AIMTo compare the effects of intravitreal injection of bevacizumab (IVB) with intravitreal triamcinolone acetonide (IVTA) on the treatment of cystoid macular edema (CME) secondary to retinal vein occlusion (RVO).METHO...AIMTo compare the effects of intravitreal injection of bevacizumab (IVB) with intravitreal triamcinolone acetonide (IVTA) on the treatment of cystoid macular edema (CME) secondary to retinal vein occlusion (RVO).METHODSA literature search was conducted using PubMed, the Cochrane Central Register of Controlled Trials, Web of Science and the Chinese Biomedical Database. The comparison was divided into two groups, group 1 conducted comparison in branch RVO (BRVO) or central RVO (CRVO), group 2 conducted comparison in ischemic-RVO or nonischemic-RVO. Pooled mean differences (MDs) for changes in visual acuity (VA), central macular thickness (CMT) and intraocular pressure (IOP) were calculated in groups at 4, 12 and 24wk after treatment respectively.RESULTSEight studies comparing the efficacy of IVB with IVTA were included in the Meta-analysis. In group 1, in BRVO, significant difference was shown on the comparison of CMT at 24wk (MD, -45.66; 95% CI, -76.03 to -15.28; P=0.003), IVB was effective on BRVO for at least 24wk; no significant differences were found in the comparison of VA at each time points (P>0.05 respectively). In CRVO, no significant differences were found in the comparison of VA or CMT between IVB and IVTA at each time points (P>0.05, respectively). In group 2, in ischemic-RVO, significant differences were shown in the comparison of VA (MD, -0.28; 95% CI, -0.42 to -0.14; P<0.0001) and CMT (MD, -86.50; 95% CI, -151.18 to -22.43; P=0.008) at 24wk; In nonischemic-RVO, no significant differences were demonstrated in the comparison of VA or CMT between IVB and IVTA at each time points (P>0.05, respectively). The occurrence of high IOP was much lower in IVB group.CONCLUSIONThis Meta-analysis suggested that IVB was effective in decreasing CMT in BRVO for at least 24wk, IVB is more effective on improving VA and reducing CMT in ischemic-RVO. IVB is more promising on RVO than IVTA.展开更多
Background:To evaluate a fully automated vascular density(VD),skeletal density(SD)and fractal dimension(FD)method for the longitudinal analysis of retinal vein occlusion(RVO)eyes using projection-resolved optical cohe...Background:To evaluate a fully automated vascular density(VD),skeletal density(SD)and fractal dimension(FD)method for the longitudinal analysis of retinal vein occlusion(RVO)eyes using projection-resolved optical coherence tomography angiography(OCTA)images and to evaluate the association between these quantitative variables and the visual prognosis in RVO eyes.Methods:Retrospective longitudinal observational case series.Patients presenting with RVO to Creteil University Eye Clinic between October 2014 and December 2018 and healthy controls were retrospectively evaluated.Group 1 consisted of central RVO(CRVO)eyes,group 2 consisted of eyes with branch RVO(BRVO)and group 3 of healthy control eyes.OCTA acquisitions(AngioVue RTVue XR Avanti,Optovue,Inc.,Freemont,CA)were performed at baseline and last follow up visit.VD,SD,and FD analysis were computed on OCTA superficial and deep vascular complex(SVC,DVC)images at baseline and final follow up using an automated algorithm.Logistic regression was performed to find if and which variable(VD,SD,FD)was predictive for the visual outcome.Results:Forty-one eyes,of which 21 consecutive eyes of 20 RVO patients(13 CRVO in group 1,8 BRVO in group 2),and 20 eyes of 20 healthy controls were included.At the level of SVC,VD and FD were significantly lower in RVO eyes compared to controls(P<0.0001 and P=0.0008 respectively).Best-corrected visual acuity(BCVA)at last follow-up visit was associated with baseline VD(P=0.013),FD(P=0.016),and SD(P=0.01)at the level of the SVC,as well as with baseline FD at the DVC level(P=0.046).Conclusions:Baseline VD,SD,and FD are associated with the visual outcome in RVO eyes.These parameters seem valuable biomarkers and may help improve the evaluation and management of RVO patients.展开更多
