In this study,the entropy weight method was used to measure the agricultural versatility of 30 provinces in China(excluding Tibet,Hong Kong,Macao,and Taiwan)from 2008 to 2019.In addition,the Theil index method and ker...In this study,the entropy weight method was used to measure the agricultural versatility of 30 provinces in China(excluding Tibet,Hong Kong,Macao,and Taiwan)from 2008 to 2019.In addition,the Theil index method and kernel density estimation were used to analyze the spatiotemporal characteristics of the agricultural versatility in each province.The results show that the agricultural product supply and social security functions rapidly developed,but the economic development was weak.From 2008 to 2019,the total functional index of agriculture increased by 6.74%;the functional index of the agricultural product supply,social security,and ecological services increased by 12.72%,5.53%,and 2.05%,respectively;and the functional index of economic development decreased by 1.32%.The development of agricultural multifunctions in China is regionally heterogeneous.Based on the Theil index method,the differences in the agricultural functions of the three regions are mainly due to intragroup differences.The contribution of intragroup differences of the eight economic regions is significantly lower than that of the three regions.However,intragroup differences dominate the agricultural product supply,economic development,and social security functions and intergroup differences control the ecological service function.The kernel density estimation curve shows that the overall agricultural functional evaluation index increased,among which the agricultural product supply function increased the most.展开更多
Peroxisomes are small,highly dynamic,and multifunctional organelles in eukaryotes.Essential to plant survival,peroxisomes house various crucial metabolic activities,such as degradation of hydrogen peroxide(H2O2),lipid...Peroxisomes are small,highly dynamic,and multifunctional organelles in eukaryotes.Essential to plant survival,peroxisomes house various crucial metabolic activities,such as degradation of hydrogen peroxide(H2O2),lipid metabolism,photorespiration,and hormone biosynthesis and catabolism,and remodel their proteome in response to developmental and environmental changes(Hu et al.2012;Pan and Hu 2018).The four reviews and three research articles in this special issue on plant peroxisomes provide new insights into the diverse roles and dynamics of these structurally simple but functionally complicated organelles,raising exciting new questions for future investigations.展开更多
A quantum teleportation network involving multiple users is essential for future quantum internet.So far,controlled quantum teleportation has been demonstrated in a three-user network.However,versatile and controlled ...A quantum teleportation network involving multiple users is essential for future quantum internet.So far,controlled quantum teleportation has been demonstrated in a three-user network.However,versatile and controlled quantum teleportation network involving more users is in demand,which satisfies different combinations of users for practical requirements.Here we propose a highly versatile and controlled teleportation network that can switch among various combinations of different users.We use a single continuous-variable six-partite Greenberger-Horne-Zeilinger(GHZ)state to realize such a task by choosing the different measurement and feedback operations.The controlled teleportation network,which includes one sub-network,two sub-networks and three sub-networks,can be realized for different application of user combinations.Furthermore,the coherent feedback control(CFC)can manipulate and improve the teleportation performance.Our approach is flexible and scalable,and would provide a versatile platform for demonstrations of complex quantum communication and quantum computing protocols.展开更多
Mesenchymal intricate stem cells(MSCs)represent a versatile population of multipotent progenitor cells with remarkable capacity for selfrenewal and differentiation[1].The fate commitment of MSCs is orchestrated by a c...Mesenchymal intricate stem cells(MSCs)represent a versatile population of multipotent progenitor cells with remarkable capacity for selfrenewal and differentiation[1].The fate commitment of MSCs is orchestrated by a complex interplay of intrinsic and extrinsic factors,encompassing signaling pathways,transcriptional regulators,epigenetic modifiers,and microenvironmental cues[2-5].展开更多
Leggings have been a staple in the fashion industry for decades,consistently remaining one of the most popular and versatile items of clothing.They have achieved viral status and continue to be a highly sought-after f...Leggings have been a staple in the fashion industry for decades,consistently remaining one of the most popular and versatile items of clothing.They have achieved viral status and continue to be a highly sought-after fashion item,transcending age and cultural barriers.The body-hugging style of leggings has remained in vogue,attracting young people of all ages and backgrounds.With their enduring popularity,it’s likely that leggings will remain a fashion staple for years to come.展开更多
