Black holes contradict the Nernst-Planck (N/P) version of the 3rd law of thermodynamics, but agree with its unattainability (U) version. This happens without contradiction, because the N/P and U versions are not equiv...Black holes contradict the Nernst-Planck (N/P) version of the 3rd law of thermodynamics, but agree with its unattainability (U) version. This happens without contradiction, because the N/P and U versions are not equivalent, namely, N/P implies U but U does not imply N/P. So, black holes obey the weaker version of the 3rd law, but not the stronger one.展开更多
Background: Accurate determination of gestational age has become important for deciding the appropriate time for termination of the pregnancy as well as to monitor the fetal growth during the entire period of pregnanc...Background: Accurate determination of gestational age has become important for deciding the appropriate time for termination of the pregnancy as well as to monitor the fetal growth during the entire period of pregnancy. Objective: The aim of the study was to assess whether the trans-cerebellar diameter, placental thickness or combining both of them is more accurate for assessment of gestational age in the 3<sup>rd</sup> trimester of pregnancy. Patients and Methods: This is a cross sectional study conducted at outpatient Clinic and Obstetric ward, Ain Shams University Maternity Hospital, over a period of six months from March 2019 to September 2019. One hundred pregnant women were recruited according to inclusion criteria either from outpatient clinic or were admitted in obstetric ward Ain Shams Maternity Hospital to find out the most accurate fetal biometric measurement in the third trimester either trans-cerebellar diameter placental thickness or both compared to reliable LMP (last menstrual period) dates confirmed by crown rump length (CRL) in the first trimester. Results: Trans-cerebellar diameter mean ± SD was 46.0 ± 3.5 with range 38.2 - 51.7. The mean of placental thickness was 39.6 ± 7.1 with range 22.8 - 54.3. Placental thickness had highest determination (0.813) for last menstrual period followed by trans-cerebellar diameter (0.802). Combining trans-cerebellar diameter and placental thickness increased determination (0.902) for last menstrual period. Conclusion: Combined use of trans-cerebellar diameter and placental thickness in the third trimester of pregnancy is a reliable indicator for gestational age in women whose last menstrual period is unreliable or unknown, but placental thickness had higher accuracy than trans-cerebellar diameter.展开更多
The boundary value problems of the third-order ordinary differential equation have many practical application backgrounds and their some special cases have been studied by many authors. However, few scholars have stud...The boundary value problems of the third-order ordinary differential equation have many practical application backgrounds and their some special cases have been studied by many authors. However, few scholars have studied the boundary value problems of the complete third-order differential equations u′′′(t) = f (t,u(t),u′(t),u′′(t)). In this paper, we discuss the existence and uniqueness of solutions and positive solutions of the fully third-order ordinary differential equation on [0,1] with the boundary condition u(0) = u′(1) = u′′(1) = 0. Under some inequality conditions on nonlinearity f some new existence and uniqueness results of solutions and positive solutions are obtained.展开更多
The present paper proposes a mathematical method to numerically treat a class of third-order linear Boundary Value Problems (BVPs). This method is based on the combination of the Adomian Decomposition Method (ADM) and...The present paper proposes a mathematical method to numerically treat a class of third-order linear Boundary Value Problems (BVPs). This method is based on the combination of the Adomian Decomposition Method (ADM) and, the modified shooting method. A complete derivation of the proposed method has been provided, in addition to its numerical implementation and, validation via the utilization of the Runge-Kutta method and, other existing methods. The method has been applied to diverse test problems and turned out to perform remarkably. Lastly, the simulated numerical results have been graphically illustrated and, also supported by some absolute error comparison tables.展开更多
The idea of research started with a crazy imaginary theory in the field of astrogeography, saying: We often taught ourselves and then convinced the students that the planet Earth moves despite not feeling the vibratio...The idea of research started with a crazy imaginary theory in the field of astrogeography, saying: We often taught ourselves and then convinced the students that the planet Earth moves despite not feeling the vibrations of traffic, and we listed successive scientific confirmations to indicate the rotation of the planet in a regular movement around its axis once every 24 hours, and it is running in another second movement around the sun once every 365¼ days, so are they only two movements, no more?! Is it possible for him to run at a regular speed in an additional direction?展开更多
A comprehensive study on the requirements for the highly efficient third harmonic generation(THG) and its inverse process, one-third harmonic generation(OTHG), in lossy waveguides is proposed. The field intensity rest...A comprehensive study on the requirements for the highly efficient third harmonic generation(THG) and its inverse process, one-third harmonic generation(OTHG), in lossy waveguides is proposed. The field intensity restrictions for both THG and OTHG caused by loss are demonstrated. The effective relative phase ranges, supporting the positive growth of signal fields of THG and OTHG are shrunken by the loss. Furthermore, it turns out that the effective relative phase ranges depend on the intensities of the interacting fields. At last, a modified definition of coherent length in loss situation, which evaluates the phase matching degree more precisely, is proposed by incorporating the shrunken relative phase range and the nonlinear phase mismatch. These theoretical analysis are valuable for guiding the experimental designs for highly efficient THG and OTHG.展开更多