目的:利用T-Scan定量分析单颗后牙种植修复体在牙尖交错位(intercuspal position,ICP)时咬合接触情况,并探讨其对种植体周围垂直骨吸收的影响。方法:选取第一磨牙常规种植修复的40例无咬合高点等不良修复现象和磨牙症等不良习惯的患者。...目的:利用T-Scan定量分析单颗后牙种植修复体在牙尖交错位(intercuspal position,ICP)时咬合接触情况,并探讨其对种植体周围垂直骨吸收的影响。方法:选取第一磨牙常规种植修复的40例无咬合高点等不良修复现象和磨牙症等不良习惯的患者。T-Scan记录种植修复体及对侧同名牙咬合接触情况的差异,分别按照咬合延迟时间、牙合力百分率比、咬合力峰值及咬合接触面积比进行分组,用影像学测量技术评估种植体周围骨组织的变化,从而分析咬合因素对种植体周围垂直骨吸收(vertical bone loss,VBL)的影响,并建立多元线性回归模型。结果:在咬合延迟时间和咬合力峰值分组比较中,平均VBL均存在显著性差异(P<0.05)。同时得出预测方程:Y=1.060-0.734X1+0.248X2-0.589X3,其中Y为平均VBL、X1为咬合延迟时间、X2为咬合力峰值、X3为咬合接触面积比。结论:在单颗后牙缺失常规种植修复时除考虑适当的咬合设计外,在调整种植修复体的咬合接触或定期咬合检查时,推荐应用T-Scan进行定量分析以确保ICP时咬合力峰值尽可能降低(即轻咬合接触),和适当延迟种植修复体首次咬合接触时间,对维持种植体周围骨的稳定性极为有益。展开更多
Objective:To systematically evaluate the clinical efficacy and safety of Simiao Yong'an Decoction in the treatment of peripheral occlusive disease(PAOD).Methods:Eight randomized controlled clinical trials(RCT)of S...Objective:To systematically evaluate the clinical efficacy and safety of Simiao Yong'an Decoction in the treatment of peripheral occlusive disease(PAOD).Methods:Eight randomized controlled clinical trials(RCT)of Simiao Yong'an Decoction in the treatment of PAOD were searched and screened from domestic and foreign databases(all from database construction to March 2020).The quality of the retrieved original studies was evaluated according to the evaluation criteria of Cochrane Handbook 5.1.0,and the included studies were meta-analyzed by RevMan5.3 software.Results:A total of 350 articles were retrieved,among which 14 studies met the inclusion criteria,with a total sample size of 1254 cases.The results of meta-analysis showed that:compared with conventional western Med,combined with Simiao Yong'an Decoction on the basis of western Med treatment can significantly improve the total clinical response rate of patients[RR=1.20,95%CI(1.14,1.27),P<0.00001],improve ankle brachial index(ABI)level[MD=0.79,95%CI(0.66,0.92),P<0.00001]and toe brachial index(TBI)level[RR=0.13,95%CI(0.10,0.16),P<0.00001],decreased c-reactive protein levels[MD=-8.55,95%CI(-8.99,-8.11),P<0.00001]and LDL levels[MD=-0.41,95%CI(-0.62,-0.19),P=0.0002],and increased HDL levels[MD=0.32(0.22,0.43),P<0.00001].There was no statistically significant difference in the incidence of adverse reactions[RR=0.50,95%CI(1.15,1.64),P=0.25].Conclusion:Simiao Yong'an Decoction combined with conventional western Med is more effective than conventional western Med in the treatment of PAOD.However,in view of the limitations of the quality of the analyzed literature,the positive results obtained in this study still need to be further verified by a large sample and multi-center clinical trial with a reliable research program.展开更多
To tackle the problem of severe occlusions in visual tracking, we propose a hierarchical template-matching method based on a layered appearance model. This model integrates holistic- and part-region matching in order ...To tackle the problem of severe occlusions in visual tracking, we propose a hierarchical template-matching method based on a layered appearance model. This model integrates holistic- and part-region matching in order to locate an object in a coarse-to-fine manner. Furthermore, in order to reduce ambiguity in object localization, only the discriminative parts of an object＇ s appearance template are chosen for similarity computing with respect to their cornerness measurements. The similarity between parts is computed in a layer-wise manner, and from this, occlusions can be evaluated. When the object is partly occluded, it can be located accurately by matching candidate regions with the appearance template. When it is completely occluded, its location can be predicted from its historical motion information using a Kalman filter. The proposed tracker is tested on several practical image sequences, and the experimental results show that it can consistently provide accurate object location for stable tracking, even for severe occlusions.展开更多
