that died after weaning and prior to use in experiments or being culled,48%were spa mice.The poor growth and decreased survival of spa mice across multiple developmental and adult ages resembled the varied survival rates observed in humans with mild or severe cerebral palsy.The understanding of the expected survival of these mice is helpful for planning breeding and animal numbers for experiments.Due to the symptoms and timing of symptom onset,spa mice will be valuable in uncovering mechanisms and long-term effects of early onset hypertonia in order to move toward interventions for these conditions.展开更多
Dry mulch, as soil moisture conservation techniques, is seldom practiced for growth and survival of transplanted tree seedlings in dry period in Eritrea. Field experiment was conducted at Halhale, Eritrea with Dry <...Dry mulch, as soil moisture conservation techniques, is seldom practiced for growth and survival of transplanted tree seedlings in dry period in Eritrea. Field experiment was conducted at Halhale, Eritrea with Dry <i><span style="font-family:Verdana;">Hyparrhenia</span></i> <i><span style="font-family:Verdana;">rufa</span></i><span style="font-family:Verdana;">, as a mulch, on a flat basin for growth and survival of seedlings of </span><i><span style="font-family:Verdana;">Grevillea</span></i> <i><span style="font-family:Verdana;">robusta</span></i><span style="font-family:Verdana;"> and </span><i><span style="font-family:Verdana;">Acacia</span></i> <i><span style="font-family:Verdana;">polyacantha</span></i> <i><span style="font-family:Verdana;">subspecies</span></i><i><span style="font-family:;" "=""> </span></i><i><span style="font-family:Verdana;">Campylacantha</span></i><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">by involving</span><span style="font-family:;" "=""><span style="font-family:Verdana;"> four </span><span style="font-family:Verdana;">management practices: 1) mulching and watering basins (MW);2)</span><span style="font-family:Verdana;"> no-mulching but watering basins (NMW);3) mulching but no-watering basins (MNW);4) no-mulching and no-watering basins (NMNW).</span></span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">The experimental design was CRD with three replications. MW and NMW were watered 180 litters (20 litters/month) but MNW and NMNW were not watered at all. Parameters such as soil moisture content of the basin, early growth performance of seedling and survival rate of the seedlings were studied. The result indicated that there were statistically significant differences (p</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;"><</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">0.05) among the treatment for soil moisture content and early growth performance of the seedlings. The average volumetric water content (VWC%) on 0</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">-</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">20</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">cm soil depth at the end of dry period of MW, NMW, MNW, and NMNW were 10.08</span><span style="font-family:Verdana;">%</span><span style="font-family:Verdana;">, 7.7</span><span style="font-family:Verdana;">%</span><span style="font-family:Verdana;">, 6.3</span><span style="font-family:Verdana;">%</span><span style="font-family:;" "=""><span style="font-family:Verdana;"> and 3.9% respectively. Mean height increment of seedlings of </span><i><span style="font-family:Verdana;">G.</span></i></span><i><span style="font-family:;" "=""> </span></i><i><span style="font-family:Verdana;">robusta</span></i><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">of MW (100</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">cm), NMW (83.3</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">cm), MNW (31.5</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">cm) and NMNW (9</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">cm) were recorded, while the mean height increments of seedlings of </span><i><span style="font-family:Verdana;">A.</span></i></span><i><span style="font-family:;" "=""> </span></i><i><span style="font-family:Verdana;">polyacantha</span></i><span style="font-family:Verdana;"> <i>subsp.</i></span><i><span style="font-family:;" "=""> </span></i><i><span style="font-family:Verdana;">Campylacantha</span></i><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">of MW (48</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">cm), NMW (25</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">cm), MNW (4.5</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">cm) and NMNW (3</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">cm) were recorded</span><span style="font-family:Verdana;">.</span><span style="font-family:;" "=""><span style="font-family:Verdana;"> The mean survival rate of </span><i><span style="font-family:Verdana;">G.</span></i> <i><span style="font-family:Verdana;">robusta</span></i><span style="font-family:Verdana;"> was 91.8% of which the highest (100%) survival rate was recorded under MW, NMW and MNW, but the lowest (66.7%) was recorded by NMNW. All seedlings of </span><i><span style="font-family:Verdana;">A.</span></i></span><i><span style="font-family:;" "=""> </span></i><i><span style="font-family:Verdana;">polyacanth</span></i><span style="font-family:Verdana;"> <i>subsp.</i></span><i><span style="font-family:;" "=""> </span></i><i><span style="font-family:Verdana;">Campylacantha</span></i><span style="font-family:Verdana;"> were survived, irrespective of the treatments. The study concluded that soil moisture content, early growth performance of seedlings, and survival rate of transplanted tree seedling was improved by application of mulch.</span>展开更多
文摘Objective:To explore the clinical effect of modified treatment after finger replantation and its impact on the survival rate of replantation.Methods:The research was conducted from March 2022 to March 2023.A total of 58 patients who underwent finger replantation at our hospital were selected.These patients were divided into two groups using the digital table grouping method:the research group(n=29)and the control group(n=29).Patients in the control group received standard treatment following finger replantation,while patients in the study group received modified treatment after the procedure.The incidence of vascular crisis and the survival rate of replantation were compared between the two groups.Results:The incidence of vascular crisis in the study group was lower than that in the control group(P<0.05);the replantation survival rate in the study group was higher than that in the control group(P<0.05).Conclusion:Modified treatment after replantation of severed fingers can reduce the incidence of vascular crisis replantation and improve the survival rate of replantation,so it should be popularized and applied in medical institutions.
