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Exploring the targets and molecular mechanism of glycyrrhetinic acid against diabetic nephropathy based on network pharmacology and molecular docking 被引量:2
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作者 Fan-Di Meng Ling Yuan +5 位作者 Duo-Jie Xu Meng-Ying Che Shao-Zhang Hou Dou-Dou Lu Wen-Jing Liu Yi Nan 《World Journal of Diabetes》 SCIE 2023年第11期1672-1692,共21页
BACKGROUND Diabetic nephropathy(DN)stands as the most prevalent chronic microvascular complication of diabetes mellitus.Approximately 50%of DN patients progress to end-stage renal disease,posing a substantial health b... BACKGROUND Diabetic nephropathy(DN)stands as the most prevalent chronic microvascular complication of diabetes mellitus.Approximately 50%of DN patients progress to end-stage renal disease,posing a substantial health burden.AIM To employ network pharmacology and molecular docking methods to predict the mechanism by which glycyrrhetinic acid(GA)treats DN,subsequently validating these predictions through experimental means.METHODS The study initially identified GA targets using Pharm Mapper and the TCMSP database.Targets relevant to DN were obtained from the Genecards,OMIM,and TTD databases.The Venny database facilitated the acquisition of intersecting targets between GA and DN.The String database was used to construct a protein interaction network,while DAVID database was used to conducted Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis and Gene Ontology(GO)analysis.Molecular docking experiments were performed using Autodock software with selected proteins.Experimental validation was conducted using renal proximal tubular cells(HK-2)as the study subjects.A hyperglycemic environment was simulated using glucose solution,and the effect of GA on cell viability was assessed through the cell counting kit-8 method.Flow cytometry was employed to detect cell cycle and apoptosis,and protein immunoblot(western blot)was used to measure the expression of proteins of the phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway and insulin resistance pathway,including insulin receptor(INSR),PI3K,p-PI3K,AKT,p-AKT,and glycogen synthase kinase-3(GSK3).RESULTS A total of 186 intersecting targets between GA and DN were identified,which were associated with 144 KEGGrelated enrichment pathways,375 GO biological process entries,45 GO cellular component entries,and 112 GO cellular function entries.Molecular docking demonstrated strong binding of GA to mitogen-activated protein kinase(MAPK)-1,SRC,PIK3R1,HSP90AA1,CASPASE9,HARS,KRAS,and MAPK14.In vitro experiments revealed that GA inhibited HK-2 cell viability,induced cell cycle arrest at the G2/M phase,and reduced apoptosis with increasing drug concentration.Western blot analysis showed that GA differentially up-regulated GSK3 protein expression,up-regulated AKT/p-AKT expression,down-regulated INSR,AKT,p-AKT,PI3K,and p-PI3K protein expression,and reduced p-PI3K/PI3K levels under high glucose conditions.CONCLUSION GA may protect renal intrinsic cells by modulating the PI3K/AKT signaling pathway,thereby inhibiting HK-2 cell viability,reducing HK-2 cell apoptosis,and inducing cell cycle arrest at the G0/G1 phase. 展开更多
关键词 Network pharmacology Molecular docking Diabetic nephropathy Glycyrrhetinic acid Mechanism of action
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Actional Mechanism of Trifluoroacetic Acid for the Separation of Biopolymers by Reversed-phase Liquid Chromatography
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作者 SHI Ya-li and GENG Xin-du (Department of Chemistry, Northwest University, Xi’an, 710069) 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 1992年第3期207-211,共5页
The present paper covers the actional mechanism of trifluoroacetic acid for the separation of biopolymers investigated by using the parameters of stoichiometric displacement model for retention(SDM-R) in reversed-phas... The present paper covers the actional mechanism of trifluoroacetic acid for the separation of biopolymers investigated by using the parameters of stoichiometric displacement model for retention(SDM-R) in reversed-phase liquid chromatography. It was found that the trifluoroacetic acid(TFA) may participate in, or stimulate the association among displacing agent molecules in mobile phase, and decrease the affinity of both the associate molecules of the displacing agent and the TFA-protein ion-pairing. The former dominates over the separation selectivity of biopolymers as the concentration of TFA is lower than a given value, and the two contrary functions partly offset to each other and the latter dominates as its concentration is greater than the given value. 展开更多