In this paper, we have presented a novel tracking method aiming at detecting objects and maintaining their la-bel/identification over the time. The key factors of this method are to use depth information and different...In this paper, we have presented a novel tracking method aiming at detecting objects and maintaining their la-bel/identification over the time. The key factors of this method are to use depth information and different strategies to track objects under various occlusion scenarios. The foreground objects are detected and refined by background subtraction and shadow cancellation. The occlusion detection is based on information of foreground blobs in successive frames. The occlusion regions are projected to the projection plane XZ to analysis occlusion situation. According to the occlusion analysis results, different objects’ corresponding strategies are introduced to track objects under various occlusion scenarios including tracking occluded objects in similar depth layer and in different depth layers. The experimental results show that our proposed method can track the moving objects under the most typical and challenging occlusion scenarios.展开更多
Occlusal force has the main role in determining the teeth health in general and determining the chewing, muscle and TMJ function. The objective of this study was to find if there was any relation between the preferred...Occlusal force has the main role in determining the teeth health in general and determining the chewing, muscle and TMJ function. The objective of this study was to find if there was any relation between the preferred chewing side and the force, measured by T-scan III system. The total number of 90 (46 female and 44 male) dental students was included in this study. They were asked whether their preferred chewing side was right, left or both. Afterwards, the occlusal forces in habitual occlusion, using T-Scan III Electronic device (IP-CO position mode, MA-mode, MA sensitivity setting) were measured. The data were presented as Mean ± SD. Spearman correlation was used to find the correlation between the occlusal force and chewing side. Differences in P 0.05) and the right side (r = 0.143, P > 0.05) according to the preferred chewing side. In this study, the relation between the preferred chewing side and occlusal force was found.展开更多
The desire to deliver measured amount of insulin continuously to patients with type I diabetes, for glycemic control, has attracted a lot of attention. Continuous subcutaneous insulin infusion has seen some success in...The desire to deliver measured amount of insulin continuously to patients with type I diabetes, for glycemic control, has attracted a lot of attention. Continuous subcutaneous insulin infusion has seen some success in recent years. However, occlusion of insulin delivery may prevent the patient from receiving the prescribed dosage, with adverse consequence. An in vitro study of insulin delivery is performed, using different insulin pumps, insulin analogs and operating conditions. The aim is to identify incidences of occlusion due to bubble formation in the infusion line. A detailed statistical analysis was performed on the data collected to determine any significant differences and deviations in insulin delivery rates that might be due to factors such as: pump type, the set basal flow rate, insulin type, vibration, and possible insulin occlusion due to air bubble formation within the infusion line. Our findings from the Graeco-Latin Square design model show that there are statistical differences due to the devices, and statistical identifiable clusters are used to distinguish the devices. Such hierarchical models used to describe the analyses, include the flow rate, the pump types, and the activity level.展开更多
