Objective: To determine the effectiveness of selective tubal catheterization in the management of female infertility due to proximal tubal obstruction. Method: This was a longitudinal descriptive study, conducted over...Objective: To determine the effectiveness of selective tubal catheterization in the management of female infertility due to proximal tubal obstruction. Method: This was a longitudinal descriptive study, conducted over a period of 24 months, which included 73 patients presenting with objectified bilateral proximal tubal obstruction after standard HSG. The intervention was performed on an outpatient basis, during the follicular phase with negative β-hCG assay the day before, in the interventional radiology room and under antibiotic coverage. Confirmatory hysterosalpingography was performed as the first step followed by selective tubal catheterization after the failure of spontaneous tubal opacification. The parameters studied related to socio-epidemiological, clinical and radiological data. Results: The age of our patients was between 24 and 42 years with an average of 33.97 years. The average duration of infertility was 3.95 years, with a predominance of primary infertility in 83.56% of cases. Voluntary termination of pregnancy (38.89%) and fibromyomas (33.33%) were the most represented gynecological-obstetrical antecedents. Selective tubal catheterization was successful in 92.14% of cases (129/140 tubes). It was possible bilaterally in 93.02% of cases and unilaterally in 6.98% of cases. The confirmatory HSG allowed a spontaneous opacification of 4.10% of the fallopian tubes. At the end of the procedure, all the recanalized tubes were opacified;62.01% of them were normal, against 37.99% pathological with a preponderance of inflammatory tubes 26.61% followed by hydrosalpinx in 5.03% of cases. No major complications were encountered. The fertility rate was 23.29%. Conclusion: Selective tubal catheterization is a simple technique, without major complications with an efficiency close to natural fertility. It should be proposed as the first intention before any other procedure in the treatment of infertility by proximal tubal obstruction.展开更多
Non-convex methods play a critical role in low-rank tensor completion for their approximation to tensor rank is tighter than that of convex methods.But they usually cost much more time for calculating singular values ...Non-convex methods play a critical role in low-rank tensor completion for their approximation to tensor rank is tighter than that of convex methods.But they usually cost much more time for calculating singular values of large tensors.In this paper,we propose a double transformed tubal nuclear norm(DTTNN)to replace the rank norm penalty in low rank tensor completion(LRTC)tasks.DTTNN turns the original non-convex penalty of a large tensor into two convex penalties of much smaller tensors,and it is shown to be an equivalent transformation.Therefore,DTTNN could take advantage of non-convex envelopes while saving time.Experimental results on color image and video inpainting tasks verify the effectiveness of DTTNN compared with state-of-the-art methods.展开更多
One thousand and twenty-nine women with microsurgical tubal reversal after tubal sterilization were followed up.The rate of intrauterine pregnancy was found to be 93.29%.The rate of intrauterine pregnancy was the high...One thousand and twenty-nine women with microsurgical tubal reversal after tubal sterilization were followed up.The rate of intrauterine pregnancy was found to be 93.29%.The rate of intrauterine pregnancy was the highest(73.28%)in the first year after tubal reversal.In the first year,the chance of pregnancy in the first 6 months was higher (54.81%)than that(40.86%)in the second 6 months(P<0.01),and the chance in the first 3 months was higher(37.41%)than that(27.80%)in the second 3 months(P<0.01).The rates of ectopic pregnancy after tubal reversal in various stages were not significantly different(P>0.05).The rate of intrauterine pregnancy was not related with the period from sterilization to tubal reversal.Early postoperative hydropertubation can only decrease the rate of intrauterine pregnancy.The rate of intra uterine pregnancy of the tubal reversal after Uchida's method and clips tubal sterilization was higher than that after Pomeroy's tubal ligation.The reanastomosis of isthmus and isthmus resulted in the highest rate of intra uterine pregnancy,so we think that Uchida's or elips tubal sterilization in the isthmus of the tubal are ideal and reversible techniques at present.展开更多
Objective To investigate the expression and change of the β3 integrin subunit and fibronectin in normal human oviductal tissue during various phases of the menstrual cycle and tubal ectopic pregnant tissueMethods Sam...Objective To investigate the expression and change of the β3 integrin subunit and fibronectin in normal human oviductal tissue during various phases of the menstrual cycle and tubal ectopic pregnant tissueMethods Samples of normal ( n=29 ) and pregnant fallopian tube ( n=22 ) tissues were obtained from women who had normal cycle and history of normal pregnancy. Normal oviductal tissue samples were divided into 4 groups based on their menstrual cycle. Both expression and distribution of the β3 subunit and fibronectin were determined with the immunohistochemical method and the image analysis.Results The β3 subunit was expressed in the cytoplasm of ciliated cells. The expression level of the β3 subunit was higher after ovulation than that before ovulation in isthmus epithelium (P<0.001), and declined significantly after ovulation in ampullae epithelium (P<0.001). In umbrella epithelium within 4 days after ovulation, the expression level of the β3 subunit was observed at rather higher level among other phases (P <0.001). The ciliated and secretory cells of the epithelium except for where the pregnancy occurred in tubal pregnancy expressed the β3 subunit, and no significant relationship was found between the normal tubal tissue of the secretory phase and tubal ectopic pregnant tissue (P>0.05). Fibronectin was expressed in the basement membrane of human oviductal epithelium and matrix. The expression level of fibronectin was higher in the hyperplastic phase than that in the secretory one (P<0.001). And it was lower in normal tubal tissue of the secretory phase than that in tubal ectopic pregnant tissue (P<0.001).Conclusion Theβ3 integrin subunit was expressed in the ciliated cells of human oviductal epithelium, and fibronectin was expressed in the basement membrane of human oviductal epithelium and matrix. Their expression and change in oviductal tissue is based on different phases of menstrual cycle. The β3 subunit could not related to the occurrence of tubal ectopic pregnancy. Fibronectin could be the potential molecular basis for the tubal ectopic pregnancy.展开更多
