Zhuo et al looked into the part of transmembrane 9 superfamily member 1(TM9SF1)in bladder cancer(BC),and evaluated if it can be used as a therapeutic target.They created a permanent BC cell line and tested the effects...Zhuo et al looked into the part of transmembrane 9 superfamily member 1(TM9SF1)in bladder cancer(BC),and evaluated if it can be used as a therapeutic target.They created a permanent BC cell line and tested the effects of TM9SF1 overexpression and suppression on BC cell growth,movement,invasion,and cell cycle advancement.Their results show that TM9SF1 can boost the growth,movement,and invasion of BC cells and their access into the G2/M stage of the cell cycle.This research gives a novel direction and concept for targeted therapy of BC.展开更多
BACKGROUND Bladder cancer(BC)is the most common urological tumor.It has a high recur-rence rate,displays tutor heterogeneity,and resists chemotherapy.Furthermore,the long-term survival rate of BC patients has remained...BACKGROUND Bladder cancer(BC)is the most common urological tumor.It has a high recur-rence rate,displays tutor heterogeneity,and resists chemotherapy.Furthermore,the long-term survival rate of BC patients has remained unchanged for decades,which seriously affects the quality of patient survival.To improve the survival rate and prognosis of BC patients,it is necessary to explore the molecular mechanisms of BC development and progression and identify targets for treatment and intervention.Transmembrane 9 superfamily member 1(TM9SF1),also known as MP70 and HMP70,is a member of a family of nine transmembrane superfamily proteins,which was first identified in 1997.TM9SF1 can be expressed in BC,but its biological function and mechanism in BC are not clear.AIM To investigate the biological function and mechanism of TM9SF1 in BC.Overexpression of TM9SF1 increased the in vitro proliferation,migration,and invasion of BC cells by promoting the entry of BC cells into the G2/M phase.Silencing of TM9SF1 inhibited in vitro proliferation,migration,and invasion of BC cells and blocked BC cells in the G1 phase.CONCLUSION TM9SF1 may be an oncogene in BC.展开更多
针对三维人体姿态估计的便捷性与准确性提升需求,提出一种基于TM-Net网络估计算法。该算法以MediaPipe为中心,融合帧率计算、动作检测、动作计数和真实坐标解析等多功能模块,实现对人体运动的精准检测与计数。针对公共数据集LSP(Leeds S...针对三维人体姿态估计的便捷性与准确性提升需求,提出一种基于TM-Net网络估计算法。该算法以MediaPipe为中心,融合帧率计算、动作检测、动作计数和真实坐标解析等多功能模块,实现对人体运动的精准检测与计数。针对公共数据集LSP(Leeds Sports Pose)和自建校园健身房运动数据集使用关键点的正确性概率(Probability of Correct Keypoint,PCK)、关节位置误差平均值(Mean Per Joint Position Error,MPJPE)和普罗克鲁斯对齐后的平均关节位置误差(Procrustes-Aligned Mean Per Joint Position Error,PA-MPJPE)等指标对该算法进行评估,并与目前先进的TP-3D网络估计算法进行对比。结果表明,TM-Net具有更高的准确率。此外,以开合跳为例进行消融实验,结果表明,TM-Net具有更强的泛化能力,能适应不同个体及拍摄角度的变化,满足了运动监测的实际需求。展开更多
目的探讨血清癌胚抗原相关细胞粘附分子1(carcino-embryonic antigen related cellular adhesion molecule 1,CEACAM1)、四次跨膜蛋白1(transmembrane 4 L six family member 1,TM4SF1)在乳腺癌组织中的表达及诊断价值。方法收集乳腺癌9...目的探讨血清癌胚抗原相关细胞粘附分子1(carcino-embryonic antigen related cellular adhesion molecule 1,CEACAM1)、四次跨膜蛋白1(transmembrane 4 L six family member 1,TM4SF1)在乳腺癌组织中的表达及诊断价值。方法收集乳腺癌96例。采用酶联免疫吸附试验检测血清CEACAM1、TM4SF1水平。统计血清CEACAM1、TM4SF1水平与临床病理参数的关系及诊断效能。结果乳腺癌血清CEACAM1、TM4SF1水平与患者年龄、肿瘤直径、病理类型、雌激素受体、孕激素受体均无关,P>0.05,与病理分化程度、TNM分期、转移情况均有关。血清CEACAM1、TM4SF1水平联合诊断效能均较单一诊断效能高,P<0.05。结论血清CEACAM1、TM4SF1水平与乳腺癌病理分化程度、TNM分期、转移情况均有关,可作为肿瘤诊断标志物,联合诊断效能更高。展开更多
文摘Zhuo et al looked into the part of transmembrane 9 superfamily member 1(TM9SF1)in bladder cancer(BC),and evaluated if it can be used as a therapeutic target.They created a permanent BC cell line and tested the effects of TM9SF1 overexpression and suppression on BC cell growth,movement,invasion,and cell cycle advancement.Their results show that TM9SF1 can boost the growth,movement,and invasion of BC cells and their access into the G2/M stage of the cell cycle.This research gives a novel direction and concept for targeted therapy of BC.