基金Supported by the Scientific Research Project of Heilongjiang Health and Family Planning Commission,No.2018086 and No.2018392.
文摘BACKGROUND Acute kidney injury(AKI)is one of the most common acute pancreatitis(AP)-associated complications that has a significant effect on AP,but the factors affecting the AP patients’survival rate remains unclear.AIM To assess the influences of AKI on the survival rate in AP patients.METHODS A total of 139 AP patients were included in this retrospective study.Patients were divided into AKI group(n=72)and non-AKI group(n=67)according to the occurrence of AKI.Data were collected from medical records of hospitalized patients.Then,these data were compared between the two groups and further analysis was performed.RESULTS AKI is more likely to occur in male AP patients(P=0.009).AP patients in AKI group exhibited a significantly higher acute physiologic assessment and chronic health evaluation II score,higher Sequential Organ Failure Assessment score,lower Glasgow Coma Scale score,and higher demand for mechanical ventilation,infusion of vasopressors,and renal replacement therapy than AP patients in non-AKI group(P<0.01,P<0.01,P=0.01,P=0.001,P<0.01,P<0.01,respectively).Significant differences were noted in dose of norepinephrine and adrenaline,duration of mechanical ventilation,maximum and mean values of intra-peritoneal pressure(IPP),maximum and mean values of procalcitonin,maximum and mean serum levels of creatinine,minimum platelet count,and length of hospitalization.Among AP patients with AKI,the survival rate of surgical intensive care unit and in-hospital were only 23%and 21%of the corresponding rates in AP patients without AKI,respectively.The factors that influenced the AP patients’survival rate included body mass index(BMI),mean values of IPP,minimum platelet count,and hospital day,of which mean values of IPP showed the greatest impact.CONCLUSION AP patients with AKI had a lower survival rate and worse relevant clinical outcomes than AP patients without AKI,which necessitates further attention to AP patients with AKI in surgical intensive care unit.
基金supported by the Forestry Commonweal Program(201404422)the National Natural Science Foundation of China(31172115)
文摘To explore the nest survival rate of Reeves' s pheasant(Syrmaticus reevesii) and the nest-site factors that affect it, we conducted artificial nest experiments with reference to natural nests at Dongzhai National Nature Reserve(DNNR), Henan Province and Pingjingguan, Hubei Province from April to June 2014 simulating the situation in its early and later breeding season. We also determined distance characteristics of the nest sites by Arc GIS 10.0. Nest survival models were constructed in Program MARK for data analysis. Results indicated that in the early breeding season, the apparent survival rate(ASR) in DNNR(52.4%) was significantly greater than that in Pingjingguan(13.5%), and the ASR in the later breeding season in DNNR(26.7%) was not indistinctively correlated with Pingjingguan(3.2%). The daily survival rate(DSR) in the later breeding season was 93.8% in DNNR and 92.0% in Pingjingguan, respectively. The DSRs were both negatively correlated with nest distance to forest edges and settlements. The DSR in Pingjingguan was positively correlated with nest distance to paths and negatively correlated with nest distance to water sources. However, the DSR in DNNR was negatively correlated with nest distance to paths but positively correlated with nest distance to water sources.