Articular cartilage serves as a low-friction,load-bearing tissue without the support with blood vessels,lymphatics and nerves,making its repair a big challenge.Transforming growth factor-beta 3(TGF-β3),a vital member...Articular cartilage serves as a low-friction,load-bearing tissue without the support with blood vessels,lymphatics and nerves,making its repair a big challenge.Transforming growth factor-beta 3(TGF-β3),a vital member of the highly conserved TGF-βsuperfamily,plays a versatile role in cartilage physiology and pathology.TGF-β3 influences the whole life cycle of chondrocytes and mediates a series of cellular responses,including cell survival,proliferation,migration,and differentiation.Since TGF-β3 is involved in maintaining the balance between chondrogenic differentiation and chondrocyte hypertrophy,its regulatory role is especially important to cartilage development.Increased TGF-β3 plays a dual role:in healthy tissues,it can facilitate chondrocyte viability,but in osteoarthritic chondrocytes,it can accelerate the progression of disease.Recently,TGF-β3 has been recognized as a potential therapeutic target for osteoarthritis(OA)owing to its protective effect,which it confers by enhancing the recruitment of autologous mesenchymal stem cells(MSCs)to damaged cartilage.However,the biological mechanism of TGF-β3 action in cartilage development and OA is not well understood.In this review,we systematically summarize recent progress in the research on TGF-β3 in cartilage physiology and pathology,providing up-to-date strategies for cartilage repair and preventive treatment.展开更多
Is Cannabis a boon or bane?Cannabis sativa has long been a versatile crop for fiber extraction(industrial hemp),traditional Chinese medicine(hemp seeds),and recreational drugs(marijuana).Cannabis faced global prohibit...Is Cannabis a boon or bane?Cannabis sativa has long been a versatile crop for fiber extraction(industrial hemp),traditional Chinese medicine(hemp seeds),and recreational drugs(marijuana).Cannabis faced global prohibition in the twentieth century because of the psychoactive properties of △^(9)-tetrahydrocannabinol;however,recently,the perspective has changed with the recognition of additional therapeutic values,particularly the pharmacological potential of cannabidiol.A comprehensive understanding of the underlying mechanism of cannabinoid biosynthesis is necessary to cultivate and promote globally the medicinal application of Cannabis resources.Here,we comprehensively review the historical usage of Cannabis,biosynthesis of trichome-specific cannabinoids,regulatory network of trichome development,and synthetic biology of cannabinoids.This review provides valuable insights into the efficient biosynthesis and green production of cannabinoids,and the development and utilization of novel Cannabis varieties.展开更多
Dear Editor,Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR)is a powerful and versatile gene editing system that has been extensively utilized in various animals and plants,which holds enormous potent...Dear Editor,Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR)is a powerful and versatile gene editing system that has been extensively utilized in various animals and plants,which holds enormous potential and value for scientific research and breeding.However,single-targeted CRISPR can only induce a few base deletions,insertions,or substitution.Ideally,thesemutations result in premature termination of the protein encoded by the target gene,leading to a loss of function[1].展开更多
Two-dimensional van der Waals magnetic materials have demonstrated great potential for new-generation high-performance and versatile spintronic devices.Among them,magnetic tunnel junctions(MTJs)based on A-type antifer...Two-dimensional van der Waals magnetic materials have demonstrated great potential for new-generation high-performance and versatile spintronic devices.Among them,magnetic tunnel junctions(MTJs)based on A-type antiferromagnets,such as CrI_(3),possess record-high tunneling magnetoresistance(TMR)because of the spin filter effect of each insulating unit ferromagnetic layer.However,the relatively low working temperature and the instability of the chromium halides hinder applications of this system.Using a different technical scheme,we fabricated the MTJs based on an air-stable A-type antiferromagnet,CrSBr,and observed a giant TMR of up to 47000%at 5 K.Meanwhile,because of a relatively high Néel temperature of CrSBr,a sizable TMR of about 50%was observed at 130 K,which makes a big step towards spintronic devices at room temperature.Our results reveal the potential of realizing magnetic information storage in CrSBr-based spin-filter MTJs.展开更多
The interest in using therapeutic nanoparticles to bind with harmful molecules or pathogens and subsequently neutralize their bioactivity has grown tremendously.Among various nanomedicine platforms,cell membrane-coate...The interest in using therapeutic nanoparticles to bind with harmful molecules or pathogens and subsequently neutralize their bioactivity has grown tremendously.Among various nanomedicine platforms,cell membrane-coated nanoparticles,namely,“cellular nanosponges,”stand out for their broadspectrum neutralization capability challenging to achieve in traditional countermeasure technologies.Such ability is attributable to their cellular function-based rather than target structure-based working principle.Integrating cellular nanosponges with various synthetic substrates further makes their applications exceptionally versatile and adaptive.This review discusses the latest cellular nanosponge technology focusing on how the structure–function relationship in different designs has led to versatile and potent medical countermeasures.Four design strategies are discussed,including harnessing native cell membrane functions for biological neutralization,functionalizing cell membrane coatings to enhance neutralization capabilities,combining cell membranes and functional cores for multimodal neutralization,and integrating cellular nanosponges with hydrogels for localized applications.Examples in each design strategy are selected,and the discussion is to highlight their structure–function relationships in complex disease settings.The review may inspire additional design strategies for cellular nanosponges and fulfill even broader medical applications.展开更多