This study investigated the general situation of metalinguistic awareness of third language learners in Chinese universities.Data analyses showed that the level of metalinguistic awareness in those learners was signif...This study investigated the general situation of metalinguistic awareness of third language learners in Chinese universities.Data analyses showed that the level of metalinguistic awareness in those learners was significantly higher than that of second language learners.And learning a third language can improve metalinguistic awareness.展开更多
Objective:Anlotinib hydrochloride is a multitarget tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor,fibroblast growth factor receptor,platelet-derived growth factor receptor,c-Kit,and...Objective:Anlotinib hydrochloride is a multitarget tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor,fibroblast growth factor receptor,platelet-derived growth factor receptor,c-Kit,and c-MET;therefore,it exhibits both antitumor and anti-angiogenetic activities.A phase III trial has shown that anlotinib improved progression-free survival(PFS)and overall survival(OS)in patients with advanced non-small cell lung cancer(NSCLC),who presented with progressive disease or intolerance after standard chemotherapy.This study aimed to analyze the characteristics of patients receiving anlotinib treatment to determine the dominant populations who are fit for the treatment.Methods:Data were collected from March 2015 to January 2017 from a randomized,double-blind,placebo-controlled,multicenter,phase III trial of anlotinib(ALTER0303).A total of 437 patients were enrolled and randomly allocated(2:1)to the anlotinib and placebo groups.Kaplan–Meier analysis and log-rank test were performed to compare PFS and OS.Cox proportional hazards model was adopted for multivariate prognostic analysis.Results:Multivariate analysis indicated that high post-therapeutic peripheral blood granulocyte/lymphocyte ratio and elevated alkaline phosphatase levels were independent risk factors for PFS.Meanwhile,elevated thyroid-stimulating hormone,blood glucose,and triglyceride levels;hypertension;and hand–foot syndrome were independent protective factors of PFS.High posttherapeutic peripheral blood granulocyte/lymphocyte ratio,an Eastern Cooperative Oncology Group(ECOG)score≥2,and the sum of the maximal target lesion length at baseline were independent risk factors of OS,and hypertriglyceridemia was an independent protective factor of OS.Conclusions:This study preliminarily explored the possible factors that affected PFS and OS after anlotinib treatment in patients with advanced refractory NSCLC,and the baseline characteristics of the therapeutically dominant populations were then identified.展开更多
AIM: To elucidate the clinicopathological characteristics of clinically early gastric cancer in the upper-third stomach and to clarify treatment precautions.METHODS: A total of 683 patients with clinical early gastric...AIM: To elucidate the clinicopathological characteristics of clinically early gastric cancer in the upper-third stomach and to clarify treatment precautions.METHODS: A total of 683 patients with clinical early gastric cancer were enrolled in this retrospective study, 128 of whom had gastric cancer in the upper-third stomach(U group). All patients underwent a double contrast barium examination, endoscopy, and computed tomography(CT), and were diagnosed preoperatively based on the findings obtained. The clinicopathological features of these patients were compared with those of patients with gastric cancer in the middle- and lower-third stomach(ML group). We also compared clinicopathological factors between accurate-diagnosis and under-diagnosis groups in order to identify factors affecting the accuracy of a preoperative diagnosis of tumor depth.RESULTS: Patients in the U group were older(P = 0.029), had a higher ratio of males to females(P = 0.015), and had more histologically differentiated tumors(P = 0.007) than patients in the ML group. A clinical under-diagnosis occurred in 57 out of 683 patients(8.3%), and was more frequent in the U group than in the ML group(16.4% vs 6.3%, P < 0.0001). Therefore, the rates of lymph node metastasis and lymphatic invasion were slightly higher in the U group than in the ML group(P = 0.071 and 0.082, respectively). An under-diagnosis was more frequent in histologically undifferentiated tumors(P = 0.094) and in those larger than 4 cm(P = 0.024). The medianfollow-up period after surgery was 56 mo(range, 1-186 mo). Overall, survival and disease-specific survival rates were significantly lower in the U group than in the ML group(P = 0.016 and 0.020, respectively). However, limited operation-related cancer recurrence was not detected in the U group in the present study.CONCLUSION: Clinical early gastric cancer in the upper-third stomach has distinguishable characteristics that increase the risk of a clinical under-diagnosis, especially in patients with larger or undifferentiated tumors.展开更多
