期刊文献+
共找到5,335篇文章
< 1 2 250 >
每页显示 20 50 100
First report of the histopathological effect of electrocautery using on the urethral taste rosea during glans penis injury by incision in rabbits
1
作者 Ozgur Caglar Ayhan Kanat +2 位作者 Mehmet Dumlu Aydin Nezih Akca Sevilay Ozmen 《Asian Journal of Urology》 CSCD 2024年第1期115-120,共6页
Objective:Currently,electrocautery devices have frequently been used in penile surgical procedures.We hypothesized that electrocautery using during penile surgical procedures may harm the taste rosea and the dorsal ne... Objective:Currently,electrocautery devices have frequently been used in penile surgical procedures.We hypothesized that electrocautery using during penile surgical procedures may harm the taste rosea and the dorsal nerve of the penis or clitoris.Methods:Eighteen young age male New Zealand rabbits were studied:five in the control(Group I,n=5),five in the penile surgery without using electrocautery(sham group,Group II,n=5),eight in the monopolar cautery(study group,Group III,n=8)groups under general anesthesia.The animals were followed for 3 weeks and sacrificed.Penile tissue—pudendal nerve root complexes and dorsal root ganglion of sacral 3 level were examined using stereological methods.The results were compared statistically.Results:The live and degenerated taste bud-like structures and degenerated neuron densities of pudendal ganglia(mean±standard deviation,n/mm3)were estimated as 198±24/mm3,4±1/mm3,and 5±1/mm3 in Group I;8±3/mm3,174±21/mm3,and 24±7/mm3 in Group II;and 21±5/mm3,137±14/mm3,and 95±12/mm3 in Group III,respectively.Neurodegeneration of taste buds and pudendal ganglia was significantly different between groups.Conclusion:Intact spinal cord and normal parasympathetic and thoracolumbar sympathetic networks are crucial for human sexual function.The present study indicates that the glans penis injury by using electrocautery may lead to pudendal ganglia degeneration.Iatrogenic damage to taste rosea and retrograde degeneration of the pudendal nerve may be the cause of sexual dysfunction responsible mechanism. 展开更多
关键词 urethral taste rosea Tastebuds Pudendalnerve Degeneration Penile surgery
下载PDF
Etiology and management of urethral calculi:A systematic review of contemporary series
2
作者 Andrew Morton Arsalan Tariq +2 位作者 Nigel Dunglison Rachel Esler Matthew J.Roberts 《Asian Journal of Urology》 CSCD 2024年第1期10-18,共9页
Objective:To conduct a systematic literature review on urethral calculi in a contemporary cohort describing etiology,investigation,and management patterns.Methods:A systematic search of MEDLINE and Cochrane Central Re... Objective:To conduct a systematic literature review on urethral calculi in a contemporary cohort describing etiology,investigation,and management patterns.Methods:A systematic search of MEDLINE and Cochrane Central Register of Controlled Trials(CENTRAL)databases was performed.Articles,including case reports and case series on urethral calculi published between January 2000 and December 2019,were included.Full-text manuscripts were reviewed for clinical parameters including symptomatology,etiology,medical history,investigations,treatment,and outcomes.Data were collated and analyzed with univariate methods.Results:Seventy-four publications met inclusion criteria,reporting on 95 cases.Voiding symptoms(41.1%),pain(40.0%),and acute urinary retention(32.6%)were common presenting features.Urethral calculi were most often initially investigated using plain X-ray(63.2%),with almost all radio-opaque(98.3%).Urethral calculi were frequently associated with coexistent bladder or upper urinary tract calculi(16.8%)and underlying urethral pathology(53.7%)including diverticulum(33.7%)or stricture(13.7%).Urethral calculi were most commonly managed with external urethrolithotomy(31.6%),retrograde manipulation(22.1%),and endoscopic in situ lithotripsy(17.9%).Conclusion:This unique systematic review of urethral calculi provided a summary of clinical features and treatment trends with a suggested treatment algorithm.Management in contemporary urological practice should be according to calculus size,shape,anatomical location,and presence of urethral pathology. 展开更多