The mortality rate decreases as the early detection of Breast Cancer(BC)methods are emerging very fast,and when the starting stage of BC is detected,it is curable.The early detection of the disease depends on the imag...The mortality rate decreases as the early detection of Breast Cancer(BC)methods are emerging very fast,and when the starting stage of BC is detected,it is curable.The early detection of the disease depends on the image processing techniques,and it is used to identify the disease easily and accurately,especially the micro calcifications are visible on mammography when they are 0.1 mm or bigger,and cancer cells are about 0.03 mm,which is crucial for identifying in the BC area.To achieve this micro calcification in the BC images,it is necessary to focus on the four main steps presented in this work.There are three significant stages of the process assigned to find the BC using a thermal image;the image processing procedures are described below.In the first stage of the process,the Gaussian filter technique is implemented to magnify the screening image.During the second stage,BC detection is separated from the pre-processed image.The Proposed Versatile K-means clustering(VKC)algorithm with segmentation is used to identify the BC detection form of the screening image.The centroids are then recalculated using proposed VKC,which takes the mean of all data points allocated to that centroid’s cluster,lowering the overall intracluster variance in comparison to the prior phase.The“means”in K-means refers to the process of averaging the data and determining a new centroid.This process eliminates unnecessary areas of interest.First,the mammogram screening image information is taken from the patient and begins with the Contiguous Convolutional Neural Network(CCNN)method.The proposed CCNN is used to classify the Micro calcification in the BC spot using the feature values is the fourth stage of the process.The assess the presence of high-definition digital infrared thermography technology and knowledge base and suggests that future diagnostic and treatment services in breast cancer imaging will be developed.The use of sophisticated CCNN techniques in thermography is being developed to attain a greater level of consistency.The implemented(CCNN)technique’s performance is examined with different classification parameters like Recall,Precision,F-measure and accuracy.Finally,the Breast Cancer stages will be classified based on the true positive and true negative values.展开更多
A mid the ever-changing tides of fashion,Arc’teryx,a high-performance outdoor equipment brand known for leading innovations in outdoor apparel tech and once beloved by middleaged outdoor enthusiasts,has now secured a...A mid the ever-changing tides of fashion,Arc’teryx,a high-performance outdoor equipment brand known for leading innovations in outdoor apparel tech and once beloved by middleaged outdoor enthusiasts,has now secured a place as social currency for Chinese trendsetters.Salomon,once associated with the“ugly shoe”aesthetic exclusive to mountaineers,has become a coveted fashion essential,commanding premium prices driven by fervent demand.In addition,as the Lululemon brand evolves from its body-conscious fit origins for yoga enthusiasts to a versatile wardrobe staple for commuters.展开更多
A versatile filmmaker who has been dedicated to directing a wide range of short films.AT the Shanghai International Advertising Festival (SHIAF) 2021 held in July 2021, director Wang Yucheng was the recipient of three...A versatile filmmaker who has been dedicated to directing a wide range of short films.AT the Shanghai International Advertising Festival (SHIAF) 2021 held in July 2021, director Wang Yucheng was the recipient of three shining trophies.Behind the scenes, he is a low-key person who is dedicated to creating advertisements and short films. He has won the nickname“chameleon director”for his passion of finding ways to exhibit a different style in each video, so as to make the artwork fit the theme and impress every audience.展开更多
为了提高FPGA（Field Programmable Gate Array）的布通率并优化电路的连线长度,在模拟退火算法的基础上,该文提出一种新的FPGA布局算法。该算法在不同的温度区间采用不同的评价函数,高温阶段采用半周长法进行快速优化布局,低温阶段在...为了提高FPGA（Field Programmable Gate Array）的布通率并优化电路的连线长度,在模拟退火算法的基础上,该文提出一种新的FPGA布局算法。该算法在不同的温度区间采用不同的评价函数,高温阶段采用半周长法进行快速优化布局,低温阶段在评价函数中加入变量因子并进行适度的回火处理,以此来优化布局。实验表明,该算法提高了布通率,优化了连线长度,与最具代表性的VPR（Versatile Place and Route）布局算法相比布线通道宽度提高了近6%,电路总的连线长度降低了4-23%。展开更多