BACKGROUND: The treatment for primary tumor in the caudate lobe of the liver is difficult because of its unique anatomical location. This study was undertaken to improve operative techniques and results by a new anato...BACKGROUND: The treatment for primary tumor in the caudate lobe of the liver is difficult because of its unique anatomical location. This study was undertaken to improve operative techniques and results by a new anatomical method of caudate lobectomy. METHODS: Clinical data of 16 patients who had had caudate lobectomy for the liver from January 1996 to November 2004 were retrospectively analyzed. The third porta hepatis anatomical method was performed in all 16 patients. Operative time, intraoperative blood loss, postoperative complications were recorded. The 1-, 3-, and 5-year survival rates of 13 patients with caudate lobe carcinoma were followed up. Anatomical status, operative routes, operative procedures, liver blood supply were evaluated. RESULTS: The operation was successful in the 16 patients. The operative time was 255±70 minutes and blood loss 740±402 ml. None of the patients died from massive bleeding during the operation, nor did complications such as biliary fistula and liver failure occurred. In 13 patients with malignant tumor, 7 died from recurrence and metastasis of the tumor and the other 6 are still alive at the end of follow-up. One patient has survived for 6 years. The 1-, 3-, and 5-year survival rates in the 13 patients were 83.9%, 58.7% and 39.2%, respectively. CONCLUSION: Caudate lobectomy by the third porta hepatis anatomical method can improve operative effect and increase the resection probability for solitary tumor in the caudate lobe.展开更多
The role of third molars in the oral cavity has been extensively studied over the years. Literature includes numerous diagnostic and treatment alternatives regarding the third molars. However, an issue that has not be...The role of third molars in the oral cavity has been extensively studied over the years. Literature includes numerous diagnostic and treatment alternatives regarding the third molars. However, an issue that has not been discussed at the same level is their involvement in orthodontic therapy. The aim of this study is to present a review of the contemporary literature regarding the most broadly discussed aspects of the multifactorial role of third molars in orthodontics and which are of general dental interest too.展开更多
Benign duodenal tumors are rare and less commonthan malignant tumors.Furthermore,vascular lesionsof the duodenum,including hemangiomas,are rarecauses of gastrointestinal bleeding.This report describes a case with blee...Benign duodenal tumors are rare and less commonthan malignant tumors.Furthermore,vascular lesionsof the duodenum,including hemangiomas,are rarecauses of gastrointestinal bleeding.This report describes a case with bleeding hemangiomas in the thirdportion of the duodenum and jejunum and their successful treatment using a laparoscopic approach.Thereis no report of totally laparoscopic resection for tumorin the third portion of duodenum.After performinga laparoscopic Kocher maneuver,the location of theduodenal hemangioma was confirmed by endoscopicand laparoscopic observation.The lesion was excisedusing ultrasonic coagulating shears and the defect inthe duodenal wall was sutured laparoscopically.Thehemangioma of the jejunum was treated extracorporeally through a 3.0 cm umbilical incision.The operatingtime was 241 min and blood loss was negligible.Thepostoperative course was uneventful.For benign duodenal tumors in the third portion,if endoscopic resection is not adapted,this less invasive technique may be a standard treatment.展开更多
During April 3^(rd)–14^(th),the Third International Ophiolite Workshop of the International Geoscience Programme"Diamonds and Recycled Mantle"(IGCP-649)was successfully held in Havana,Cuba(Fig.1a).After the...During April 3^(rd)–14^(th),the Third International Ophiolite Workshop of the International Geoscience Programme"Diamonds and Recycled Mantle"(IGCP-649)was successfully held in Havana,Cuba(Fig.1a).After the workshop,participants participated in a field trip to the Mayarí-Baracoa ophiolites and related chromitites展开更多
Analysis is performed to study the slip efects on the peristaltic flow of non-Newtonian fluid in a curved channel with wall properties. The resulting nonlinear partial diferential equations are transformed to a single...Analysis is performed to study the slip efects on the peristaltic flow of non-Newtonian fluid in a curved channel with wall properties. The resulting nonlinear partial diferential equations are transformed to a single ordinary diferential equation in a stream function by using the assumptions of long wavelength and low Reynolds number. This diferential equation is solved numerically by employing the built-in routine for solving nonlinear boundary value problems(BVPs) through the software Mathematica. In addition, the analytic solutions for small Deborah number are computed with a regular perturbation technique. It is noticed that the symmetry of bolus is destroyed in a curved channel. An intensification in the slip efect results in a larger magnitude of axial velocity. Further, the size and circulation of the trapped boluses increase with an increase in the slip parameter. Diferent from the case of planar channel, the axial velocity profiles are tilted towards the lower part of the channel. A comparative study between analytic and numerical solutions shows excellent agreement.展开更多