关键词 Trifluoroacetic acid actional mechanism Reversed-phase liquid chroma-tography SEPARATION Biopolymers
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Comparison of Hypolipidemic Effect of Refined Konjac Meal With Several Common Dietary Fibers and Their Mechanisms of Action 被引量:5
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作者 WU JIE AND PENG +1 位作者 SHU-SHENG (Department of Nutrition and Food Hygiene, Nantong Medical College, Nantong City, 226001, Jiangsu, China Department of Nutrition and Food Hygiene, West China University of Medical Sciences,Chengdu, Sichuan, China) 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 1997年第1期27-37,共11页
The effects of RKM in comparison with pectin, algin and agar on lipid levels in serum and liver and on liver histopathology in rats were studied. In addition, the effects of all the tested materials on the composition... The effects of RKM in comparison with pectin, algin and agar on lipid levels in serum and liver and on liver histopathology in rats were studied. In addition, the effects of all the tested materials on the composition and output of fecal bile acid were observed. All four kinds of dietary fiber were given at a level of 5% of diet to young male rats of Wistar strain fed on a lipid-rich diet contalning 5 % lard, 1% cholesteral and 0. 25 % cholate. All the dietary fibers tested have similar effects on serum lipid composition. In all groups, these substances prevent ed increases in total cholesterol in fasting serum, but the level of triglyceride was tmchangd.The concentrations of totaI cholesterol and triglyceride in the liver were lower in the RKM group than in the control group and the other three groups. Hepatic histopathological exami nation also showed the most significant lipotropic effect in the RKM group. The daily output of fecal bile acids (CDCA+GDCA) was significantly increased in the four experimental groups than in the normal group and the control group. The increase of CDCA was more significant than GDCA, suggesting that the increase of fecal bile acids, especially CDCA, may be one of the mechanisms by which RKM and the other three dietary fibers exerts a hypocholesterolemic effect 展开更多
关键词 acid Am Br Comparison of Hypolipidemic Effect of Refined Konjac Meal With Several Common Dietary Fibers and their Mechanisms of action CDCA
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Role of Lactic Acid Bacteria-Myeloperoxidase Synergy in Establishing and Maintaining the Normal Flora in Man
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作者 Robert C. Allen Jackson T. Stephens Jr. 《Food and Nutrition Sciences》 2013年第11期67-72,共6页
Lactic acid bacteria (LAB) are incapable of cytochrome synthesis and lack the heme electron transport mechanisms required for efficient oxygen-based metabolism. Consequently, LAB redox activity is flavoenzyme-based an... Lactic acid bacteria (LAB) are incapable of cytochrome synthesis and lack the heme electron transport mechanisms required for efficient oxygen-based metabolism. Consequently, LAB redox activity is flavoenzyme-based and metabolism is fermentative, producing lactic acid, and in many cases, hydrogen peroxide (H2O2). Despite this seeming metabolic limitation, LAB dominate in the normal flora of the mouth, vagina and lower gastrointestinal tract in man. Myeloperoxidase (MPO) is produced by the neutrophil leukocytes and monocytes that provide the innate phagocyte defense against infecting pathogens. MPO is unique in its ability to catalyze the H2O2-dependent oxidation of chloride (Cl-) to hypochlorite (OCl-). In turn, this OCl- directly reacts with a second H2O2 to produce singlet molecular oxygen (), a metastable electronic excitation state of oxygen with a microsecond lifetime that restricts its combustive reactivity within a submicron radius of its point of generation. Each day a healthy human adult produces about a hundred billion neutrophils containing about 4 femtograms