基金Supported by National Natural Science Foundation of China,No.82260785.
文摘BACKGROUND Bladder cancer(BC)is the most common urological tumor.It has a high recur-rence rate,displays tutor heterogeneity,and resists chemotherapy.Furthermore,the long-term survival rate of BC patients has remained unchanged for decades,which seriously affects the quality of patient survival.To improve the survival rate and prognosis of BC patients,it is necessary to explore the molecular mechanisms of BC development and progression and identify targets for treatment and intervention.Transmembrane 9 superfamily member 1(TM9SF1),also known as MP70 and HMP70,is a member of a family of nine transmembrane superfamily proteins,which was first identified in 1997.TM9SF1 can be expressed in BC,but its biological function and mechanism in BC are not clear.AIM To investigate the biological function and mechanism of TM9SF1 in BC.Overexpression of TM9SF1 increased the in vitro proliferation,migration,and invasion of BC cells by promoting the entry of BC cells into the G2/M phase.Silencing of TM9SF1 inhibited in vitro proliferation,migration,and invasion of BC cells and blocked BC cells in the G1 phase.CONCLUSION TM9SF1 may be an oncogene in BC.
文摘针对三维人体姿态估计的便捷性与准确性提升需求,提出一种基于TM-Net网络估计算法。该算法以MediaPipe为中心,融合帧率计算、动作检测、动作计数和真实坐标解析等多功能模块,实现对人体运动的精准检测与计数。针对公共数据集LSP(Leeds Sports Pose)和自建校园健身房运动数据集使用关键点的正确性概率(Probability of Correct Keypoint,PCK)、关节位置误差平均值(Mean Per Joint Position Error,MPJPE)和普罗克鲁斯对齐后的平均关节位置误差(Procrustes-Aligned Mean Per Joint Position Error,PA-MPJPE)等指标对该算法进行评估,并与目前先进的TP-3D网络估计算法进行对比。结果表明,TM-Net具有更高的准确率。此外,以开合跳为例进行消融实验,结果表明,TM-Net具有更强的泛化能力,能适应不同个体及拍摄角度的变化,满足了运动监测的实际需求。
文摘目的探讨血清癌胚抗原相关细胞粘附分子1(carcino-embryonic antigen related cellular adhesion molecule 1,CEACAM1)、四次跨膜蛋白1(transmembrane 4 L six family member 1,TM4SF1)在乳腺癌组织中的表达及诊断价值。方法收集乳腺癌96例。采用酶联免疫吸附试验检测血清CEACAM1、TM4SF1水平。统计血清CEACAM1、TM4SF1水平与临床病理参数的关系及诊断效能。结果乳腺癌血清CEACAM1、TM4SF1水平与患者年龄、肿瘤直径、病理类型、雌激素受体、孕激素受体均无关,P>0.05,与病理分化程度、TNM分期、转移情况均有关。血清CEACAM1、TM4SF1水平联合诊断效能均较单一诊断效能高,P<0.05。结论血清CEACAM1、TM4SF1水平与乳腺癌病理分化程度、TNM分期、转移情况均有关,可作为肿瘤诊断标志物,联合诊断效能更高。