The status quo of Chinese agro-products logistics is analyzed from the following five aspects:the circulation mode,exchange mode,storage and transportation situation,food security.The following problems in Chinese agr...The status quo of Chinese agro-products logistics is analyzed from the following five aspects:the circulation mode,exchange mode,storage and transportation situation,food security.The following problems in Chinese agro-products logistics are pointed out,including excessive circulation sections,bad time efficiency,single payment,slow circulation,backward information processing,obvious bullwhip effect,low logistics efficiency,low logistics technology,inadequate professional equipments,low standardization degree,organized operation mode and low degree of scale.The third-party logistics mode of agro-products is analyzed and the advantages of the mode are analyzed as well.Firstly,establishing information network through integrating circulation section to accelerate the circulation of agro-products;secondly,making the operation norms by providing professional equipments to secure the quality of agricultural products;thirdly,improving the core competitiveness of the whole logistics chain by intensifying specialized work division in each section of the supply chain;fourthly,through forming scale economy to reduce logistics costs and increase the diversity of products;fifthly,through signing contracts to clarify duties and responsibilities and materialize the profit integration of the supply chain.The measures for establishing the third-party logistics of agro-products are put forward,including establish the awareness and concept of socialized logistics services;intensify the support on the third-party logistics enterprises of agro-products;lay stress on the cultivation of logistics talents of agro-products;and vigorously apply the modern marketing means.展开更多
Surgical extraction of the third molar is the most commonly performed surgical procedure in the clinical practice of oral surgery.Third molar surgery is warranted when there is inadequate space for eruption,malpositio...Surgical extraction of the third molar is the most commonly performed surgical procedure in the clinical practice of oral surgery.Third molar surgery is warranted when there is inadequate space for eruption,malpositioning,or risk for cyst or odontogenic tumor formation.Preoperative assessment should include a detailed morphologic analysis of the third molar and its relationship to adjacent structures and surrounding tissues.Due to developments in medical engineering technology,computed tomography(CT)now plays a critical role in providing the clear images required for adequate assessment prior to third molar surgery.Removal of the maxillary third molar is associated with a risk for maxillary sinus perforation,whereas removal of the mandibular third molar can put patients at risk for a neurosensory deficit from damage to the lingual nerve or inferior alveolar nerve.Multiple factors,including demographic,anatomic,and treatment-related factors,influence the incidence of nerve injury during or following removal of the third molar.CT assessment of the third molar prior to surgery can identify some of these risk factors,such as the absence of cortication between themandibular third molar and the inferior alveolar canal,prior to surgery to reduce the risk for nerve damage.This topic highlight presents an overview of the clinical significance of CT assessment in third molar surgery.展开更多
Aims & Objectives: This study was performed to evaluate the incidence, risk factors (age, sex, infection, radiographic difficulty of the extraction, tobacco use) contributing to the development of dry socket and c...Aims & Objectives: This study was performed to evaluate the incidence, risk factors (age, sex, infection, radiographic difficulty of the extraction, tobacco use) contributing to the development of dry socket and clinical features following surgical removal of impacted mandibular third molar. Materials and Methods: The study included 63 patients during period of September 2009 to September 2011 in the age group of 18 to 53 years with impacted mandibular third molars all of which were surgically removed under local anesthesia by the same operator. Following surgery all patients received a single dose of 4 mg corticosteroid intravenously and similar prescriptions for analgesics, antibiotics and postoperative instructions. All patients were reviewed at 3rd and 7th day postoperatively. Results: In this study incidence of dry socket was 6.3%. We also noticed onset of symptom mostly appeared within 48 hours. Postoperatively pain, bare bone and halitosis were the most significant clinical feature at 3rd postoperative day and pain, empty socket and bare bone were most significant clinical feature at 7th postoperative day. Variables like right 3rd molar impaction, patients mean age between 19 - 32 years, female, preoperative infection, radiographically difficult impaction and habitual tobacco users showed a higher incidence of dry socket formation. Conclusion: Incidence of dry socket formation is multifactorial and therefore, there is need to evaluate all factors, with special attentions in handling these patients to reduce the incidence of dry socket formation.展开更多
Denote S to be the class of functions which are analytic,normalized and univalent in the open unit disk U={z:|z|<1}.The important subclasses of S are the class of starlike and convex functions,which we denote by S ...Denote S to be the class of functions which are analytic,normalized and univalent in the open unit disk U={z:|z|<1}.The important subclasses of S are the class of starlike and convex functions,which we denote by S and C.In this paper,we obtain the third Hankel determinant for the inverse of functions f(z)=z+∞Σn=2 anz^n belonging to S^*and C.展开更多