关键词 Urinary calculi URETHRA urethral calculi Management algorithm
下载PDF
Investigation of risk factors in the development of recurrent urethral stricture after internal urethrotomy
3
作者 Abdullah Gul Ozgur Ekici +2 位作者 Salim Zengin Deniz Barali Tarik Keskin 《World Journal of Clinical Cases》 SCIE 2024年第14期2324-2331,共8页
BACKGROUND Urethral stricture is a condition that often develops with trauma and results in narrowing of the urethral lumen.Although endoscopic methods are mostly used in its treatment,it has high recurrence rates.The... BACKGROUND Urethral stricture is a condition that often develops with trauma and results in narrowing of the urethral lumen.Although endoscopic methods are mostly used in its treatment,it has high recurrence rates.Therefore,open urethroplasty is recommended after unsuccessful endoscopic treatments.AIM To investigate the risk factors associated with urethral stricture recurrence.METHODS The data of male patients who underwent internal urethrotomy for urethral stricture between January 2017 and January 2023 were retrospectively analyzed.Demographic data,comorbidities,preoperative haemogram,and biochemical values obtained from peripheral blood and operative data were recorded.Patients were divided into two groups in terms of recurrence development;recurrence and non-recurrence.Initially recorded data were compared between the two groups.RESULTS A total of 303 patients were included in the study.The mean age of the patients was 66.6±13.6 years.The mean duration of recurrence development was 9.63±9.84(min-max:1-39)months in the recurrence group.Recurrence did not occur in non-recurrence group throughout the follow-up period with an average time of 44.15±24.07(min-max:12-84)months.In the comparison of both groups,the presence of diabetes mellitus(DM),hypertension(HT),and multiple comorbidi-ties were significantly higher in the recurrence(+)group(P=0.038,P=0.012,P=0.013).Blood group,postoperative use of non-steroidal anti-inflammatory drugs,preoperative cystostomy,cause of stricture,iatrogenic cause of stricture,location and length of stricture,indwelling urinary cathater size and day of catheter removal did not differ between the two groups.No statistically significant difference was observed between the two groups in terms of age,uroflowmetric maximum flow rate value,hemo-gram parameters,aspartate aminotransferase(AST),alanine aminotransferase(ALT),fasting blood sugar,creati-nine,glomerular filtration rate,neutrophil-lymphocyte ratio,platelet-lymphocyte ratio,lymphocyte-monocyte ratio,monocyte-lymphocyte ratio and AST/ALT ratios.CONCLUSION In patients with urethral stricture recurrence,only the frequency of DM and HT was high,while inflammation marker levels and stricture-related parameters were similar between the groups. 展开更多
关键词 INFLAMMATION Internal urethrotomy RECURRENCE urethral stricture URETHRA
下载PDF
Endoscopic Internal Urethrotomy in the Treatment of Male Urethral Stenosis in the Urology-Andrology Department of KARA Teaching Hospital (Togo)
4
作者 Musapudi Éric Mbuya Komi Hola Sikpa +4 位作者 Edoe Viyome Sewa Messan Semefa Agbedey Gnimdou Botcho Kodjo Tengue Tchilabalo Matchonna Kpatcha 《Open Journal of Urology》 2024年第1期20-26,共7页
Introduction: Endoscopic internal urethrotomy (EIU) is a method for stricture opening using transurethral incision by direct visualisation of the urethral channel, resulting in a widening of the urinary canal with the... Introduction: Endoscopic internal urethrotomy (EIU) is a method for stricture opening using transurethral incision by direct visualisation of the urethral channel, resulting in a widening of the urinary canal with the aim of improving the quality of bladder emptying. The aim of the study was to evaluate the indication and results of EIU in the treatment of stenosis of the male urethra in the Urology-Andrology Department of Kara Teaching Hospital. Methodology: This was a cross-sectional descriptive study with retrospective data collection in the Urology-Andrology department of Kara Teaching Hospital. It involved 21 records of patients with urethral stenosis treated by endoscopic internal urethrotomy (EIU) in the said department during the period from January 2021 to September 2023. The following