Serous tubal intraepithelial carcinoma is a putative precursor of high-grade serous carcinoma, which is the most common histological type of ovarian or pelvic peritoneal cancer. Serous tubal intraepithelial carcinoma ...Serous tubal intraepithelial carcinoma is a putative precursor of high-grade serous carcinoma, which is the most common histological type of ovarian or pelvic peritoneal cancer. Serous tubal intraepithelial carcinoma is commonly found in patients with breast cancer susceptibility gene mutations who undergo risk-reducing salpingo-oophorectomy. Incidental serous tubal intraepithelial carcinoma found by a non-prophylactic surgery is rare. A 33-year-old woman referred to our hospital for a diagnosis of ectopic pregnancy. She underwent a laparoscopic right salpingectomy. Pathologically, ectopic pregnancy in the ampulla of the right fallopian tube was confirmed and serous tubal intraepithelial carcinoma was observed in the fallopian tube. Subsequently, she underwent a laparoscopic hysterectomy, bilateral oophorectomy, and left salpingectomy as additional treatment. She has experienced no recurrence thus far for 37 months since the surgery.展开更多
Broad ligament pregnancy is a rare event and always delays in diagnosis. A pregnant woman in early twenties presented for our center. Routine ultra-sonography revealed a first trimester abdominal pregnancy. Broad liga...Broad ligament pregnancy is a rare event and always delays in diagnosis. A pregnant woman in early twenties presented for our center. Routine ultra-sonography revealed a first trimester abdominal pregnancy. Broad ligament pregnancy was diagnosed intraoperation and treated with laparoscopic resection successfully. The patient has a history of right tubal pregnancy 2 years ago and terminated with Laparoscopic Salpingostomy. According to the long term followed-up for the patient, we found that she had recurrent right tubal pregnancy 5 months after the broad ligment ectopic pregnancy. She received the salpingectomy laparoscopically. We presented the case to discuss the clinical management of broad ligament ectopic pregnancy and options of surgical treatments of tubal pregnancy to reduce the risk of recurrent.展开更多
Objective To investigate the safety, feasibility, and effectiveness of uterine artery embolization in association with methotrexate(MTX) infusion for the treatment of tubal ectopic pregnancy. Methods Fifty-one patient...Objective To investigate the safety, feasibility, and effectiveness of uterine artery embolization in association with methotrexate(MTX) infusion for the treatment of tubal ectopic pregnancy. Methods Fifty-one patients with tubal ectopic pregnancy were referred for interventional management. All patients received super-selective arteriography of the uterine artery, were infused with 50–100 mg methotrexate(MTX) through a catheter, and underwent embolization of the uterine artery with a gel-foam pledge. Clinical presentation, findings of physical examination, β-HCG values, and the size of the ectopic mass were documented for comparison. The concentration of MTX in blood was evaluated at 0.5, 6, 12, 24, 36, and 48 hours after the procedure. Results Forty-seven out of the 51 patients had clinical resolution of their tubal pregnancy(92.2%). The average time for the β-HCG value to decrease and come back to normal was 9.16 ± 2.54 days(mean +/-SD). MTX levels in peripheral blood could not be detected for patients who received 50 or 75 mg MTX at 36 hours after the procedure, while the MTX level was 0.01 μmol/L at 48 hours after the procedure for patients who received 100 mg. Out of the 4 cases whose ectopic mass size was ≥5 cm, 3 failed to respond to the treatment; however, those whose ectopic mass size was ≤5 cm responded positively to the treatment, regardless of the β-HCG concentration and abdominal bleeding, except for 1 patient who had to undergo laparoscopy for severe abdominal pain and who showed a reduction in her β-HCG level. Conclusion Uterine artery embolization in association with methotrexate infusion is safe and effective in the treatment of tubal ectopic pregnancy, especially for those women with mild to moderate bleeding, or for those at risk of a major hemorrhage. The selection criterion of mass size >5 cm should, therefore, be carefully considered.展开更多
This research paper presents the infrequent case of a heterotopic pregnancy based on a tubal ectopic pregnancy with molar degeneration in concurrent eutopic pregnancy. Treatment with evacuation/suction curettage and p...This research paper presents the infrequent case of a heterotopic pregnancy based on a tubal ectopic pregnancy with molar degeneration in concurrent eutopic pregnancy. Treatment with evacuation/suction curettage and perlaparoscopic salpingectomy was required. This case report confirms what is biologically valid in the statistically unlikely.展开更多
Summary:The optimal assisted reproductive treatment strategy for infertile women with unilateral tubal obstruction remains uncertain.To investigate the role of intrauterine insemination(IUI)in the treatment of inferti...Summary:The optimal assisted reproductive treatment strategy for infertile women with unilateral tubal obstruction remains uncertain.To investigate the role of intrauterine insemination(IUI)in the treatment of infertile women with unilateral tubal occlusion,the data of 148 couples were retrospectively collected and analyzed.Seventy-eight infertile women with unilateral occlusion diagnosed by hysterosalpingography(HSG)were categorized as the study group and 70 others with unexplained infertility as the control group.The study group was divided into a proximal occlusion subgroup and a mid-distal occlusion subgroup for further analysis.The main outcomes,namely the clinical pregnancy rate(CPR),ongoing pregnancy rate(OPR),and live birth rate(LBR)per cycle,were analyzed.Our results showed a tendency of lower CPR,OPR,and LBR in the study group than in the control group,without statistical significance.Further investigations revealed that the unilateral proximal occlusion subgroup had similar CPR,OPR,and LBR as the control group,while the unilateral mid-distal occlusion subgroup had significantly lower CPR(5.1%vs.20.0%,P=0.035),OPR(5.1%vs.20.0%,P=0.035),and LBR(5.1%vs.20.0%,P=0.035)than the control group.In conclusion,the clinical outcomes of IUI were worse in patients with unilateral tubal occlusion than in those with unexplained infertility.This might be primarily caused by the worse outcome of patients with unilateral mid-distal tubal occlusion instead of proximal occlusion.展开更多
Objectives: Numerous factors can cause infertility. Tubal factor accounts for approximately 30% of infertility in females. This study was conducted to evaluate the rate of asymptomatic Mycoplasma hominis and Ureaplasm...Objectives: Numerous factors can cause infertility. Tubal factor accounts for approximately 30% of infertility in females. This study was conducted to evaluate the rate of asymptomatic Mycoplasma hominis and Ureaplasma urealyticum infection in females diagnosed with tubal obstruction. Methods: This is a retrospective case-control study conducted at New Life Fertility Centre. We have identified and reviewed the health records of 167 subfertile women that had HSG and an endocervical swab for Mycoplasma hominis and Ureaplasma urealyticum done. Results: We compared the endocervical swab results of ureaplasma and mycoplasma in the patients with tubal obstruction (group 1) to the patients with normal patent tubes (group 2). Diagnosis of tubal patency was based on the HSG results. Our results show that there is a significantly higher rate of Ureaplasma urealyticum/Mycoplasma hominis infection in group 1 compared to group 2. Conclusion: Our data shows that there is a high rate of U. urealyticum and M. hominis infection in patients diagnosed with tubal factor of infertility and it can be a marker in the prediction of the tubal pathology.展开更多
