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Analysis of doping control test results in individual and team sports from 2003 to 2015 被引量:1
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作者 Millan Aguilar-Navarro Jesus Munoz-Guerra +1 位作者 Maria del Mar Plara Juan Del Cosoa 《Journal of Sport and Health Science》 SCIE 2020年第2期160-169,共10页
Background:Determining the prevalence of doping in sport might be useful for anti-doping authorities to gauge the effectiveness of anti-doping policies implemented to prevent positive attitudes toward doping.Using que... Background:Determining the prevalence of doping in sport might be useful for anti-doping authorities to gauge the effectiveness of anti-doping policies implemented to prevent positive attitudes toward doping.Using questionnaires and personal interviews,previous investigations have found that the prevalence of doping might be different among different sports disciplines;however,there is no sport-specific information about the proportion of adverse and atypical findings(AAF) in samples used for doping control.The aim of the present investigation was to assess the differences in the frequency of adverse analytical and atypical findings among sports using the data made available by the World Anti-Doping Agency.Methods:The data included in this investigation were gathered from the Testing Figures Reports made available annually from 2003 to 2015 by the World Anti-Doping Agency.These Testing Figures Reports include information about the number of samples analyzed,the number of AAFs reported,and the most commonly found drugs in the urine and blood samples analyzed.A total of 1,347,213 samples were analyzed from the individual sports selected for this investigation,and 698,371 samples were analyzed for disciplines catalogued as team sports.Results:In individual sports,the highest proportions of AAF were 3.3%±1.0% in cycling,3.0%±0.6% in weightlifting,and 2.9%±0.6% in boxing.In team sports,the highest proportions of AAF were 2.2%±0.5% in ice hockey,2.0%±0.5% in rugby,and 2.0%±0.5% in basketball.Gymnastics and skating had the lowest proportions at(≤1.0%) for individual sports,and field hockey,volleyball and football had the lowest proportions for team sports(≤1.4%).Conclusion:As suggested by the analysis,the incidence of AAF was not uniform across all sports disciplines,with the different proportions pointing to an uneven use of banned substances depending on the sport.This information might be useful for increasing the strength and efficacy of anti-doping policies in those sports with the highest prevalence in the use of banned substances. 展开更多
关键词 ANTI-DOPING ATTITUDE Banned DRUGS ELITE ATHLETE Type of SPORT
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基于TeamSTEPPS风险防控模式的护理在气管切开患者感染防控中的应用
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作者 裴中霞 李伟 +5 位作者 刘莉莉 李志萍 江云兰 朱育琼 刘丹 李小月 《中国中西医结合耳鼻咽喉科杂志》 2024年第1期73-76,共4页
目的 探讨基于强化临床表现和医疗安全的团队策略与工具(Team STEPPS)?风险防控模式的护理在气管切开患者感染防控中的应用。方法 选取2021年1月~2022年12月在安庆市第一人民医院入住的82例气管切开患者。其中2021年41例为对照组,实施... 目的 探讨基于强化临床表现和医疗安全的团队策略与工具(Team STEPPS)?风险防控模式的护理在气管切开患者感染防控中的应用。方法 选取2021年1月~2022年12月在安庆市第一人民医院入住的82例气管切开患者。其中2021年41例为对照组,实施常规的气管切开术后护理;2022年41例为观察组,在常规的气管切开术后护理基础上,基于Team STEPPS风险防控模式的护理措施。比较两组患者感染高风险事件发生率、医护合作情况、患者满意度。结果 观察组患者感染高风险事件发生率低于对照组,医护合作得分、患者满意度明显高于对照组(P<0.05)。结论 基于Team STEPPS风险防控模式的护理在气管切开患者感染防控中应用,降低了感染风险发生的事件、医护合作程度明显增强,患者的满意度提高显著,值得在临床推广应用。 展开更多
关键词 团队策略与工具 气管切开 感染防控 风险评估
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The Boundless Benefits of Team Sports
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作者 Derek Ho 《城市漫步(GBA版)》 2023年第6期44-45,共2页
Panthers Basketball and Football Academy strives to create pathways towards athletic and life success via team sports.We believe that sports preparation and competition teachvaluable lessons about the benefits of hard... Panthers Basketball and Football Academy strives to create pathways towards athletic and life success via team sports.We believe that sports preparation and competition teachvaluable lessons about the benefits of hard work and perseverance.Boys and girls in our programs learn how to carry themselves with dignity after both wins and losses. 展开更多
关键词 BASKETBALL CARRY sports
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Orientation and Decision-Making for Soccer Based on Sports Analytics and AI:A Systematic Review