基金This work was supported by Open Fund of Key Laboratory of Biodiversity Science and Ecological Engineering,Ministry of Education to Yang Liu,the China Postdoctoral Science Foundation(No.2019M663221)the British Ornithologists’Union’s Career Development Bursary in 2019 to Zitan Song,the National Natural Science Foundation of China(Nos.31600297)to Pinjia Queby the Hungarian Scientific Funding Agency,NKFIH(éLVONAL KKP-126949,K-116310)to Tamás Székely.
文摘Background:The allocation of resources between offspring size and number is a central question of life-history theory.Although several studies have tested the existence of this trade-off,few studies have investigated how environmental variation influences the allocation of resources to offspring size and offspring number.Additionally,the relationship between population dynamics and the offspring size and number allocation is far less understood.Methods:We investigate whether resource allocation between egg size and clutch size is influenced by the ambient temperature and whether it may be related to apparent nest survival rate.We measured 1548 eggs from 541 nests of two closely related shorebird species,the Kentish Plover(Charadrius alexandrinus)and the White-faced Plover(C.dealbatus)in China,in four populations that exhibit contrasting ambient environments.We weighed females,monitored nest survival,and calculated the variance of ambient temperature.Results:Although we found that egg size and clutch size were all different between the four breeding populations,the reproductive investment(i.e.total clutch volume)was similar between populations.We also found that populations with a high survival rate had relatively larger eggs and a smaller clutch than populations with a low nest survival rate.The latter result is in line with a conservative/diversified bet-hedging strategy.Conclusions:Our findings suggest that plovers may increasing fitness by investing fewer,larger or many,small according local nest survival rate to make a similar investment in reproduction,and thereby may have an impact on population demography.
文摘Breast cancer is one of the leading diseases that affect women’s lives. It affects their lives in so many ways by denying them the required standard of health needed to carry out all of their daily activities for some days, weeks, months or years before eventually causing death. This research estimates the survival rate of breast cancer patients and investigates the effects of stage of tumor, gender, age, ethnic group, occupation, marital status and type of cancer upon the survival of patients. Data used for the study were extracted from the case file of patients in the Radiation Oncology Department, University College Hospital, Ibadan using a well-structured pro forma in which 74 observations were censored and 30 events occurred. The Kaplan-Meier estimator was used to estimate the overall survival probability of breast cancer patients following their recruitment into the study and determine the mean and median survival times of breast cancer patients following their time of recruitment into the study. Since there are different groups with respect to the stages of tumor at the time of diagnosis, the log-rank test was used to compare the survival curve of the stages of tumor with considering p-values below 0.05 as statistically significant. Multivariate Cox regression was used to investigate the effects of some variables on the survival of patients. The overall cumulative survival probability obtained is 0.175 (17.5%). The overall estimated mean time until death is 28.751 weeks while the median time between admission and death is 23 weeks. As the p-value (0.000032) of the log-rank test for comparing stages of tumor is less than 0.05, it is concluded that there is significant evidence of a difference in survival times for the stages of tumor. The survival function plot for the stages of tumor shows that patients with stage III tumor are less likely to survive. From the estimated mean time until death for the stages of tumor, it was deduced that stage I tumor patients have an increased chance of survival. Types of cancer, gender, marital status, ethnic group, occupation and patient’s age at entry into the study are not important predictors of chances of survival.
文摘Objective To investigate the effect of adipose stromal vascular fraction cells(SVFs)on the survival rate of fat ransplantation.Methods 0.5mL autologous fat tissue was mixed with: ① DiI-labeled autologous SVFs (Group A);②
基金Supported by the National Key R&D Program of China(No.2018YFD0901502)the Ningbo Key R&D Science and Technology Program(Nos.2019B10009,2021Z114)the Natural Science Foundation of Zhejiang Province(Nos.LY19C190003,LQ20C190002)。
文摘Three polyamines(PAs)(spermidine(Spd),spermine(Spm),and putrescine(Put))were used as growth regulators to the marine macroalgae Gracilariopsis lemaneiformis and to female gametophyte and reproductive tissues(cystocarps were constructed),which led to early maturation of cystocarps and spore release.Laboratory cultivation revealed that exogenous PA application accelerated the development of cystocarps,and the mean sporeling growth rate was 20%–50%/d during the initial week of cultivation.The spore count(SC),survival rate(SR),and germination rate(GR)of G.lemaneiformis showed different responses to PA(10-6 mol/L and 10-3 mol/L)treatments under different temperatures(18,26,and 34℃),light intensities(30,60,and 90μmol photons/(m^(2)·s)),salinities(25,30,and 35),and nutrient levels(25꞉2.5,50꞉5.0,and 75꞉7.5μmol/L NH4Cl꞉K2HPO4),and the optimal conditions were 26℃,light intensity of 60μmol/(m^(2)·s),salinity of 35,and nutrient level of 50꞉5.0μmol/L NH4Cl꞉K2HPO4.Under the optimum conditions,the SC per cystocarp increased by 82.38%,and the spore SR and GR increased by 33.07%and 46.44%,respectively.Each experiment lasted for 7 days,with the highest SC on Day 4 and plateauing on Day 7.The results indicate that PAs could promote the early maturation,spore release,survival,and germination of G.lemaneiformis under laboratory conditions.