Metal halide perovskites are crystalline materials originally developed out of scientific curiosity. They have shown great potential as active materials in optoelectronic applications. In the last 6 years, their certi...Metal halide perovskites are crystalline materials originally developed out of scientific curiosity. They have shown great potential as active materials in optoelectronic applications. In the last 6 years, their certified photovoltaic efficiencies have reached 22.1%. Compared to bulk halide perovskites, low-dimensional ones exhibited novel physical properties. The photoluminescence quantum yields of perovskite quantum dots are close to 100%. The external quantum efficiencies and current efficiencies of perovskite quantum dot light-emitting diodes have reached 8% and 43 cd A^(-1),respectively, and their nanowire lasers show ultralow-threshold room-temperature lasing with emission tunability and ease of synthesis. Perovskite nanowire photodetectors reached a responsivity of 10 A W^(-1)and a specific normalized detectivity of the order of 10^(12 )Jones. Different from most reported reviews focusing on photovoltaic applications, we summarize the rapid progress in the study of low-dimensional perovskite materials, as well as their promising applications in optoelectronic devices. In particular, we review the wide tunability of fabrication methods and the state-of-the-art research outputs of low-dimensional perovskite optoelectronic devices. Finally, the anticipated challenges and potential for this exciting research are proposed.展开更多
A novel Zn-based metal–organic framework Zn(dobdc)(datz)[Zn_(2)(H2dobdc)(datz)2$1.5DMF]with plentiful hydrogen bond donors(HBD)groups was facilely synthesized from mixed ligands.The dual activation of metal Zn sites ...A novel Zn-based metal–organic framework Zn(dobdc)(datz)[Zn_(2)(H2dobdc)(datz)2$1.5DMF]with plentiful hydrogen bond donors(HBD)groups was facilely synthesized from mixed ligands.The dual activation of metal Zn sites and HBD groups for epoxides by forming Zn–O adduct and hydrogen bonds facilitated the ring-opening of epoxide substrate,which is critical for the subsequent CO_(2) fixation.Also,the existence of micropores and N-rich units in Zn(dobdc)(datz)afforded affinity towards CO_(2),which is beneficial to further improvement on catalytic CO_(2) conversion performance.Satisfactorily,Zn(dobdc)(datz)/Bu4NBr system was proved efficient heterogeneous catalyst for the CO_(2) cycloaddition with epoxides,and 98%propylene carbonate yield was obtained under mild conditions(80C,1.5 MPa and solvent-free).In addition,Zn(dobdc)(datz)/Bu4NBr exhibited remarkable versatility to different epoxides and could be completely recycled over six runs with high catalytic activity.The highly stable,easily recycle and solvent-free Zn-based MOF reported here displays eco-friendly and efficient performance to CO_(2)conversion.展开更多
The paper starts with a presentation of the versatile leadership model developed by Kaplan and Kaiser and of their 360 feedback tool Leadership Versatility Index （LVI）. Versatility can be generally defined as a mast...The paper starts with a presentation of the versatile leadership model developed by Kaplan and Kaiser and of their 360 feedback tool Leadership Versatility Index （LVI）. Versatility can be generally defined as a mastery of opposites, as the ability to play multiple roles, even contradictory ones, without emphasizing some at the expense of others. The LVI has been designed to help managers understand their repertoire and how they can become more versatile leaders. It employs an innovative rating scale on which ideal score ＂0＂ is in the middle of it （the right amount）, flanked by underdoing to the left （too little） and overdoing to the right （too much）. The idea is to avoid the ＂more is better＂ design trap by providing a way for raters to indicate when managers go to counterproductive extremes. The LVI works with two-sided view of leadership based on two major pairs of opposites： directive vs. supportive leadership and execution vs. strategy. Interventions based on the LVI results help to overcome traditional behaviorism as they combine the outer work （behavioral change） with the inner work （personal change） of development. Application of the LV1 on a sample of the managers from Skoda Auto a.s. and verification of its practical value represented the core of the SAVS IGA project MM/O7/02. The last part of the paper is devoted to a presentation of the findings from this project. The LVI has been found to be both original and a very useful 360 feedback tool which can be addressed to two general groups of clients： （1） experienced senior managers; and （2） young perspective managers in the beginning of their career.展开更多
文摘In this study,the entropy weight method was used to measure the agricultural versatility of 30 provinces in China(excluding Tibet,Hong Kong,Macao,and Taiwan)from 2008 to 2019.In addition,the Theil index method and kernel density estimation were used to analyze the spatiotemporal characteristics of the agricultural versatility in each province.The results show that the agricultural product supply and social security functions rapidly developed,but the economic development was weak.From 2008 to 2019,the total functional index of agriculture increased by 6.74%;the functional index of the agricultural product supply,social security,and ecological services increased by 12.72%,5.53%,and 2.05%,respectively;and the functional index of economic development decreased by 1.32%.The development of agricultural multifunctions in China is regionally heterogeneous.Based on the Theil index method,the differences in the agricultural functions of the three regions are mainly due to intragroup differences.The contribution of intragroup differences of the eight economic regions is significantly lower than that of the three regions.However,intragroup differences dominate the agricultural product supply,economic development,and social security functions and intergroup differences control the ecological service function.The kernel density estimation curve shows that the overall agricultural functional evaluation index increased,among which the agricultural product supply function increased the most.