variables were evaluated: age, circumstance of discovery, site, length, number, etiology of the urethral stenosis and evolution of the patients. Results: The mean age of the patients was 59.2 ± 11.7 years. Infectious etiology of stenosis was predominant with 10 patients (47.6%) followed by trauma with 5 cases (23.8%). The bulbar urethra was the most frequently observed site, with 11 cases (52.4%). The length was mostly less than 2 cm in 12 patients (57.1%). Stenosis was unique in 14 patients (66.7%). The mean postoperative follow-up time was 3.2 months. The result was immediately better in 11 patients (52.4%) and it was poor in 8 patients (38.1%) who required maintenance dilation sessions. 展开更多
关键词 Internal Urethrotomy urethral Stenosis Kara TOGO
下载PDF
Double-face urethroplasty in patients with obliterative bulbar strictures post-transurethral resection of the prostate mid-term outcomes in high-volume referral center
5
作者 Pankaj M.Joshi Manuel Hevia +6 位作者 Yatam Lakshmi Sreeranga Marco Bandini Amey Patil Shreyas Bhadranavar Vipin Sharma Sandeep Bafna Sanjay B.Kulkarni 《Asian Journal of Urology》 CSCD 2023年第4期512-517,共6页
Objective Incidences of post-transurethral resection of the prostate(post-TURP)strictures are between 2.2%and 9.8%.Stricture commonly occurs within the first 6 months.Our objective was to assess the outcomes of patien... Objective Incidences of post-transurethral resection of the prostate(post-TURP)strictures are between 2.2%and 9.8%.Stricture commonly occurs within the first 6 months.Our objective was to assess the outcomes of patients with obliterative strictures post-TURP that underwent a double-face urethroplasty.Methods This is a single-center prospective study of 17 patients with obliterative proximal bulbar stricture post-TURP who underwent double-face graft urethroplasty by two surgeons between January 2014 and January 2020.We defined post-TURP obliterative strictures as those patients who presented with complete or almost complete obstruction of the urethral lumen and who have had a history of acute urine retention.We have excluded patients with bladder neck contracture.Primary outcome was treatment success,defined as the no need for further treatments.Secondary outcome was post-urethroplasty continent rate.Results Seventeen patients were included in the study with median age of 66(interquartile range 40-77)years;median time of follow-up was 24(interquartile range 12-84)months;median stricture length was 4(interquartile range 2-6)cm.Of the 17 patients,15(88.2%)were successful.All patients were continent after urethroplasty.Conclusion With mid-term follow-up,treatment of obliterative proximal bulbar strictures with double-face buccal mucosa graft is a safe and effective procedure.Obliterative proximal bulbar strictures merit double-face urethroplasty with high-rate success and functional outcomes. 展开更多
关键词 Double-face urethroplasty Obliterative urethral stricture Post-transurethral resection of prostate urethral stricture Spongiofibrosis Iatrogenic stricture
下载PDF
Severe Coital Accident: A Rare Case of Simultaneous Fracture of the Penis and a Complete Urethral Rupture at the University Hospital of Bouake
6
作者 Avion Kouassi Patrice N’diamoi Akassimadou +9 位作者 Ouattara Fatoumata Aguia Brice Zouan Freddy Alloka Venance Kamara Sadia Samah David Kouadio Malick Soro Kramo Nykan Anzoua Kacou Dje Koffi 《Open Journal of Urology》 2023年第6期194-200,共7页
Cavernous body fracture is a rare urological emergency. Its association with complete rupture of the urethra remains exceptional. This is a report of simultaneous penile fracture and complete rupture of the urethra fo... Cavernous body fracture is a rare urological emergency. Its association with complete rupture of the urethra remains exceptional. This is a report of simultaneous penile fracture and complete rupture of the urethra following a misstep in coitus. It is about a 41-year-old young adult, admitted to the surgical emergency department of the University Hospital of Bouaké on March 2, 2020 for penile pain associated with acute retention of urine. The clinical examination confirmed the diagnosis of a corpus cavernosa fracture associated with a ruptured urethra. The patient underwent cystostomy, right cavernoraphy and urethrorrhaphy. The postoperative follow-up was straightforward and the patient was discharged from the hospital on D3 postoperatively. The urethral catheter was removed on D21 postoperatively. With a follow-up of 1 year, the patient presents a good erection and does not report any voiding disorder. 展开更多