MPO per neutrophil. Inflammatory states and G-CSF treatment increase both neutrophil production and the quantity of MPO per neutrophil. After a short circulating lifetime, neutrophils leave the blood and migrate into body spaces including the mouth, vagina, urinary tract, and gastrointestinal tract. Greater than a hundred thousand neutrophils are lavaged from the mouths of healthy humans;the quantity lavaged is proportional to the blood neutrophil count. MPO selectively and avidly binds to most Gram-positive and all Gram-negative bacteria tested, but LAB do not show significant MPO binding. Neutrophils migrating to normal flora sites release MPO into the LAB-conditioned milieu containing adequate acidity and H2O2 to support extra-phagocyte MPO microbicidal action. In combination, LAB plus MPO exert a potent synergistic microbicidal action against high MPO-binding microbes. This LAB-MPO synergy provides a mechanism for the establishment and maintenance of LAB in the normal flora of man. 展开更多
关键词 MYELOPEROXIDASE LACTIC acid Bacteria Hydrogen PEROXIDE HYPOCHLORITE SINGLET Oxygen SELECTIVE Binding SELECTIVE Microbicidal action Normal Flora
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Effects of diphosphonic acid on ilmenorutile collecting property and research of action mechanism 被引量:9
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作者 HaoRen FeifeiJi +2 位作者 ShuxiangZhang MengBao QufeiZhang 《Journal of University of Science and Technology Beijing》 CSCD 2002年第4期249-252,共4页
The effects of several collectors and their dosage on pure ilmenorutile atdifferent pH values were studied and the collecting strength of several representative collectorswas investigated. The experimental results ind... The effects of several collectors and their dosage on pure ilmenorutile atdifferent pH values were studied and the collecting strength of several representative collectorswas investigated. The experimental results indicate that diphosphonic acid is a good collector forilmenorutile and the recovery of ilmenorutile ranges from 90.87 percent to 91.70 percent when thepulp pH value is 2.0-4.0 and the dosage is 75 mg/L. The sequence of collecting ability for severalcollectors is as follows: diphosphonic acid> TF279 > cyclic allryl hydroximic acid > benzyl arsenicacid> salicylic hydroximic acid> alkyl hydroximic acid. Meanwhile, IAS (infrared absorptionspectrum) and XPS (X-ray photoelectron spectroscopy) were used to detect and analyze the actionmechanism of diphosphonic acid on ilmenorutile. IAS results showed that the characteristicabsorption peak relating to P=O as well as P-O vibration occurred between wave numeber 1140 and 1032cm^(-1), and diphosphonic acid had adsorbed on the surface of ilmenorutile. XPS results indicatedthat the binding energy of P2P peak of ilmenorutile had changed 0.45 eV after treated bydiphosphonic acid. This proves that the adsorption is mainly chemical adsorption. 展开更多
关键词 COLLECTOR diphosphonic acid ilmenorutile action mechanism
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INHIBITIVE ACTION OF INORGANIC COMPOUND ON CORROSION OF ALUMINIUM IN HYDROCHLORIC ACID
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作者 Qing Hai CAI Bin LU Ling Fei CUI Department of Chemistry,Harbin Normal University,Harbin 150080 《Chinese Chemical Letters》 SCIE CAS CSCD 1992年第1期75-76,共2页
The inhibitive action of CaSO_4 towards corrosion of aluminium in 1 mol/L HCl has been inveetigated by using fluorometrio and weight loss techniques.The results show that the inhibitor exhibits an outstanding function... The inhibitive action of CaSO_4 towards corrosion of aluminium in 1 mol/L HCl has been inveetigated by using fluorometrio and weight loss techniques.The results show that the inhibitor exhibits an outstanding function of inhibition,especially at higher tempe- ratures,and it was found to be predomiantly of cathodic rate control.Ths mechanism of inhibition and the effect of CdSO_4 on the corrosion kinetics are also discussed. 展开更多
关键词 action INHIBITIVE action of INORGANIC COMPOUND ON CORROSION of ALUMINIUM IN HYDROCHLORIC acid
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Alleviation effects of Ce^(3+) on inhibition of photochemical activity caused by linolenic acid in spinach chloroplast 被引量:1