基金supported by the grants from the China Agriculture Research System Project(No.CARS-49)the Earmarked Fund for Agriculture Seed Improvement Project of Shandong Province(No.2020LZGC016).
文摘Heterosis has been exploited to enhance the yield and adaptability in various shellfish species;however,the molecular basis of it remains unclear.The Pacific oyster Crassostrea gigas is one of the most economically important aquaculture species,and its productive traits can be improved by hybridization.Here,an intraspecific cross between orange shell(O,10th generation)and‘Haida No.1’(H,13th generation)of C.gigas was performed to assess the heterosis of survival trait.Survival rates of hybrid family(OH)and inbred families(HH and OO)were compared at larval stage,and eyed-pediveliger larvae of three families were subjected to transcriptome analysis.The analysis results of best-parent heterosis and mid-parent heterosis showed that the hybrid family exhi-bited a high heterosis in survival relative to the parental families.The OH-M(OH vs.OO)and OH-P(OH vs.HH)had 425 and 512 dif-ferentially expressed genes(DEGs),respectively.Functional enrichment analysis of these DEGs revealed that the significantly enrich-ed genes function in virion binding,C-type lectin receptor signaling pathway,cellular defense response and other immune-related pro-cesses,which involves perlucin-like protein,CD209 antigen-like protein,ZNFX1,caspase-3 and acan genes.These differentially ex-pressed genes in OH-M and OH-P,together with the immune-related processes mentioned above may play an important role in the larval survival of C.gigas.In addition,three genes(CYP450,fucolectin and perlucin-like)are associated with the orange shell and low survival of maternal oyster OO.These findings provide support for the application of hybrid with superior survival and will facilitate the understanding of heterosis formation in the Pacific oyster.
基金supported by the State Forestry Administration of China and the National Key Technology R&D Program of China(No.2016YFC0503200)
文摘Background: Restoring a viable population by reintroduction is the ultimate goal of a large number of ex situ conservation projects for endangered animals. However, many reintroductions fail to establish a population in the wild, partly because released animals cannot acclimate to the native environment of the release site, resulting in very low survival rates. Acclimation training is a technique to resolve this problem, although it does not have positive results in all species. We tested whether acclimation training and soft-release could improve the reintroduction success for captive-bred Cabot's Tragopan(Tragopan caboti), an endangered pheasant in southern China.Methods: Reintroduction of captive-bred Cabot's Tragopan was carried out in the Taoyuandong National Nature Reserve, China from 2010 to 2011. We built a soft-release enclosure for acclimation training in the typical montane habitat of this pheasant. Nine birds were acclimated to the environment of this release site in this cage for more than 50 days before release("trained birds"), while 11 birds remained only in the cage for 3 days prior to release("untrained birds"). Released birds were tagged with a collar radio-transmitter.Results: Post-release monitoring revealed that the survival rate of trained birds was higher than that of untrained birds after 50 days(trained: 85.7%; untrained: 20.0%). Cox regression analysis showed that there was a significant difference in the mortality rates between the trained and untrained birds. In addition, a survey of the habitat of the experimental and the control groups showed significant differences in habitat selection between the groups.Conclusion: Our study suggests that pre-release acclimatization training is an important factor that can lead to improved survival and habitat selection of captive-bred reintroduced tragopans.
