The most common comorbid psychiatric disorders in children with type 1 diabetes mellitus(T1DM)are depression,anxiety and behavioral disorders.Patients with comorbid psychopathology are less capable of psychically adju...The most common comorbid psychiatric disorders in children with type 1 diabetes mellitus(T1DM)are depression,anxiety and behavioral disorders.Patients with comorbid psychopathology are less capable of psychically adjusting to the new life situation resulting from T1DM,which may negatively affect glycemic control and adherence related to the treatment.We aimed to investigate the association between mental health and type 1 diabetes including illness representation.115 children and adolescents with T1DM were recruited through the outpatient clinic in Debrecen,Hungary.Measures:PRISM-D,Child Depression Inventory(CDI),Cantril Ladder and Self-Rated Health,Glycosylaeted haemoglobin(HbA1C)were measured.Children having depressive symptoms drew fewer circles with less area.Children not drawing any important relationships possessed more depressive symptoms.Those diagnosed at a younger age displayed smaller distance between the Self-and Illness-circles.The PRISM-D test can be a promising tool to analyse emotional and cognitive representations and the psychological burden of T1DM.展开更多
Type 1 diabetes mellitus(T1DM) lacks insulin secretion due to autoimmune deficiency of pancreaticβ-cells.Protecting pancreatic islets and enhancing insulin secretion has been therapeutic approaches.Mannogalactoglucan...Type 1 diabetes mellitus(T1DM) lacks insulin secretion due to autoimmune deficiency of pancreaticβ-cells.Protecting pancreatic islets and enhancing insulin secretion has been therapeutic approaches.Mannogalactoglucan is the main type of polysaccharide from natural mushroom,which has potential medicinal prospects.Nevertheless,the antidiabetic property of mannogalactoglucan in T1DM has not been fully elucidated.In this study,we obtained the neutral fraction of alkali-soluble Armillaria mellea polysaccharide(AAMP-N) with the structure of mannogalactoglucan from the fruiting body of A.mellea and investigated the potential therapeutic value of AAMP-N in T1DM.We demonstrated that AAMP-N lowered blood glucose and improved diabetes symptoms in T1DM mice.AAMP-N activated unfolded protein response(UPR) signaling pathway to maintain ER protein folding homeostasis and promote insulin secretion in vivo.Besides that,AAMP-N promoted insulin synthesis via upregulating the expression of transcription factors,increased Ca^(2+) signals to stimulate intracellular insulin secretory vesicle transport via activating calcium/calmodulin-dependent kinase Ⅱ(CamkⅡ) and cAMP/PKA signals,and enhanced insulin secretory vesicle fusion with the plasma membrane via vesicle-associated membrane protein 2(VAMP2).Collectively,these studies demonstrated that the therapeutic potential of AAMP-N on pancreatic islets function,indicating that mannogalactoglucan could be natural nutraceutical used for the treatment of T1DM.展开更多
文摘The most common comorbid psychiatric disorders in children with type 1 diabetes mellitus(T1DM)are depression,anxiety and behavioral disorders.Patients with comorbid psychopathology are less capable of psychically adjusting to the new life situation resulting from T1DM,which may negatively affect glycemic control and adherence related to the treatment.We aimed to investigate the association between mental health and type 1 diabetes including illness representation.115 children and adolescents with T1DM were recruited through the outpatient clinic in Debrecen,Hungary.Measures:PRISM-D,Child Depression Inventory(CDI),Cantril Ladder and Self-Rated Health,Glycosylaeted haemoglobin(HbA1C)were measured.Children having depressive symptoms drew fewer circles with less area.Children not drawing any important relationships possessed more depressive symptoms.Those diagnosed at a younger age displayed smaller distance between the Self-and Illness-circles.The PRISM-D test can be a promising tool to analyse emotional and cognitive representations and the psychological burden of T1DM.
文摘1型糖尿病(type 1 diabetes mellitus,T1DM)是一种全球范围内流行的自身免疫性疾病,给社会和家庭带来沉重的负担。T1DM的发生发展是由遗传和环境因素共同决定的。"卫生假说"认为自身免疫性疾病发病率的上升与卫生条件改善、机体接触病原体减少有关,而寄生虫作为一类能够参与宿主免疫应答调节的病原体,多项动物实验都证实其有防治T1DM的作用。除了辅助性T细胞(helper T cell,Th)和调节性T细胞(regulatory T cell,Treg),一些固有免疫细胞,如树突状细胞(dendritic cell,DC)、自然杀伤T细胞(natural killer T cell,NKT)和替代性活化巨噬细胞(alternatively activated macrophage,AAMφ),参与寄生虫免疫调节的过程近年来也受到重视。本文基于以往动物实验结果就寄生虫治疗T1DM的研究现状、分子机制及应用前景作一综述。
基金funded by the National Natural Science Foundation of China (32371341,31872674)the Scientific and Technologic Foundation of Jilin Province (20230202050NC)the Fundamental Research Funds for the Central Universities (CGZH202206)。
文摘Type 1 diabetes mellitus(T1DM) lacks insulin secretion due to autoimmune deficiency of pancreaticβ-cells.Protecting pancreatic islets and enhancing insulin secretion has been therapeutic approaches.Mannogalactoglucan is the main type of polysaccharide from natural mushroom,which has potential medicinal prospects.Nevertheless,the antidiabetic property of mannogalactoglucan in T1DM has not been fully elucidated.In this study,we obtained the neutral fraction of alkali-soluble Armillaria mellea polysaccharide(AAMP-N) with the structure of mannogalactoglucan from the fruiting body of A.mellea and investigated the potential therapeutic value of AAMP-N in T1DM.We demonstrated that AAMP-N lowered blood glucose and improved diabetes symptoms in T1DM mice.AAMP-N activated unfolded protein response(UPR) signaling pathway to maintain ER protein folding homeostasis and promote insulin secretion in vivo.Besides that,AAMP-N promoted insulin synthesis via upregulating the expression of transcription factors,increased Ca^(2+) signals to stimulate intracellular insulin secretory vesicle transport via activating calcium/calmodulin-dependent kinase Ⅱ(CamkⅡ) and cAMP/PKA signals,and enhanced insulin secretory vesicle fusion with the plasma membrane via vesicle-associated membrane protein 2(VAMP2).Collectively,these studies demonstrated that the therapeutic potential of AAMP-N on pancreatic islets function,indicating that mannogalactoglucan could be natural nutraceutical used for the treatment of T1DM.