针对窄间隙熔化极气体保护焊(Gas Metal Arc Welding,GMAW)焊道侧壁处局部咬边缺陷检测困难的问题,提出了一种基于电弧声信号特征提取与处理的咬边缺陷在线检测方法。通过分析正常、临界咬边和咬边这3种焊接状态的电弧形态和电弧声信号...针对窄间隙熔化极气体保护焊(Gas Metal Arc Welding,GMAW)焊道侧壁处局部咬边缺陷检测困难的问题,提出了一种基于电弧声信号特征提取与处理的咬边缺陷在线检测方法。通过分析正常、临界咬边和咬边这3种焊接状态的电弧形态和电弧声信号特征,证实坡口侧壁引起的电弧形态变化是影响电弧声信号变化的重要因素。在此基础上采用小波包时频分析,同时引入特征类间标准差作为评价指标,确定了能有效识别3种焊接状态的敏感特征。采用Sigmoid支持向量机和五折交叉验证建立预测模型,实验结果表明该模型能较好地实现3种焊接状态的预测分类,识别准确率达到96.0%。展开更多
文摘AIMTo compare the effects of intravitreal injection of bevacizumab (IVB) with intravitreal triamcinolone acetonide (IVTA) on the treatment of cystoid macular edema (CME) secondary to retinal vein occlusion (RVO).METHODSA literature search was conducted using PubMed, the Cochrane Central Register of Controlled Trials, Web of Science and the Chinese Biomedical Database. The comparison was divided into two groups, group 1 conducted comparison in branch RVO (BRVO) or central RVO (CRVO), group 2 conducted comparison in ischemic-RVO or nonischemic-RVO. Pooled mean differences (MDs) for changes in visual acuity (VA), central macular thickness (CMT) and intraocular pressure (IOP) were calculated in groups at 4, 12 and 24wk after treatment respectively.RESULTSEight studies comparing the efficacy of IVB with IVTA were included in the Meta-analysis. In group 1, in BRVO, significant difference was shown on the comparison of CMT at 24wk (MD, -45.66; 95% CI, -76.03 to -15.28; P=0.003), IVB was effective on BRVO for at least 24wk; no significant differences were found in the comparison of VA at each time points (P>0.05 respectively). In CRVO, no significant differences were found in the comparison of VA or CMT between IVB and IVTA at each time points (P>0.05, respectively). In group 2, in ischemic-RVO, significant differences were shown in the comparison of VA (MD, -0.28; 95% CI, -0.42 to -0.14; P<0.0001) and CMT (MD, -86.50; 95% CI, -151.18 to -22.43; P=0.008) at 24wk; In nonischemic-RVO, no significant differences were demonstrated in the comparison of VA or CMT between IVB and IVTA at each time points (P>0.05, respectively). The occurrence of high IOP was much lower in IVB group.CONCLUSIONThis Meta-analysis suggested that IVB was effective in decreasing CMT in BRVO for at least 24wk, IVB is more effective on improving VA and reducing CMT in ischemic-RVO. IVB is more promising on RVO than IVTA.
文摘Background:To evaluate a fully automated vascular density(VD),skeletal density(SD)and fractal dimension(FD)method for the longitudinal analysis of retinal vein occlusion(RVO)eyes using projection-resolved optical coherence tomography angiography(OCTA)images and to evaluate the association between these quantitative variables and the visual prognosis in RVO eyes.Methods:Retrospective longitudinal observational case series.Patients presenting with RVO to Creteil University Eye Clinic between October 2014 and December 2018 and healthy controls were retrospectively evaluated.Group 1 consisted of central RVO(CRVO)eyes,group 2 consisted of eyes with branch RVO(BRVO)and group 3 of healthy control eyes.OCTA acquisitions(AngioVue RTVue XR Avanti,Optovue,Inc.,Freemont,CA)were performed at baseline and last follow up visit.VD,SD,and FD analysis were computed on OCTA superficial and deep vascular complex(SVC,DVC)images at baseline and final follow up using an automated algorithm.Logistic regression was performed to find if and which variable(VD,SD,FD)was predictive for the visual outcome.Results:Forty-one eyes,of which 21 consecutive eyes of 20 RVO patients(13 CRVO in group 1,8 BRVO in group 2),and 20 eyes of 20 healthy controls were included.At the level of SVC,VD and FD were significantly lower in RVO eyes compared to controls(P<0.0001 and P=0.0008 respectively).Best-corrected visual acuity(BCVA)at last follow-up visit was associated with baseline VD(P=0.013),FD(P=0.016),and SD(P=0.01)at the level of the SVC,as well as with baseline FD at the DVC level(P=0.046).Conclusions:Baseline VD,SD,and FD are associated with the visual outcome in RVO eyes.These parameters seem valuable biomarkers and may help improve the evaluation and management of RVO patients.