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作者 刘晓晴 黄浩 +4 位作者 刘超 马玲兰 刘洁 殷四涛 洪法水 《Journal of Rare Earths》 SCIE EI CAS CSCD 2008年第6期875-879,共5页
Linolenic acid has great effects on the structure and function of chloroplast. The function of Ce^3+ on the improvement of chloroplast photoreduction activity and oxygen evolution damaged by linolenic acid in spinach... Linolenic acid has great effects on the structure and function of chloroplast. The function of Ce^3+ on the improvement of chloroplast photoreduction activity and oxygen evolution damaged by linolenic acid in spinach by in vitro investigation was studied. Results showed that adding Ce^3+ to the linolenic acid treated chloroplast could greatly decrease the reduction linolenic acid exerted on the whole chain electron transport rate and the photoreduction activity of photosystem Ⅱ (PSII) and photosystem Ⅰ (PSI) as well as the oxygen evolution rate of chloroplast. It indicated that Ce^3+ had the ability to relieve the inhibition of the photochemical reaction of chloroplast caused by linolenic acid to some extent. 展开更多
关键词 Ce^3+ linolenic acid CHLOROPLAST photochemical action rare earths
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Pharmacological Modulation by Shakuyakukanzoto (Shao-Yao-Gan-Cao-Tang) and the Ingredients in Rat Intestinal Smooth Muscle 被引量:2
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作者 Hiroyasu Satoh Kiminori Tsuro 《Chinese Medicine》 2011年第2期62-70,共9页
Shakuyakukanzoto (Shao-Yao-Gan-Cao-Tang), a formulation of Japanese herbal (Kampo) medicines, is composed of Paeoniae Radix and Glycyrrhizae Radix. Effects of Shakuyakukanzoto and the ingredients on rat intestinal tra... Shakuyakukanzoto (Shao-Yao-Gan-Cao-Tang), a formulation of Japanese herbal (Kampo) medicines, is composed of Paeoniae Radix and Glycyrrhizae Radix. Effects of Shakuyakukanzoto and the ingredients on rat intestinal tract were examined. Shakuyakukanzoto (0.01 - 0.3 mg/ml) relaxed a carbachol (CCh, 0.3 μM) - induced contraction in a concentration-dependent manner. Both components (Paeoniae radix and Glycyrrhizae radix) also relaxed the CCh-induced contraction. At 0.1 to 1 mM, their constituents (paeoniflorin and glycyrrhetic acid) and the metabolic products (18-α- and 18-β-glycyrrhetinic acids) exerted almost the same actions. The relaxations induced by Shakuyakukanzoto were not modified by 1 μM nicardipine, 10 μM suramin (ATP receptor inhibitor) and several K+ channel inhibitors, but was attenuated by 20 μM IBMX (a phosphodiesterase inhibitor). Also, IBMX inhibited the relaxations induced by paeoniflorin and glycyrrhetic acid, but not by other ingredients. Nicardipine decreased the relaxation of just 18-α-glycyrrhetinic acid. Even in non-treatment with CCh, Shakuyakukanzoto relaxed the intestinal tract. CCh (0.3 μM) elicited spontaneous contractions in 23% specimens, depressed by application of Shakuyakukanzoto. These results indicate that Shakuyakukanzoto causes a remarkable relaxation by the anti-cholinergic and the PDE inhibitory actions, but by minor contribution of Ca2+ channel inhibition. Thus, Shakuyakukanzoto exerts an anti-spasmodic action due to the interaction with pharmacological effects of its ingredients. 展开更多
关键词 Shakuyakukanzoto Paeoniae Radix PAEONIFLORIN Glycyrrhetic acid PDE INHIBITION Anti-Cholinergic action Ca2+ Channel INHIBITION Intestinal TRACT
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Metabolic disturbance and phytochemical changes in Andrographis paniculata and possible action mode of andrographolide
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作者 Netiya Karaket Nuchada Maneejantra +3 位作者 Patoomratana Tuchinda Jirapna Kunapin Choowong Auesukaree Kanyaratt Supaibulwatana 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2018年第2期85-91,共7页