关键词 FRACTURE PENIS urethral Rupture Cavernorrhaphy Urethrorraphy
下载PDF
Tunica albuginea versus buccal mucosa graft urethroplasty for anterior urethral stricture: A prospective randomised pilot study
7
作者 Mohammad Shazib Faridi Vikas Sharma +1 位作者 Adittya K.Sharma Rahul Yadav 《Asian Journal of Urology》 CSCD 2023年第2期189-194,共6页
Objective:The objective of the study was to compare the outcome of tunica albuginea urethroplasty(TAU)and buccal mucosa graft(BMG)urethroplasty for anterior urethral stricture.Methods:Thirty patients who met the inclu... Objective:The objective of the study was to compare the outcome of tunica albuginea urethroplasty(TAU)and buccal mucosa graft(BMG)urethroplasty for anterior urethral stricture.Methods:Thirty patients who met the inclusion criteria were randomised into two groups:TAU(Group A)and BMG urethroplasty(Group B).Surgical outcome was evaluated with pre-and post-operative work-up involving retrograde urethrogram,voiding cystourethrogram,uroflowmetry,and urethroscopy.Patients were followed up till 1 year.Results:Mean duration of surgery was statistically significant between two groups(p=0.0005).Maximum urine flow rate was comparable when compared between two groups(p=0.22)but statistically significant when compared pre-and post-operatively(p<0.001).At follow-up of 1 year,the successful outcomes were 80% in Group A and 87%in Group B.A total of five patients who had unsuccessful results required redo urethroplasty.Complications were minimal in both the groups.Conclusion:TAU provides outcomes equivalent to those of BMG urethroplasty.TAU has less operative time,easy to perform,and beneficial in patients with poor oral hygiene. 展开更多
关键词 Buccal mucosa Male urologic surgery Tunica albuginea urethral stricture URETHROPLASTY
下载PDF
Direct Visual Internal Urethrotomy (DVIU) in the Management of Male Urethral Strictures. A Single Center Experience about 44 Patients
8
作者 Adama Ouattara Abdoul-Karim Paré +5 位作者 Tioulé Mamadou Traoré Delphine Yé Moahmed Simporé Mickael Rouamba Fasnéwindé Aristide Kaboré Timothée Kambou 《Open Journal of Urology》 2023年第8期293-301,共9页
Introduction: Male urethral stricture is one of the oldest urological disorders. Many techniques have been proposed to treat them, including endoscopic internal urethrotomy (DVIU). Material and Methods: To evaluate th... Introduction: Male urethral stricture is one of the oldest urological disorders. Many techniques have been proposed to treat them, including endoscopic internal urethrotomy (DVIU). Material and Methods: To evaluate the contribution of this technique in the treatment of urethra narrowing, a retrospective study on the records of patients with urethral stricture treated with endoscopic internal urethrotomy between January 2014 and December 2021 in the urology division of the Souro Sanou University Teaching Hospital. Results: A total of 44 male patients with urethral stricture were treated with this technique and 48 procedures were performed. The average age of the patients was 53.2 ± 18.2 years. The etiology of the stricture was dominated by iatrogenic, infectious, traumatic and idiopathic causes in 43.2% (n = 19), 27.3% (n = 12), 20.4 % (n = 9), and 9.1% (n = 4) respectively. The location of the stricture was bulbar in 72.7%, and the anterior penile urethra in 15.9%. The overall success rate was 72.7% with satisfactory urination without dysuria, evaluated after removal of the urinary catheter, at three months this rate fell to 69.1%, and at 6 months this rate was 67.5%. Five cases (5) of extravasation of blood or irrigation fluid into the scrotum were reported and managed conservatively as well as two (2) cases of false routes with postoperative oedema of the penis were observed. Conclusion: DVIU is a simple technique, free of major morbidity and requiring only short-term hospitalization. It can be proposed as a first-line treatment for urethral stricture. 展开更多