基金supported by the Natural Sciences and Engineering Research Council of Canada(Innovation Enhancement Grants—NSERC CCIP 517845-17)。
文摘Red osier dogwood(Cornus sericea L.),widely distributed throughout North America,is essential for wildlife,thus biodiversity.It is recommended for reclamation or revegetation of sites disturbed by oil and gas extraction because it tolerates a wide range of soil types and high pH levels.Since germination of this species is extremely difficult with long stratification requirements and poor germination,cuttings facilitate propagation.In this study,to develop techniques to propagate the species from stem cuttings,four concentrations of indole-3-butyric acid(IBA)and two cutting ages previous year’s growth(PYG)and current year’s growth(CYG)were investigated for survival and growth.After 4 months,survival rate,height growth,and shoot biomass from PYG cuttings were enhanced with IB A.In contrast,IB A did not affect these parameters in CYG cuttings.Root morphology was significantly affected by IB A concentration and cutting age.IBA,at higher concentrations,increased root surface and length.Total root surface area and length of PYG cuttings were increased,which may facilitate the absorption of essential resources and consequently increase growth.The results indicate that increasing the concentration of IB A may be an effective way to have better plant survival and growth of previous year’s cuttings in red osier dogwood.
基金Supported by the Research Fund from E-Da Hospital,No.EDAHS110012.
文摘BACKGROUND Recurrent hepatocellular carcinoma(rHCC)is a common outcome after curative treatment.Retreatment for rHCC is recommended,but no guidelines exist.AIM To compare curative treatments such as repeated hepatectomy(RH),radiofrequency ablation(RFA),transarterial chemoembolization(TACE)and liver transplantation(LT)for patients with rHCC after primary hepatectomy by conducting a network meta-analysis(NMA).METHODS From 2011 to 2021,30 articles involving patients with rHCC after primary liver resection were retrieved for this NMA.The Q test was used to assess heterogeneity among studies,and Egger’s test was used to assess publication bias.The efficacy of rHCC treatment was assessed using disease-free survival(DFS)and overall survival(OS).RESULTS From 30 articles,a total of 17,11,8,and 12 arms of RH,RFA,TACE,and LT subgroups were collected for analysis.Forest plot analysis revealed that the LT subgroup had a better cumulative DFS and 1-year OS than the RH subgroup,with an odds ratio(OR)of 0.96(95%CI:0.31-2.96).However,the RH subgroup had a better 3-year and 5-year OS compared to the LT,RFA,and TACE subgroups.Hierarchic step diagram of different subgroups measured by the Wald test yielded the same results as the forest plot analysis.LT had a better 1-year OS(OR:1.04,95%CI:0.34-03.20),and LT was inferior to RH in 3-year OS(OR:10.61,95%CI:0.21-1.73)and 5-year OS(OR:0.95,95%CI:0.39-2.34).According to the predictive P score evaluation,the LT subgroup had a better DFS,and RH had the best OS.However,meta-regression analysis revealed that LT had a better DFS(P<0.001)as well as 3-year OS(P=0.881)and 5-year OS(P=0.188).The differences in superiority between DFS and OS were due to the different testing methods used.CONCLUSION According to this NMA,RH and LT had better DFS and OS for rHCC than RFA and TACE.However,treatment strategies should be determined by the recurrent tumor characteristics,the patient’s general health status,and the care program at each institution.
基金This work was supported by funding from the National Key Project of Research and Development Program of China(Grant No.2016YFC1302503)the National Key Basic Research Program of China“973 Program”(Grant No.2015CB554000).
文摘This review will describe the global patterns and trends of colorectal cancer survival,using data from the population-based studies or cancer registration.We performed a systematic search of China National Knowledge Infrastructure(CNKI),Wanfang Data,PubMed,Web of Science,EMBASE,and SEER and collected all population-based survival studies of colorectal cancer(up to June 2020).Estimates of observed and relative survival rates of colorectal cancer by sex,period,and country were extracted from original studies to describe the temporal patterns and trends from the late 1990s to the early 21st century.Globally,5-year observed survival rates were higher in Seoul,Republic of Korea(1993–1997;56.8%and 54.3%for colon and rectum cancers,respectively),Zhejiang province(2005–2010;52.9%for colon cancer),Tianjin(1991–1999;52.5%for colon cancer),Shanghai(2002–2006;50.0%for rectum cancer)of China,and in Japan(1993–1996,59.6%for colorectal cancer).Five-year relative survival rates of colorectal cancer in the Republic of Korea(2010–2014),Queensland,Australia(2005–2012),and the USA(2005–2009)ranked at relatively higher positions compared to other countries.In general,colorectal cancer survival rates are improving over time worldwide.Sex disparities in survival rates were also observed in the colon,rectum,and colorectal cancers in most countries or regions.The poorest age-specific 5-year relative survival rate was observed in patients>75 years of age.In conclusion,over the past 3 decades,colorectal cancer survival has gradually improved.Geographic variations,sex differences,and age gradients were also observed globally in colorectal cancer survival.Further studies are therefore warranted to investigate the prognostic factors of colorectal cancer.