Objecive: To explore the effect of gibberellic acid(GA_3) and its inhibitor paclobutrazol(PBZ)on chemical composition and their pharmacological effects on Andrographis paniculata(Burm.f.) Wall. ex Nees, and to clarify... Objecive: To explore the effect of gibberellic acid(GA_3) and its inhibitor paclobutrazol(PBZ)on chemical composition and their pharmacological effects on Andrographis paniculata(Burm.f.) Wall. ex Nees, and to clarify action mode of andrographolide.Methods: The chemical composition was extracted by sequential extraction with hexane, dichloromethane, ethyl acetate and methanol, respectively. Andrographolide and its derivatives were evaluated by HPLC. Moreover, the metabolic profiling was analyzed by GC-MS. Inhibitory effect of crude extracts was tested against Staphylococcus aureus using agar well diffusion method. Mode of action was tested against mutant yeast by spotting assay. Andrographolide were tested for their mode of action against eukaryotes. Rsults: Among different solvents, dichloromethane gave the highest yield of crude(3.58% DW), with the highest andrographolide content(8.3 mg/g DW). The effect of plant hormone(10 mg/L GA_3 or PBZ) on phytochemical variations and bioactivity of Andrographis paniculata was demonstrated. It was found that PBZ promoted sesquiterpene compounds about 3.5 times over than GA_3 treatment. But inhibitory effect of extracts against Staphylococcus aureus was highest in GA_3 treated plants; andrographolide and 14-deoxy-11,12-didehydroandrographolide contents were significantly higher than those of water or PBZ. It was found that there were 11 strains involving in ergosterol biosynthesis, V-ATPase activity and homeostasis, and superoxide detoxification process. In this regard, andrographolide might cause the damage on the lipid bilayer of yeast cell and plasma membrane by interfering ergosterol biosynthesis.Conclusions: It is found that GA_3 promotes andrographolide and 14-deoxy-11,12-didehydroandrographolide content while PBZ promotes sesquiterpene content. Andrographolide might cause the damage on the lipid bilayer of yeast cell and plasma membrane by interfering ergosterol biosynthesis. It might also affect mitochondria electron transport chain, leading to the occurrence of ROS, which can further harm cell organelles. However, the library screening is the first step to investigate mode of action of andrographolide. 展开更多
关键词 Andrographis paniculata ANDROGRAPHOLIDE Cell elicitation Gibberellic acid PACLOBUTRAZOL Mode of action
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Screening Research of Pharmaceutical Compositions Based on Succinic Acid, Ascorbic Acid and Rutin
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作者 Mariya Leleka Olha Zalis'ka Galyna Kozyr 《Journal of Pharmacy and Pharmacology》 2016年第9期486-491,共6页
We conduct research on the development of new medicines based on succinic acid, ascorbic acid and rutin. We studied the anti-inflammatory action (exudative inflammation, model of carrageenan-induced paw edema of rats... We conduct research on the development of new medicines based on succinic acid, ascorbic acid and rutin. We studied the anti-inflammatory action (exudative inflammation, model of carrageenan-induced paw edema of rats), the hepatoprotective (injury of rats with carbon tetrachloride) and renal protectie action. In the study, the anti-inflammatory activity of our medicines (exudative inflammation, karahenin model of inflammatory edema of paws rats) is set to ability of suppression of the inflammatory response by 24.4 %. Against the background, the action of carbon tetrachloride observed a positive effect on cholesterol- and pigment- forming liver function. Reducing the activity of enzymes ALT (alanine transaminase) and AST (aspartate transaminase) in groups of animals, which treated with our medication, talks about their ability to recover morpho functional integrity of the membranes of hepatocytes and warn of changes in the liver damage with carbon tetrachloride. Renal protective action screening study found that investigated mixture capable of increasingly lower level of creatinine in the blood of rats: 27.27-39.18 mmol/L in Lespeflan. Similarly, the concentration of urea in the smaller of the studied using mixtures is 5.18 mmol/L, while the application lespeflanu urea concentration slightly higher is 6.78 mmol/L. This shows that hypoazotemic effect is traced compared with the control group, and better than the comparator Lespeflan. Study of acute toxicity showed that the investigated mixture refers to practically nontoxic drugs. It is confirmed the need for further studies on the pharmacological activity of our facility to determine the effect on capillaries and the immune system, and as a result, prevention and treatment of influenza and ARI (acute respiratory infections). 展开更多
关键词 Succinic acid ascorbic acid RUTIN pharmacological action acute toxicity.