关键词 Internal Urethrotomy urethral Stricture OUTCOMES COMPLICATIONS
下载PDF
Male Urethral Stricture: Epidemiological, Clinical, and Therapeutic Aspects in Kara
9
作者 Komi Hola Sikpa Gnimdou Botcho +7 位作者 Edoe Viyome Sewa Sabi Rachid Sade Essomindedou Leloua Messan Semefa Agbedey Essodina Padja Kossiwa Rose Assou Kodjo Tengue Tchilabalo Matchonna Kpatcha 《Open Journal of Urology》 2023年第4期101-107,共7页
Background: Urethral stricture is a pathology frequently encountered in urological practice. Management is often surgical, with possible recurrences. What about this pathology in Kara, a semi-urban city? Objective: As... Background: Urethral stricture is a pathology frequently encountered in urological practice. Management is often surgical, with possible recurrences. What about this pathology in Kara, a semi-urban city? Objective: Assess the management of male urethral stricture in Kara. Patients and Methods: This was a descriptive study with retrospective data collection. The study took place in the urology department of the teaching hospital of Kara, from December 2020 to December 2022. All cases of male urethral stricture, surgically treated at the teaching hospital of Kara, were listed. The inclusion criteria were as follows: any patient who had been treated surgically for male urethral stricture in the urology department of the teaching Hospital of Kara. The operating theater register and hospital records were used to collect the data. The diagnosis of urethral stricture had been made with retrograde urethrogram. A total of 24 patients were treated for male urethral stricture during the study period. The following variables were studied: age, reason for consultation, location, length, and etiology of the stricture;the type of treatment received: optical internal urethrotomy, or anastomotic urethroplasty, and the results. The result was considered good if, after removal of the urethral catheter, the patient regained his micturition without the need for dilatation;the result was considered average if, after removal of the urethral catheter, the patient needed one or more dilatation sessions to regain urination;the result was considered poor if, after removal of the catheter, the patient did not regain good micturition despite the urethral dilatation sessions. Microsoft excel and epi info 7 software were used for data processing. Results: The average age of our patients was 43.7 years ± 10.18 with extremes ranging from 27 to 70 years. The most represented age groups were that of 40 to 50 years, with 37.5% of cases;and that of 30 to 40 years with 33.3% of cases. The patients had consulted for urine retention in 66.6% of cases;the location of urethral stricture was bulbar in 45.8% of cases. The most found etiology was infectious in 58.3% of cases. Among our patients, 58.3% had received optical internal urethrotomy as treatment, while 41.6% of our patients had received anastomotic urethroplasty as treatment. Postoperatively, after removal of the urinary catheter, 87.5% of patients had benefited from one or repeated dilatation. In terms of results, we had a good result in 20.8% of patients;the result was average in 45.8% of patients, and poor in 33.3% of patients. The average duration of follow-up was 14.3 +/- 7.2 months (3-27). Conclusion: Male urethral stricture mainly affects young adults in Kara. Surgical management is done by optical internal urethrotomy and/or anastomotic urethroplasty. 展开更多
关键词 Male urethral Stricture Optical Internal Urethrotomy Anastomotic Urethroplasty Kara TOGO
下载PDF
Management of urethral strictures and stenosis caused by the endo-urological treatment of benign prostatic hyperplasiad-a single-center experience
10
作者 Rajiv N.Kore 《Asian Journal of Urology》 CSCD 2023年第2期137-143,共7页