基金the CAMS Initiative for Innovative Medicine,No.2016-I2M-1-007。
文摘BACKGROUND The prognosis of gastric cancer in an advanced stage remains poor. The exact efficacy of the use of intraoperative sustained-release chemotherapy with 5-fluorouracil(5-FU) in advanced-stage gastric cancer is still unelucidated.AIM To explore the long-term survival benefit of using sustained-release 5-FU implants in stage Ⅱ and stage Ⅲ gastric cancer patients.METHODS Patients with gastric cancer in a locally advanced stage and who underwent an R0 radical resection between Jan 2014, to Dec 2016, in this single institution were included. Patients with pathological diagnoses other than adenocarcinoma were excluded. All included patients were grouped according to whether intraoperative sustained-release(SR) chemotherapy with 5-FU was used or not(NSR). The primary end-point was 5-year overall survival. Kaplan–Meier method with logrank test was used to analyze the overall survival of patients and Cox analysis was used to analyze prognosis factors of these patients.RESULTS In total, there were 563 patients with gastric cancer with locally advanced stage, who underwent an R0 radical resection. 309 patients were included in the final analysis. 219(70.9%) were men, with an average age of 58.25 years. Furthermore, 56(18.1%) received neoadjuvant chemotherapy, and 191(61.8%) were in TNM stage Ⅲ. In addition, 158 patients received intraoperative sustainedrelease chemotherapy with 5-FU and were included in the SR group, while the other 161 patients were included in the NSR group. The overall complication rate was 12.94% in the whole group and 10.81%, 16.46% in SR and NSR groups, respectively. There were no significant differences between the two groups in overall survival and complication rate(P > 0.05). The multivariate cox analysis indicated that only N Stage and neoadjuvant therapy were independent influencing factors of survival.CONCLUSION Intraoperative sustained-release chemotherapy usage with 5-FU, did not improve the survival of patients who underwent an R0 radical resection in locally advanced stage of gastric cancer.
基金This research was funded by the National Key Research and Development Program of China(2018YFD1000900)the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).
文摘Mechanized transplanting of rapeseed(Brassica napus L.)blanket seedling is an innovative cultivation technology.Cultivating high quality blanket seedling to ensure high survival rate of seedling after transplanting is the key of the technology.The effects of different uniconazole rates of 0,0.5,1.0,1.5 and 2.0 mg/tray,spraying at one leaf and one heart stage,on selected agronomic traits,physiological indexes and survival rate of two rapeseed cultivars(‘Qinyou 100 and’Yangyou 90)were investigated in 2018 and 2019.Our results showed that the plant height decreased significantly with the increase of uniconazole rate.However,the collar diameter increased significantly with the increase of uniconazole rate up to 1.5 mg/tray,and the leaf area,dry weights of root and shoot increased with increased uniconazole rate up to 1.0 mg/tray.The root to shoot ratios,N concentrations of root and shoot with the uniconazole rates of 1.0 and 1.5 mg/tray were higher than those with other treatments.As uniconazole rate increasing,gibberellin(GA)and auxin(IAA)concentrations of root and shoot decreased,while abscisic acid(ABA)concentrations increased,and cytokinin(CTK)concentrations topped at uniconazole rate of 1.0 mg/tray and decreased thereafter.The seedling survival rates with 1.0 and 1.5 mg/tray were greatly higher than those in other treatments.Regression analysis suggested plant survival rate was positively related to CTK concentrations and negatively to GA concentrations of root and shoot.To achieve high survival rate after mechanized transplanting,our study revealed that the uniconazole applied at a rate of 1.0 mg/tray was recommended as the best,followed by 1.5 mg/tray.The findings would help to enhance qualities of rapeseed blanket seedling and to promote popularization of mechanized transplanting of rapeseed production.