文摘Peroxisomes are small,highly dynamic,and multifunctional organelles in eukaryotes.Essential to plant survival,peroxisomes house various crucial metabolic activities,such as degradation of hydrogen peroxide(H2O2),lipid metabolism,photorespiration,and hormone biosynthesis and catabolism,and remodel their proteome in response to developmental and environmental changes(Hu et al.2012;Pan and Hu 2018).The four reviews and three research articles in this special issue on plant peroxisomes provide new insights into the diverse roles and dynamics of these structurally simple but functionally complicated organelles,raising exciting new questions for future investigations.
基金Project supported by the Natural Science Foundation of Shanxi Province of China (Grant No. 202203021221214)the National Natural Science Foundation of China (Grant Nos. 62122044, 62135008, 61925503, 11904218, 12004276, 12147215, and 11834010)+4 种基金the Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi Province of China (Grant Nos. 2019L0092 and 2020L0029)the Key Project of the National Key Research and Development Program of China (Grant No. 2022YFA1404500)the Program for the Innovative Talents of Higher Education Institutions of Shanxi Province of Chinathe Program for the Outstanding Innovative Teams of Higher Learning Institutions of Shanxithe Fund for Shanxi “1331 Project” Key Subjects Construction
文摘A quantum teleportation network involving multiple users is essential for future quantum internet.So far,controlled quantum teleportation has been demonstrated in a three-user network.However,versatile and controlled quantum teleportation network involving more users is in demand,which satisfies different combinations of users for practical requirements.Here we propose a highly versatile and controlled teleportation network that can switch among various combinations of different users.We use a single continuous-variable six-partite Greenberger-Horne-Zeilinger(GHZ)state to realize such a task by choosing the different measurement and feedback operations.The controlled teleportation network,which includes one sub-network,two sub-networks and three sub-networks,can be realized for different application of user combinations.Furthermore,the coherent feedback control(CFC)can manipulate and improve the teleportation performance.Our approach is flexible and scalable,and would provide a versatile platform for demonstrations of complex quantum communication and quantum computing protocols.
文摘Mesenchymal intricate stem cells(MSCs)represent a versatile population of multipotent progenitor cells with remarkable capacity for selfrenewal and differentiation[1].The fate commitment of MSCs is orchestrated by a complex interplay of intrinsic and extrinsic factors,encompassing signaling pathways,transcriptional regulators,epigenetic modifiers,and microenvironmental cues[2-5].
文摘Leggings have been a staple in the fashion industry for decades,consistently remaining one of the most popular and versatile items of clothing.They have achieved viral status and continue to be a highly sought-after fashion item,transcending age and cultural barriers.The body-hugging style of leggings has remained in vogue,attracting young people of all ages and backgrounds.With their enduring popularity,it’s likely that leggings will remain a fashion staple for years to come.