Tubal obstructive in fertility is often due to insufficiency of kidney-Qi, dysfunction andvascular obstruction of the uterine collaterals, in view of these pahogenetic characteristics, we havetreated 116 cases of tuba...Tubal obstructive in fertility is often due to insufficiency of kidney-Qi, dysfunction andvascular obstruction of the uterine collaterals, in view of these pahogenetic characteristics, we havetreated 116 cases of tubal obstructive in fertility based on .differentiation of symptoms and signs byacupuncture at Guanyuan(CV4 ), Shuidao (ST 26), Guilai (ST 29 ), Diji (SP 8 ), Sanyinjiao (SP 6 ),Taixi(KI 3), Taichong(LR 3) which have functions of removing obstruction in collaterals by warmingkidney, regulating functions of the Chongmai and removing obstruction of the Renmai, increasihg levelsof female sex hormones, activating ovarian function, and external application to Guanyuan(CV 4) pointwith fresh Radix Aconiti Praeparata, Herb of Garden Balsam, Radix Salviae Miltiorrhizae, Fructus Evodiae, Fructus Foeniculi, Mirabilitum, Ramulus Cinnamomi, Fructus Liguidambaris, etc., which have thefunction of softening and resolving hard masses, subduing swelling and disintegrating masses, improvingblood circulation of the pelvic cavity, promoting absorption of the obstructed focus. AInong them 83cases were cured (pregnancy) accounting for 71. 6 %. The effective rate reached 90. 5 %. Clinically, itis proved that the combination of acupuncture with drugs has satis factory effects.展开更多
Objectives To study characteristics of psychosomatic symptoms related to sterilization, to find out risk factors and their roles ascribed to psychosomatic symptoms, and to establish a mathematic model for screening...Objectives To study characteristics of psychosomatic symptoms related to sterilization, to find out risk factors and their roles ascribed to psychosomatic symptoms, and to establish a mathematic model for screening out susceptible women. Methods: This study enrolled 776 women in rural area at three counties of Linxiang, Qiyang, Changsha of Hunan province in China between February 1990 and April 1992. Brief Neurosis Screening Scale (BNSS), Symptom Checklist 90 (SCL-90), sensitivity to pain, suggestibility were used to indicate subjects' psychological status. Logistic regression model and retrograde discriminant analysis were applied to develop a mathematical model. Results: Prevalence of psychosomatic reactions or symptoms was 54.8% before sterilization, 26.6% at three months and 16.4% at one year after operation respectively. Psychosomatic symptoms were verified to be the result of joint effects of multiple risk factors. The following risk factors were associated with postoperative symptoms: anger-hostility (RR=33.71), high suggestibility (RR=4.53), high neuroticism (RR=3.44), sensitivity to pain (RR=2.14) and operative sites (RR=2.05). A mathematical model to estimate the probability of developing psychosomatic symptoms in sterilization was established.Conclusions: More than half of women suffered from psychosomatic reactions before operation, and some of them did not recover after operation. The postoperative psychosomatic symptoms are the joint effect of multiple risk factors.展开更多
A multi center randomized clinical trial was adopted in the present study. 1705 eligible women with identical demographic and gynecological characteristics were divided into two groups: 871 using phenol atabrine pas...A multi center randomized clinical trial was adopted in the present study. 1705 eligible women with identical demographic and gynecological characteristics were divided into two groups: 871 using phenol atabrine paste (PAP) and 834 using phenol mucilage (PM). The five year follow up rates for the two groups were 97.5% and 98.1%, respectively. The multiple decrement life table analysis showed that there was a significant difference in the gross cumulative failure rates between the two groups. The 60th month gross cumulative failure rates for PAP group and PM group were 4.61% and 11.87%, respectively, thus indicating the efficacy of PAP to be significantly higher than that of PM. 97.7% users had cervical smear examinations, but no suspected cancer cells or cancer cells were found. Meanwhile, there was no known diseases related to the chemical reagent. This follow up study indicates that tubal sterilization by chemical instillation is a simple,safe and efficient female method. It suggested that this method would be introduced to a wider use on the basis of modification in the composition of chemical agents, standardized operational procedure, and improved administrative regulation in the use of this technology.展开更多
Objective: To compare the effects of treatment of tubal pregnancy (TP)and its following second pregnancy by intratubal methotrexate injection(IMI) alone and combination of IMI with Chinese herbal medicine. Methods: Th...Objective: To compare the effects of treatment of tubal pregnancy (TP)and its following second pregnancy by intratubal methotrexate injection(IMI) alone and combination of IMI with Chinese herbal medicine. Methods: Thirty-five patients suffering from unruptured TP were divided into two groups at random, to the 19 patients in the treated group, the treatment of combined IMI with Ectopic Pregnancy decoction No. 2 (EP2, a traditional Chinese medical decoction) was applied, and to the other 16 patients in the control group, IMI alone was applied for control. Serum concentrations of human chorionic gonadotro-pinβ(β-HCG), size of the gestational sac, existent time of fetal cardiac beat and peritoneal fluid were measured before and after treatment. And hysterosalpingography were performed 6 months after ending the treatment to verify the presence of tubal obstruction and the condition of relapse.Results: The treatment of all the 35 women was successful. The recovery duration of serumβ-HCG, disappearance duration of TP sac and existent time of peritoneal fluid in the treated group were 20.0±7. 8 days, 1.2±0. 7 months and 10. 7±2. 9 days respectively, which were significantly different from those in the control group (24. 4 ±8.1 days, 3.6±1.7 months and 19.1±3. 2 days respectively(P<0. 05, P<0.01 and P<0. 05 respectively), but the existent time of fetal cardiac beat in the two groups (8.8±1. 9 days vs 9.0±1. 3 days) was not significantly different (P>0.05). The post-treatment oviduct obstructive rate in the two groups was 10.5% and 43.8% respectively, that in the treatment group was less significant (P<0.05). The relapse rate of EP in the treatment group was insignificantly different from that in the control group (5.3% vs 18.8%, P>0.05). Conclusion: The two therapies (IMI alone and IMI combined with EP2) could obtain e-qual efficacy in curing TP. Compared with IMI alone, the combined therapy appears to have the effects of accelerating the resorption of gestational sac and peritoneal fluid, improving the patency of fallopian tube and ameliorating the circumstance of pregnancy, which is favorable to improvement of the re-pregnancy rate and reduction of the re-occurrence of ectopic pregnancy as well as to the enhancement of the effect of IMI in killing trophocytes. But there is not enough proof to show the potency of EP2 in killing embryo.展开更多