Third order singulary perturbed boundary value problem by means of differential inequality theories is studied. Based on the given results of second order nonlinear boundary value problem, the upper and lower solution...Third order singulary perturbed boundary value problem by means of differential inequality theories is studied. Based on the given results of second order nonlinear boundary value problem, the upper and lower solutions method of third order nonlinear boundary value problems by making use of Volterra type integral operator was established. Specific upper and lower solutions were constructed, and existence and asymptotic estimates of solutions under suitable conditions were obtained. The result shows that it seems to be new to apply these techniques to solving these kinds of third order singularly perturbed boundary value problem. An example is given to demonstrate the applications.展开更多
The introduction of third-party evaluation system and the implementation of third-party evaluation system in poverty alleviation is a major innovation in the targeted poverty alleviation work in China.In order to impr...The introduction of third-party evaluation system and the implementation of third-party evaluation system in poverty alleviation is a major innovation in the targeted poverty alleviation work in China.In order to improve the third-party evaluation mechanism,further improve the efficiency of third-party evaluation,and enhance the effectiveness of targeted poverty alleviation,this paper analyzes and summarizes the main problems existing in the current third-party evaluation practice.In view of the related problems,this paper puts forward the corresponding policy recommendations,which are believed to play a positive role in further promoting the development and improvement of the third-party evaluation of getting rid of poverty.展开更多
文摘Black holes contradict the Nernst-Planck (N/P) version of the 3rd law of thermodynamics, but agree with its unattainability (U) version. This happens without contradiction, because the N/P and U versions are not equivalent, namely, N/P implies U but U does not imply N/P. So, black holes obey the weaker version of the 3rd law, but not the stronger one.
文摘Background: Accurate determination of gestational age has become important for deciding the appropriate time for termination of the pregnancy as well as to monitor the fetal growth during the entire period of pregnancy. Objective: The aim of the study was to assess whether the trans-cerebellar diameter, placental thickness or combining both of them is more accurate for assessment of gestational age in the 3<sup>rd</sup> trimester of pregnancy. Patients and Methods: This is a cross sectional study conducted at outpatient Clinic and Obstetric ward, Ain Shams University Maternity Hospital, over a period of six months from March 2019 to September 2019. One hundred pregnant women were recruited according to inclusion criteria either from outpatient clinic or were admitted in obstetric ward Ain Shams Maternity Hospital to find out the most accurate fetal biometric measurement in the third trimester either trans-cerebellar diameter placental thickness or both compared to reliable LMP (last menstrual period) dates confirmed by crown rump length (CRL) in the first trimester. Results: Trans-cerebellar diameter mean ± SD was 46.0 ± 3.5 with range 38.2 - 51.7. The mean of placental thickness was 39.6 ± 7.1 with range 22.8 - 54.3. Placental thickness had highest determination (0.813) for last menstrual period followed by trans-cerebellar diameter (0.802). Combining trans-cerebellar diameter and placental thickness increased determination (0.902) for last menstrual period. Conclusion: Combined use of trans-cerebellar diameter and placental thickness in the third trimester of pregnancy is a reliable indicator for gestational age in women whose last menstrual period is unreliable or unknown, but placental thickness had higher accuracy than trans-cerebellar diameter.
文摘The boundary value problems of the third-order ordinary differential equation have many practical application backgrounds and their some special cases have been studied by many authors. However, few scholars have studied the boundary value problems of the complete third-order differential equations u′′′(t) = f (t,u(t),u′(t),u′′(t)). In this paper, we discuss the existence and uniqueness of solutions and positive solutions of the fully third-order ordinary differential equation on [0,1] with the boundary condition u(0) = u′(1) = u′′(1) = 0. Under some inequality conditions on nonlinearity f some new existence and uniqueness results of solutions and positive solutions are obtained.
文摘The present paper proposes a mathematical method to numerically treat a class of third-order linear Boundary Value Problems (BVPs). This method is based on the combination of the Adomian Decomposition Method (ADM) and, the modified shooting method. A complete derivation of the proposed method has been provided, in addition to its numerical implementation and, validation via the utilization of the Runge-Kutta method and, other existing methods. The method has been applied to diverse test problems and turned out to perform remarkably. Lastly, the simulated numerical results have been graphically illustrated and, also supported by some absolute error comparison tables.
文摘The idea of research started with a crazy imaginary theory in the field of astrogeography, saying: We often taught ourselves and then convinced the students that the planet Earth moves despite not feeling the vibrations of traffic, and we listed successive scientific confirmations to indicate the rotation of the planet in a regular movement around its axis once every 24 hours, and it is running in another second movement around the sun once every 365¼ days, so are they only two movements, no more?! Is it possible for him to run at a regular speed in an additional direction?
