We develop universal quantum computing models that form a family of quantum von Neumann architectures,with modular units of memory,control,CPU,and internet,besides input and output.This family contains three generatio...We develop universal quantum computing models that form a family of quantum von Neumann architectures,with modular units of memory,control,CPU,and internet,besides input and output.This family contains three generations characterized by dynamical quantum resource theory,and it also circumvents no-go theorems on quantum programming and control.Besides universality,such a family satisfies other desirable engineering requirements on system and algorithm design,such as modularity and programmability,hence serves as a unique approach to building universal quantum computers.展开更多
Given a compact and regular Hausdorff measure space (X, μ), with μ a Radon measure, it is known that the generalised space M(X) of all the positive Radon measures on X is isomorphic to the space of essentially bound...Given a compact and regular Hausdorff measure space (X, μ), with μ a Radon measure, it is known that the generalised space M(X) of all the positive Radon measures on X is isomorphic to the space of essentially bounded functions L<sup>∞</sup>(X, μ) on X. We confirm that the commutative von Neumann algebras M⊂B(H), with H=L<sup>2</sup>(X, μ), are unitary equivariant to the maximal ideals of the commutative algebra C(X). Subsequenly, we use the measure groupoid to formulate the algebraic and topological structures of the commutative algebra C(X) following its action on M(X) and define its representation and ergodic dynamical system on the commutative von Neumann algebras of M of B(H) .展开更多
Von Hippel-Lindau病(VHL病)是VHL基因变异导致的遗传肿瘤综合征。VHL病相关肿瘤常为多发,其常规治疗方法为手术,但术后易复发。VHL基因具有缺氧诱导因子(HIF)依赖及HIF非依赖的肿瘤抑制作用,关于VHL病遗传学机制的研究为该病的治疗奠...Von Hippel-Lindau病(VHL病)是VHL基因变异导致的遗传肿瘤综合征。VHL病相关肿瘤常为多发,其常规治疗方法为手术,但术后易复发。VHL基因具有缺氧诱导因子(HIF)依赖及HIF非依赖的肿瘤抑制作用,关于VHL病遗传学机制的研究为该病的治疗奠定了基础。近年来针对VHL病遗传学机制靶向药物的出现,为该病的治疗提供了新的思路,作用于缺氧诱导通路的小分子靶向药物,如belzutifan、酪氨酸激酶抑制剂,在临床试验中对VHL病的治疗展示了良好的应用前景。本文对VHL病遗传学机制及相关治疗进展进行总结。针对VHL病靶向药物更深入的临床研究将会为该病患者提供更多的治疗选择。展开更多
Scutellaria baicalensis Georgi produces abundant root-specific f lavones(RSFs),which provide various benefits to human health.We have elucidated the complete biosynthetic pathways of baicalein and wogonin.However,the ...Scutellaria baicalensis Georgi produces abundant root-specific f lavones(RSFs),which provide various benefits to human health.We have elucidated the complete biosynthetic pathways of baicalein and wogonin.However,the transcriptional regulation of f lavone biosynthesis in S.baicalensis remains unclear.We show that the SbMYB3 transcription factor functions as a transcriptional activator involved in the biosynthesis of RSFs in S.baicalensis.Yeast one-hybrid and transcriptional activation assays showed that SbMYB3 binds to the promoter of flavone synthase II-2(SbFNSII-2)and enhances its transcription.In S.baicalensis hairy roots,RNAi of SbMYB3 reduced the accumulation of baicalin and wogonoside,and SbMYB3 knockout decreased the biosynthesis of baicalein,baicalin,wogonin,and wogonoside,whereas SbMYB3 overexpression enhanced the contents of baicalein,baicalin,wogonin,and wogonoside.Transcript profiling by qRT–PCR demonstrated that SbMYB3 activates SbFNSII-2 expression directly,thus leading to more abundant accumulation of RSFs.This study provides a potential target for metabolic engineering of RSFs.展开更多
基金Project supported by the National Natural Science Foundation of China (Grant Nos.12047503 and 12105343)。
文摘We develop universal quantum computing models that form a family of quantum von Neumann architectures,with modular units of memory,control,CPU,and internet,besides input and output.This family contains three generations characterized by dynamical quantum resource theory,and it also circumvents no-go theorems on quantum programming and control.Besides universality,such a family satisfies other desirable engineering requirements on system and algorithm design,such as modularity and programmability,hence serves as a unique approach to building universal quantum computers.
文摘Given a compact and regular Hausdorff measure space (X, μ), with μ a Radon measure, it is known that the generalised space M(X) of all the positive Radon measures on X is isomorphic to the space of essentially bounded functions L<sup>∞</sup>(X, μ) on X. We confirm that the commutative von Neumann algebras M⊂B(H), with H=L<sup>2</sup>(X, μ), are unitary equivariant to the maximal ideals of the commutative algebra C(X). Subsequenly, we use the measure groupoid to formulate the algebraic and topological structures of the commutative algebra C(X) following its action on M(X) and define its representation and ergodic dynamical system on the commutative von Neumann algebras of M of B(H) .
基金supported by the National Key R&D Program of China(2018YFC1706200)the National Natural Science Foundation of China(31870282 and 31700268)+1 种基金the Chenshan Special Fund for Shanghai Landscaping Administration Bureau Program(G182401,G192419,and G212401)the Youth Innovation Promotion Association,Chinese Academy of Sciences.
文摘Scutellaria baicalensis Georgi produces abundant root-specific f lavones(RSFs),which provide various benefits to human health.We have elucidated the complete biosynthetic pathways of baicalein and wogonin.However,the transcriptional regulation of f lavone biosynthesis in S.baicalensis remains unclear.We show that the SbMYB3 transcription factor functions as a transcriptional activator involved in the biosynthesis of RSFs in S.baicalensis.Yeast one-hybrid and transcriptional activation assays showed that SbMYB3 binds to the promoter of flavone synthase II-2(SbFNSII-2)and enhances its transcription.In S.baicalensis hairy roots,RNAi of SbMYB3 reduced the accumulation of baicalin and wogonoside,and SbMYB3 knockout decreased the biosynthesis of baicalein,baicalin,wogonin,and wogonoside,whereas SbMYB3 overexpression enhanced the contents of baicalein,baicalin,wogonin,and wogonoside.Transcript profiling by qRT–PCR demonstrated that SbMYB3 activates SbFNSII-2 expression directly,thus leading to more abundant accumulation of RSFs.This study provides a potential target for metabolic engineering of RSFs.