Tubal ligation or tubectomy (also known as having one's "tubes tied" (ligation)) is a surgical procedure for sterilization in which a woman's fallopian tubes are clamped and blocked, or severed and s...Tubal ligation or tubectomy (also known as having one's "tubes tied" (ligation)) is a surgical procedure for sterilization in which a woman's fallopian tubes are clamped and blocked, or severed and sealed, either method of which prevents eggs from展开更多
Background: Hysterosalpingogram (HSG) and Laparoscopy and dye tests for tubal assessment for a virgin who places high premium on her virginity could be challenging. Routine HSG may result in loss or damage to the hyme...Background: Hysterosalpingogram (HSG) and Laparoscopy and dye tests for tubal assessment for a virgin who places high premium on her virginity could be challenging. Routine HSG may result in loss or damage to the hymen and loss of virginity. Aim: The aim of the procedure of retrograde dye test was explored to see the possibility of assessing tubal patency during laparotomy. Case Presentation: At laparotomy and after myomectomy in a 32 year old virgin, a moderate sized Wilkinson’s cannula was gently inserted at the fimbrial end of the both tubes and 50mls of dilute Methylene-Blue solution was injected in each tube at a time to see whether the dye will appear at the vagina introitus. There was no resistance to flow of the dye in both tubes. Inspection of the vaginal introitus revealed a gush of dye flowing through it as the dye was introduced through each tube confirming the patency of both tubes. Conclusion: Retrograde dye test at the time of abdominal procedures like myomectomy, pelvic adhesiolysis and excision of endometriotic cyst can be cost effective. This procedure is also useful in assessing tubal patency for women who undergo laparotomy and also wish to preserve their virginity.展开更多
Tubal obstructive infertility is one of the most common causes of female infertility.At present,the main treatment is surgical mechanical dredging and restoration of tubal anatomy.Although the success rate of recanali...Tubal obstructive infertility is one of the most common causes of female infertility.At present,the main treatment is surgical mechanical dredging and restoration of tubal anatomy.Although the success rate of recanalization is high,the postoperative reocclusion rate is also high.In addition to the destruction of fallopian tubal function,it seriously affects the long-term pregnancy rate of women.Therefore,how to reduce the re-adhesion rate after recanalization is a more concerned issue at present.This article reviews the research progress of drug therapy for anti-adhesion after recanalization of tubal obstructive infertility.展开更多
Laparoscopic surgery is the standard surgical approach for ectopic pregnancy. However, some surgeons prefer laparotomy for patients with acute bleeding. We evaluated four cases of tubal pregnancy with massive hemoperi...Laparoscopic surgery is the standard surgical approach for ectopic pregnancy. However, some surgeons prefer laparotomy for patients with acute bleeding. We evaluated four cases of tubal pregnancy with massive hemoperitoneum (>800 ml) and performed laparoscopic surgery. The patient age ranged from 20 to 37 years, and the gestational age ranged from 5 to 8 weeks. All cases were hemodynamically unstable. Two cases had hemoperitoneum of >2000 mL, which was caused by the rupture of the left isthmus tube. In three cases, surgery could be started within approximately 30 min, and in one case, the start time extended owing to difficulty in anesthesia introduction. Moreover, in three cases, the target lesion was reached within 7 min, and the lesion was excised in approximately 20 min from the start of insufflation, and in one case with a lesion exceeding 7 cm, the time extended. All patients were safely treated via laparoscopic surgery. To initiate surgery without deterioration of the hemodynamic condition, blood transfusion can be started simultaneously with preparation for laparoscopic surgery. Lifting the lesion with a pair of forceps can help immediately stop bleeding, even if it is difficult to secure the visual field owing to massive bleeding. When there is difficulty in anesthesia or a large pregnancy lesion, care should be taken to avoid an increase in the amount of bleeding associated with extension of the perioperative period.展开更多
Background:?Chlamydia trachomatis?infection is an important preventable cause of infertility. In women, up to 70% of genital infection with?Chlamydia trachomatis?are asymptomatic. In the management of infertility pati...Background:?Chlamydia trachomatis?infection is an important preventable cause of infertility. In women, up to 70% of genital infection with?Chlamydia trachomatis?are asymptomatic. In the management of infertility patients, a lot of clinicians or centres do not routinely screen for?Chlamydia trachomatis?infection. Hence all patients being investigated for infertility may potentially be at risk of tubal blockage in addition to non-tubal factor aetiology. Those with primary tubal blockage also are at risk of worsening of the blockage. Objective: To determine if there is a relationship between IgG and IgM Chlamydia antibody testing (CAT) and tubal factor infertility. Design: It was a cross sectional descriptive study. Method: The sera of 400 consecutive consenting infertile patients presenting to the gynaecological clinic of the Ahmadu Bello University Teaching Hospital, Zaria, Northern Nigeria were tested for Chlamydia antibodies using ELISA IgG and IgM kits produced by Diagnostic Automation, Inc., 23961 Craftsman Road, Suite D/E/F, Calabasas, CA 91302, USA. Results: Up to 264 (66%) of the patients had tubal factor, 64 (16%) had uterine, 56 (14%) had ovarian, 50 (12.5%) had male while 40 (10%) had others. The causative factors were not mutually exclusive. The sero-prevalence of IgG and IgMChlamydia trachomatis?amongst patients with tubal infertility were 35.6% and 35.6% respectively. There was a stronger significant relation (P = 0.008) between IgM sero-positivity which suggests recent infection and tubal infertility. The relation between IgG sero-positivity which suggest chronic infection and tubal infertility was also significant (P = 0.036) but relatively lower. Conclusion: The sero-prevalence of?Chlamydia trachomatis?infection, IgG and IgM was significantly higher among the sub-population with tubal infertility. Chlamydia antibody testing (CAT) has predictive value for tubal infertility.展开更多