基金Project supported by Shenzhen Municipal Science and Technology Plan Project,China(Grant Nos.JCYJ20160427183803458 and JCYJ20150403161923546)
文摘A comprehensive study on the requirements for the highly efficient third harmonic generation(THG) and its inverse process, one-third harmonic generation(OTHG), in lossy waveguides is proposed. The field intensity restrictions for both THG and OTHG caused by loss are demonstrated. The effective relative phase ranges, supporting the positive growth of signal fields of THG and OTHG are shrunken by the loss. Furthermore, it turns out that the effective relative phase ranges depend on the intensities of the interacting fields. At last, a modified definition of coherent length in loss situation, which evaluates the phase matching degree more precisely, is proposed by incorporating the shrunken relative phase range and the nonlinear phase mismatch. These theoretical analysis are valuable for guiding the experimental designs for highly efficient THG and OTHG.
文摘This study investigated the general situation of metalinguistic awareness of third language learners in Chinese universities.Data analyses showed that the level of metalinguistic awareness in those learners was significantly higher than that of second language learners.And learning a third language can improve metalinguistic awareness.
文摘Objective:Anlotinib hydrochloride is a multitarget tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor,fibroblast growth factor receptor,platelet-derived growth factor receptor,c-Kit,and c-MET;therefore,it exhibits both antitumor and anti-angiogenetic activities.A phase III trial has shown that anlotinib improved progression-free survival(PFS)and overall survival(OS)in patients with advanced non-small cell lung cancer(NSCLC),who presented with progressive disease or intolerance after standard chemotherapy.This study aimed to analyze the characteristics of patients receiving anlotinib treatment to determine the dominant populations who are fit for the treatment.Methods:Data were collected from March 2015 to January 2017 from a randomized,double-blind,placebo-controlled,multicenter,phase III trial of anlotinib(ALTER0303).A total of 437 patients were enrolled and randomly allocated(2:1)to the anlotinib and placebo groups.Kaplan–Meier analysis and log-rank test were performed to compare PFS and OS.Cox proportional hazards model was adopted for multivariate prognostic analysis.Results:Multivariate analysis indicated that high post-therapeutic peripheral blood granulocyte/lymphocyte ratio and elevated alkaline phosphatase levels were independent risk factors for PFS.Meanwhile,elevated thyroid-stimulating hormone,blood glucose,and triglyceride levels;hypertension;and hand–foot syndrome were independent protective factors of PFS.High posttherapeutic peripheral blood granulocyte/lymphocyte ratio,an Eastern Cooperative Oncology Group(ECOG)score≥2,and the sum of the maximal target lesion length at baseline were independent risk factors of OS,and hypertriglyceridemia was an independent protective factor of OS.Conclusions:This study preliminarily explored the possible factors that affected PFS and OS after anlotinib treatment in patients with advanced refractory NSCLC,and the baseline characteristics of the therapeutically dominant populations were then identified.
文摘AIM: To elucidate the clinicopathological characteristics of clinically early gastric cancer in the upper-third stomach and to clarify treatment precautions.METHODS: A total of 683 patients with clinical early gastric cancer were enrolled in this retrospective study, 128 of whom had gastric cancer in the upper-third stomach(U group). All patients underwent a double contrast barium examination, endoscopy, and computed tomography(CT), and were diagnosed preoperatively based on the findings obtained. The clinicopathological features of these patients were compared with those of patients with gastric cancer in the middle- and lower-third stomach(ML group). We also compared clinicopathological factors between accurate-diagnosis and under-diagnosis groups in order to identify factors affecting the accuracy of a preoperative diagnosis of tumor depth.RESULTS: Patients in the U group were older(P = 0.029), had a higher ratio of males to females(P = 0.015), and had more histologically differentiated tumors(P = 0.007) than patients in the ML group. A clinical under-diagnosis occurred in 57 out of 683 patients(8.3%), and was more frequent in the U group than in the ML group(16.4% vs 6.3%, P < 0.0001). Therefore, the rates of lymph node metastasis and lymphatic invasion were slightly higher in the U group than in the ML group(P = 0.071 and 0.082, respectively). An under-diagnosis was more frequent in histologically undifferentiated tumors(P = 0.094) and in those larger than 4 cm(P = 0.024). The medianfollow-up period after surgery was 56 mo(range, 1-186 mo). Overall, survival and disease-specific survival rates were significantly lower in the U group than in the ML group(P = 0.016 and 0.020, respectively). However, limited operation-related cancer recurrence was not detected in the U group in the present study.CONCLUSION: Clinical early gastric cancer in the upper-third stomach has distinguishable characteristics that increase the risk of a clinical under-diagnosis, especially in patients with larger or undifferentiated tumors.
