Hepatocellular carcinoma (HCC) is a cancer with high incidence and mortality rates worldwide. In the various treatment methods for HCC, the lack of cancer cell specificity and the development of multidrug resistance (...Hepatocellular carcinoma (HCC) is a cancer with high incidence and mortality rates worldwide. In the various treatment methods for HCC, the lack of cancer cell specificity and the development of multidrug resistance (MDR) are two major obstacles in the treatment of HCC. P-glycoprotein (P-gp) is an ATP-dependent drug efflux pump that can reduce the accumulation of drugs in cells and make cancer cells acquire drug resistance. D-α-tocopheryl polyethylene glycol succinate (Vitamin E TPGS or TPGS) can inhibit the activity of ATP-dependent P-gp and serves as an effective excipient for overcoming tumor multidrug resistance (MDR). TPGS has been approved by the FDA as a safe adjuvant and is widely used in drug delivery systems. The biological and physicochemical properties of TPGS provide multiple advantages for its application in drug delivery, such as high biocompatibility, enhanced drug solubility, improved drug permeation, and selective antitumor activity. In recent years, more and more studies have found that using TPGS-modified nanomaterials to load chemotherapy drugs to treat tumors can effectively reverse the drug resistance of tumors, including HCC. This review summarizes and discusses the role of TPGS in reversing tumor drug resistance and the therapeutic effects of TPGS-based drugs on drug-resistant HCC.展开更多
1 TPG公司的基本情况
荷兰TPG公司是一家提供邮件、快运和物流服务的全球性公司,在1997年荷兰邮政集团公司KPN兼并了澳大利亚TNT集团公司后,KPN公司将其皇家PTT邮政与原TNT集团合并组建TPG公司,TPG是TNT Post Group的英文缩写,于1998年...1 TPG公司的基本情况
荷兰TPG公司是一家提供邮件、快运和物流服务的全球性公司,在1997年荷兰邮政集团公司KPN兼并了澳大利亚TNT集团公司后,KPN公司将其皇家PTT邮政与原TNT集团合并组建TPG公司,TPG是TNT Post Group的英文缩写,于1998年6月挂牌上市,是世界上最大的国际商务邮件服务商,也是唯一在欧洲各主要城市拥有网络的快件服务商.展开更多
文摘Hepatocellular carcinoma (HCC) is a cancer with high incidence and mortality rates worldwide. In the various treatment methods for HCC, the lack of cancer cell specificity and the development of multidrug resistance (MDR) are two major obstacles in the treatment of HCC. P-glycoprotein (P-gp) is an ATP-dependent drug efflux pump that can reduce the accumulation of drugs in cells and make cancer cells acquire drug resistance. D-α-tocopheryl polyethylene glycol succinate (Vitamin E TPGS or TPGS) can inhibit the activity of ATP-dependent P-gp and serves as an effective excipient for overcoming tumor multidrug resistance (MDR). TPGS has been approved by the FDA as a safe adjuvant and is widely used in drug delivery systems. The biological and physicochemical properties of TPGS provide multiple advantages for its application in drug delivery, such as high biocompatibility, enhanced drug solubility, improved drug permeation, and selective antitumor activity. In recent years, more and more studies have found that using TPGS-modified nanomaterials to load chemotherapy drugs to treat tumors can effectively reverse the drug resistance of tumors, including HCC. This review summarizes and discusses the role of TPGS in reversing tumor drug resistance and the therapeutic effects of TPGS-based drugs on drug-resistant HCC.
文摘1 TPG公司的基本情况
荷兰TPG公司是一家提供邮件、快运和物流服务的全球性公司,在1997年荷兰邮政集团公司KPN兼并了澳大利亚TNT集团公司后,KPN公司将其皇家PTT邮政与原TNT集团合并组建TPG公司,TPG是TNT Post Group的英文缩写,于1998年6月挂牌上市,是世界上最大的国际商务邮件服务商,也是唯一在欧洲各主要城市拥有网络的快件服务商.