Bilateral tubal ectopic pregnancy is very rare and usually occurs following ovulation stimulation. Moreover preoperative diagnosis is very difficult. We are presenting a case of bilateral tubal ectopic pregnancy occur...Bilateral tubal ectopic pregnancy is very rare and usually occurs following ovulation stimulation. Moreover preoperative diagnosis is very difficult. We are presenting a case of bilateral tubal ectopic pregnancy occurring spontaneously. Hence careful follow-up with combination of color Doppler and serum beta HCG estimation of patients after laparoscopic or open surgery for ectopic pregnancies is needed to avoid such unusual event.展开更多
文摘Objective: To determine the effectiveness of selective tubal catheterization in the management of female infertility due to proximal tubal obstruction. Method: This was a longitudinal descriptive study, conducted over a period of 24 months, which included 73 patients presenting with objectified bilateral proximal tubal obstruction after standard HSG. The intervention was performed on an outpatient basis, during the follicular phase with negative β-hCG assay the day before, in the interventional radiology room and under antibiotic coverage. Confirmatory hysterosalpingography was performed as the first step followed by selective tubal catheterization after the failure of spontaneous tubal opacification. The parameters studied related to socio-epidemiological, clinical and radiological data. Results: The age of our patients was between 24 and 42 years with an average of 33.97 years. The average duration of infertility was 3.95 years, with a predominance of primary infertility in 83.56% of cases. Voluntary termination of pregnancy (38.89%) and fibromyomas (33.33%) were the most represented gynecological-obstetrical antecedents. Selective tubal catheterization was successful in 92.14% of cases (129/140 tubes). It was possible bilaterally in 93.02% of cases and unilaterally in 6.98% of cases. The confirmatory HSG allowed a spontaneous opacification of 4.10% of the fallopian tubes. At the end of the procedure, all the recanalized tubes were opacified;62.01% of them were normal, against 37.99% pathological with a preponderance of inflammatory tubes 26.61% followed by hydrosalpinx in 5.03% of cases. No major complications were encountered. The fertility rate was 23.29%. Conclusion: Selective tubal catheterization is a simple technique, without major complications with an efficiency close to natural fertility. It should be proposed as the first intention before any other procedure in the treatment of infertility by proximal tubal obstruction.
基金financially supported by the National Nautral Science Foundation of China(No.61703206)
文摘Non-convex methods play a critical role in low-rank tensor completion for their approximation to tensor rank is tighter than that of convex methods.But they usually cost much more time for calculating singular values of large tensors.In this paper,we propose a double transformed tubal nuclear norm(DTTNN)to replace the rank norm penalty in low rank tensor completion(LRTC)tasks.DTTNN turns the original non-convex penalty of a large tensor into two convex penalties of much smaller tensors,and it is shown to be an equivalent transformation.Therefore,DTTNN could take advantage of non-convex envelopes while saving time.Experimental results on color image and video inpainting tasks verify the effectiveness of DTTNN compared with state-of-the-art methods.
文摘One thousand and twenty-nine women with microsurgical tubal reversal after tubal sterilization were followed up.The rate of intrauterine pregnancy was found to be 93.29%.The rate of intrauterine pregnancy was the highest(73.28%)in the first year after tubal reversal.In the first year,the chance of pregnancy in the first 6 months was higher (54.81%)than that(40.86%)in the second 6 months(P<0.01),and the chance in the first 3 months was higher(37.41%)than that(27.80%)in the second 3 months(P<0.01).The rates of ectopic pregnancy after tubal reversal in various stages were not significantly different(P>0.05).The rate of intrauterine pregnancy was not related with the period from sterilization to tubal reversal.Early postoperative hydropertubation can only decrease the rate of intrauterine pregnancy.The rate of intra uterine pregnancy of the tubal reversal after Uchida's method and clips tubal sterilization was higher than that after Pomeroy's tubal ligation.The reanastomosis of isthmus and isthmus resulted in the highest rate of intra uterine pregnancy,so we think that Uchida's or elips tubal sterilization in the isthmus of the tubal are ideal and reversible techniques at present.
基金This is a part of the project supported by Natural Science Foundation of Guangdong Province,China.
文摘Objective To investigate the expression and change of the β3 integrin subunit and fibronectin in normal human oviductal tissue during various phases of the menstrual cycle and tubal ectopic pregnant tissueMethods Samples of normal ( n=29 ) and pregnant fallopian tube ( n=22 ) tissues were obtained from women who had normal cycle and history of normal pregnancy. Normal oviductal tissue samples were divided into 4 groups based on their menstrual cycle. Both expression and distribution of the β3 subunit and fibronectin were determined with the immunohistochemical method and the image analysis.Results The β3 subunit was expressed in the cytoplasm of ciliated cells. The expression level of the β3 subunit was higher after ovulation than that before ovulation in isthmus epithelium (P<0.001), and declined significantly after ovulation in ampullae epithelium (P<0.001). In umbrella epithelium within 4 days after ovulation, the expression level of the β3 subunit was observed at rather higher level among other phases (P <0.001). The ciliated and secretory cells of the epithelium except for where the pregnancy occurred in tubal pregnancy expressed the β3 subunit, and no significant relationship was found between the normal tubal tissue of the secretory phase and tubal ectopic pregnant tissue (P>0.05). Fibronectin was expressed in the basement membrane of human oviductal epithelium and matrix. The expression level of fibronectin was higher in the hyperplastic phase than that in the secretory one (P<0.001). And it was lower in normal tubal tissue of the secretory phase than that in tubal ectopic pregnant tissue (P<0.001).Conclusion Theβ3 integrin subunit was expressed in the ciliated cells of human oviductal epithelium, and fibronectin was expressed in the basement membrane of human oviductal epithelium and matrix. Their expression and change in oviductal tissue is based on different phases of menstrual cycle. The β3 subunit could not related to the occurrence of tubal ectopic pregnancy. Fibronectin could be the potential molecular basis for the tubal ectopic pregnancy.