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作者 Zhiqiang Pu Yi Pan +4 位作者 Shijie Wang Boyin Liu Min Chen Hao Ma Yixiong Cui 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第1期37-57,共21页
Due to ever-growing soccer data collection approaches and progressing artificial intelligence(AI) methods, soccer analysis, evaluation, and decision-making have received increasing interest from not only the professio... Due to ever-growing soccer data collection approaches and progressing artificial intelligence(AI) methods, soccer analysis, evaluation, and decision-making have received increasing interest from not only the professional sports analytics realm but also the academic AI research community. AI brings gamechanging approaches for soccer analytics where soccer has been a typical benchmark for AI research. The combination has been an emerging topic. In this paper, soccer match analytics are taken as a complete observation-orientation-decision-action(OODA) loop.In addition, as in AI frameworks such as that for reinforcement learning, interacting with a virtual environment enables an evolving model. Therefore, both soccer analytics in the real world and virtual domains are discussed. With the intersection of the OODA loop and the real-virtual domains, available soccer data, including event and tracking data, and diverse orientation and decisionmaking models for both real-world and virtual soccer matches are comprehensively reviewed. Finally, some promising directions in this interdisciplinary area are pointed out. It is claimed that paradigms for both professional sports analytics and AI research could be combined. Moreover, it is quite promising to bridge the gap between the real and virtual domains for soccer match analysis and decision-making. 展开更多
关键词 Artificial intelligence(AI) DECISION-MAKING FOOTBALL review SOCCER sports analytics
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An integrated spatial planning of the mountainous landscapes for ski sports in a case area at the eastern Türkiye
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作者 SATIR Onur TOSUN Busra +2 位作者 COSKUN OZYOL Funda OZDEMIR Omer Faruk BERBEROGLU Suha 《Journal of Mountain Science》 SCIE CSCD 2024年第3期754-767,共14页
Mountainous regions have disadvantages in economic development because of harsh physical and climatic conditions.However,winter tourism activities are one of the key components for supporting economic development in t... Mountainous regions have disadvantages in economic development because of harsh physical and climatic conditions.However,winter tourism activities are one of the key components for supporting economic development in the highlands.Establishing a ski resort area supports direct and indirect employment in a region,and it stops immigration from mountainous regions to other places.This research aimed to assess the potential ski areas using a multi criteria evaluation technique in the Van region which is located in the eastern part of Türkiye.In this context,snow cover duration,sun effect,slope,slope length,elevation,population density,distance from main roads and lake visibility were used as input factors in the decision making process.Each factor was standardized using a fuzzy technique based on existing well-known ski centers in Türkiye.The weight of inputs was defined by applying a survey to the professional skiers.The most important factors were detected as transportation opportunities and snow covers whereas,the least important factors were elevation and population density.Additionally,lake visibility was very important to make a difference from other existing facilities in the region.Therefore,it was included as constraints and lake visible areas were extracted at the final stage of the research.Potential ski areas were mapped in three levels as professional,intermediate and beginner skiers.One of the suitable areas was selected as a sample projection and for the 3D simulation of the ski investment area.Potential costs and benefits were discussed.It was found that a ski tourism area investment can be amortized in 3 years in the region. 展开更多
关键词 Winter sports and tourism Decision making 3D simulation and modelling Landscape planning GIS
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The Influence of Swimming Athletes’ Burnout on Their Sports Participation Motivation in Hunan, China