Objective:Urethral stricture disease after endo-urological treatment of benign prostatic hyperplasia(BPH)is a sparsely described complication.We describe management of five categories of these strictures in this retro... Objective:Urethral stricture disease after endo-urological treatment of benign prostatic hyperplasia(BPH)is a sparsely described complication.We describe management of five categories of these strictures in this retrospective observational case series.Methods:One hundred and twenty-one patients presenting with symptoms of bladder outflow obstruction after endo-urological intervention for BPH from February 2016 to March 2019 were evaluated.Among them,76 were eligible for this study and underwent reconstructive surgery.Preoperative and postoperative assessments were done with symptom scores,uroflowmetry,ultrasound for post-void residue,and urethrogram.Any intervention during follow-up was classed as a failure.The recurrence and 95%confidence interval for recurrence percentage were calculated.Results:The following five categories of patients were identified:Bulbo-membranous(33[43.4%]),navicular fossa(21[27.6%]),penile/peno-bulbar(8[10.5%]),bladder neck stenosis(6[7.9%]),and multiple locations(8[10.5%]).The average age was 69 years(range:60-84 years).Overall average symptom score,flow rate,and post-void residue changed from 21 to 7,6 mL/s to 19 mL/s,and 210 mL to 20 mL,respectively.The average follow-up was 34 months(range:12-58 months).Overall recurrence and complication rates were 10.5%and 9.2%,respectively.The recurrence in each category was seen in 3,1,2,1,and 1 patient,respectively.Overall 95% confidence interval for recurrence percentage was 4.66-19.69.Conclusion:Urethral stricture disease is a major long-term complication of endo-urological treatment of BPH.The bulbo-membranous strictures need continence preserving approach.Navicular fossa strictures require minimally invasive and cosmetic consideration.Peno-bulbar strictures require judicious use of grafts and flaps.Bladder neck stenosis in this cohort could be treated with endoscopic measures.Multiple locations need treatment based on their sites in single-stage as far as possible. 展开更多
关键词 urethral stricture Benign prostatic hyperplasia Transurethral resection of prostate URETHROPLASTY Holmium laser enucleation of prostate Trans-urethral bipolar electro-enucleation Bladder neck stenosis
下载PDF
Phallic rubber band application to prevent enuresis unusual cause of urethral stricture in a child:A case report
11
作者 Abdullahi Khalid Musa Nasiru +3 位作者 Abdullahi Abdulwahab-Ahmed Abubakar Sadiq Muhammad Ngwobia Peter Agwu Christopher Suiye Lukong 《World Journal of Clinical Urology》 2023年第2期10-16,共7页
BACKGROUND Urethral stricture is the abnormal narrowing of the urethra due to spongiofibrosis.The established aetiological factors for urethral stricture abound in our environment.However,the application of a penile r... BACKGROUND Urethral stricture is the abnormal narrowing of the urethra due to spongiofibrosis.The established aetiological factors for urethral stricture abound in our environment.However,the application of a penile rubber band to prevent enuresis thereby causing this pathology is not a familiar occurrence.Patients with enuresis can suffer psycho-social challenges and trauma,especially for a child due to peer stigmatization.This has a great impact on the child's psyche and may affect even his performance at school.The aim of this paper is to highlight the psychosocial impact and management challenges of a child with enuresis(nocturnal urinary incontinence).CASE SUMMARY This is the case of a 10-year-old boy who presented with a history of nocturnal urinary incontinence since birth and lower urinary tract symptoms(LUTS)for 3 years culminating in chronic urinary retention.He maintained a normal urge to micturate and continent of urine during the daytime before the onset of LUTS.He had an antecedent longstanding history of tying a rubber band to the penile shaft mostly before going to the bed at night to prevent enuresis due to his peer stigmatization.He was acutely ill-looking,with distended suprapubic region.The phallus and scrotum were enlarged and oedematous with a circumferential proximal penile shaft scar and ventral penile shaft urethrocutaneous fistula.He was diagnosed to have complete short segment bulbopenile stricture and right ectopic ureter.He subsequent had augmented anastomotic urethroplasty and bilateral non-refluxing ureteroneocystostomy at different sitting.CONCLUSION The adherence to surgical principles of urethral stricture and enuresis management where surgically correctable in a child is associated with the resolution of enuresis and social reintegration. 展开更多