文摘Serous tubal intraepithelial carcinoma is a putative precursor of high-grade serous carcinoma, which is the most common histological type of ovarian or pelvic peritoneal cancer. Serous tubal intraepithelial carcinoma is commonly found in patients with breast cancer susceptibility gene mutations who undergo risk-reducing salpingo-oophorectomy. Incidental serous tubal intraepithelial carcinoma found by a non-prophylactic surgery is rare. A 33-year-old woman referred to our hospital for a diagnosis of ectopic pregnancy. She underwent a laparoscopic right salpingectomy. Pathologically, ectopic pregnancy in the ampulla of the right fallopian tube was confirmed and serous tubal intraepithelial carcinoma was observed in the fallopian tube. Subsequently, she underwent a laparoscopic hysterectomy, bilateral oophorectomy, and left salpingectomy as additional treatment. She has experienced no recurrence thus far for 37 months since the surgery.
文摘Broad ligament pregnancy is a rare event and always delays in diagnosis. A pregnant woman in early twenties presented for our center. Routine ultra-sonography revealed a first trimester abdominal pregnancy. Broad ligament pregnancy was diagnosed intraoperation and treated with laparoscopic resection successfully. The patient has a history of right tubal pregnancy 2 years ago and terminated with Laparoscopic Salpingostomy. According to the long term followed-up for the patient, we found that she had recurrent right tubal pregnancy 5 months after the broad ligment ectopic pregnancy. She received the salpingectomy laparoscopically. We presented the case to discuss the clinical management of broad ligament ectopic pregnancy and options of surgical treatments of tubal pregnancy to reduce the risk of recurrent.
基金supported by a grant from Jiangsu Provincial Medical Youth Talent(QNRC2016711)
文摘Objective To investigate the safety, feasibility, and effectiveness of uterine artery embolization in association with methotrexate(MTX) infusion for the treatment of tubal ectopic pregnancy. Methods Fifty-one patients with tubal ectopic pregnancy were referred for interventional management. All patients received super-selective arteriography of the uterine artery, were infused with 50–100 mg methotrexate(MTX) through a catheter, and underwent embolization of the uterine artery with a gel-foam pledge. Clinical presentation, findings of physical examination, β-HCG values, and the size of the ectopic mass were documented for comparison. The concentration of MTX in blood was evaluated at 0.5, 6, 12, 24, 36, and 48 hours after the procedure. Results Forty-seven out of the 51 patients had clinical resolution of their tubal pregnancy(92.2%). The average time for the β-HCG value to decrease and come back to normal was 9.16 ± 2.54 days(mean +/-SD). MTX levels in peripheral blood could not be detected for patients who received 50 or 75 mg MTX at 36 hours after the procedure, while the MTX level was 0.01 μmol/L at 48 hours after the procedure for patients who received 100 mg. Out of the 4 cases whose ectopic mass size was ≥5 cm, 3 failed to respond to the treatment; however, those whose ectopic mass size was ≤5 cm responded positively to the treatment, regardless of the β-HCG concentration and abdominal bleeding, except for 1 patient who had to undergo laparoscopy for severe abdominal pain and who showed a reduction in her β-HCG level. Conclusion Uterine artery embolization in association with methotrexate infusion is safe and effective in the treatment of tubal ectopic pregnancy, especially for those women with mild to moderate bleeding, or for those at risk of a major hemorrhage. The selection criterion of mass size >5 cm should, therefore, be carefully considered.
文摘This research paper presents the infrequent case of a heterotopic pregnancy based on a tubal ectopic pregnancy with molar degeneration in concurrent eutopic pregnancy. Treatment with evacuation/suction curettage and perlaparoscopic salpingectomy was required. This case report confirms what is biologically valid in the statistically unlikely.
基金This study was supported by grants from the Research Team of Female Reproductive Health and Fertility Preservation(No.SZSM201612065)Project for Medical Discipline Advancement of Health and Family Planning Commission of Shenzhen Municipality(No.SZXJ2017003).
文摘Summary:The optimal assisted reproductive treatment strategy for infertile women with unilateral tubal obstruction remains uncertain.To investigate the role of intrauterine insemination(IUI)in the treatment of infertile women with unilateral tubal occlusion,the data of 148 couples were retrospectively collected and analyzed.Seventy-eight infertile women with unilateral occlusion diagnosed by hysterosalpingography(HSG)were categorized as the study group and 70 others with unexplained infertility as the control group.The study group was divided into a proximal occlusion subgroup and a mid-distal occlusion subgroup for further analysis.The main outcomes,namely the clinical pregnancy rate(CPR),ongoing pregnancy rate(OPR),and live birth rate(LBR)per cycle,were analyzed.Our results showed a tendency of lower CPR,OPR,and LBR in the study group than in the control group,without statistical significance.Further investigations revealed that the unilateral proximal occlusion subgroup had similar CPR,OPR,and LBR as the control group,while the unilateral mid-distal occlusion subgroup had significantly lower CPR(5.1%vs.20.0%,P=0.035),OPR(5.1%vs.20.0%,P=0.035),and LBR(5.1%vs.20.0%,P=0.035)than the control group.In conclusion,the clinical outcomes of IUI were worse in patients with unilateral tubal occlusion than in those with unexplained infertility.This might be primarily caused by the worse outcome of patients with unilateral mid-distal tubal occlusion instead of proximal occlusion.