基金National Natural Science Foundation of China(81771047 to J.X.,81670978 and 81870754 to X.Z.)Sichuan Science&Technology Innovation Talent Project(2022JDRC0044)。
文摘Articular cartilage serves as a low-friction,load-bearing tissue without the support with blood vessels,lymphatics and nerves,making its repair a big challenge.Transforming growth factor-beta 3(TGF-β3),a vital member of the highly conserved TGF-βsuperfamily,plays a versatile role in cartilage physiology and pathology.TGF-β3 influences the whole life cycle of chondrocytes and mediates a series of cellular responses,including cell survival,proliferation,migration,and differentiation.Since TGF-β3 is involved in maintaining the balance between chondrogenic differentiation and chondrocyte hypertrophy,its regulatory role is especially important to cartilage development.Increased TGF-β3 plays a dual role:in healthy tissues,it can facilitate chondrocyte viability,but in osteoarthritic chondrocytes,it can accelerate the progression of disease.Recently,TGF-β3 has been recognized as a potential therapeutic target for osteoarthritis(OA)owing to its protective effect,which it confers by enhancing the recruitment of autologous mesenchymal stem cells(MSCs)to damaged cartilage.However,the biological mechanism of TGF-β3 action in cartilage development and OA is not well understood.In this review,we systematically summarize recent progress in the research on TGF-β3 in cartilage physiology and pathology,providing up-to-date strategies for cartilage repair and preventive treatment.
基金supported by the National Natural Science Foundation of China(82204579)the Fundamental Research Funds for the Central Universities(2572022DX06)+1 种基金the Scientific and Technological Innovation Project of China Academy of Chinese Medical Science(CI2021A04113)Heilongjiang Touyan Innovation Team Program(Tree Genetics and Breeding Innovation Team).
文摘Is Cannabis a boon or bane?Cannabis sativa has long been a versatile crop for fiber extraction(industrial hemp),traditional Chinese medicine(hemp seeds),and recreational drugs(marijuana).Cannabis faced global prohibition in the twentieth century because of the psychoactive properties of △^(9)-tetrahydrocannabinol;however,recently,the perspective has changed with the recognition of additional therapeutic values,particularly the pharmacological potential of cannabidiol.A comprehensive understanding of the underlying mechanism of cannabinoid biosynthesis is necessary to cultivate and promote globally the medicinal application of Cannabis resources.Here,we comprehensively review the historical usage of Cannabis,biosynthesis of trichome-specific cannabinoids,regulatory network of trichome development,and synthetic biology of cannabinoids.This review provides valuable insights into the efficient biosynthesis and green production of cannabinoids,and the development and utilization of novel Cannabis varieties.
基金We thank Professor Pengcheng Wei of Anhui Agricultural University for his guidance on the experimental methods.This work was supported by the National Key Research and Development Program of China(Grant No.2022YFD2100101)the Joint NSFC-ISF Research Program(Grant No.32061143022)+1 种基金the 2115 Talent Development Program of China Agricultural University(Grant No.1061-00109017)to HZthe National Natural Science Foundation of China(Grant No.3217180159).
文摘Dear Editor,Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR)is a powerful and versatile gene editing system that has been extensively utilized in various animals and plants,which holds enormous potential and value for scientific research and breeding.However,single-targeted CRISPR can only induce a few base deletions,insertions,or substitution.Ideally,thesemutations result in premature termination of the protein encoded by the target gene,leading to a loss of function[1].
基金the National Key Research and Development Program of China(Grant No.2021YFB3601300)the National Natural Science Foundation of China(Grants Nos.52161160334,52271237,12274437,12134017,and 12174426)+2 种基金the Science Center of the National Science Foundation of China(Grant No.52088101)the Beijing Natural Science Foundation(Grant No.Z190009)the K.C.Wong Education Foundation(Grant No.GJTD2019-14)。
文摘Two-dimensional van der Waals magnetic materials have demonstrated great potential for new-generation high-performance and versatile spintronic devices.Among them,magnetic tunnel junctions(MTJs)based on A-type antiferromagnets,such as CrI_(3),possess record-high tunneling magnetoresistance(TMR)because of the spin filter effect of each insulating unit ferromagnetic layer.However,the relatively low working temperature and the instability of the chromium halides hinder applications of this system.Using a different technical scheme,we fabricated the MTJs based on an air-stable A-type antiferromagnet,CrSBr,and observed a giant TMR of up to 47000%at 5 K.Meanwhile,because of a relatively high Néel temperature of CrSBr,a sizable TMR of about 50%was observed at 130 K,which makes a big step towards spintronic devices at room temperature.Our results reveal the potential of realizing magnetic information storage in CrSBr-based spin-filter MTJs.
基金This work is supported by the Defense Threat Reduction Agency Joint Science and Technology Office for Chemical and Biological Defense under Award Numbers HDTRA1-21-1-0010 and HDTRA1-21-C-0019.