关键词 ENURESIS Double ureter Ectopic ureter Rubber band urethral stricture Case report
下载PDF
电针通过调节膀胱及尿道平滑肌中的血清素受体表达改善骶上脊髓损伤大鼠的排尿功能
12
作者 张雨辰 许明 +4 位作者 刘琼 胡碧浓 唐丽亚 张泓 艾坤 《湖南中医药大学学报》 CAS 2024年第2期307-313,共7页
目的观察电针治疗后骶上脊髓损伤(suprasacral cord injury,SSCI)大鼠的膀胱最大容量(maximum cystometric capacity,MCC)、漏尿点压力(leakage point pressure,LPP),结合分析逼尿肌、内尿道括约肌(internal urethral sphincter,IUS)中... 目的观察电针治疗后骶上脊髓损伤(suprasacral cord injury,SSCI)大鼠的膀胱最大容量(maximum cystometric capacity,MCC)、漏尿点压力(leakage point pressure,LPP),结合分析逼尿肌、内尿道括约肌(internal urethral sphincter,IUS)中血清素(5-hydroxytryptamine,5-HT)不同亚型受体的表达,探讨电针治疗通过突触后5-HT受体调节逼尿肌-尿道括约肌协同失调(detrusor sphincter dyssynergia,DSD)大鼠排尿功能的效应机制。方法36只SD雌性大鼠,随机抽取12只作为空白组,剩余24只采用改良Hassan Shaker脊髓横断法在T10脊髓节段全横断制作SSCI大鼠模型,成模后随机分为模型组和电针组,每组12只。电针组取次髎、中极、三阴交穴予持续电针刺激40 min,1次/d,连续治疗7 d;空白组与模型组只捆绑不治疗。采用膀胱造瘘法进行尿流动力学检测;处死大鼠后取逼尿肌和近端尿道组织,采用Western blot法检测5-HT受体含量。结果模型组大鼠MCC、LPP显著高于空白组(P<0.01);电针组MCC显著低于模型组且高于空白组(P<0.01),LPP显著低于模型组(P<0.01)。与空白组比较,5-HT1A受体在模型组大鼠逼尿肌中表达显著降低(P<0.01),IUS中显著增高(P<0.01);电针组大鼠逼尿肌中5-HT1A受体显著高于模型组(P<0.01),IUS中5-HT1A受体低于模型组(P<0.05),但仍显著高于空白组(P<0.01)。模型组大鼠逼尿肌中5-HT2B受体表达高于空白组(P<0.05);电针组大鼠逼尿肌中5-HT2B受体表达低于模型组和空白组(P<0.05)。与空白组比较,5-HT7受体在模型组大鼠逼尿肌中表达显著降低(P<0.01),IUS中表达显著增高(P<0.01);电针组大鼠逼尿肌和IUS中5-HT7受体的表达均低于模型组(P<0.05)。结论电针刺激SSCI后DSD大鼠次髎、三阴交、中极穴引起膀胱及尿道平滑肌中5-HT受体表达变化,5-HT1A和5-HT2B受体可能通过Ca^(2+)流入使平滑肌产生相性和/或强直性收缩,5-HT7受体可能通过环磷酸腺苷(cyclic adenosine monophosphate,cAMP)途径影响大电导Ca^(2+)激活K^(+)(big-conductance Ca^(2+)-activated K^(+),BK)通道活性介导平滑肌松弛,电针治疗由此抑制逼尿肌过度活动、增加其收缩能力并协调尿道阻力以改善SSCI后DSD大鼠下尿路功能。 展开更多
关键词 神经源性膀胱 膀胱平滑肌 膀胱部分出口梗阻 外尿道括约肌爆发模式 尿道Cajal间质细胞 机械拉伸 平滑肌张力
下载PDF
电针气海、中极、关元穴改善压力性尿失禁尿道括约肌线粒体损伤机制研究
13
作者 杨明 朱旭东 +5 位作者 马波 盛梦钰 蔡晓清 李海涛 邵轶群 叶和松 《陕西中医》 CAS 2024年第4期440-445,共6页
目的:观察电针对压力性尿失禁(SUI)环境下尿控的影响,并基于线粒体动力学探讨相关作用机制。方法:对SD大鼠进行随机分组,空白组未采取任何处理,假手术组完成手术解剖未干预,模型组行双侧卵巢切除+阴道扩张,假针组予非穴位电针,电针组进... 目的:观察电针对压力性尿失禁(SUI)环境下尿控的影响,并基于线粒体动力学探讨相关作用机制。方法:对SD大鼠进行随机分组,空白组未采取任何处理,假手术组完成手术解剖未干预,模型组行双侧卵巢切除+阴道扩张,假针组予非穴位电针,电针组进行穴位电针。尿动力学仪测量各组大鼠的最大膀胱容量(MBC)和腹腔漏尿点压力(ALPP)和漏尿点压力(LPP);HE染色观察尿道括约肌肌纤维形态改变;ELISA试剂盒检测线粒体膜电位、ATP和氧化应激相关指标;电镜观察尿道括约肌线粒体形态;Western blot检测尿道括约肌线粒体动力学相关因子线粒体融合素1(Mfn1)、Mfn2、线粒体动力相关蛋白1(Drp1)、线粒体分裂因子(MFF)、沉默信息调节因子1(SIRT1)和过氧化物酶体增殖物激活受体γ共激活因子-1α(PGC-1α)蛋白表达。结果:与假手术组比较,模型组大鼠尿控指标MBC、ALPP和LPP显著降低(均P<0.05),尿道括约肌纤维断裂、排列紊乱,线粒体明显肿胀,嵴增宽;线粒体膜电位、ATP、琥珀酸脱氢酶(SDH)和超氧化物歧化酶(SOD)水平显著降低(均P<0.05),丙二醛(MDA)水平显著升高(P<0.05);SIRT1、PGC-1α、Mfn1和Mfn2蛋白表达显著降低(均P<0.05),Drp1和MFF蛋白表达显著升高(均P<0.05)。与假针组比较,电针组大鼠的MBC、ALPP和LPP显著升高(均P<0.05),尿道括约肌纤维断裂、排列紊乱及线粒体的肿胀、嵴增宽情况显著改善;线粒体膜电位和ATP水平以及SDH和SOD活性显著升高(均P<0.05),MDA水平显著降低(P<0.05);SIRT1、PGC-1α、Mfn1、Mfn2蛋白表达显著升高(均P<0.05),Drp1和MFF蛋白表达显著降低(均P<0.05)。结论:电针可通过调控线粒体动力学改善SUI环境下尿道括约肌肌纤维形态和线粒体形态及功能障碍。 展开更多
关键词 压力性尿失禁 电针 尿控 尿道括约肌 线粒体动力学 大鼠
下载PDF
经尿道棒状电极等离子电切术与尿道端端吻合术治疗短段尿道狭窄早期临床疗效比较
14
作者 张剑飞 沈鹤 +1 位作者 邱建宏 赵新鸿 《临床外科杂志》 2024年第2期144-147,共4页
目的 探讨经尿道棒状电极等离子电切术与尿道端端吻合术治疗短段尿道狭窄早期临床疗效。方法 2014年1月~2020年12月本院收治的男性短段尿道狭窄病人125例,根据手术方式的不同分为经尿道棒状电极等离子电切术(微创组)和尿道端端吻合术(... 目的 探讨经尿道棒状电极等离子电切术与尿道端端吻合术治疗短段尿道狭窄早期临床疗效。方法 2014年1月~2020年12月本院收治的男性短段尿道狭窄病人125例,根据手术方式的不同分为经尿道棒状电极等离子电切术(微创组)和尿道端端吻合术(开放组)。进一步根据尿道狭窄长度的不同,将微创组分为微创一组(狭窄段长度≤1 cm)和微创二组(狭窄段长度1~2 cm),开放一组(狭窄段长度≤1 cm)和开放二组(狭窄段长度1~2 cm)。比较4组之间的手术成功率。结果 微创一组与开放一组手术成功率分别为88.57%和93.10%,两组比较,差异无统计学意义(P>0.05)。微创二组与开放二组手术成功率分别为67.86%和90.91%,微创二组手术成功率低于开放二组,差异有统计学意义(P<0.05)。微创一组与微创二组手术成功率分别为88.57%和67.86%,差异有统计学意义(P<0.05)。开放一组与开放二组手术成功率分别为93.10%和90.91%,差异无统计学意义(P>0.05)。结论 对于狭窄段长度≤1cm尿道狭窄,因经尿道棒状电极等离子电切术与开放手术手术成功率相同,手术创伤小,恢复快,因此首选经尿道棒状电极等离子电切术微创治疗。对于1~2 cm尿道狭窄,微创手术创伤小,恢复快,但开放手术成功率更高,手术方式的选择需权衡利弊,综合考虑。 展开更多
关键词 等离子电切术 棒状电极 尿道狭窄 尿道端端吻合术
原文传递
括约肌间窗式减压瘘管激光闭合术治疗经括约肌肛瘘的临床研究
15
作者 闵丽 厉越 +4 位作者 万伯顺 张少军 熊国华 高洪娣 应光耀 《中国中西医结合外科杂志》 CAS 2024年第2期175-180,共6页
目的:观察括约肌间窗式减压瘘管激光闭合术、瘘管激光闭合术与肛瘘切除术治疗经括约肌肛瘘(ParksⅡ型肛瘘)的临床疗效。方法:将2021年1月—2022年12月上海市嘉定区中医医院肛肠科收治的132例ParksⅡ型肛瘘患者,分为治疗1组(瘘管激光闭... 目的:观察括约肌间窗式减压瘘管激光闭合术、瘘管激光闭合术与肛瘘切除术治疗经括约肌肛瘘(ParksⅡ型肛瘘)的临床疗效。方法:将2021年1月—2022年12月上海市嘉定区中医医院肛肠科收治的132例ParksⅡ型肛瘘患者,分为治疗1组(瘘管激光闭合术组)、治疗2组(括约肌间窗式减压瘘管激光闭合术组)与对照组(瘘管切除术组),每组44例。记录三组治愈时间、肛管直肠测压(治疗前、术后1个月及术后6个月)、术后症状及体征评分(手术即日、术后第1、3、7、14天对疼痛、发热、渗出、尿潴留、临床疗效及复发率进行评价。结果:治疗2组伤口愈合时间最短,对照组最长;三组比较,差异有统计学意义(P<0.001)。治疗后,三组肛管收缩压及肛管静息压较治疗前均有不同程度下降;与对照组比较,治疗1组与治疗2组肛管收缩压治疗前后差值差异均有统计学意义(P<0.01),治疗2组与对照组肛管静息压治疗前后差值比较,差异有统计学意义(P<0.05)。手术即日、术后第1、3、7、14天,三组发热、尿潴留评分比较,差异均无统计学意义(P>0.05);手术即日、术后第1、3、7天,与对照组比较,治疗1组与治疗2组渗出及疼痛评分,差异均有统计学意义(P<0.01)。三组总有效率比较,差异无统计学意义(P>0.05)。术后6个月,三组均无复发病例。结论:括约肌间窗式减压瘘管激光闭合术是治疗ParksⅡ型肛瘘的有效术式,具有创伤小、术后疼痛轻、渗出少、愈合时间短等优势,是一种值得临床推广的保护括约肌术式。 展开更多