文摘Objectives: Numerous factors can cause infertility. Tubal factor accounts for approximately 30% of infertility in females. This study was conducted to evaluate the rate of asymptomatic Mycoplasma hominis and Ureaplasma urealyticum infection in females diagnosed with tubal obstruction. Methods: This is a retrospective case-control study conducted at New Life Fertility Centre. We have identified and reviewed the health records of 167 subfertile women that had HSG and an endocervical swab for Mycoplasma hominis and Ureaplasma urealyticum done. Results: We compared the endocervical swab results of ureaplasma and mycoplasma in the patients with tubal obstruction (group 1) to the patients with normal patent tubes (group 2). Diagnosis of tubal patency was based on the HSG results. Our results show that there is a significantly higher rate of Ureaplasma urealyticum/Mycoplasma hominis infection in group 1 compared to group 2. Conclusion: Our data shows that there is a high rate of U. urealyticum and M. hominis infection in patients diagnosed with tubal factor of infertility and it can be a marker in the prediction of the tubal pathology.
文摘Tubal obstructive in fertility is often due to insufficiency of kidney-Qi, dysfunction andvascular obstruction of the uterine collaterals, in view of these pahogenetic characteristics, we havetreated 116 cases of tubal obstructive in fertility based on .differentiation of symptoms and signs byacupuncture at Guanyuan(CV4 ), Shuidao (ST 26), Guilai (ST 29 ), Diji (SP 8 ), Sanyinjiao (SP 6 ),Taixi(KI 3), Taichong(LR 3) which have functions of removing obstruction in collaterals by warmingkidney, regulating functions of the Chongmai and removing obstruction of the Renmai, increasihg levelsof female sex hormones, activating ovarian function, and external application to Guanyuan(CV 4) pointwith fresh Radix Aconiti Praeparata, Herb of Garden Balsam, Radix Salviae Miltiorrhizae, Fructus Evodiae, Fructus Foeniculi, Mirabilitum, Ramulus Cinnamomi, Fructus Liguidambaris, etc., which have thefunction of softening and resolving hard masses, subduing swelling and disintegrating masses, improvingblood circulation of the pelvic cavity, promoting absorption of the obstructed focus. AInong them 83cases were cured (pregnancy) accounting for 71. 6 %. The effective rate reached 90. 5 %. Clinically, itis proved that the combination of acupuncture with drugs has satis factory effects.
文摘Objectives To study characteristics of psychosomatic symptoms related to sterilization, to find out risk factors and their roles ascribed to psychosomatic symptoms, and to establish a mathematic model for screening out susceptible women. Methods: This study enrolled 776 women in rural area at three counties of Linxiang, Qiyang, Changsha of Hunan province in China between February 1990 and April 1992. Brief Neurosis Screening Scale (BNSS), Symptom Checklist 90 (SCL-90), sensitivity to pain, suggestibility were used to indicate subjects' psychological status. Logistic regression model and retrograde discriminant analysis were applied to develop a mathematical model. Results: Prevalence of psychosomatic reactions or symptoms was 54.8% before sterilization, 26.6% at three months and 16.4% at one year after operation respectively. Psychosomatic symptoms were verified to be the result of joint effects of multiple risk factors. The following risk factors were associated with postoperative symptoms: anger-hostility (RR=33.71), high suggestibility (RR=4.53), high neuroticism (RR=3.44), sensitivity to pain (RR=2.14) and operative sites (RR=2.05). A mathematical model to estimate the probability of developing psychosomatic symptoms in sterilization was established.Conclusions: More than half of women suffered from psychosomatic reactions before operation, and some of them did not recover after operation. The postoperative psychosomatic symptoms are the joint effect of multiple risk factors.
文摘A multi center randomized clinical trial was adopted in the present study. 1705 eligible women with identical demographic and gynecological characteristics were divided into two groups: 871 using phenol atabrine paste (PAP) and 834 using phenol mucilage (PM). The five year follow up rates for the two groups were 97.5% and 98.1%, respectively. The multiple decrement life table analysis showed that there was a significant difference in the gross cumulative failure rates between the two groups. The 60th month gross cumulative failure rates for PAP group and PM group were 4.61% and 11.87%, respectively, thus indicating the efficacy of PAP to be significantly higher than that of PM. 97.7% users had cervical smear examinations, but no suspected cancer cells or cancer cells were found. Meanwhile, there was no known diseases related to the chemical reagent. This follow up study indicates that tubal sterilization by chemical instillation is a simple,safe and efficient female method. It suggested that this method would be introduced to a wider use on the basis of modification in the composition of chemical agents, standardized operational procedure, and improved administrative regulation in the use of this technology.
文摘Objective: To compare the effects of treatment of tubal pregnancy (TP)and its following second pregnancy by intratubal methotrexate injection(IMI) alone and combination of IMI with Chinese herbal medicine. Methods: Thirty-five patients suffering from unruptured TP were divided into two groups at random, to the 19 patients in the treated group, the treatment of combined IMI with Ectopic Pregnancy decoction No. 2 (EP2, a traditional Chinese medical decoction) was applied, and to the other 16 patients in the control group, IMI alone was applied for control. Serum concentrations of human chorionic gonadotro-pinβ(β-HCG), size of the gestational sac, existent time of fetal cardiac beat and peritoneal fluid were measured before and after treatment. And hysterosalpingography were performed 6 months after ending the treatment to verify the presence of tubal obstruction and the condition of relapse.Results: The treatment of all the 35 women was successful. The recovery duration of serumβ-HCG, disappearance duration of TP sac and existent time of peritoneal fluid in the treated group were 20.0±7. 8 days, 1.2±0. 7 months and 10. 7±2. 9 days respectively, which were significantly different from those in the control group (24. 4 ±8.1 days, 3.6±1.7 months and 19.1±3. 2 days respectively(P<0. 05, P<0.01 and P<0. 05 respectively), but the existent time of fetal cardiac beat in the two groups (8.8±1. 9 days vs 9.0±1. 3 days) was not significantly different (P>0.05). The post-treatment oviduct obstructive rate in the two groups was 10.5% and 43.8% respectively, that in the treatment group was less significant (P<0.05). The relapse rate of EP in the treatment group was insignificantly different from that in the control group (5.3% vs 18.8%, P>0.05). Conclusion: The two therapies (IMI alone and IMI combined with EP2) could obtain e-qual efficacy in curing TP. Compared with IMI alone, the combined therapy appears to have the effects of accelerating the resorption of gestational sac and peritoneal fluid, improving the patency of fallopian tube and ameliorating the circumstance of pregnancy, which is favorable to improvement of the re-pregnancy rate and reduction of the re-occurrence of ectopic pregnancy as well as to the enhancement of the effect of IMI in killing trophocytes. But there is not enough proof to show the potency of EP2 in killing embryo.