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半夏化学成分、药理作用研究进展及其质量标志物预测分析 被引量:8
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作者 王婉怡 朱志军 +1 位作者 李航飞 许淑美 《辽宁中医药大学学报》 CAS 2024年第3期203-215,共13页
半夏始载于《神农本草经》,味多辛苦,性多温燥,有毒,主归脾、胃、肺经,是我国常见的大宗药材,具有燥湿化痰、降逆止呕、消痞散结之功,常配伍于中药方剂作为君药使用。半夏来源广泛,成分丰富,药效显著,在我国临床治疗史上具有广阔前景。... 半夏始载于《神农本草经》,味多辛苦,性多温燥,有毒,主归脾、胃、肺经,是我国常见的大宗药材,具有燥湿化痰、降逆止呕、消痞散结之功,常配伍于中药方剂作为君药使用。半夏来源广泛,成分丰富,药效显著,在我国临床治疗史上具有广阔前景。该文以质量标志物(Q-Marker)理论为指导,结合国内外文献报道,归纳总结了半夏化学成分和药理作用,从亲缘关系、传统药性、化学成分有效性、成分可测性和不同配伍环境等方面对半夏进行Q-Marker的预测分析,以期为半夏建立更科学、更合理的质量评价体系,为其进一步综合利用提供参考。 展开更多
关键词 半夏 质量标志物 化学成分 药理作用 生物碱类 有机酸类 挥发油类
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山楂酸药理作用的研究进展 被引量:1
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作者 张林晨 张小琴 张俊平 《药学实践与服务》 CAS 2024年第5期185-189,共5页
山楂酸是一种五环三萜类化合物,广泛存在于油橄榄和山楂等多种天然植物中。山楂酸具有抗肿瘤、抗炎、抗氧化、抗菌、心血管保护、神经保护等药理作用。针对山楂酸的药理活性研究进展及其作用机制进行综述,为其进一步开发和应用提供参考... 山楂酸是一种五环三萜类化合物,广泛存在于油橄榄和山楂等多种天然植物中。山楂酸具有抗肿瘤、抗炎、抗氧化、抗菌、心血管保护、神经保护等药理作用。针对山楂酸的药理活性研究进展及其作用机制进行综述,为其进一步开发和应用提供参考依据。 展开更多
关键词 山楂酸 药理活性 作用机制
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乳酸菌抗氧化机制研究进展及在食品领域的应用 被引量:1
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作者 尹树磊 杜香 +3 位作者 张小希 刘璐 易俊洁 王艳菲 《食品科学》 EI CAS CSCD 北大核心 2024年第13期345-355,共11页
乳酸菌不仅有助于改善发酵食品的风味,提高营养价值,还有助于预防由于氧化反应而引发的多种疾病。这些有益功能的发挥与乳酸菌的抗氧化活性密不可分。本文详细阐述了乳酸菌的抗氧化机制,包括调节抗氧化酶类、调控信号通路、清除自由基... 乳酸菌不仅有助于改善发酵食品的风味,提高营养价值,还有助于预防由于氧化反应而引发的多种疾病。这些有益功能的发挥与乳酸菌的抗氧化活性密不可分。本文详细阐述了乳酸菌的抗氧化机制,包括调节抗氧化酶类、调控信号通路、清除自由基系统、抑制脂质过氧化作用及金属离子螯合作用;总结了乳酸菌的抗氧化特性在乳制品、肉制品、水产品和果蔬制品等领域的应用现状;概述了乳酸菌抗氧化活性的体外和体内评估方法,旨在为乳酸菌在食品加工领域的深层次应用提供相关参考。 展开更多
关键词 乳酸菌 抗氧化活性 作用机制 食品加工 评估方法
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氨甲环酸联合SRI-HAPAM在老年股骨颈骨折全髋关节置换术后的应用价值 被引量:1
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作者 单礼旦 朱月英 +2 位作者 陈海棠 黄逸爽 黄林拓 《中国药师》 CAS 2024年第2期279-286,共8页