文摘目的:利用T-Scan定量分析单颗后牙种植修复体在牙尖交错位(intercuspal position,ICP)时咬合接触情况,并探讨其对种植体周围垂直骨吸收的影响。方法:选取第一磨牙常规种植修复的40例无咬合高点等不良修复现象和磨牙症等不良习惯的患者。T-Scan记录种植修复体及对侧同名牙咬合接触情况的差异,分别按照咬合延迟时间、牙合力百分率比、咬合力峰值及咬合接触面积比进行分组,用影像学测量技术评估种植体周围骨组织的变化,从而分析咬合因素对种植体周围垂直骨吸收(vertical bone loss,VBL)的影响,并建立多元线性回归模型。结果:在咬合延迟时间和咬合力峰值分组比较中,平均VBL均存在显著性差异(P<0.05)。同时得出预测方程:Y=1.060-0.734X1+0.248X2-0.589X3,其中Y为平均VBL、X1为咬合延迟时间、X2为咬合力峰值、X3为咬合接触面积比。结论:在单颗后牙缺失常规种植修复时除考虑适当的咬合设计外,在调整种植修复体的咬合接触或定期咬合检查时,推荐应用T-Scan进行定量分析以确保ICP时咬合力峰值尽可能降低(即轻咬合接触),和适当延迟种植修复体首次咬合接触时间,对维持种植体周围骨的稳定性极为有益。
基金Traditional Chinese Med Technology Development Foundation of Shandong Province,China(No.2019-0205,2013ZDZK-047)Natural Science Foundation of Shandong Province,China(General Program)(No.ZR2017MH038)
文摘Objective:To systematically evaluate the clinical efficacy and safety of Simiao Yong'an Decoction in the treatment of peripheral occlusive disease(PAOD).Methods:Eight randomized controlled clinical trials(RCT)of Simiao Yong'an Decoction in the treatment of PAOD were searched and screened from domestic and foreign databases(all from database construction to March 2020).The quality of the retrieved original studies was evaluated according to the evaluation criteria of Cochrane Handbook 5.1.0,and the included studies were meta-analyzed by RevMan5.3 software.Results:A total of 350 articles were retrieved,among which 14 studies met the inclusion criteria,with a total sample size of 1254 cases.The results of meta-analysis showed that:compared with conventional western Med,combined with Simiao Yong'an Decoction on the basis of western Med treatment can significantly improve the total clinical response rate of patients[RR=1.20,95%CI(1.14,1.27),P<0.00001],improve ankle brachial index(ABI)level[MD=0.79,95%CI(0.66,0.92),P<0.00001]and toe brachial index(TBI)level[RR=0.13,95%CI(0.10,0.16),P<0.00001],decreased c-reactive protein levels[MD=-8.55,95%CI(-8.99,-8.11),P<0.00001]and LDL levels[MD=-0.41,95%CI(-0.62,-0.19),P=0.0002],and increased HDL levels[MD=0.32(0.22,0.43),P<0.00001].There was no statistically significant difference in the incidence of adverse reactions[RR=0.50,95%CI(1.15,1.64),P=0.25].Conclusion:Simiao Yong'an Decoction combined with conventional western Med is more effective than conventional western Med in the treatment of PAOD.However,in view of the limitations of the quality of the analyzed literature,the positive results obtained in this study still need to be further verified by a large sample and multi-center clinical trial with a reliable research program.