基金financially supported by Chonnam National University in 2013
文摘Trumpet shell(Charonia lampas sauliae)(Mollusca, Heterogastropoda, Cymatidae) has extensive economic value. Studies on the artificial larval development of C. lampas sauliae for aquaculture utilization have become especially important due to the finite natural resources. In the present study, the growth and survival rate of the larvae of C. lampas sauliae broodstocks fed three types of starfish diets, Asterina pectinifera Müller & Troschel 1842, A. amurensis Lütken 1871 and their mixture were compared. The larval size increased gradually between day 10 and day 20 after hatching at 15℃ and 20℃. No difference was found in body size and specific growth rate(SGR)(two-way ANOVA; P > 0.05). However, during transition from trochophore to veliger stage 20 days after hatching, significant increases in larval survival and growth rates were observed. The maximum survival rate was observed on day 10. The mean survival rate was 0.463, 0.730 and 0.515 at 15℃, and 0.369, 0.713 and 0.444 at 20 when ℃ A. pectinifera, A. amurensis and their mixture were fed, respectively. The SGR and survival rate of the larvae were definitely influenced by the diets(P < 0.05), and the effect of A. amurensis alone was higher than that of A. pectinifera alone and their mixture.
基金supported by the National Key Research Program of China 2016YFC1302601。
文摘Objective Testicular germ cell tumors(TGCT) are the most common cancer among men aged 15 to 39 years. Previous studies have considered factors related to TGCT survival rate and race/ethnicity, but histological type of the diagnosed cancer has not yet been thoroughly assessed.Methods The data came from 42,854 eligible patients from 1992 to 2015 in the Surveillance Epidemiology and End Results 18. Frequencies and column percent by seminoma and nonseminoma subtypes were determined for each covariates. We used Cox proportional hazard regression to assess the impact of multiple factors on post-diagnostic mortality of TGCT.Results Black males were diagnosed at a later stage, more commonly with local or distant metastases.The incidence of TGCT in black non-seminoma tumors increased most significantly. The difference in survival rates between different ethnic and histological subtypes, overall survival(OS) in patients with non-seminoma was significantly worse than in patients with seminoma. The most important quantitative predictor of death was the stage at the time of diagnosis, and older diagnostic age is also important factor affecting mortality.Conclusion Histological type of testicular germ cell tumor is an important factor in determining the prognosis of testicular cancer in males of different ethnic groups.
基金Supported by the National Key R&D Program of China(No.2018YFD0901302)the China Agriculture Research System-48(No.CARS-48)。
文摘Ridgetail white prawn Exopalaemon carinicauda is an important economic marine species in China.To improve the germplasm quality of cultured E.carinicauda,for the fi rst time,we estimated the heritability of ammonia tolerance and survival of E.carinicauda,covering 263 full-sib families in multiple generations.Analysis models including binary linear animal model(BLA),binary linear sire-dam model(BLSD),probit threshold animal model(PTA),and probit threshold sire-dam model(PTSD)were used.The estimated heritability of tolerance to ammonia in diff erent models ranged from 0.09 to 0.22,and that of survival rate ranged from 0.06 to 0.16.Concerning the tolerance to ammonia,both the PTSD and BLSD models showed comparatively better prediction accuracies(0.48 and 0.47,respectively)than PTA and BLA models(0.40 and 0.26,respectively),while to the survival rate,all four models presented relatively low predictive abilities(0.16-0.26).This study provided important information for the future breeding program of E.carinicauda.
基金National Institute on Aging,Grant/Award Number:R01-AG044615National Heart,Lung,and Blood Institute,Grant/Award Number:R01-HL96750+2 种基金Mayo ClinicCenter for Clinical and Translational Science,Mayo Clinic,Grant/Award Number:UL1TR000135National Health and Medical Research Council,Grant/Award Number:CJ Martin Fellowship。
文摘Characterization of growth and survival of mice displaying early onset hypertonic symptoms is critical as these animals are important for research investigating mechanisms and treatments of pediatric conditions associated with hypertonia,such as cerebral palsy.Currently,most animal models of cerebral palsy reproduce risk factors for developing this condition,with most failing to develop the physical symptoms or failing to survive in the postnatal period.The B6.Cg-Glrb spa/J(Gly receptor mutation)transgenic mouse(spa mouse),displays symptoms of early onset hypertonia,though little has been reported on growth and survival,with no reports of growth and survival since genotyping became available.We found that the majority of spa mice display symptoms by P14-P16.Of mice surviving to weaning,only^9%were spa mice.By weaning age,spa mice had significantly lower weights than their heterozygote and wild-type littermates.Of mice that died after weaning and prior to use in experiments or being culled,48%were spa mice.The poor growth and decreased survival of spa mice across multiple developmental and adult ages resembled the varied survival rates observed in humans with mild or severe cerebral palsy.The understanding of the expected survival of these mice is helpful for planning breeding and animal numbers for experiments.Due to the symptoms and timing of symptom onset,spa mice will be valuable in uncovering mechanisms and long-term effects of early onset hypertonia in order to move toward interventions for these conditions.