文摘The interest in using therapeutic nanoparticles to bind with harmful molecules or pathogens and subsequently neutralize their bioactivity has grown tremendously.Among various nanomedicine platforms,cell membrane-coated nanoparticles,namely,“cellular nanosponges,”stand out for their broadspectrum neutralization capability challenging to achieve in traditional countermeasure technologies.Such ability is attributable to their cellular function-based rather than target structure-based working principle.Integrating cellular nanosponges with various synthetic substrates further makes their applications exceptionally versatile and adaptive.This review discusses the latest cellular nanosponge technology focusing on how the structure–function relationship in different designs has led to versatile and potent medical countermeasures.Four design strategies are discussed,including harnessing native cell membrane functions for biological neutralization,functionalizing cell membrane coatings to enhance neutralization capabilities,combining cell membranes and functional cores for multimodal neutralization,and integrating cellular nanosponges with hydrogels for localized applications.Examples in each design strategy are selected,and the discussion is to highlight their structure–function relationships in complex disease settings.The review may inspire additional design strategies for cellular nanosponges and fulfill even broader medical applications.
文摘The mortality rate decreases as the early detection of Breast Cancer(BC)methods are emerging very fast,and when the starting stage of BC is detected,it is curable.The early detection of the disease depends on the image processing techniques,and it is used to identify the disease easily and accurately,especially the micro calcifications are visible on mammography when they are 0.1 mm or bigger,and cancer cells are about 0.03 mm,which is crucial for identifying in the BC area.To achieve this micro calcification in the BC images,it is necessary to focus on the four main steps presented in this work.There are three significant stages of the process assigned to find the BC using a thermal image;the image processing procedures are described below.In the first stage of the process,the Gaussian filter technique is implemented to magnify the screening image.During the second stage,BC detection is separated from the pre-processed image.The Proposed Versatile K-means clustering(VKC)algorithm with segmentation is used to identify the BC detection form of the screening image.The centroids are then recalculated using proposed VKC,which takes the mean of all data points allocated to that centroid’s cluster,lowering the overall intracluster variance in comparison to the prior phase.The“means”in K-means refers to the process of averaging the data and determining a new centroid.This process eliminates unnecessary areas of interest.First,the mammogram screening image information is taken from the patient and begins with the Contiguous Convolutional Neural Network(CCNN)method.The proposed CCNN is used to classify the Micro calcification in the BC spot using the feature values is the fourth stage of the process.The assess the presence of high-definition digital infrared thermography technology and knowledge base and suggests that future diagnostic and treatment services in breast cancer imaging will be developed.The use of sophisticated CCNN techniques in thermography is being developed to attain a greater level of consistency.The implemented(CCNN)technique’s performance is examined with different classification parameters like Recall,Precision,F-measure and accuracy.Finally,the Breast Cancer stages will be classified based on the true positive and true negative values.
文摘A mid the ever-changing tides of fashion,Arc’teryx,a high-performance outdoor equipment brand known for leading innovations in outdoor apparel tech and once beloved by middleaged outdoor enthusiasts,has now secured a place as social currency for Chinese trendsetters.Salomon,once associated with the“ugly shoe”aesthetic exclusive to mountaineers,has become a coveted fashion essential,commanding premium prices driven by fervent demand.In addition,as the Lululemon brand evolves from its body-conscious fit origins for yoga enthusiasts to a versatile wardrobe staple for commuters.
文摘A versatile filmmaker who has been dedicated to directing a wide range of short films.AT the Shanghai International Advertising Festival (SHIAF) 2021 held in July 2021, director Wang Yucheng was the recipient of three shining trophies.Behind the scenes, he is a low-key person who is dedicated to creating advertisements and short films. He has won the nickname“chameleon director”for his passion of finding ways to exhibit a different style in each video, so as to make the artwork fit the theme and impress every audience.
