<strong>Aim:</strong><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> Despite recent advances in the...<strong>Aim:</strong><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> Despite recent advances in the treatment of ovarian cancer, recurrence of the disease is still frequent. This study evaluated whether multiple lines of chemotherapy have impact on overall survival (OS), progression free survival (PFS) or on treatment free intervals (TFIs) after serial chemotherapy lines in recurrent settings.</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">Methods: </span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">A total of 189 patients with ovarian cancer (including fallopian tube and primary peritoneal cancer), who were treated in Kuopio University Hospital in Finland during 2009-2014, were enrolled. The medical files of these patients were retrospectively reviewed.</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">Results:</span></b></span></span><span><span><b><span style="font-family:""> </span></b></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">Median OS and PFS were significantly higher at the time of the first relapse compared to subsequent relapses (p < 0.001). TFIs shortened significantly after the first relapse (p < 0.001). The differences in TFIs were also seen when comparing </span><span style="font-family:Verdana;">platinum sensitive, semi-sensitive and platinum resistant patients. The total</span> <span style="font-family:Verdana;">amount of TFI times during the whole follow-up time was significantly re</span><span style="font-family:Verdana;">duced in those patients that received at least one form of aggressive care at </span><span style="font-family:Verdana;">the end </span><span style="font-family:Verdana;">of life (p = 0.004). </span><b><span style="font-family:Verdana;">Conclusions:</span></b><span style="font-family:Verdana;"> Ovarian cancer patients received often mul</span><span style="font-family:Verdana;">tiple lines of chemotherapy. TFIs after subsequent chemotherapy lines de</span><span style="font-family:Verdana;">creased during the disease course. More efforts should be taken to avoid unne</span><span style="font-family:Verdana;">cessary and ineffective treatments especially in recurrent phase of the disease.</span></span></span></span>展开更多
Objective: To observe the influence of different intervals of acupuncture treatment on bone intensity in primary osteoporosis subjects. Methods: A total of 45 cases of primary osteoporosis female patients were randoml...Objective: To observe the influence of different intervals of acupuncture treatment on bone intensity in primary osteoporosis subjects. Methods: A total of 45 cases of primary osteoporosis female patients were randomly divided into 1 treatment/week (1-T/W), 2 treatments/week (2-T/W) and 3 treatments/week (3-T/W) groups, with 15 cases being in each group. Guanyuan (CV 4), Zusanli (ST 36), Sanyinjiao (SP 6), Shenshu (BL 23), Taixi (KI 3) and Pishu (BL 20) were used and stimulated with reinforcing needling manipulation. For patients with deficiency syndrome of kidney-yang, thermal acupuncture was applied to Shenshu (BL 23), and for patients with spleen-deficiency syndrome, thermal acupuncture applied to Zusanli (ST 36). Results: After 6 months’ treatment, in 1-T/W group, no apparent change of bone intensity was observed, while in 2-T/W and 3-T/W groups, the bone intensity was increased significantly (P<0.05, 0.01). Conclusion: Acupuncture plus moxibustion treatment twice or 3 times every week can obviously improve the bone intensity.展开更多
Rural sewage treatment is in need of more capital investment,in which the financing model of PPP(public-private partnership)is able to encourage the investment of social capital in this sector.Risk sharing is one of t...Rural sewage treatment is in need of more capital investment,in which the financing model of PPP(public-private partnership)is able to encourage the investment of social capital in this sector.Risk sharing is one of the core features in the PPP model.In view that the risk loss of projects cannot be accurately estimated,this article describes the uncertainty of risk loss with fuzzy numbers and allocates the distribution of risk loss among the participants of rural sewage treatment PPP projects with interval fuzzy Shapley value to ensure a more reasonable and effective risk distribution.展开更多
文摘<strong>Aim:</strong><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> Despite recent advances in the treatment of ovarian cancer, recurrence of the disease is still frequent. This study evaluated whether multiple lines of chemotherapy have impact on overall survival (OS), progression free survival (PFS) or on treatment free intervals (TFIs) after serial chemotherapy lines in recurrent settings.</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">Methods: </span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">A total of 189 patients with ovarian cancer (including fallopian tube and primary peritoneal cancer), who were treated in Kuopio University Hospital in Finland during 2009-2014, were enrolled. The medical files of these patients were retrospectively reviewed.</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">Results:</span></b></span></span><span><span><b><span style="font-family:""> </span></b></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">Median OS and PFS were significantly higher at the time of the first relapse compared to subsequent relapses (p < 0.001). TFIs shortened significantly after the first relapse (p < 0.001). The differences in TFIs were also seen when comparing </span><span style="font-family:Verdana;">platinum sensitive, semi-sensitive and platinum resistant patients. The total</span> <span style="font-family:Verdana;">amount of TFI times during the whole follow-up time was significantly re</span><span style="font-family:Verdana;">duced in those patients that received at least one form of aggressive care at </span><span style="font-family:Verdana;">the end </span><span style="font-family:Verdana;">of life (p = 0.004). </span><b><span style="font-family:Verdana;">Conclusions:</span></b><span style="font-family:Verdana;"> Ovarian cancer patients received often mul</span><span style="font-family:Verdana;">tiple lines of chemotherapy. TFIs after subsequent chemotherapy lines de</span><span style="font-family:Verdana;">creased during the disease course. More efforts should be taken to avoid unne</span><span style="font-family:Verdana;">cessary and ineffective treatments especially in recurrent phase of the disease.</span></span></span></span>
文摘Objective: To observe the influence of different intervals of acupuncture treatment on bone intensity in primary osteoporosis subjects. Methods: A total of 45 cases of primary osteoporosis female patients were randomly divided into 1 treatment/week (1-T/W), 2 treatments/week (2-T/W) and 3 treatments/week (3-T/W) groups, with 15 cases being in each group. Guanyuan (CV 4), Zusanli (ST 36), Sanyinjiao (SP 6), Shenshu (BL 23), Taixi (KI 3) and Pishu (BL 20) were used and stimulated with reinforcing needling manipulation. For patients with deficiency syndrome of kidney-yang, thermal acupuncture was applied to Shenshu (BL 23), and for patients with spleen-deficiency syndrome, thermal acupuncture applied to Zusanli (ST 36). Results: After 6 months’ treatment, in 1-T/W group, no apparent change of bone intensity was observed, while in 2-T/W and 3-T/W groups, the bone intensity was increased significantly (P<0.05, 0.01). Conclusion: Acupuncture plus moxibustion treatment twice or 3 times every week can obviously improve the bone intensity.
文摘Rural sewage treatment is in need of more capital investment,in which the financing model of PPP(public-private partnership)is able to encourage the investment of social capital in this sector.Risk sharing is one of the core features in the PPP model.In view that the risk loss of projects cannot be accurately estimated,this article describes the uncertainty of risk loss with fuzzy numbers and allocates the distribution of risk loss among the participants of rural sewage treatment PPP projects with interval fuzzy Shapley value to ensure a more reasonable and effective risk distribution.