目的 探究氨甲环酸(TXA)联合健康行为过程取向模型(HAPA)下阶段式康复干预(SRI-HAPAM)对行全髋关节置换术(THA)老年股骨颈骨折(FNF)患者的应用价值。方法 纳入2022年12月至2023年6月温州医科大学附属第一医院行单侧THA老年FNF患者为研... 目的 探究氨甲环酸(TXA)联合健康行为过程取向模型(HAPA)下阶段式康复干预(SRI-HAPAM)对行全髋关节置换术(THA)老年股骨颈骨折(FNF)患者的应用价值。方法 纳入2022年12月至2023年6月温州医科大学附属第一医院行单侧THA老年FNF患者为研究对象。根据随机数字表法,将患者为常规护理(RN)组和TXA+SRI-HAPAM组。RN组术后接受常规治疗,TXA+SRI-HAPAM组术后接受TXA联合SRI-HAPAM治疗。比较两组术后24 h出血指标[隐性失血量(HBL)、显性出血量(EBL)和输血量(BTV)]、血红蛋白(Hb)、C-反应蛋白(CRP)和D-二聚体(DD)水平。比较两组术后3个月髋关节功能[关节畸形(JD)、关节功能(JF)、关节疼痛(JP)、关节活动(JM)和髋关节功能总分(THF)]、焦虑抑郁情绪[焦虑自评量表(SAS)和抑郁自评量表(SDS)]、护理满意度和并发症发生情况。结果 研究共纳入100例因FNF行单侧THA老年患者,TXA+SRI-HAPAM组54例,RN组46例。术前,两组Hb、CRP、DD、JD、JF、JP、JM、THF、SAS差异无统计学意义(P> 0.05)。术后24 h,两组Hb较术前下降,而CRP和DD较术前上升(P <0.05);TXA+SRI-HAPAM组Hb的下降程度和CRP、DD的上升程度以及HBL、EBL和BTV均低于RN组(P <0.05)。术后3月,两组患者JD、JF、JP、JM和THF均较术前上升,而SAS和SDS较术前均下降(P <0.05);且TXA+SRI-HAPAM组JD、JF、JP、JM和THF评分显著高于RN组,SAS和SDS评分低于RN组(P <0.05)。术后3个月,TXA+SRI-HAPAM组护理满意度明显高于RN组,而总并发症发生率低于RN组(P <0.05)。结论 与常规护理比较,TXA联合SRIHAPAM可更有效地促进THA患者术后恢复。 展开更多
关键词 氨甲环酸 健康行为过程取向模型 阶段式康复干预 老年股骨颈骨折 全髋关节置换术
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二十二碳六烯酸治疗癫痫的作用机制研究进展
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作者 余丽 曾玉萍 +3 位作者 汪莉 邹晓毅 尤佳伟 吴倩 《中国医药导报》 CAS 2024年第23期56-60,共5页
癫痫是一种神经系统的慢性疾病,主要由大脑异常放电引起,可导致患者头痛、认知障碍及情绪异常波动等,严重影响患者身心健康,给家庭和社会带来沉重负担。目前关于癫痫的具体发病机制研究较少,且治疗癫痫的药物效果有限,还可产生一定的副... 癫痫是一种神经系统的慢性疾病,主要由大脑异常放电引起,可导致患者头痛、认知障碍及情绪异常波动等,严重影响患者身心健康,给家庭和社会带来沉重负担。目前关于癫痫的具体发病机制研究较少,且治疗癫痫的药物效果有限,还可产生一定的副作用,因此需寻找更多安全有效的天然产物预防和治疗癫痫。二十二碳六烯酸是人体必需的一种多不饱和脂肪酸,主要来源于海洋生物,具有提供能量、影响炎症反应、免疫反应和保护神经等多种生物功能。本文主要综述抑制细胞凋亡、抗氧化和抗炎等多种途径对二十二碳六烯酸治疗癫痫的研究,为癫痫治疗的新思路提供参考依据。 展开更多
关键词 癫痫 二十二碳六烯酸 作用机制 炎症 凋亡
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乳酸菌在蔬菜发酵中的作用机制研究进展
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作者 郑超 侯信哲 +5 位作者 陈天花 刘彩丽 朱宗河 徐雅芫 周可金 张付贵 《中国调味品》 CAS 北大核心 2024年第8期205-210,共6页
发酵蔬菜历史悠久、风味独特,深受人们喜爱,乳酸菌作为蔬菜发酵中的关键菌,发挥着重要作用。文章主要探讨了影响发酵蔬菜品质和乳酸菌代谢的环境因素、蔬菜发酵过程中乳酸菌对其他细菌的影响以及乳酸菌提高发酵蔬菜品质的作用,以期全面... 发酵蔬菜历史悠久、风味独特,深受人们喜爱,乳酸菌作为蔬菜发酵中的关键菌,发挥着重要作用。文章主要探讨了影响发酵蔬菜品质和乳酸菌代谢的环境因素、蔬菜发酵过程中乳酸菌对其他细菌的影响以及乳酸菌提高发酵蔬菜品质的作用,以期全面了解乳酸菌在蔬菜发酵中的作用机理,为其在发酵蔬菜中的深入研究和应用提供理论依据。 展开更多
关键词 乳酸菌 蔬菜发酵 作用机制
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后生元的作用机制及其在食品领域的应用