基金supported by the Aeronautical Science Foundation of China under Grant 20115169016supported in part by the technique cooperation project of ZTE on Intelligent Video Analysis in 2012
文摘To tackle the problem of severe occlusions in visual tracking, we propose a hierarchical template-matching method based on a layered appearance model. This model integrates holistic- and part-region matching in order to locate an object in a coarse-to-fine manner. Furthermore, in order to reduce ambiguity in object localization, only the discriminative parts of an object＇ s appearance template are chosen for similarity computing with respect to their cornerness measurements. The similarity between parts is computed in a layer-wise manner, and from this, occlusions can be evaluated. When the object is partly occluded, it can be located accurately by matching candidate regions with the appearance template. When it is completely occluded, its location can be predicted from its historical motion information using a Kalman filter. The proposed tracker is tested on several practical image sequences, and the experimental results show that it can consistently provide accurate object location for stable tracking, even for severe occlusions.
文摘In this paper, we have presented a novel tracking method aiming at detecting objects and maintaining their la-bel/identification over the time. The key factors of this method are to use depth information and different strategies to track objects under various occlusion scenarios. The foreground objects are detected and refined by background subtraction and shadow cancellation. The occlusion detection is based on information of foreground blobs in successive frames. The occlusion regions are projected to the projection plane XZ to analysis occlusion situation. According to the occlusion analysis results, different objects’ corresponding strategies are introduced to track objects under various occlusion scenarios including tracking occluded objects in similar depth layer and in different depth layers. The experimental results show that our proposed method can track the moving objects under the most typical and challenging occlusion scenarios.
文摘Occlusal force has the main role in determining the teeth health in general and determining the chewing, muscle and TMJ function. The objective of this study was to find if there was any relation between the preferred chewing side and the force, measured by T-scan III system. The total number of 90 (46 female and 44 male) dental students was included in this study. They were asked whether their preferred chewing side was right, left or both. Afterwards, the occlusal forces in habitual occlusion, using T-Scan III Electronic device (IP-CO position mode, MA-mode, MA sensitivity setting) were measured. The data were presented as Mean ± SD. Spearman correlation was used to find the correlation between the occlusal force and chewing side. Differences in P 0.05) and the right side (r = 0.143, P > 0.05) according to the preferred chewing side. In this study, the relation between the preferred chewing side and occlusal force was found.
文摘The desire to deliver measured amount of insulin continuously to patients with type I diabetes, for glycemic control, has attracted a lot of attention. Continuous subcutaneous insulin infusion has seen some success in recent years. However, occlusion of insulin delivery may prevent the patient from receiving the prescribed dosage, with adverse consequence. An in vitro study of insulin delivery is performed, using different insulin pumps, insulin analogs and operating conditions. The aim is to identify incidences of occlusion due to bubble formation in the infusion line. A detailed statistical analysis was performed on the data collected to determine any significant differences and deviations in insulin delivery rates that might be due to factors such as: pump type, the set basal flow rate, insulin type, vibration, and possible insulin occlusion due to air bubble formation within the infusion line. Our findings from the Graeco-Latin Square design model show that there are statistical differences due to the devices, and statistical identifiable clusters are used to distinguish the devices. Such hierarchical models used to describe the analyses, include the flow rate, the pump types, and the activity level.
文摘针对窄间隙熔化极气体保护焊(Gas Metal Arc Welding,GMAW)焊道侧壁处局部咬边缺陷检测困难的问题,提出了一种基于电弧声信号特征提取与处理的咬边缺陷在线检测方法。通过分析正常、临界咬边和咬边这3种焊接状态的电弧形态和电弧声信号特征,证实坡口侧壁引起的电弧形态变化是影响电弧声信号变化的重要因素。在此基础上采用小波包时频分析,同时引入特征类间标准差作为评价指标,确定了能有效识别3种焊接状态的敏感特征。采用Sigmoid支持向量机和五折交叉验证建立预测模型,实验结果表明该模型能较好地实现3种焊接状态的预测分类,识别准确率达到96.0%。