文摘Tubal ligation or tubectomy (also known as having one's "tubes tied" (ligation)) is a surgical procedure for sterilization in which a woman's fallopian tubes are clamped and blocked, or severed and sealed, either method of which prevents eggs from
文摘Background: Hysterosalpingogram (HSG) and Laparoscopy and dye tests for tubal assessment for a virgin who places high premium on her virginity could be challenging. Routine HSG may result in loss or damage to the hymen and loss of virginity. Aim: The aim of the procedure of retrograde dye test was explored to see the possibility of assessing tubal patency during laparotomy. Case Presentation: At laparotomy and after myomectomy in a 32 year old virgin, a moderate sized Wilkinson’s cannula was gently inserted at the fimbrial end of the both tubes and 50mls of dilute Methylene-Blue solution was injected in each tube at a time to see whether the dye will appear at the vagina introitus. There was no resistance to flow of the dye in both tubes. Inspection of the vaginal introitus revealed a gush of dye flowing through it as the dye was introduced through each tube confirming the patency of both tubes. Conclusion: Retrograde dye test at the time of abdominal procedures like myomectomy, pelvic adhesiolysis and excision of endometriotic cyst can be cost effective. This procedure is also useful in assessing tubal patency for women who undergo laparotomy and also wish to preserve their virginity.
基金National R&D Program"Study on the Prevention and Control of Reproductive Health and Major Birth Defects"Key Special Project"Effect of Immunity on Gametogenesis and Embryo Development"(No.2018YFC1003900)。
文摘Tubal obstructive infertility is one of the most common causes of female infertility.At present,the main treatment is surgical mechanical dredging and restoration of tubal anatomy.Although the success rate of recanalization is high,the postoperative reocclusion rate is also high.In addition to the destruction of fallopian tubal function,it seriously affects the long-term pregnancy rate of women.Therefore,how to reduce the re-adhesion rate after recanalization is a more concerned issue at present.This article reviews the research progress of drug therapy for anti-adhesion after recanalization of tubal obstructive infertility.
文摘Laparoscopic surgery is the standard surgical approach for ectopic pregnancy. However, some surgeons prefer laparotomy for patients with acute bleeding. We evaluated four cases of tubal pregnancy with massive hemoperitoneum (>800 ml) and performed laparoscopic surgery. The patient age ranged from 20 to 37 years, and the gestational age ranged from 5 to 8 weeks. All cases were hemodynamically unstable. Two cases had hemoperitoneum of >2000 mL, which was caused by the rupture of the left isthmus tube. In three cases, surgery could be started within approximately 30 min, and in one case, the start time extended owing to difficulty in anesthesia introduction. Moreover, in three cases, the target lesion was reached within 7 min, and the lesion was excised in approximately 20 min from the start of insufflation, and in one case with a lesion exceeding 7 cm, the time extended. All patients were safely treated via laparoscopic surgery. To initiate surgery without deterioration of the hemodynamic condition, blood transfusion can be started simultaneously with preparation for laparoscopic surgery. Lifting the lesion with a pair of forceps can help immediately stop bleeding, even if it is difficult to secure the visual field owing to massive bleeding. When there is difficulty in anesthesia or a large pregnancy lesion, care should be taken to avoid an increase in the amount of bleeding associated with extension of the perioperative period.
文摘Background:?Chlamydia trachomatis?infection is an important preventable cause of infertility. In women, up to 70% of genital infection with?Chlamydia trachomatis?are asymptomatic. In the management of infertility patients, a lot of clinicians or centres do not routinely screen for?Chlamydia trachomatis?infection. Hence all patients being investigated for infertility may potentially be at risk of tubal blockage in addition to non-tubal factor aetiology. Those with primary tubal blockage also are at risk of worsening of the blockage. Objective: To determine if there is a relationship between IgG and IgM Chlamydia antibody testing (CAT) and tubal factor infertility. Design: It was a cross sectional descriptive study. Method: The sera of 400 consecutive consenting infertile patients presenting to the gynaecological clinic of the Ahmadu Bello University Teaching Hospital, Zaria, Northern Nigeria were tested for Chlamydia antibodies using ELISA IgG and IgM kits produced by Diagnostic Automation, Inc., 23961 Craftsman Road, Suite D/E/F, Calabasas, CA 91302, USA. Results: Up to 264 (66%) of the patients had tubal factor, 64 (16%) had uterine, 56 (14%) had ovarian, 50 (12.5%) had male while 40 (10%) had others. The causative factors were not mutually exclusive. The sero-prevalence of IgG and IgMChlamydia trachomatis?amongst patients with tubal infertility were 35.6% and 35.6% respectively. There was a stronger significant relation (P = 0.008) between IgM sero-positivity which suggests recent infection and tubal infertility. The relation between IgG sero-positivity which suggest chronic infection and tubal infertility was also significant (P = 0.036) but relatively lower. Conclusion: The sero-prevalence of?Chlamydia trachomatis?infection, IgG and IgM was significantly higher among the sub-population with tubal infertility. Chlamydia antibody testing (CAT) has predictive value for tubal infertility.
文摘Bilateral tubal ectopic pregnancy is very rare and usually occurs following ovulation stimulation. Moreover preoperative diagnosis is very difficult. We are presenting a case of bilateral tubal ectopic pregnancy occurring spontaneously. Hence careful follow-up with combination of color Doppler and serum beta HCG estimation of patients after laparoscopic or open surgery for ectopic pregnancies is needed to avoid such unusual event.