关键词 括约肌间窗式减压瘘管激光闭合术 瘘管激光闭合术 ParksⅡ型肛瘘
下载PDF
经尿道内对比增强超声在尿道狭窄中的应用
16
作者 何萍 崔立刚 《中国医学影像学杂志》 CSCD 北大核心 2024年第4期353-357,共5页
目的探讨经尿道内对比增强超声对尿道狭窄的诊断价值。资料与方法回顾性分析2021年8月—2023年9月在北京大学第三医院行经尿道内对比增强超声检查,并诊断为尿道狭窄的5例男性,分析其影像资料。结果5例患者均出现排尿困难。5例尿道狭窄... 目的探讨经尿道内对比增强超声对尿道狭窄的诊断价值。资料与方法回顾性分析2021年8月—2023年9月在北京大学第三医院行经尿道内对比增强超声检查,并诊断为尿道狭窄的5例男性,分析其影像资料。结果5例患者均出现排尿困难。5例尿道狭窄均为单发,2例狭窄位于尿道球部,1例位于尿道膜部,1例位于尿道舟状窝,1例位于尿道前列腺部。2例狭窄<1 cm,3例狭窄长度为1~2 cm。周围瘢痕厚度均<1 cm。2例合并尿道结石,1例合并尿道憩室和假道。结论经尿道内对比增强超声可以无创评估尿道狭窄的位置、长度、单发/多发、瘢痕厚度、有无尿道断裂、有无憩室、有无假道等。超声医师应掌握经尿道内对比增强超声的操作规范,促进其临床推广。 展开更多
关键词 尿道狭窄 超声检查 经尿道内对比增强超声 诊断
下载PDF
逆行松解神经血管束且保留Retzius间隙机器人辅助腹腔镜根治性前列腺切除术的技术要点(“大家泌尿网”观看手术视频)
17
作者 王勇 刘子豪 +3 位作者 刘洋 黄华 邵渊 牛远杰 《现代泌尿外科杂志》 2024年第1期1-4,共4页
保留耻骨后间隙的前列腺癌根治术(RS-RARP)可以显著提高术后即刻尿控且不增加切缘阳性率。然而该术式学习曲线长,目前能掌握的学者不到10%,尚未推广。基于对前列腺解剖结构及手术方式的认识,本中心对RS-RARP进行优化。我们首创了完全后... 保留耻骨后间隙的前列腺癌根治术(RS-RARP)可以显著提高术后即刻尿控且不增加切缘阳性率。然而该术式学习曲线长,目前能掌握的学者不到10%,尚未推广。基于对前列腺解剖结构及手术方式的认识,本中心对RS-RARP进行优化。我们首创了完全后入路逆行松解神经血管束的RARP,最大限度保留神经血管束,简化手术操作,仅使用一根缝线即可完成尿道吻合,无需使用Hem-o-lok,减少相关并发症。我们在本中心常规开展该术式,通过多维度分析认为这是一种“肿瘤控制可、尿控保护好、性功能恢复快、并发症少、可操作性强”的手术方式。本文详细介绍该术式的关键步骤及操作体会。 展开更多
关键词 前列腺癌 神经血管束 逆行松解 机器人辅助下前列腺根治性切除术 尿道吻合 Retzius间隙
下载PDF
应用200μm钬激光光纤治疗球、膜部尿道狭窄临床分析及新思考
18
作者 高江涛 程梦雅 +1 位作者 毛长青 谢遵江 《黑龙江医学》 2024年第5期521-524,共4页
目的:分析和思考内镜下应用(200μm)钬激光光纤治疗球、膜部尿道狭窄的疗效及治疗经验。方法:选取2018年1月—2020年6月样本医院收治的86例内镜下应用冷刀及200μm钬激光光纤治疗男性球、膜部尿道狭窄患者的临床资料进行分析。所有患者... 目的:分析和思考内镜下应用(200μm)钬激光光纤治疗球、膜部尿道狭窄的疗效及治疗经验。方法:选取2018年1月—2020年6月样本医院收治的86例内镜下应用冷刀及200μm钬激光光纤治疗男性球、膜部尿道狭窄患者的临床资料进行分析。所有患者尿道造影均提示狭窄段<1 cm,彩超检查提示瘢痕厚度<0.5 cm和(或)合并部分假道。按手术方式分为两组,对照组(冷刀组,41例):应用冷刀纵形辐射状切开狭窄段至正常海绵体深度;观察组(激光组,45例):采用200μm钬激光光纤,“同轴法”纵向切开狭窄段并切除尿道瘢痕,深度同对照组。术后均留置16 F硅胶尿管,2周后拔除,观察其自行排尿情况。结果:观察组患者手术时间长于对照组,术中、术后出血量少于对照组,差异有统计学意义(t=8.494、15.112、14.351、13.300,P<0.05);两组患者术后即刻、术后3个月、术后12个月其自行排尿情况同时复查最大尿流率比较,差异无统计学意义(t=0.130、0.528、0.298、0.312,P>0.05);术后2周,两组患者生理、心理、社会、环境、独立评分均较治疗前明显升高,且观察组高于对照组,差异有统计学意义(t=13.416、5.429、14.367、9.426、5.529,P<0.05)。结论:直视下尿道内切开术(DVIU)应用200μm钬激光光纤较冷刀不增加并发症,术后患者生活质量更高,评估手术疗效则需要狭窄长度和瘢痕厚度综合考虑。 展开更多
关键词 尿道内切开 200μm钬激光光纤 球、膜部尿道狭窄 冷刀 疗效
下载PDF
中性粒细胞胞外诱捕网浸润促进尿道创伤后尿道成纤维细胞活化和增生性瘢痕形成
19
作者 陈烨辉 许以城 +3 位作者 阮中天 林婷婷 薛学义 许宁 《中国病理生理杂志》 CAS CSCD 北大核心 2024年第1期103-109,共7页
目的:探讨中性粒细胞胞外诱捕网(NETs)对创伤后尿道瘢痕形成的影响。方法:(1)2021年6月至2022年12月,收集福建医科大学附属第一医院泌尿外科患者的临床样本,比较尿道创伤患者(n=20)与健康志愿者(n=20)血液和尿液NETs水平的差异,并分析... 目的:探讨中性粒细胞胞外诱捕网(NETs)对创伤后尿道瘢痕形成的影响。方法:(1)2021年6月至2022年12月,收集福建医科大学附属第一医院泌尿外科患者的临床样本,比较尿道创伤患者(n=20)与健康志愿者(n=20)血液和尿液NETs水平的差异,并分析其与尿道瘢痕形成的关系。(2)从尿道瘢痕组织中提取原代尿道成纤维细胞,体外诱导中性粒细胞以获得NETs,分别以生理盐水、0.5 mg/L NETs和1.5 mg/L NETs处理尿道成纤维细胞,探索NETs对尿道成纤维细胞活化和胶原合成的影响。(3)构建尿道创伤新西兰兔模型,将动物分为非手术组、手术+转化生长因子β1(TGF-β1)注射(阳性对照)组、手术+生理盐水注射组和手术+脱氧核糖核酸酶I(DNase I)溶液注射组,探索NETs降解剂DNase I对尿道瘢痕形成的治疗作用。结果:尿道创伤后,患者尿液NETs水平显著升高(P<0.05),而血液NETs水平无显著差异(P>0.05)。尿道创伤新西兰兔模型中,创伤后尿液NETs水平越高,形成的尿道瘢痕纤维化程度越高(P<0.05);在细胞层面上,NETs促进尿道成纤维细胞活力、迁移与胶原合成(P<0.05)。在新西兰兔尿道创伤模型中,创伤后尿道注射DNase I可降低局部NETs水平,抑制尿道瘢痕形成(P<0.05)。结论:NETs浸润促进尿道创伤后尿道成纤维细胞活化和增生性瘢痕形成。 展开更多
关键词 中性粒细胞胞外诱捕网 创伤后尿道狭窄 瘢痕形成 尿道成纤维细胞
下载PDF
术前大肠杆菌培养阳性对尿道狭窄成形术后感染及发热的影响
20
作者 潘昊 刘彧 +2 位作者 金熙 李虹 王坤杰 《陆军军医大学学报》 CAS CSCD 北大核心 2024年第3期277-282,共6页
目的 探究大肠杆菌相较其他病原体感染,是否增加尿道成形术后的手术部位感染以及术后发热。方法 采用回顾性队列研究的方式,纳入华西医院泌尿外科2011-2019年接受尿道狭窄段切除和端端吻合术来治疗尿道球部或后尿道狭窄的患者共506例,... 目的 探究大肠杆菌相较其他病原体感染,是否增加尿道成形术后的手术部位感染以及术后发热。方法 采用回顾性队列研究的方式,纳入华西医院泌尿外科2011-2019年接受尿道狭窄段切除和端端吻合术来治疗尿道球部或后尿道狭窄的患者共506例,按术后是否发生手术部位感染(surgical site infection,SSI)和术后发热(postoperative fever,POF)分别分为SSI组(19例)和非SSI组(487例),POF组(61例)和非POF组(445例);采用多元Logistic回归分析与LASSO算法筛选潜在的危险因素;按照术前尿培养结果将患者分为大肠杆菌感染组(80例)和其他病原体感染组(222例),通过倾向评分匹配减少潜在偏倚后(匹配后大肠杆菌组:48例;其他病原体组:192例),比较大肠杆菌感染组与其他病原体感染组在手术部位感染和术后发热方面的差异。结果 在多元Logistic回归分析与LASSO算法中,术前尿培养阳性是预测手术部位感染(P=0.012)和术后发热(P<0.01)的独立危险因素,在302例术前尿培养阳性的患者中,大肠杆菌感染比例位居第一(26.5%)。倾向评分匹配处理后,大肠杆菌组与其他病原体组的手术部位感染的比例分别为29.2%和2.1%(P<0.01)。与其他病原体感染组相比,大肠杆菌感染组的术后发热比例也较高(27.1%vs 13.5%,P=0.02)。结论 与其他病原体感染相比,术前大肠杆菌感染会增加尿道成形术后的手术部位感染、术后发热风险。 展开更多
关键词 尿道成形术 尿道狭窄 手术部位感染 风险因素
原文传递
上一页 1 2 250 下一页 到第
使用帮助 返回顶部