文摘BACKGROUND: The treatment for primary tumor in the caudate lobe of the liver is difficult because of its unique anatomical location. This study was undertaken to improve operative techniques and results by a new anatomical method of caudate lobectomy. METHODS: Clinical data of 16 patients who had had caudate lobectomy for the liver from January 1996 to November 2004 were retrospectively analyzed. The third porta hepatis anatomical method was performed in all 16 patients. Operative time, intraoperative blood loss, postoperative complications were recorded. The 1-, 3-, and 5-year survival rates of 13 patients with caudate lobe carcinoma were followed up. Anatomical status, operative routes, operative procedures, liver blood supply were evaluated. RESULTS: The operation was successful in the 16 patients. The operative time was 255±70 minutes and blood loss 740±402 ml. None of the patients died from massive bleeding during the operation, nor did complications such as biliary fistula and liver failure occurred. In 13 patients with malignant tumor, 7 died from recurrence and metastasis of the tumor and the other 6 are still alive at the end of follow-up. One patient has survived for 6 years. The 1-, 3-, and 5-year survival rates in the 13 patients were 83.9%, 58.7% and 39.2%, respectively. CONCLUSION: Caudate lobectomy by the third porta hepatis anatomical method can improve operative effect and increase the resection probability for solitary tumor in the caudate lobe.
文摘The role of third molars in the oral cavity has been extensively studied over the years. Literature includes numerous diagnostic and treatment alternatives regarding the third molars. However, an issue that has not been discussed at the same level is their involvement in orthodontic therapy. The aim of this study is to present a review of the contemporary literature regarding the most broadly discussed aspects of the multifactorial role of third molars in orthodontics and which are of general dental interest too.
文摘Benign duodenal tumors are rare and less commonthan malignant tumors.Furthermore,vascular lesionsof the duodenum,including hemangiomas,are rarecauses of gastrointestinal bleeding.This report describes a case with bleeding hemangiomas in the thirdportion of the duodenum and jejunum and their successful treatment using a laparoscopic approach.Thereis no report of totally laparoscopic resection for tumorin the third portion of duodenum.After performinga laparoscopic Kocher maneuver,the location of theduodenal hemangioma was confirmed by endoscopicand laparoscopic observation.The lesion was excisedusing ultrasonic coagulating shears and the defect inthe duodenal wall was sutured laparoscopically.Thehemangioma of the jejunum was treated extracorporeally through a 3.0 cm umbilical incision.The operatingtime was 241 min and blood loss was negligible.Thepostoperative course was uneventful.For benign duodenal tumors in the third portion,if endoscopic resection is not adapted,this less invasive technique may be a standard treatment.
文摘During April 3^(rd)–14^(th),the Third International Ophiolite Workshop of the International Geoscience Programme"Diamonds and Recycled Mantle"(IGCP-649)was successfully held in Havana,Cuba(Fig.1a).After the workshop,participants participated in a field trip to the Mayarí-Baracoa ophiolites and related chromitites
文摘Analysis is performed to study the slip efects on the peristaltic flow of non-Newtonian fluid in a curved channel with wall properties. The resulting nonlinear partial diferential equations are transformed to a single ordinary diferential equation in a stream function by using the assumptions of long wavelength and low Reynolds number. This diferential equation is solved numerically by employing the built-in routine for solving nonlinear boundary value problems(BVPs) through the software Mathematica. In addition, the analytic solutions for small Deborah number are computed with a regular perturbation technique. It is noticed that the symmetry of bolus is destroyed in a curved channel. An intensification in the slip efect results in a larger magnitude of axial velocity. Further, the size and circulation of the trapped boluses increase with an increase in the slip parameter. Diferent from the case of planar channel, the axial velocity profiles are tilted towards the lower part of the channel. A comparative study between analytic and numerical solutions shows excellent agreement.
文摘The status quo of Chinese agro-products logistics is analyzed from the following five aspects:the circulation mode,exchange mode,storage and transportation situation,food security.The following problems in Chinese agro-products logistics are pointed out,including excessive circulation sections,bad time efficiency,single payment,slow circulation,backward information processing,obvious bullwhip effect,low logistics efficiency,low logistics technology,inadequate professional equipments,low standardization degree,organized operation mode and low degree of scale.The third-party logistics mode of agro-products is analyzed and the advantages of the mode are analyzed as well.Firstly,establishing information network through integrating circulation section to accelerate the circulation of agro-products;secondly,making the operation norms by providing professional equipments to secure the quality of agricultural products;thirdly,improving the core competitiveness of the whole logistics chain by intensifying specialized work division in each section of the supply chain;fourthly,through forming scale economy to reduce logistics costs and increase the diversity of products;fifthly,through signing contracts to clarify duties and responsibilities and materialize the profit integration of the supply chain.The measures for establishing the third-party logistics of agro-products are put forward,including establish the awareness and concept of socialized logistics services;intensify the support on the third-party logistics enterprises of agro-products;lay stress on the cultivation of logistics talents of agro-products;and vigorously apply the modern marketing means.