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作者 Lejia Ou 《Journal of Contemporary Educational Research》 2024年第3期179-186,共8页
Objective:This study aims to explore the effect of swimming athletes’burnout on their sports motivation in Hunan University,China.It seeks to understand how burnout influences various motivational factors,providing i... Objective:This study aims to explore the effect of swimming athletes’burnout on their sports motivation in Hunan University,China.It seeks to understand how burnout influences various motivational factors,providing insights for optimizing swimming sports courses and enhancing student participation.Method:Employing random sampling,the study surveyed 260 swimming athletes from Hunan University.The research utilized a questionnaire divided into three parts:demographic information,the Athlete Burnout Questionnaire(ABQ),and the Intrinsic Motivation Inventory(IMI).Pearson’s r correlation analysis was conducted using SPSS to examine the relationships between burnout dimensions and motivational factors.Results:The study found significant correlations between a reduced sense of accomplishment and various motivational dimensions,including“interest/enjoyment,”“perceived competence,”“perceived choice,”and particularly“perceived tension.”Physical exhaustion showed a significant correlation only with“perceived tension,”indicating a strong link between psychological stress and physical fatigue.Sports devaluation was significantly correlated with“perceived tension,”suggesting that psychological stress impacts athletes’valuation of their sport.Conclusion:The findings highlight the complex interplay between burnout and motivation in swimming athletes.Psychological stress,as indicated by“perceived tension,”emerges as a key factor influencing both the physical and emotional aspects of burnout.The study underscores the need for holistic training approaches that balance physical training with psychological well-being,personalized coaching,and supportive environments to enhance intrinsic motivation and manage stress effectively. 展开更多
关键词 Swimmer sports participation motivation Athletes’burnout
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The Impact of Sports Games on the Psychological Health of Middle School Students
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作者 Zhuozhuo Xin Seong Pek Lim Haojun Zhao 《Journal of Contemporary Educational Research》 2024年第3期95-100,共6页
This study conducted a 16-week comparative experiment with 160 students from Jinan No.5 Middle School in Shandong Province as the experimental subjects.During the implementation of the experiment,the subjects were div... This study conducted a 16-week comparative experiment with 160 students from Jinan No.5 Middle School in Shandong Province as the experimental subjects.During the implementation of the experiment,the subjects were divided into two groups:an experimental group and a control group.The experimental group was subjected to physical exercise interventions using sports game teaching methods during physical education class,while the control group followed traditional physical education teaching methods.The results showed that the psychological health status of the students in the experimental group was significantly better than that of the control group after the experiment.The application of sports games helps to improve the psychological health of middle school students in the course of physical education,promoting a positive and forward direction in student psychology and is an effective means to enhance the psychological health level of middle school students. 展开更多
关键词 sports games Physical education Middle school students Psychological health
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Evaluation of Attending Medical Teams and Their Impact on the DRG Components of Cholecystectomy
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作者 Qi Zhang Chuanyu Chen +3 位作者 Yan Wang Huachen Fan Wenping Sun Jing Deng 《Journal of Clinical and Nursing Research》 2024年第1期113-118,共6页
