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Infectious Disease Update in Obstetrics: A Modern Approach to the Patient with a Positive Screening Test for Syphyilis in Pregnancy
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作者 Papa Essilfie 《Open Journal of Obstetrics and Gynecology》 2024年第1期102-109,共8页
Screening for maternal syphilis has been an essential component of routine antenatal screening tests in most countries for many years. This is not only because of the virulence of the spirochete which causes the infec... Screening for maternal syphilis has been an essential component of routine antenatal screening tests in most countries for many years. This is not only because of the virulence of the spirochete which causes the infection but also because of its vertical transmission rate and the potential severe adverse complications/morbidity that can result from its transmission to the fetus. Although the incidence of maternal syphilis and its fetal sequalae in low-income countries has been considerable for several years, the disease has been almost non-existent in high income countries with wide antenatal screening coverage and effective treatment programmes for Syphilis. The recent alarming increase in the incidence of maternal syphilis in high income countries has spawned a renewed public health interest in the infection, with several countries updating and strengthening public health guidance in an attempt to stem this dramatic trend. This is a short clinical update for the practising obstetrician on how to manage the antenatal patient with a positive syphilis screening test. 展开更多
关键词 Treponema Pallidum Chancre Condyloma Lata Gummas vdrl test RPR test Revere-Sequence testing Jarisch-Herxheimer Reaction
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梅毒螺旋体明胶凝集试验定量检测在神经梅毒诊疗中的临床意义 被引量:7
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作者 毕超 梁景耀 +4 位作者 梁艳华 黎小东 曹文苓 杨日东 王建琴 《中国艾滋病性病》 CAS CSCD 北大核心 2019年第8期845-847,共3页
目的探讨梅毒螺旋体明胶凝集试验(TPPA)定量检测在神经梅毒诊疗中的应用。方法统计神经梅毒患者初次确诊时脑脊液性病研究实验室试验(VDRL)、快速血浆反应素环状卡片试验(RPR)、TPPA、梅毒螺旋体抗体吸收试验(FTA-ABS)IgG、FTA-ABS IgM... 目的探讨梅毒螺旋体明胶凝集试验(TPPA)定量检测在神经梅毒诊疗中的应用。方法统计神经梅毒患者初次确诊时脑脊液性病研究实验室试验(VDRL)、快速血浆反应素环状卡片试验(RPR)、TPPA、梅毒螺旋体抗体吸收试验(FTA-ABS)IgG、FTA-ABS IgM和血清RPR的检验数据,治疗规范半年后、1年后复查上述检验项目,分析3次数据与治疗效果的关系。结果经规范治疗后,神经梅毒患者脑脊液TPPA的滴度逐渐下降,半年稀释倍数与首次相比(t=3.533,P=0.002)、1年稀释倍数与首次相比(t=4.555,P=0.000),差异均有统计学意义;有2例患者脑脊液TPPA转为阴性;TPPA稀释倍数与脑脊液RPR(r=0.430 1,P=0.031 9)、VDRL(r=0.703 7,P=0.000 1)稀释倍数呈相关性;脑脊液TPPA稀释倍数与血清RPR稀释倍数无相关性;脑脊液和血清TPPA定性结果与FTA-ABS IgG完全一致。结论 TPPA定量检测与VDRL、RPR相比,对神经梅毒疗效观察有较好的价值。 展开更多
关键词 神经梅毒 梅毒螺旋体明胶凝集定量试验 性病研究实验室试验 快速血浆反应素环状卡片试验
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