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原发性肠系膜肿瘤的诊断─—附59例分析 被引量:5
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作者 孙学英 寿楠海 +2 位作者 胡继康 姜希宏 李占元 《中国普通外科杂志》 CAS CSCD 1994年第2期87-89,共3页
原发性肠系膜肿瘤临床少见,易误诊和漏诊。本文回顾分析我院1960~1993年间经手术病理证实的原发性肠系膜肿瘤59例,对其临床表现、辅助检查、误诊率、误诊疾病、治疗和病理类型等情况进行了总结,并就原发性肠系膜肿瘤的解... 原发性肠系膜肿瘤临床少见,易误诊和漏诊。本文回顾分析我院1960~1993年间经手术病理证实的原发性肠系膜肿瘤59例,对其临床表现、辅助检查、误诊率、误诊疾病、治疗和病理类型等情况进行了总结,并就原发性肠系膜肿瘤的解剖及临床特点及诊断等问题进行了讨论。 展开更多
关键词 原发性 肠系膜肿瘤 诊断 病理
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人结肠腺癌裸鼠移植瘤模型的建立和生物学特性及放射免疫显象的研究 被引量:1
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作者 蔡成机 陈可靖 +4 位作者 陈长春 薛琼 俞永富 刘荣慧 盛民立 《上海医科大学学报》 CSCD 1992年第5期353-357,共5页
我院自1989年2月建立的人结肠癌裸鼠移植瘤模型(CTNM),至今已传27代,传代裸鼠共80只,移植成功率100%。对移植瘤和瘤源作系统的生物学特性的研究,测定其肿瘤组织与宿主血液中的癌胚抗原(CEA)值。并应用免疫组化法观察肿瘤组织中CEA分布... 我院自1989年2月建立的人结肠癌裸鼠移植瘤模型(CTNM),至今已传27代,传代裸鼠共80只,移植成功率100%。对移植瘤和瘤源作系统的生物学特性的研究,测定其肿瘤组织与宿主血液中的癌胚抗原(CEA)值。并应用免疫组化法观察肿瘤组织中CEA分布。结果显示,移植瘤的形态和功能特性与瘤源基本一致。对荷瘤裸鼠放射免疫显象结果表明:经腹腔内注射^(131)I-CEA-McAb 72h后,肿瘤显象满意,瘤/肠(T/NT)值为4.3,标记抗体能在肿瘤组织中浓聚。 展开更多
关键词 结肠 腺癌 裸鼠 移植瘤
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Dysregulation of non-coding RNAs in gastric cancer 被引量:1
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作者 Qing Yang Ren-Wen Zhang +2 位作者 Peng-Cheng Sui Hai-Tao He Lei Ding 《World Journal of Gastroenterology》 SCIE CAS 2015年第39期10956-10981,共26页
Gastric cancer(GC) is one of the most common cancers in the world and a significant threat to the health of patients, especially those from China and Japan. The prognosis for patients with late stage GC receiving the ... Gastric cancer(GC) is one of the most common cancers in the world and a significant threat to the health of patients, especially those from China and Japan. The prognosis for patients with late stage GC receiving the standard of care treatment, including surgery, chemotherapy and radiotherapy, remains poor. Developing novel treatment strategies, identifying new molecules for targeted therapy, and devising screening techniques to detect this cancer in its early stages are needed for GC patients. The discovery of non-coding RNAs(nc RNAs), primarily micro RNAs(mi RNAs) and long non-coding RNAs(lnc RNAs), helped to elucidate the mechanisms of tumorigenesis, diagnosis and treatment of GC. Recently, significant research has been conducted on non-coding RNAs and how the regulatory dysfunction of these RNAs impacts the tumorigenesis of GC. In this study, we review papers published in the last five years concerning the dysregulation of noncoding RNAs, especially mi RNAs and lnc RNAs, in GC. We summarize instances of aberrant expression of the ncR NAs in GC and their effect on survival-related events, including cell cycle regulation, AKT signaling, apoptosis and drug resistance. Additionally, we evaluate how nc RNA dysregulation affects the metastatic process, including the epithelial-mesenchymal transition, stem cells, transcription factor activity, and oncogene and tumor suppressor expression. Lastly, we determine how ncR NAs affect angiogenesis in the microenvironment of GC. We further discuss the use of ncR NAs as potential biomarkers for use in clinical screening, early diagnosis and prognosis of GC. At present, no ideal ncR NAs have been identified as targets for the treatment of GC. 展开更多
关键词 GASTRIC CANCER DYSREGULATION NON-CODING RNA tumori
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Successful management of an intra-operative pulmonary tumor embolism during resection of a retroperitoneal leiomyosarcoma 被引量:1
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作者 ZHU Sheng-mei GUO Shao-hui LI Li-juan LUO Li-hui YAO Yong-xing 《Chinese Medical Journal》 SCIE CAS CSCD 2013年第5期980-981,共2页
Pulmonary tumor embolisms due to renal cell carcinoma are common. In contrast, intra-operative puhnonary artery embolisms due to the release of large tumor fragments during surgery for retroperitoneal leiomyosarcoma h... Pulmonary tumor embolisms due to renal cell carcinoma are common. In contrast, intra-operative puhnonary artery embolisms due to the release of large tumor fragments during surgery for retroperitoneal leiomyosarcoma have not been reported. When a massive tumor embolus does occur, a patient's survival depends on prompt surgical intervention.2 In this report, a patient experienced a pulmonary tumor embolism during resection of a retroperitoneal leiomyosarcoma, and the condition was successfully treated. However, for the hemodynamic collapse that occurred, a puhnonary arteriography was followed by an emergency puhnonary embolectomy with cardiopulmonary bypass. 展开更多
关键词 puhnonary tumori embolismi retroperitoneal leiomyosarcoma
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