文摘Dry mulch, as soil moisture conservation techniques, is seldom practiced for growth and survival of transplanted tree seedlings in dry period in Eritrea. Field experiment was conducted at Halhale, Eritrea with Dry <i><span style="font-family:Verdana;">Hyparrhenia</span></i> <i><span style="font-family:Verdana;">rufa</span></i><span style="font-family:Verdana;">, as a mulch, on a flat basin for growth and survival of seedlings of </span><i><span style="font-family:Verdana;">Grevillea</span></i> <i><span style="font-family:Verdana;">robusta</span></i><span style="font-family:Verdana;"> and </span><i><span style="font-family:Verdana;">Acacia</span></i> <i><span style="font-family:Verdana;">polyacantha</span></i> <i><span style="font-family:Verdana;">subspecies</span></i><i><span style="font-family:;" "=""> </span></i><i><span style="font-family:Verdana;">Campylacantha</span></i><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">by involving</span><span style="font-family:;" "=""><span style="font-family:Verdana;"> four </span><span style="font-family:Verdana;">management practices: 1) mulching and watering basins (MW);2)</span><span style="font-family:Verdana;"> no-mulching but watering basins (NMW);3) mulching but no-watering basins (MNW);4) no-mulching and no-watering basins (NMNW).</span></span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">The experimental design was CRD with three replications. MW and NMW were watered 180 litters (20 litters/month) but MNW and NMNW were not watered at all. Parameters such as soil moisture content of the basin, early growth performance of seedling and survival rate of the seedlings were studied. The result indicated that there were statistically significant differences (p</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;"><</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">0.05) among the treatment for soil moisture content and early growth performance of the seedlings. The average volumetric water content (VWC%) on 0</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">-</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">20</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">cm soil depth at the end of dry period of MW, NMW, MNW, and NMNW were 10.08</span><span style="font-family:Verdana;">%</span><span style="font-family:Verdana;">, 7.7</span><span style="font-family:Verdana;">%</span><span style="font-family:Verdana;">, 6.3</span><span style="font-family:Verdana;">%</span><span style="font-family:;" "=""><span style="font-family:Verdana;"> and 3.9% respectively. Mean height increment of seedlings of </span><i><span style="font-family:Verdana;">G.</span></i></span><i><span style="font-family:;" "=""> </span></i><i><span style="font-family:Verdana;">robusta</span></i><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">of MW (100</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">cm), NMW (83.3</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">cm), MNW (31.5</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">cm) and NMNW (9</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">cm) were recorded, while the mean height increments of seedlings of </span><i><span style="font-family:Verdana;">A.</span></i></span><i><span style="font-family:;" "=""> </span></i><i><span style="font-family:Verdana;">polyacantha</span></i><span style="font-family:Verdana;"> <i>subsp.</i></span><i><span style="font-family:;" "=""> </span></i><i><span style="font-family:Verdana;">Campylacantha</span></i><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">of MW (48</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">cm), NMW (25</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">cm), MNW (4.5</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">cm) and NMNW (3</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">cm) were recorded</span><span style="font-family:Verdana;">.</span><span style="font-family:;" "=""><span style="font-family:Verdana;"> The mean survival rate of </span><i><span style="font-family:Verdana;">G.</span></i> <i><span style="font-family:Verdana;">robusta</span></i><span style="font-family:Verdana;"> was 91.8% of which the highest (100%) survival rate was recorded under MW, NMW and MNW, but the lowest (66.7%) was recorded by NMNW. All seedlings of </span><i><span style="font-family:Verdana;">A.</span></i></span><i><span style="font-family:;" "=""> </span></i><i><span style="font-family:Verdana;">polyacanth</span></i><span style="font-family:Verdana;"> <i>subsp.</i></span><i><span style="font-family:;" "=""> </span></i><i><span style="font-family:Verdana;">Campylacantha</span></i><span style="font-family:Verdana;"> were survived, irrespective of the treatments. The study concluded that soil moisture content, early growth performance of seedlings, and survival rate of transplanted tree seedling was improved by application of mulch.</span>