Objective:This study assessed the role of the attending medical team in the cost control of the cholecystectomy DRG components.Methods:The association between team structure,workflow,and treatment outcomes was analyze... Objective:This study assessed the role of the attending medical team in the cost control of the cholecystectomy DRG components.Methods:The association between team structure,workflow,and treatment outcomes was analyzed using a mixed-methods approach combining quantitative data and qualitative interviews from 628 patients.Results:Inter-professional teamwork significantly affected length of stay,treatment costs,and recurrence rates,with experienced teams performing better in terms of emergency response and collaborative efficiency.Patient satisfaction was generally high,indicating that good teamwork enhances treatment outcomes.Significance:The study highlights the importance of optimizing team configuration to improve the quality,efficiency,and cost control of healthcare. 展开更多
关键词 Attending medical team intervention Diagnosis-related group(DRG)system Healthcare quality and efficiency Interprofessional collaboration
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敦煌文化在数字领域中的设计研究——以Team Lab为例
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作者 严春露 闫朝群 +1 位作者 闵元元 郭译蔓 《鞋类工艺与设计》 2024年第6期45-47,共3页
敦煌壁画在中国古代艺术中占据着至关重要的地位,其独特的艺术风格和丰富的文化内涵使其成为中国古代文化的瑰宝之一。而提及对敦煌壁画的保护和传承,“数字敦煌”居功至伟。在此基础上,敦煌壁画的数字艺术设计得以蓬勃发展。本文旨在... 敦煌壁画在中国古代艺术中占据着至关重要的地位,其独特的艺术风格和丰富的文化内涵使其成为中国古代文化的瑰宝之一。而提及对敦煌壁画的保护和传承,“数字敦煌”居功至伟。在此基础上,敦煌壁画的数字艺术设计得以蓬勃发展。本文旨在探究敦煌壁画在数字领域下的设计研究,通过对日本Team Lab及其作品的分析,探索敦煌文化在数字领域中的设计创新实践及其所面临的挑战,并展望其未来的发展。 展开更多
关键词 敦煌壁画 数字化设计 数字媒体艺术 teamlab
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TeamSTEPPS模式在消化内镜室综合管理中的应用效果
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作者 李雪蕊 杨海霞 +2 位作者 刘冬冬 崔艳艳 郑晓永 《河南医学研究》 CAS 2024年第9期1696-1699,共4页
目的探讨提高医疗质量与患者安全的团队策略和工具包(TeamSTEPPS)模式在消化内镜室综合管理中的应用效果。方法选取2021年6月至2022年2月河南省直第三人民医院消化内镜室收治的118例肠息肉患者作为对照组,接受常规管理;选取2022年3—9... 目的探讨提高医疗质量与患者安全的团队策略和工具包(TeamSTEPPS)模式在消化内镜室综合管理中的应用效果。方法选取2021年6月至2022年2月河南省直第三人民医院消化内镜室收治的118例肠息肉患者作为对照组,接受常规管理;选取2022年3—9月河南省直第三人民医院消化内镜室收治的126例肠息肉患者作为研究组,接受TeamSTEPPS模式综合管理。对比两组护理风险、不良事件发生率、护理质量、患者满意度。结果两组管理后护理风险评分均高于管理前(P<0.05),研究组管理后急救药品、消毒隔离、护理安全、仪器使用以及岗位安全等护理风险评分高于对照组(P<0.05);研究组不良事件发生率低于对照组(P<0.05);两组管理后护理质量评分高于管理前(P<0.05),管理后,相较于对照组,研究组技能操作、专科护理、病房护理、基础护理、消毒护理及分级护理评分均较高(P<0.05);研究组患者对服务态度、手术护理、专业素质等护理满意度高于对照组(P<0.05)。结论TeamSTEPPS模式下综合管理有助于减少消化内镜室护理不良事件发生,提高护理质量与患者对护理满意度。 展开更多
关键词 提高医疗质量与患者安全的团队策略和工具包 综合管理 消化内镜室 护理不良事件 护理质量
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The Effect of Workplace-Based Sports Participation on the Mental Status of Japanese Workers
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作者 Yosuke Shibata Yasunari Kurita Toshiyuki Ojima 《Occupational Diseases and Environmental Medicine》 2023年第3期150-156,共7页
Whether workplace-based sports are part of a company’s employee welfare program in terms of mental status is unknown. This study examined the impact of workplace-based sports participation on the mental status of Jap... Whether workplace-based sports are part of a company’s employee welfare program in terms of mental status is unknown. This study examined the impact of workplace-based sports participation on the mental status of Japanese workers. It involved a single-arm intervention comprising participation in a company’s volleyball team. Data on mental status were collected using a simplified version of the Brief Job Stress Questionnaire. Overall, 11 individuals participated, 9 (81.8%) of whom were women;the mean participant age was 38.2 years. Because the intervention was conducted during busy periods, the median (25th and 75th percentiles) score for qualitative job overload significantly increased from 3.0 (2.0, 4.0) to 3.0 (3.0, 4.3) (p = 0.03). Nonetheless, the fatigue score significantly decreased from 3.0 (3.0, 4.3) to 3.0 (2.0, 4.0) (p = 0.03). These results indicate that participation in workplace-based sports can prevent the deterioration of mental status during busy periods. 展开更多
关键词 Mental Health Occupational Stress team sports VOLLEYBALL Occupation Groups
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The Effect of Workplace-Based Sports Participation on the Mental Status of Japanese Workers
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作者 Yosuke Shibata Yasunari Kurita Toshiyuki Ojima 《Journal of Power and Energy Engineering》 2023年第3期150-156,共7页