文摘Surgical extraction of the third molar is the most commonly performed surgical procedure in the clinical practice of oral surgery.Third molar surgery is warranted when there is inadequate space for eruption,malpositioning,or risk for cyst or odontogenic tumor formation.Preoperative assessment should include a detailed morphologic analysis of the third molar and its relationship to adjacent structures and surrounding tissues.Due to developments in medical engineering technology,computed tomography(CT)now plays a critical role in providing the clear images required for adequate assessment prior to third molar surgery.Removal of the maxillary third molar is associated with a risk for maxillary sinus perforation,whereas removal of the mandibular third molar can put patients at risk for a neurosensory deficit from damage to the lingual nerve or inferior alveolar nerve.Multiple factors,including demographic,anatomic,and treatment-related factors,influence the incidence of nerve injury during or following removal of the third molar.CT assessment of the third molar prior to surgery can identify some of these risk factors,such as the absence of cortication between themandibular third molar and the inferior alveolar canal,prior to surgery to reduce the risk for nerve damage.This topic highlight presents an overview of the clinical significance of CT assessment in third molar surgery.
文摘Aims & Objectives: This study was performed to evaluate the incidence, risk factors (age, sex, infection, radiographic difficulty of the extraction, tobacco use) contributing to the development of dry socket and clinical features following surgical removal of impacted mandibular third molar. Materials and Methods: The study included 63 patients during period of September 2009 to September 2011 in the age group of 18 to 53 years with impacted mandibular third molars all of which were surgically removed under local anesthesia by the same operator. Following surgery all patients received a single dose of 4 mg corticosteroid intravenously and similar prescriptions for analgesics, antibiotics and postoperative instructions. All patients were reviewed at 3rd and 7th day postoperatively. Results: In this study incidence of dry socket was 6.3%. We also noticed onset of symptom mostly appeared within 48 hours. Postoperatively pain, bare bone and halitosis were the most significant clinical feature at 3rd postoperative day and pain, empty socket and bare bone were most significant clinical feature at 7th postoperative day. Variables like right 3rd molar impaction, patients mean age between 19 - 32 years, female, preoperative infection, radiographically difficult impaction and habitual tobacco users showed a higher incidence of dry socket formation. Conclusion: Incidence of dry socket formation is multifactorial and therefore, there is need to evaluate all factors, with special attentions in handling these patients to reduce the incidence of dry socket formation.
基金The NSF(11561001)of Chinathe NSF(2014MS0101)of Inner Mongolia Province+1 种基金the Higher School Foundation(NJZY19211)of Inner Mongolia of Chinathe NSF(KJ2018A0839,KJ2018A0833)of Anhui Provincial Department of Education
文摘Denote S to be the class of functions which are analytic,normalized and univalent in the open unit disk U={z:|z|<1}.The important subclasses of S are the class of starlike and convex functions,which we denote by S and C.In this paper,we obtain the third Hankel determinant for the inverse of functions f(z)=z+∞Σn=2 anz^n belonging to S^*and C.
文摘Third order singulary perturbed boundary value problem by means of differential inequality theories is studied. Based on the given results of second order nonlinear boundary value problem, the upper and lower solutions method of third order nonlinear boundary value problems by making use of Volterra type integral operator was established. Specific upper and lower solutions were constructed, and existence and asymptotic estimates of solutions under suitable conditions were obtained. The result shows that it seems to be new to apply these techniques to solving these kinds of third order singularly perturbed boundary value problem. An example is given to demonstrate the applications.
基金Supported by the Construction Project of Party Branch Secretary’s Studio of "Double Leader" Teachers in Colleges and Universities of the Ministry of Education of ChinaThe Project of Party Construction Research of Yunnan University of Finance and Economics
文摘The introduction of third-party evaluation system and the implementation of third-party evaluation system in poverty alleviation is a major innovation in the targeted poverty alleviation work in China.In order to improve the third-party evaluation mechanism,further improve the efficiency of third-party evaluation,and enhance the effectiveness of targeted poverty alleviation,this paper analyzes and summarizes the main problems existing in the current third-party evaluation practice.In view of the related problems,this paper puts forward the corresponding policy recommendations,which are believed to play a positive role in further promoting the development and improvement of the third-party evaluation of getting rid of poverty.