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作者 谢莹莹 庞旭 +6 位作者 周海泳 徐健 祁姣姣 朱剑锋 李雪玲 杨美艳 胡文锋 《食品科学》 EI CAS CSCD 北大核心 2024年第8期354-363,共10页
后生元是由对宿主健康有益的无生命的微生物细胞和/或其成分,以及其代谢产物制成的微生态制剂。后生元具有调节肠道菌群平衡、增强免疫力、抗炎抗菌等功效。与由活性细胞组成的益生菌相比,后生元更安全、更稳定、更有效和更方便。本文... 后生元是由对宿主健康有益的无生命的微生物细胞和/或其成分,以及其代谢产物制成的微生态制剂。后生元具有调节肠道菌群平衡、增强免疫力、抗炎抗菌等功效。与由活性细胞组成的益生菌相比,后生元更安全、更稳定、更有效和更方便。本文概述了后生元的由来、来源菌株、制备途径及其优点,并与益生菌进行对比,阐述了后生元的作用机制。此外,本文从功能性食品补充剂、食品品质改良剂、食品防腐剂以及食品脱毒剂4个方面介绍后生元在食品的应用。相信随着后生元的定义、分类、作用成分变得更加清晰,它将会更广泛地应用于普通食品、营养保健品、特殊医学食品、婴幼儿食品和个护日化产品等领域,还将推动一系列基础科学与应用科学的跨越式发展。 展开更多
关键词 后生元 灭活乳酸菌 作用机制 食品 应用
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氯胺酮快速抗抑郁作用机制研究进展 被引量:1
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作者 苏荣 李晓凤 +2 位作者 杨敏雪 郭艳浩 张亚通 《中国医药科学》 2024年第7期59-63,共5页
氯胺酮的发现,掀起了作用于N-甲基-D-天门冬氨酸(NMDA)受体(NMDAR)抗抑郁药的研究热潮。氯胺酮发挥抗抑郁的作用机制尚不明确,根据现有研究科学家提出了一系列的假说,如去抑制假说、突触可塑性假说等。谷氨酸(Glu)作为中枢神经系统中重... 氯胺酮的发现,掀起了作用于N-甲基-D-天门冬氨酸(NMDA)受体(NMDAR)抗抑郁药的研究热潮。氯胺酮发挥抗抑郁的作用机制尚不明确,根据现有研究科学家提出了一系列的假说,如去抑制假说、突触可塑性假说等。谷氨酸(Glu)作为中枢神经系统中重要的兴奋性递质与抑郁症有着密切联系,其中NMDAR在抑郁症治疗中起着关键作用,然而氯胺酮因具有致幻性和成瘾性而存在风险,限制了其应用。尽管如此,了解氯胺酮快速持续抗抑郁作用的治疗靶点和相关信号通路对于研发相关药物有重要作用。 展开更多
关键词 抑郁症 氯胺酮 N-甲基-D-天门冬氨酸受体 谷氨酸 抗抑郁 作用机制
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酸枣仁的化学成分、药理作用和临床应用研究进展
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作者 曲彤 耿飞飞 +7 位作者 李宁 鲁文静 任慧 崔小敏 胡静 梁超 陈志永 张红 《药学前沿》 CAS 2024年第9期98-108,共11页
酸枣仁主要含有皂苷类、黄酮类、生物碱类、脂肪酸类等成分,具有镇静催眠、抗焦虑、抗抑郁、保护神经、保护心脑血管、保肝、抗氧化等多种活性,广泛应用于医药、食品、保健食品等领域。本文通过查阅文献,系统整理归纳了酸枣仁的化学成... 酸枣仁主要含有皂苷类、黄酮类、生物碱类、脂肪酸类等成分,具有镇静催眠、抗焦虑、抗抑郁、保护神经、保护心脑血管、保肝、抗氧化等多种活性,广泛应用于医药、食品、保健食品等领域。本文通过查阅文献,系统整理归纳了酸枣仁的化学成分、药理作用及临床应用,以期为酸枣仁资源的可持续开发和合理使用提供理论指导。 展开更多
关键词 酸枣仁 化学成分 药理作用 临床研究 皂苷 黄酮 生物碱 脂肪酸
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中药治疗尿酸性肾病的研究进展
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作者 张琳俪 王琳 +1 位作者 陈以平 张先闻 《上海中医药杂志》 CSCD 2024年第9期96-101,共6页
综述中药治疗尿酸性肾病的研究进展。近年研究发现,在尿酸性肾病治疗中,中药复方及单味药在减少尿酸盐沉积、抗氧化、保护内皮细胞、改善炎症反应等方面发挥了保护肾功能的作用,为进一步优化尿酸性肾病临床治疗方案提供了思路。
关键词 尿酸性肾病 高尿酸血症 慢性肾脏病 病因病机 作用机制 中药研究
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