Whether workplace-based sports are part of a company’s employee welfare program in terms of mental status is unknown. This study examined the impact of workplace-based sports participation on the mental status of Jap... Whether workplace-based sports are part of a company’s employee welfare program in terms of mental status is unknown. This study examined the impact of workplace-based sports participation on the mental status of Japanese workers. It involved a single-arm intervention comprising participation in a company’s volleyball team. Data on mental status were collected using a simplified version of the Brief Job Stress Questionnaire. Overall, 11 individuals participated, 9 (81.8%) of whom were women;the mean participant age was 38.2 years. Because the intervention was conducted during busy periods, the median (25th and 75th percentiles) score for qualitative job overload significantly increased from 3.0 (2.0, 4.0) to 3.0 (3.0, 4.3) (p = 0.03). Nonetheless, the fatigue score significantly decreased from 3.0 (3.0, 4.3) to 3.0 (2.0, 4.0) (p = 0.03). These results indicate that participation in workplace-based sports can prevent the deterioration of mental status during busy periods. 展开更多
关键词 Mental Health Occupational Stress team sports VOLLEYBALL Occupation Groups
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Do States with Professional Sports Teams Have Lower Suicide Rates?
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作者 Paul M. Sommers 《Open Journal of Statistics》 2018年第5期760-769,共10页
The author examines six age-group specific suicide rates in 2016 between states (in the continental United States) with and without professional sports teams in baseball [MLB], football [NFL], hockey [NHL], and basket... The author examines six age-group specific suicide rates in 2016 between states (in the continental United States) with and without professional sports teams in baseball [MLB], football [NFL], hockey [NHL], and basketball [NBA]. States with at least one team in baseball or football have significantly lower suicide rates among adults in all six age groups (over 20 years of age). States with at least one hockey team have significantly lower suicide rates for all adults over the age of 20, except the oldest age group (adults 65 years of age or over). The results are weakest for states with at least one basketball team. Adults only between 25 and 44 years of age and 65 years of age or over have significantly lower suicide rates with at least one NBA team. 展开更多
关键词 PROFESSIONAL team sports SUICIDE Rates U.S. STATES 2-Sample t-Tests Chi-Squared Test
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基于Team STEPPS模型强化呼吸道管理在机械通气病人中的应用
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作者 张玉静 张运辉 张丽 《全科护理》 2023年第34期4863-4865,共3页
目的:探讨基于Team STEPPS模型强化呼吸道管理在机械通气病人中的应用。方法:回顾性分析2022年1月—11月在医院重症监护室(ICU)接受机械通气的124例病人的临床资料,根据气道管理方式不同分为对照组(50例)和研究组(74例)。对照组病人接... 目的:探讨基于Team STEPPS模型强化呼吸道管理在机械通气病人中的应用。方法:回顾性分析2022年1月—11月在医院重症监护室(ICU)接受机械通气的124例病人的临床资料,根据气道管理方式不同分为对照组(50例)和研究组(74例)。对照组病人接受常规护理干预,研究组病人接受基于Team STEPPS模型强化呼吸道管理。比较两组机械通气时间;ICU入住时间;入住ICU第1天和第7天的动脉血氧分压(PaO_(2))、血氧饱和度(SaO_(2))及氧合指数变化;并记录两组住院期间并发症发生情况。结果:研究组机械通气时间和ICU入住时间均短于对照组(P<0.05);两组入住ICU第7天PaO_(2)、SaO_(2)及氧合指数高于第1天,且研究组均高于对照组(P<0.05);研究组病人住院期间并发症总发生率低于对照组(P<0.05)。结论:基于Team STEPPS模型的强化呼吸道管理可缩短机械通气病人机械通气时间和ICU入住时间,改善病人血气指标,纠正低氧血症状态,降低并发症发生率,改善病人预后。 展开更多
关键词 team STEPPS模型 强化呼吸道管理 机械通气
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Investigation and Research on the Ordinary University High Level Track and Field Sports Teams in Sichuan Province
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作者 Dawei Li Bin Wang 《Open Journal of Applied Sciences》 2012年第4期148-153,共6页
by using the method of literature, questionnaire and mathematical statistics and comparative analysis and ?research method of sichuan university high level survey of the Track and field team, sichuan university high l... by using the method of literature, questionnaire and mathematical statistics and comparative analysis and ?research method of sichuan university high level survey of the Track and field team, sichuan university high level Track and field team and the analysis of existing problems and research, in order to sichuan university of high level Track and field teams development to provide the reference. 展开更多
关键词 SICHUAN Ordinary UNIVERSITY The high leve TRACK and FIELD team RESEARCH
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Using Sports Wagering Markets to Evaluate and Compare Team Winning Streaks in Sports
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作者 R. Alan Bowman Thomas Ashman James Lambrinos 《American Journal of Operations Research》 2015年第5期357-366,共10页