文摘随着现场可编程门阵列(Field Programmable Gate Array,FPGA)在现代航天领域的广泛应用,FPGA的单粒子效应(Single Event Effect,SEE)逐渐成为人们的研究热点。选择Microsemi公司Flash型FPGA分布范围最广的可编程逻辑资源VersaTile和对单粒子效应敏感的嵌入式RAM单元RAM Block作为单粒子效应的主要测试对象,提出了两种不同的单粒子效应测试方法;然后,使用仿真工具ModelSim对提出的两种电路的可行性进行了仿真验证;最后,基于自主研发的实验测试平台,在兰州重离子加速器(Heavy Ion Research Facility in Lanzhou,HIRFL)上使用86Kr束进行了束流辐照实验,实验结果表明,测试方法合理有效。
文摘为了提高FPGA（Field Programmable Gate Array）的布通率并优化电路的连线长度,在模拟退火算法的基础上,该文提出一种新的FPGA布局算法。该算法在不同的温度区间采用不同的评价函数,高温阶段采用半周长法进行快速优化布局,低温阶段在评价函数中加入变量因子并进行适度的回火处理,以此来优化布局。实验表明,该算法提高了布通率,优化了连线长度,与最具代表性的VPR（Versatile Place and Route）布局算法相比布线通道宽度提高了近6%,电路总的连线长度降低了4-23%。
基金supported by the Doctoral Program of Higher Education(20130142120075)the Fundamental Research Funds for the Central Universities(HUST:2016YXMS032)National Key Research and Development Program of China(Grant No.2016YFB0700702)
文摘Metal halide perovskites are crystalline materials originally developed out of scientific curiosity. They have shown great potential as active materials in optoelectronic applications. In the last 6 years, their certified photovoltaic efficiencies have reached 22.1%. Compared to bulk halide perovskites, low-dimensional ones exhibited novel physical properties. The photoluminescence quantum yields of perovskite quantum dots are close to 100%. The external quantum efficiencies and current efficiencies of perovskite quantum dot light-emitting diodes have reached 8% and 43 cd A^(-1),respectively, and their nanowire lasers show ultralow-threshold room-temperature lasing with emission tunability and ease of synthesis. Perovskite nanowire photodetectors reached a responsivity of 10 A W^(-1)and a specific normalized detectivity of the order of 10^(12 )Jones. Different from most reported reviews focusing on photovoltaic applications, we summarize the rapid progress in the study of low-dimensional perovskite materials, as well as their promising applications in optoelectronic devices. In particular, we review the wide tunability of fabrication methods and the state-of-the-art research outputs of low-dimensional perovskite optoelectronic devices. Finally, the anticipated challenges and potential for this exciting research are proposed.
基金the National Natural Science Foundation of China(21972034,21673060)the State Key Lab of Urban Water Resource and Environment of Harbin Institute of Technology(HIT2019DX12).
文摘A novel Zn-based metal–organic framework Zn(dobdc)(datz)[Zn_(2)(H2dobdc)(datz)2$1.5DMF]with plentiful hydrogen bond donors(HBD)groups was facilely synthesized from mixed ligands.The dual activation of metal Zn sites and HBD groups for epoxides by forming Zn–O adduct and hydrogen bonds facilitated the ring-opening of epoxide substrate,which is critical for the subsequent CO_(2) fixation.Also,the existence of micropores and N-rich units in Zn(dobdc)(datz)afforded affinity towards CO_(2),which is beneficial to further improvement on catalytic CO_(2) conversion performance.Satisfactorily,Zn(dobdc)(datz)/Bu4NBr system was proved efficient heterogeneous catalyst for the CO_(2) cycloaddition with epoxides,and 98%propylene carbonate yield was obtained under mild conditions(80C,1.5 MPa and solvent-free).In addition,Zn(dobdc)(datz)/Bu4NBr exhibited remarkable versatility to different epoxides and could be completely recycled over six runs with high catalytic activity.The highly stable,easily recycle and solvent-free Zn-based MOF reported here displays eco-friendly and efficient performance to CO_(2)conversion.
文摘The paper starts with a presentation of the versatile leadership model developed by Kaplan and Kaiser and of their 360 feedback tool Leadership Versatility Index （LVI）. Versatility can be generally defined as a mastery of opposites, as the ability to play multiple roles, even contradictory ones, without emphasizing some at the expense of others. The LVI has been designed to help managers understand their repertoire and how they can become more versatile leaders. It employs an innovative rating scale on which ideal score ＂0＂ is in the middle of it （the right amount）, flanked by underdoing to the left （too little） and overdoing to the right （too much）. The idea is to avoid the ＂more is better＂ design trap by providing a way for raters to indicate when managers go to counterproductive extremes. The LVI works with two-sided view of leadership based on two major pairs of opposites： directive vs. supportive leadership and execution vs. strategy. Interventions based on the LVI results help to overcome traditional behaviorism as they combine the outer work （behavioral change） with the inner work （personal change） of development. Application of the LV1 on a sample of the managers from Skoda Auto a.s. and verification of its practical value represented the core of the SAVS IGA project MM/O7/02. The last part of the paper is devoted to a presentation of the findings from this project. The LVI has been found to be both original and a very useful 360 feedback tool which can be addressed to two general groups of clients： （1） experienced senior managers; and （2） young perspective managers in the beginning of their career.