Point spreads and money lines from sports wagering markets are used to evaluate the impressiveness of team streaks. Sports wagering data have previously been useful in assessing competitive balance in sports. Our appr... Point spreads and money lines from sports wagering markets are used to evaluate the impressiveness of team streaks. Sports wagering data have previously been useful in assessing competitive balance in sports. Our approach was motivated by the amount of media scrutiny that accompanied the winning streak of the NBA’s Miami Heat and the point streak of the NHL’s Chicago Blackhawks which occurred simultaneously for the most part in 2013. The topic came to the forefront again with the 2014-2015 winning streak of the Atlanta Hawks. Three streaks are highlighted in our paper. The length of the streaks, the quality of the competition, injuries, and a variety of other factors were mentioned in the media but the discussion was limited to subjective opinions as no way of properly weighing relative influence of the factors was identified. Wagering markets provide an excellent source of information for making these judgments. Several complementary measures are described and the most impressive team streaks within and across professional baseball, basketball, football, and ice hockey are identified. 展开更多
关键词 Winning STREAKS sports Wagering Markets BASEBALL BASKETBALL Football HOCKEY
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Common Sports Injuries and Preventive Measures for Athletes—Take The Track and Field Team Athletes in Yushan County as an Example
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作者 Jieqiong Xie 《教育研究前沿(中英文版)》 2019年第4期313-317,共5页
Taking the common sports injuries and preventive measures of Yushan County middle school track and field athletes as the research object,the sports injuries of Yushan County middle school track and field athletes were... Taking the common sports injuries and preventive measures of Yushan County middle school track and field athletes as the research object,the sports injuries of Yushan County middle school track and field athletes were investigated and analyzed from the angle,type,location and nature of sports injury.Research on sports injury problems,trying to find the causes of sports injuries in daily training of track and field athletes,and proposed targeted preventive measures based on the specific situation of Yushan County Middle School.The results show that 77.70%of track and field athletes have suffered sports injury and periostitis and ligament/muscle strains are the most common forms of injury,and lower limbs are more prone to sports injuries than upper limbs. 展开更多
关键词 Middle School Track and Field sports Injuries Preventive Measures
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The First China Sports and Health Conference was Held in Beijing
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《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2023年第6期566-566,共1页
On May 27,2023,the first China Sports and Health Conference was successfully held in Beijing,which was hosted by the Chinese Preventive Medicine Association(CMPA)and organized by the Capital University of Physical Edu... On May 27,2023,the first China Sports and Health Conference was successfully held in Beijing,which was hosted by the Chinese Preventive Medicine Association(CMPA)and organized by the Capital University of Physical Education and Sports(Beijing Institute for International Olympic Studies)and the Sports and Health Branch of the CMPA. 展开更多
关键词 sports was HEALTH
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Probability Theory Predicts That Winning Streak Is a Shortcut for the Underdog Team to Win the World Series
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作者 Motohisa Osaka 《Applied Mathematics》 2023年第10期696-703,共8页
It is common for two teams or two players to play a game in which the first one to win a majority of the initially determined number of matches wins the championship. We will explore the probabilistic conditions under... It is common for two teams or two players to play a game in which the first one to win a majority of the initially determined number of matches wins the championship. We will explore the probabilistic conditions under which a team (or player) that is considered weak may win the championship over a team (or player) that is considered strong, or a game may go all the way to the end, creating excitement among fans. It is unlikely to occur if the initially estimated probability remains constant when the weaker one wins each game against the stronger one. The purpose of this study is to identify probabilistically what conditions are necessary to increase the probability of such an outcome. We examine probabilistically by quantifying momentum gains to see if momentum gains by a weaker team (or player) winning a series of games would increase the likelihood of such an outcome occurring. If the weaker one gains momentum by winning a series of games and the probability of winning the next game is greater than the initial probability, we can see that such a result will occur in this study. Especially when the number of games is limited to seven, the initial probability that a weaker one will beat a stronger one in each game must be 0.35 or higher in order to win the championship and excite the fans by having the game go all the way to the end. 展开更多
关键词 Game sports Underdog World Series Upset Championship
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Refinement of saliva microRNA biomarkers for sports-related concussion
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作者 Steven D.Hicks Cayce Onks +17 位作者 Raymond Y.Kim Kevin J.Zhen Jayson Loeffert Andrea C.Loeffert Robert P.Olympia Gregory Fedorchak Samantha DeVita Zofia Gagnon Callan McLoughlin Miguel M.Madeira Scott L.Zuckerman Timothy Lee Matthew Heller Chuck Monteith Thomas R.Campbell Christopher Neville Elise Fengler Michael N.Dretsch 《Journal of Sport and Health Science》 SCIE CSCD 2023年第3期369-378,共10页
Background:Recognizing sport-related concussion(SRC)is challenging and relies heavily on subjective symptom reports.An objective,biological marker could improve recognition and understanding of SRC.There is emerging e... Background:Recognizing sport-related concussion(SRC)is challenging and relies heavily on subjective symptom reports.An objective,biological marker could improve recognition and understanding of SRC.There is emerging evidence that salivary micro-ribonucleic acids(miRNAs)may serve as biomarkers of concussion;however,it remains unclear whether concussion-related miRNAs are impacted by exercise.We sought to determine whether40 miRNAs previously implicated in concussion pathophysiology were affected by participation in a variety of contact and non-contact sports.Our goal was to refine a miRNA-based tool capable of identifying athletes with SRC without the confounding effects of exercise.Methods:This case-control study harmonized data from concussed and non-concussed athletes recruited across 10 sites.Levels of salivary miRNAs within 455 samples from 314 individuals were measured with RNA sequencing.Within-subjects testing was used to identify and exclude miRNAs that changed with either(a)a single episode of exercise(166 samples from 83 individuals)or(b)season-long participation in contact sports(212 samples from 106 individuals).The miRNAs that were not impacted by exercise were interrogated for SRC diagnostic utility using logistic regression(172 samples from 75 concussed and 97 non-concussed individuals).Results:Two miRNAs(miR-532-5p and miR-182-5p)decreased(adjusted p<0.05)after a single episode of exercise,and 1 miRNA(miR-4510)increased only after contact sports participation.Twenty-three miRNAs changed at the end of a contact sports season.Two of these miRNAs(miR-26b-3p and miR-29c-3p)were associated(R>0.50;adjusted p<0.05)with the number of head impacts sustained in a single football practice.Among the 15 miRNAs not confounded by exercise or season-long contact sports participation,11 demonstrated a significant difference(adjusted p<0.05)between concussed and non-concussed participants,and 6 displayed moderate ability(area under curve>0.70)to identify concussion.A single ratio(miR-27a-5p/miR-30a-3p)displayed the highest accuracy(AUC=0.810,sensitivity=82.4%,specificity=73.3%)for differentiating concussed and non-concussed participants.Accuracy did not differ between participants with SRC and non-SRC(z=0.5,p=0.60).Conclusion:Salivary miRNA levels may accurately identify SRC when not confounded by exercise.Refinement of this approach in a large cohort of athletes could eventually lead to a non-invasive,sideline adjunct for SRC assessment. 展开更多
关键词 Biomarker Contact sports FOOTBALL RNA Traumatic brain injury
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